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    Wyświetlanie 1-4 z 4
    Tytuł:
    Selectivity of oxidative stress targeting in estrogen-induced experimental nephrocarcinogenesis.
    Autorzy:
    Kobiela, Jarek
    Krajewski, Jacek
    Kalińska-Błach, Beata
    Stefaniak, Tomasz
    Powiązania:
    https://bibliotekanauki.pl/articles/1043806.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    estrogen-induced carcinogenesis
    protein carbonyl group
    renal carcinogenesis
    oxidative stress
    Opis:
    Specificity of targeting of the oxidative stress towards lipid and protein fractions in a model of estrogen-induced Syrian hamster nephrocarcinogenesis was evaluated. The amount of proteins modified by oxidative stress was significantly elevated as early as one month after the initial implantation of estradiol to the experimental versus the control group, while the stress did not affect lipids. Subcellular localization of the oxidative stress target was determined by the analysis of protein oxidation in subcellular fractions of kidney cells. The endoplasmic reticulum membranes were the fraction most affected by the oxidative stress.
    Źródło:
    Acta Biochimica Polonica; 2002, 49, 1; 51-58
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Bariatric surgery in morbidly obese patients with chronic renal failure, prepared for kidney transplantation – case reports
    Autorzy:
    Proczko, Monika
    Kaska, Łukasz
    Kobiela, Jarek
    Stefaniak, Tomasz
    Zadrożny, Dariusz
    Śledziński, Zbigniew
    Powiązania:
    https://bibliotekanauki.pl/articles/1396227.pdf
    Data publikacji:
    2013-07-01
    Wydawca:
    Index Copernicus International
    Tematy:
    chronic kidney disease
    kidney transplant
    morbid obesity
    Roux-en-Y gastric by-pass (RYGB)
    Opis:
    Recent years, obesity is a growing health problem also in patients with chronic renal failure and end it’s end stage. This situation has a negative impact both on the extension of the waiting period for transplantation, and the survival rate of the transplanted organ and the recipient. Weight loss through lifestyle modification before transplantation is ambiguous. Its well known fact of rapid body mass gain after transplantation, and finnaly the results of transplantation are not better than those of patients who have not reduced body weight. The paper presents preliminary experience associated with bariatric operations of three chronic dialysed patients with morbid obesity BMI> 35 kg/m2, all patients had been treated by Roux-en-Y gastric by-pass (RYGB). All operated patients were classified as potential recipients were listed by Poltransplant. One of them three months after RYGB surgery underwent without complications a renal transplantation. Preliminary experiences based on operating these three caese confirmed the complete safety of this type of approach in patients with end-stage chronic kidney disease (CKD).
    Źródło:
    Polish Journal of Surgery; 2013, 85, 7; 407-411
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Sources of medical information of patients referred to colorectal surgery outpatient clinic for hemorrhoidal disease
    Autorzy:
    Spychalski, Piotr
    Perdyan, Adrian
    Łaski, Dariusz
    Kobiela, Jarek
    Błażyńska-Spychalska, Agata
    Łachiński, Andrzej
    Śledziński, Zbigniew
    Powiązania:
    https://bibliotekanauki.pl/articles/895825.pdf
    Data publikacji:
    2019-06-04
    Wydawca:
    Gdański Uniwersytet Medyczny
    Tematy:
    hemorrhoids
    internet
    patient preference
    google trends
    search engine
    Opis:
    Background: We surveyed patients with hemorrhoids about their behavior regarding searching for information about that disease and confronted it with data obtained from Google Trends website and Google searches. We aimed to determine sources of information on hemorrhoids used by patients. Secondary aim was to assess the quality of information provided by Internet in particular. Material and methods: We collected 78 surveys from patients of the outpatient surgical clinic at Medical University of Gdańsk, in which we asked about sources of information about hemorrhoids. We used Google Trends to analyze most often used search queries associated with that topic. In result, we analyzed the content of top 10 Google search results of that queries in order to verify reliability. Results: Over 80% of surveyed patients looked for information about that disease online, 50% of whom were satisfied with the quality of information obtained. Our Google Trends analysis showed that term hemorrhoids has overwhelming prevalence in comparison to remaining terms. Analysis of top 10 Google search results showed that 7 in 10 organic links lead to websites with professional information about hemorrhoids. Conclusions: Patients use the Internet as a source of knowledge about hemorrhoids and find it satisfactory. Moreover, our research indicates that this information is reliable.
    Źródło:
    European Journal of Translational and Clinical Medicine; 2019, 2, 1; 36-43
    2657-3148
    2657-3156
    Pojawia się w:
    European Journal of Translational and Clinical Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Dynamics of estrogen-induced oxidative stress
    Autorzy:
    Kobiela, Jarek
    Stefaniak, Tomasz
    Krajewski, Jacek
    Kalinska-Blach, Beata
    Zurawa-Janicka, Dorota
    Lachinski, Andrzej
    Gackowski, Daniel
    Olinski, Ryszard
    Nowak, Jerzy
    Knap, narcyz
    Lipinska, Barbara
    Sledzinski, Zbigniew
    Wozniak, Michal
    Powiązania:
    https://bibliotekanauki.pl/articles/1041076.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    8-oxodGuo
    estradiol
    protein oxidation
    carcinogenesis
    DNA damage
    lipid peroxidation
    Opis:
    The objective of this study was to assess the dynamics of oxidative damage to cellular macromolecules such as proteins, lipids and DNA under conditions of oxidative stress triggering early stages of estrogen-dependent carcinogenesis. A rodent model of carcinogenesis was used. Syrian hamsters were sacrificed after 1, 3, 5 h and one month from the initial implantation of estradiol. Matching control groups were used. Kidneys as target organs for estradiol-mediated oxidative stress were excised and homogenized for biochemical assays. Subcellular fractions were isolated. Carbonyl groups (as a marker of protein oxidation) and lipid hydroxyperoxides were assessed. DNA was isolated and 8-oxodGuo was assessed. Electron paramagnetic resonance spectroscopy was used to confirm the results for lipid peroxidation. Exposition to estradiol in the rodent model leads to damage of macromolecules of the cell, including proteins and DNA, but not lipids. Proteins appear to be the primary target of the damage but are closely followed by DNA. It has previously been speculated that protein peroxides can increase DNA modifications. This time sequence was observed in our study. Nevertheless, the direct relation between protein and DNA damage still remains unsolved.
    Źródło:
    Acta Biochimica Polonica; 2007, 54, 2; 289-295
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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