Wszystkie pola: Stefanek, Tomasz - Katalog OPAC zbiorów

Tytuł:: Hydrogel microspheres containing dextran-based nanoparticles as novel anticancer drug delivery system
Autorzy:: Kulikowska-Darłak, Aleksandra
Stefanek, Agata
Wasiak-Wojasińska, Iga
Wiechecka-Ożdżyńska, Paulina
Ciach, Tomasz
Powiązania:: https://bibliotekanauki.pl/articles/2202877.pdf
Data publikacji:: 2022
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: alginate
dextran
nanoparticles
microspheres
drug delivery
alginian
dekstran
nanocząstki
mikrosfery
dostarczanie leków
Opis:: Developing an effective and safe cancer therapy could significantly reduce the number of deaths and improve the quality of life of treated patients. Nowadays medicine has developed a wide range of anticancer chemotherapeutics but at the same time there is a lack of effective drug delivery methods. Therefore, the development of the targeted drug delivery system which will selectively release drug into the cancer cells is a key challenge of modern medicine. The main aim of the presented research was to investigate the targeting effect of a drug delivery system based on the controlled release of dextran nanoparticles containing the anticancer drug – doxorubicin from the alginate microspheres coated with chitosan multilayers. During the research the physicochemical properties of the alginate microspheres and its stability in the physiological environment were investigated. Moreover, the kinetics of the nanoparticles with doxorubicin release from the alginate microspheres covered with chitosan multilayers was characterized, depending on the thickness of the chitosan layer. Further, the cytotoxicity study of the alginate microspheres covered with chitosan multilayer and containing nanoparticles was performed to determine the therapeutic effect of the released nanoparticles with doxorubicin on the HeLa cells during the in vitro cell culture.
Źródło:: Chemical and Process Engineering; 2022, 43, 3; 405--417
0208-6425
2300-1925
Pojawia się w:: Chemical and Process Engineering
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Biomimetic alginate/perfluorocarbon microcapsules - tthe effect on in vitro metabolic activity and long-term cell culture
Autorzy:: Stefanek, Agata
Kulikowska-Darłak, Aleksandra
Bogaj, Karolina
Nowak, Aleksandra
Dembska, Joanna
Ciach, Tomasz
Powiązania:: https://bibliotekanauki.pl/articles/2173417.pdf
Data publikacji:: 2022
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: alginian
mikrokapsułki
hodowla komórkowa
perfluorowęglowodory
metabolizm
alginate
microcapsules
cell culture
perfluorocarbons
metabolism
Opis:: Cell encapsulation seems to be a promising tool in tissue engineering. However, it has been shown to have several limitations in terms of long-term cell cultures due to an insufficient oxygen supply. In this study we propose the use of novel microcapsules designed for long-term cell culture consisting of an alginate shell and perfluorocarbon (PFC) core, which works as a synthetic oxygen carrier and reservoir. The influence of PFC presence in the culture as well as the size of structures on cell metabolism was evaluated during 21-day cultures in normoxia and hypoxia. We showed significant improvement in cell metabolism in groups where cells were encapsulated in hydrogel structures with a PFC core. The cells maintained a typical metabolism (oxidative phosphorylation) through all 21 days of the culture, overcoming the oxygen supply shortage even in large structures (diameter ¡ 1 mm). Applying PFC in alginate matrices can improve cell metabolism and adaptation in long-term cell cultures.
Źródło:: Chemical and Process Engineering; 2022, 43, 1; 81--95
0208-6425
2300-1925
Pojawia się w:: Chemical and Process Engineering
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Sacrum i profanum na tle krótkiej działalności Muzeum Diecezjalnego w Łomży
Sacred and profane against a backdrop of the short activity of the Diocesan Museum in Łomża
Autorzy:: Grabowski, Tomasz
Powiązania:: https://bibliotekanauki.pl/articles/1022236.pdf
Data publikacji:: 2016-06-01
Wydawca:: Katolicki Uniwersytet Lubelski Jana Pawła II
Tematy:: Stanislaw Stefanek
Tadeusz Bronakowski
Muzeum Diecezjalne w Łomży
sakralny
koncerty
kształcenie artystyczne
Diocesian Museum Lomza
built
sacral
concerts
teaches Art
Opis:: Diocesan Museum has been in Łomża since 2012. The first attempt to build it was made in 1925. The plan was to establish the museum as one building but the Diocese did not have enough money. Therefore, Museum had its place in Perish house. Then in 1981 Seminary and Pensioner Priests house was built. Diocesan Museum was to built next to the Priest House but unfortunately there was still no money. In 2009 the Bishop of Łomża Stanisław Stefanek after talks with bishop Tadeusz Bronakowski decided to run for European grant. Finally on 16th April 2012 Diocesan Museum was officially opened. The Museum is opened every day and it is visited by people who adore art especially sacral one. While visiting museum people have chance to come across regularly changed displays, sculptures and paintings. Museum organizes concerts of classical music and meetings with books’ authors. To sum up, Diocesan Museum is a great institution which teaches about Art, God and culture. So feel welcomed.
Źródło:: Archiwa, Biblioteki i Muzea Kościelne; 2016, 105; 45-51
0518-3766
2545-3491
Pojawia się w:: Archiwa, Biblioteki i Muzea Kościelne
Dostawca treści:: Biblioteka Nauki

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