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    Wyświetlanie 1-7 z 7
    Tytuł:
    Adhesion, growth and differentiation of human osteoblast-like cells on thermally oxidized Ti and TiNb substrates
    Autorzy:
    Bacakova, L.
    Vandrovcova, M.
    Jirka, I.
    Novotna, K.
    Stary, V.
    Powiązania:
    https://bibliotekanauki.pl/articles/285115.pdf
    Data publikacji:
    2013
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    osteoblasts
    substrates
    metallic materials
    Opis:
    Metallic materials are essential for construction of load-bearing bone implants, such as replacements of hip, knee and other joints. For these applications, modern materials used in advanced tissue engineering, e.g. resorbable porous or fibrous polymeric and ceramic scaffolds are mechanically insufficient, even if these materials enable the ingrowth of bone cells and bone tissue formation. Therefore, searching for new metallic materials and their surface modifications improving their biocompatibility and osseointegration is still desirable. As first metallic materials for bone implantation, AISI 316L stainless steel and Co-Cr alloys were used. In the 1950’s, the Ti-6Al-4V alloy was developed. These materials are still frequently used for construction of implants because of their relatively low price [1]. However, these materials are biomechanically incompatible with the bone tissue, because their Young’s modulus is markedly higher (110-220 GPa) than that of the bone (10-40 GPa). Implants with high stiffness take over a considerable part of load from the bone. This phenomenon, referred as “stress-shielding effect”, can then cause the bone resorption and loosening of the implant [1]. Also chemical compositions of the mentioned metallic materials limit their biocompatibility, because they contain harmful elements as V, Al, Co and Cr, which can act as cytotoxic, catabolic, immunogenic or even carcinogenic agents [2,3], and can also cause serious neurological problems [4]. Due to these adverse reactions, new types of Ti-alloys have been developed, namely low-rigidity β-type Ti alloys, containing non-toxic and non-allergenic elements (Nb, Ta, Zr etc.) and having good mechanical properties and workability [4,5]. The goal of this study was to evaluate the adhesion, growth and differentiation of osteoblast-like MG-63 and Saos-2 cells on titanium-niobium alloys after their surface modification by thermal oxidation at two different temperatures (165°C and 600°C). Pure titanium (treated at 165°C and 600°C) and polystyrene culture dishes (PS) were used as control materials. Possible immune activation of the cells was tested by the levels of TNF-alpha secreted to the cell culture media by murine macrophage-like RAW 264.7 cells cultured on the tested materials. On samples treated at 165°C, the number of initially adhered MG-63 and Saos-2 cells was on an average higher on TiNb than on Ti or PS. On day 3 after seeding, the trend of the cell numbers remained similar, with the highest cell density found on TiNb. Similar results were obtained on samples treated at 600°C, where the difference in cell number between TiNb and Ti samples became more apparent. This cell behavior could be attributed to a less negative zeta potential on TiNb samples. In samples treated at 165°C, the zeta potential of TiNb surfaces was on the average less negative than on Ti surfaces, but this difference was not significant. However, in samples treated at 600°C, this difference became much more pronounced, which was probably due to the formation of T-Nb2O5 phase on the surface of the TiNb samples. This phase was of a crystalline structure, while at 165°C, the structure of Nb2O5 was amorphous. In addition, both Ti and TiNb samples treated at 600°C contained rutile, while the samples treated at 165°C contained anatase in their surface layer. It has been shown that rutile films deposited on PEEK enhanced the adhesion and growth of osteoblasts more than anatase films [6]. This phenomenon was explained by an increase in the material surface wettability, and particularly to the presence of –OH- groups on the rutile films. The expression of collagen I and osteocalcin, i.e. an early and late marker of osteogenic cell differentiation, respectively, was higher on Ti than on TiNb samples, and this difference was more apparent in samples treated at 165°C. At the same time, no considerable immune activation of the cells on all tested samples was found. The production of TNF-α by RAW 264.7 cells was very low in comparison with cells grown in the presence of bacterial lipopolysaccharide, and also significantly lower than on untreated samples. These results indicate that TiNb substrates increased the proliferation of human bone cells, while pure Ti rather supported the cell differentiation. The effect on cell proliferation was more apparent in samples treated at the higher temperature (600°C), while the effect on cell differentiation was more pronounced at the lower temperature (165°C). None of the tested samples induce significant cell proinflammatory activation. Thus, all tested samples are suitable as carriers for bone cells; only an appropriate application (i.e., requiring either proliferation or quick differentiation of osteogenic cells) should be selected.
    Źródło:
    Engineering of Biomaterials; 2013, 16, no. 122-123 spec. iss.; 75-76
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Human osteoblast-like MG 63 cells in cultures on carbon fibre-reinforced carbon composites coated with zirconium nitride
    Autorzy:
    Paul, J.
    Bacakova, L.
    Douderova, M.
    Stary, V.
    Vyskocil, J.
    Lisa, V.
    Ślósarczyk, A.
