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Tytuł:
Peripheral regulatory T cells and anti-inflammatory cytokines in children with juvenile idiopathic arthritis
Autorzy:
Sznurkowska, Katarzyna
Boćkowska, Małgorzata
Zieliński, Maciej
Plata-Nazar, Katarzyna
Trzonkowski, Piotr
Liberek, Anna
Kamińska, Barbara
Szlagatys-Sidorkiewicz, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1038532.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Tregs
IL-10
TGF-β1
juvenile idiopathic arthritis
Opis:
Background: Juvenile idiopathic arthritis (JIA) is a chronic, heterogenous inflammatory disease of unclear pathogenesis. JIA is hypothesized to be linked to a defective immune regulation. Anti-inflammatory cytokines belong to the best known regulatory factors. T-regulatory cells are a crucial cellular component of immune tolerance. One of their functions is synthesis of interleukin 10 (IL-10) and transforming growth factor beta1 (TGF-β1). The aim of this study was to determine the proportion of T-regulatory cells (CD4+CD25highFOXP3+) in peripheral blood, and serum levels of TGF-β1 and IL-10 in patients with JIA. Methods: The study included 25 patients with newly diagnosed JIA: oligoarthritis (n=17) and polyarthritis (n=8). The control group was comprised of 17 healthy children. CD4+CD25highFOXP3+ T cells in peripheral blood were quantified by means of three-color flow cytometry. Serum concentrations of TGF-β1 and IL-10 were estimated with ELISA. Results: The proportion of peripheral CD4+CD25highFOXP3+ cells in patients with JIA was significantly higher than in the controls (p=0.04). The two groups did not differ significantly in terms of their TGF-β1 and IL-10 concentrations. Conclusions: At the time of diagnosis, children with JIA presented with an elevated proportion of T-regulatory cells (CD4+CD25highFOXP3+) in peripheral blood. Anti-inflammatory cytokines, IL-10 and TGF-β1, are not upregulated in the serum of patients with JIA, and therefore should not be considered as biomarkers of this condition.
Źródło:
Acta Biochimica Polonica; 2018, 65, 1; 119-123
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of clinical usefulness of serum neopterin determination in children with bacterial infections
Autorzy:
Plata-Nazar, Katarzyna
Luczak, Grażyna
Liberek, Anna
Dudzinska-Gehrmann, Julita
Sznurkowska, Katarzyna
Landowski, Piotr
Kaminska, Barbara
Powiązania:
https://bibliotekanauki.pl/articles/1039150.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
neopterin
children
urinary tract infections
Opis:
Neopterin (NPT) (6-D-erythro-trihydroxypropyl pteridin) is one of the indicators of the immune system activity. Elevated neopterin concentration occurs in diseases mostly involving stimulation of cellular immunity. The determination of neopterin concentration, usually in blood serum and urine but also in many other bodily fluids, has already been applied in many areas of medicine, such as transfusiology, transplantology, oncology, infectious diseases and autoimmunological diseases. Objective. The aim of this work is to evaluate clinical usefulness of serum neopterin determination in children with urinary tract infections of confirmed bacterial etiology. Material. The study involved 56 children with bacterial urinary tract infections - patients of the Clinic of Paediatrics, Paediatric Gastroenterology, Hepatology & Paediatric Nutrition of Medical University of Gdańsk in the years 2012-2013. The control group included 105 healthy children. Results. The values of NPT concentration in blood serum obtained in the group of children with urinary tract infections did not significantly differ from the values obtained in the control group. Conclusions. The determination of neopterin concentration in children with bacterial urinary tract infections is not a clinically useful parameter.
Źródło:
Acta Biochimica Polonica; 2015, 62, 1; 133-137
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Przydatność bioimpedancji segmentalnej z segmentu goleni w ocenie stanu nawodnienia organizmu ludzkiego
Autorzy:
Panasiuk-Kamińska, Katarzyna
Żmurowska, Barbara
Załuska, Alicja
Załuska, Wojciech
Jaroszyński, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/552174.pdf
Data publikacji:
2014
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
nawodnienie
bioimpedancja segmentalna
CNR .
Źródło:
Family Medicine & Primary Care Review; 2014, 3; 271-273
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Późna dorosłość z perspektywy logopedii
Late adulthood from the perspective of speech therapy
Autorzy:
Milewski, Stanisław
Kaczorowska-Bray, Katarzyna
Kamińska, Barbara
Powiązania:
https://bibliotekanauki.pl/articles/952174.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet w Białymstoku. Wydawnictwo Uniwersytetu w Białymstoku
Tematy:
late adulthood
geriatric speech therapy
gerontological linguistics
changes in linguistic communication
Opis:
Observed demographic changes mean that we are becoming a ‘greying society.’ This makes it necessary to introduce new curriculum content in the vocational training of speech therapists and creates a need for specialists in the area of therapy and functional assistance of seniors. At the same time, this indicates the need for conducting extensive studies in the field of gerontological linguistics, concerning the particularities of speech related to age as well as the specific features of communication with the elderly. In this speech the authors would like to discuss one of the directions of research on language phenomena related to old age, i.e. research on the particular manner of communication of those in the senior’s close environment (family, doctors, therapists, among others) with the senior. The style of communication with a person of senior age, being a result of social stereotypes of elderly people, may increase their discomfort and indicate paternalistic and condescending treatment of those in the highest age group. This may even be a sign of ageism, i.e. social discrimination based on people’s age.
Źródło:
Pogranicze. Studia Społeczne; 2016, 28
1230-2392
Pojawia się w:
Pogranicze. Studia Społeczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
TGF-β1, IL-10 and IL-4 in colostrum of allergic and nonallergic mothers
Autorzy:
Marek, Andrzej
Zagierski, Maciej
Liberek, Anna
Aleksandrowicz, Ewa
Korzon, Michał
Krzykowski, Grzegorz
Kamińska, Barbara
Szlagatys-Sidorkiewicz, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1040529.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
IL-10
allergy
IL-4
human milk
TGF-β1
Opis:
Objective: To determine transforming growth factor (TGF) β1, interleukin (IL) 4, and IL-10 concentrations in human milk and to assess the relationship between allergic disorders in mothers and the content of the interleukins in their milk. Material and methods: Thirty allergic and 46 healthy mothers were included in the study. Colostrum was collected 2-3 days after delivery. Cytokine concentrations were determined with commercial enzyme-linked immunosorbent systems. Results: TGF-β1was found in milk from 23 women in the control group (53.49%) and 11 in the allergy group (37.93%). When TGF-β1 was present, the median concentration was higher in the allergy group than in the control (61.5 and 30.4 pg/mL, respectively; P < 0.004). IL-10 was present in the colostrum of all the women and the median IL-10 concentration did not differ between the allergy (50.5 pg/mL) and control (51.5 pg/mL) groups. The probability of occurrence of a positive IL-4 value in the allergy group was greater than in the control group (chi-squared [df=1] = 2.60, P < 0.053). Median IL-4 level did not differ significantly between the two groups (0.5 and 0.5 pg/mL respectively). Conclusions: TGF-β1 was detected less often in the colostrum of allergic mothers than in that of mothers without allergy (but the difference was not statistically significant). IL-4 was found more often in the colostrum of allergic mothers than nonallergic ones. The allergy status did not correlate with IL-10 concentration.
Źródło:
Acta Biochimica Polonica; 2009, 56, 3; 411-414
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clinical parameters of inflammatory bowel disease in children do not correlate with four common polymorphisms of the transforming growth factor β1 gene
Autorzy:
Liberek, Anna
Jakóbkiewicz-Banecka, Joanna
Kloska, Anna
Świderska, Joanna
Kmieć, Zbigniew
Łuczak, Grażyna
Wierzbicki, Piotr
Liberek, Tomasz
Marek, Krzysztof
Plata-Nazar, Katarzyna
Sikorska-Wiśniewska, Grażyna
Kamińska, Barbara
Węgrzyn, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1039871.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
pediatric patients
gene polymorphism
Transforming growth factor β1
inflammatory bowel disease
Opis:
Transforming growth factor β1 (TGF-β1) is a cytokine affecting cell proliferation and development, which also has an immunomodulatory activity. Correlations between polymorphisms of the TGF-β1 gene and clinical parameters of inflammatory bowel disease (IBD) were reported previously in adults. Here, we tested whether such correlations occur in pediatric patients suffering from IBD. One hundred and four pediatric IBD patients were involved in this study. Among them, 36 were diagnosed with Crohn's Disease (CD) and 68 were diagnosed with ulcerative colitis (UC). The control group consisted of 103 children, in which IBD was excluded. TGF-β1 levels were determined in plasma and intestinal mucosa samples. The presence of the TGF β1 protein and the amount of TGF β1 mRNA were estimated in intestinal mucosa by immunohistochemistry and reverse transcription Real-Time PCR, respectively. Four common polymorphisms of the TGF-β1 gene were investigated: -800G/A, -509C/T, 869T/C and 915G/C. No significant correlation between TGF-β1 genotypes and (i) TGF-β1 levels in plasma and tissue samples, (ii) TGF-β1 gene expression efficiency in intestinal mucosa, (iii) IBD clinical parameters and (iv) inflammatory activity could be detected in children suffering from IBD. We conclude that, contrary to previous suggestions, the four common polymorphisms of the TGF-β1 gene do not influence the susceptibility to or clinical parameters of IBD in the tested population of children.