    Zima, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/284293.pdf
    Data publikacji:
    2007
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    CFRC
    włókna węglowe
    carbon fibres
    Opis:
    Zirconium nitride is considered as a promising material for strengthening for surface of various materials, especially those designed for hard tissue surgery. In this study, five groups of materials were prepared: non-modified carbon fibre-reinforced carbon composites (CFRC), CFRC ground with metallographic paper, non-ground CFRC with a layer of ZrN deposited by magnetron sputtering, ground CFRC with a ZrN layer deposited by the arc technique, and ground CFRC with a ZrN layer deposited by a magnetron. We found that all samples gave good support for the adhesion and growth of human-osteoblast-like MG 63 cells, though the cell numbers on these materials were often lower than on standard cell culture polystyrene dishes and microscopic glass coverslips. Nevertheless, ZrN films can be considered as suitable materials for surface modification of bone implants in order to improve their mechanical properties and their integration with the surrounding tissue.
    Źródło:
    Engineering of Biomaterials; 2007, 10, no. 67-68; 5-8
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ocena przydatności czterech odmian topól do uprawy w dolinie Popradu na przykładzie plantacji w Starym Sączu
    Ocenka prigodnosti chetyrjokh raznovidnostejj topolejj dlja razvedenija v doline reki Poprad na primere plantacii v nadlesnichestve Stary Sonch
    Appraisal of the usefulness of four varieties of poplars for the cultivation in the Poprad Valley on an example of the plantation at Stary Sacz
    Autorzy:
    Fabijanowski, J.
    Jaworski, A.
    Rzeszotko, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/811357.pdf
    Data publikacji:
    1974
    Wydawca:
    Polskie Towarzystwo Leśne
    Źródło:
    Sylwan; 1974, 118, 02
    0039-7660
    Pojawia się w:
    Sylwan
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The meaning of the noun ὁρκισμός in 1 Macc 6:62
    Autorzy:
    Nawrot, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1375675.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet im. Adama Mickiewicza w Poznaniu
    Tematy:
    Biblical exegesis
    Old Testament
    deuterocanonical books
    The First Book of the Maccabees
    Antiochus V Eupator
    Judas Maccabaeus
    egzegeza biblijna
    Stary Testament
    księgi deuterokanoniczne
    Pierwsza Księga Machabejska
    Antioch V Eupator
    Juda Machabeusz
    Opis:
    The discussed text of 1 Macc 6:62 contains the noun ὁρκισμός, which defines an oath givento the leader of the Maccabean revolt by the king, and which is worthy of investigation. The fact that this oath is taken by the most noble person in the country, and is given to his adversary who played the highest role in the insurrection, i.e. that of the leader, reveals the term’s significant value. Additionally, the two surrounding verbs related to the activity of taking an oath show that the term must be interpreted as an extremely important activity undertaken solemnly with a high degree of responsibility on the part of the one who takes it, so that he can keep it. What is at stake is personal honor, which guarantees the trust of the other party. An oath taken in such a way should be kept by any means necessary, even if this would require the highest costs and efforts from the one who made an oath to its beneficiary. If breaking the oath entirely ruins one’s honor, then no office can compensate for one’s loss of authority. In the discussed book, this downfall is also related to the fact that, contrary to the Jews, promises are never kept by the Gentiles.
    Źródło:
    Poznańskie Studia Teologiczne; 2018, 32; 7-27
    0209-3472
    Pojawia się w:
    Poznańskie Studia Teologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The degree of air pollution in the atmosphere at Stary Sącz, and its relation to selected meteorological elements
    Stopień zanieczyszczenia powietrza atmosferycznego w Starym Sączu i jego związek z wybranymi elementami meteorologicznymi
    Stepen' zagrjaznenija atmosfernogo vozdukha v Starom Sonche i ee svjaz' s izbrannymi meteorologicheskimi ehlementami
    Autorzy:
    Miczynski, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/797726.pdf
    Data publikacji:
    1989
    Wydawca:
    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie. Wydawnictwo Szkoły Głównej Gospodarstwa Wiejskiego w Warszawie
    Opis:
    During the years of 1976 and 1977, in Stary Sącz, the concentration of dust and sulfur dioxide in the atmosphere was measured. Periodic occurrence of relatively high concentration of air pollution was observed, and its relation to the meteorological conditions was studies.
    W latach 1976-1977 mierzono stężenie pyłu i dwutlenku siarki w powietrzu w Starym Sączu. Stwierdzono okresowe występowanie stosunkowo wysokich stężeń zanieczyszczeń powietrza. Badano ich związek z warunkami meteorologicznymi.
    В 1976-1977 гг. измерялась концентрация пыли и двуокиси серы в воздухе в Старом Сонче. Отмечено периодическое появление сравнительно высоких концентраций загрязнений воздуха. Исследовалась их связь о метеорологическими условиями.
    Źródło:
    Zeszyty Problemowe Postępów Nauk Rolniczych; 1989, 369
    0084-5477
    Pojawia się w:
    Zeszyty Problemowe Postępów Nauk Rolniczych
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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