Źródło:
Acta Biochimica Polonica; 2011, 58, 4; 641-644
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polyadenylation and decay of 26S rRNA as part of Nicotiana tabacum response to cadmium
Autorzy:
Lewandowska, Małgorzata
Borcz, Barbara
Kamińska, Jolanta
Wawrzyński, Adam
Sirko, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1040862.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
polyadenylation of rRNA
RNA decay
programmed cell death
cadmium
tobacco
Opis:
In contrast to mRNAs, ribosomal RNAs are generally not considered to be polyadenylated. Only a few recent reports describe non-abundant polyadenylated rRNA-related transcripts that have been detected and characterized in yeast and in human cells. Here we depict the phenomenon of 26S rRNA polyadenylation and degradation that was observed in shoots of Nicotiana tabaccum plants grown in the presence of cadmium. Fragments corresponding to 26S rRNA were identified using suppression subtractive hybridization during screening for genes induced in tobacco plants upon a three-week exposure to 15 µM cadmium chloride. Extracts prepared from the above-ground tissues of cadmium-treated tobacco plants were supposed to contain exclusively polyadenylated mRNAs. Surprisingly, numerous polyadenylated fragments matching parts of 26S rRNA were identified and their presence was confirmed by Northern blot and cDNA amplification techniques. To our knowledge this is the first report on rRNA polyadenylation in plants.
Źródło:
Acta Biochimica Polonica; 2007, 54, 4; 747-755
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Helicobacter pylori increases expression of proapoptotic markers Fas and FasL on CD4 lymphocytes in children
Autorzy:
Kotłowska-Kmieć, Aldona
Bąkowska, Alicja
Szarszewski, Adam
Kamińska, Barbara
Łuczak, Grażyna
Radys, Wojciech
Landowski, Piotr
Brodzicki, Jacek
Korzon, Maria
Liberek, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1040535.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
T cell
H. pylori
FasL
Fas
apoptosis
lymphocyte
Opis:
The pathomechanism of Helicobacter pylori action upon gastric mucosa and its role in the pathogenesis of gastritis have not been fully elucidated. The aim of this study was to evaluate the most prevalent lymphocyte subpopulations of the gastric mucosa in gastritis in children, as well as to evaluate the expression of Fas and Fas ligand receptors (FasL), periapoptotic markers of gastric mucosa lymphocytes before and after H. pylori eradication. Forty nine patients aged 6 to 17 years, investigated due to chronic abdominal pain, were studied. The obtained tissue samples were analysed by immunohistochemistry. Different lymphocyte subsets were quantified on the basis of surface antigen expression (CD3, CD4, CD8, CD20), secreted cytokines (IL-4, IL-6, IFNγ) and Fas and FasL proteins in the gastric mucosa. B and T helper lymphocytes were found to play a major role in the inflammatory infiltration in the gastric mucosa in children during H. pylori infection. Their expression was found to decrease after eradication. The enhanced expression of Fas receptor on lymphocytes before treatment and a decrease of this expression after eradication of H. pylori were shown. It was demonstrated that there is a correlation between CD4 and Fas receptor expression that may induce apoptosis of the helper lymphocytes in infected children.
Źródło:
Acta Biochimica Polonica; 2009, 56, 3; 433-438
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Narodziny szpitala
Autorzy:
Kamińska-Lenard, Barbara "Basia".
Leżeński, Cezary.
Powiązania:
Zetrzyj z włosów pył bitewny Warszawa, 1996 S. 91-94
Data publikacji:
1996
Tematy:
Boye, Maria "Tapta"
Kessel, Kazimierz
Górski, Janusz
Bayer, Stanisław "Leliwa"
Kondracka-Bayer, Jadwiga
Nowakowska, Kazimiera
Warszawa. Szpital Polowy ul. Wilcza 61 sierpień 1944 r. pamiętniki
Powstanie warszawskie (1944)
Zabezpieczenie medyczne
Pamiętniki i wspomnienia
Opis:
Wspomnienia sanitariuszki -- zorganizowanie szpitala "Wilcza 61" w mieszkaniu p. Boye.
Dostawca treści:
Bibliografia CBW
Artykuł
Tytuł:
Edukacja międzykulturowa w warunkach kultury globalnej. Od rozważań definicyjnych do praktycznych zastosowań. Sprawozdanie z XI Międzynarodowej Konferencji Naukowej z cyklu „Edukacja XXI wieku”, Zakopane 23-25 października 2013 r. Barbara Kamińska-Czubała
Autorzy:
Kamińska-Czubała, Barbara
Powiązania:
https://bibliotekanauki.pl/articles/554870.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej w Krakowie
Źródło:
Biblioteka i Edukacja; 2014, 5
2299-565X
Pojawia się w:
Biblioteka i Edukacja
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Praca nad tempem mówienia w logopedii artystycznej i medialnej – potrzeby i możliwości
Working on the Rate of Speaking in Artistic Speech Therapy for the Mass-Media – Needs and Possibilities
Autorzy:
Kamińska, Barbara
Powiązania:
https://bibliotekanauki.pl/articles/892699.pdf
Data publikacji:
2020-08-27
Wydawca:
Polskie Towarzystwo Logopedyczne
Tematy:
tempo mówienia
logopedia artystyczna
logopedia medialna
speed of speaking
artistic speech therapy
speech therapy for the mass-media
Opis:
W artykule poruszono problem tempa jako jednego z kilku elementów tekstu przygotowywanego do odczytania lub wygłoszenia, podkreślając związek tempa z wyrazistością mówienia. Wskazano na używane w literaturze z zakresu fonetyki i fonologii, ortofonii, logopedii artystycznej terminy określające szybkość mówienia i opisujące jego zróżnicowanie. Na podstawie analizy przykładowych nagrań tekstów, które są lub mogą być przedmiotem pracy w logopedii artystycznej i/lub medialnej, pokazano różnice tempa, wynikające z charakteru tekstu, typu i sytuacji wypowiedzi. Zwrócono także uwagę na czynniki, jakie powinny być brane pod uwagę przy pracy nad tempem mówienia.
The article discusses the problem of pace as one of several elements of the text prepared to be read or delivered, emphasizing the relationship between pace and clarity of speaking. The terms defining the speed of speaking and describing its diversity, used in the literature in the field of phonetics and phonology, orthophony and artistic speech therapy, are indicated. On the basis of the analysis of sample recordings of texts that are or may be the subject of work in artistic speech therapy and/or speech therapy for the mass-media, differences in pace, resulting from the nature of the text, type and situation of the speech, have been shown. The article also highlights the factors that should be taken into account when working on the pace of speaking.
Źródło:
Logopedia; 2018, 47, 2; 317-328
0459-6935
Pojawia się w:
Logopedia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Przyczyny i konsekwencje zmian w narządzie żucia u osób starszych
Autorzy:
Kamińska, Barbara
Kaczorowska-Bray, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/667550.pdf
Data publikacji:
2017
Wydawca:
Wydawnictwo Uniwersytetu Śląskiego
Opis:
Causes and Consequences of Changes in Chewing Organ of the ElderlyThe article discusses the phenomena connected with physiological changes occurring in the stomatognathic system of the elderly. It points to their relation with the activities of chewing and swallowing as well as the general state of health and social functioning of older people. The issues addressed in the text are of vital importance not only for dentists and geriatrists, but also for speech therapists and other specialists working with seniors.Key words: gerontologopaedics, stomatognathic system, chewing organ
Źródło:
Logopedia Silesiana; 2017, 6; 46-56
2300-5246
2391-4297
Pojawia się w:
Logopedia Silesiana
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The vocal competence of children and youth - diagnostic research
Autorzy:
Kamińska, Barbara
Powiązania:
https://bibliotekanauki.pl/articles/780243.pdf
Data publikacji:
2011
Wydawca:
Uniwersytet im. Adama Mickiewicza w Poznaniu
Tematy:
vocal competence
diagnostic research on singing
vocal development
assessment of singing
scale of vocal competence
Opis:
There is a prevailing conviction that Poles cannot sing. The custom of singing has died out in families, and it is even waning in music lessons in school. There is a general perception that singing skills are conditioned by the possession of special musical abilities and that not everyone can master them. This article presents the results of my diagnostic research carried out at the end of the 1980s and reprised by other scholars in recent years. Because the same research method and procedures were used in all this research, it is possible to compare the results and observe any changes in the level of singing skills over the space of around twenty years. The research signals an alarming situation in respect to such an important musical competence as singing. After the twenty years that have passed since the first research, we observe a decline in the ability to sing among children and youngsters.
Źródło:
Interdisciplinary Studies in Musicology; 2011, 10; 87-96
1734-2406
Pojawia się w:
Interdisciplinary Studies in Musicology
Dostawca treści:
Biblioteka Nauki
Artykuł
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