Wszystkie pola: Jankowski, Maciej - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Metformin reduces NAD(P)H oxidase activity in mouse cultured podocytes through purinergic dependent mechanism by increasing extracellular ATP concentration
Autorzy:: Piwkowska, Agnieszka
Rogacka, Dorota
Jankowski, Maciej
Angielski, Stefan
Powiązania:: https://bibliotekanauki.pl/articles/1039452.pdf
Data publikacji:: 2013
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: AMP-activated kinase
free radicals
metformin
NAD(P)H oxidase
podocytes
purinoceptors
Opis:: Hyperglycemia affects the functioning numbers of podocytes and leads to a gradual decline of renal function. The normalization of glucose level is a principle therapeutic goal in diabetic patients and metformin is a popular hypoglycemic drug used in type 2 diabetes mellitus. Metformin activates AMP-activated kinase (AMPK) and decreases NAD(P)H oxidase activity in podocytes leading to reduction of free radical generation. Similar effects are observed after activation of P2 receptors. Therefore, we investigated whether metformin increases extracellular ATP concentration and affects the activities of NAD(P)H oxidase and AMPK through P2 receptors. Experiments were performed on cultured mouse podocytes. NAD(P)H oxidase activity was measured by chemiluminescence and changes in AMPK activity were estimated by immunoblotting against AMPKα-Thr172-P. Metformin increased extracellular ATP concentration by reduction of ecto-ATPase activity, decreased NAD(P)H oxidase activity and increased AMPK phosphorylation. A P2 receptor antagonist, suramin (300 µM), prevented metformin action on NAD(P)H oxidase and AMPK phosphorylation. The data suggests a novel mechanism of metformin action, at least in podocytes. Metformin, which increases extracellular ATP concentration leads to activation of P2 receptors and consequent modulation of the podocytes' metabolism through AMPK and NAD(P)H oxidase which, in turn, may affect podocyte functioning.
Źródło:: Acta Biochimica Polonica; 2013, 60, 4; 607-612
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Sejm 14 marca 2001.
Autorzy:: Janowski, Gabriel (1947- ).
Jankowski, Maciej Stanisław.
Ujazdowski, Kazimierz Michał (1964- ).
Lityński, Jan (1946-2021).
Powiązania:: Orzeł Biały. Miesięcznik Zrzeszenia Wolność i Niezawisłość 2001, nr 9, s. 3-4
Data publikacji:: 2001
Tematy:: Sejm (1997-2001)
Zrzeszenie "Wolność i Niezawisłość" (1945-1947)
Dostawca treści:: Bibliografia CBW

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Skocz do pozycji: 3.

Tytuł:: Lewostronna przepuklina Spigela z nietypową zawartością worka
Autorzy:: Karkocha, Dominika
Lech, Gustaw
Jankowski, Mieczysław
Słodkowski, Maciej
Powiązania:: https://bibliotekanauki.pl/articles/1392124.pdf
Data publikacji:: 2019
Wydawca:: Index Copernicus International
Tematy:: leczenie operacyjne przepuklin
przepuklina Spigela
wyrostek robaczkowy
Opis:: Przepuklina Spigela należy do najrzadziej występujących przepuklin przedniej ściany jamy brzusznej. Autorzy przedstawiają przypadek 53-letniej chorej z lewostronną przepukliną Spigela o nietypowej zawartości, którą stanowiła kątnica z wyrostkiem robaczkowym i kilkoma pętlami jelita cienkiego. Epizod przebytej przed kilku laty operacji pęcherza moczowego wskazywał na przepuklinę pooperacyjną. Jednak prawidłowe rozpoznanie zostało postawione dopiero śródoperacyjnie. Plastykę przepukliny wykonano z użyciem siatki. Przebieg pooperacyjny był niepowikłany.
Źródło:: Polish Journal of Surgery; 2019, 91, 6; 47-49
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Left-sided Spigelian hernia with nontypical hernial sac content
Autorzy:: Karkocha, Dominika
Lech, Gustaw
Jankowski, Mieczysław
Słodkowski, Maciej
Powiązania:: https://bibliotekanauki.pl/articles/1392102.pdf
Data publikacji:: 2019
Wydawca:: Index Copernicus International
Tematy:: appendix
hernia-operative treatment
Spigelian hernia
Opis:: Spigelian hernia is one of the most uncommon hernia of the abdominal wall. Authors present 53 years old women with left sided spigelian hernia containing: caecum with appendix and ileum, which was an uncommon content of hernial sac. Past medical history of urinary bladder operation suggested postoperative hernia. However, the correct diagnosis was made during the operation. Hernioplasty was made with mesh onlay method. The postoperative course was unevenful.
Źródło:: Polish Journal of Surgery; 2019, 91, 6; 47-49
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Interdisciplinary interventional and physiotherapy management of facet joint syndrome
Autorzy:: Broda, Maciej
Miler, Julia
Jankowski, Konrad
Rogowski, Bartosz
Krakowiak, Mateusz
Sokal, Paweł
Powiązania:: https://bibliotekanauki.pl/articles/24987721.pdf
Data publikacji:: 2023-07-11
Wydawca:: Gdański Uniwersytet Medyczny
Tematy:: Low-back pain
Facet joint syndrome
Radiofrequency facets denervation
physiotherapy
Opis:: Low back-pain is the most common pain syndrome. Radiofrequency facet denervation (RFD) is a minimally invasive method of treatment of chronic low back pain caused by facet joint syndrome. In this procedure electric current with frequency of radio waves are used to cause thermal injury to a small branch nerve that innervates painful facets. There are numerous studies confirming the effectiveness of this therapy. A good outcome of RFD can be sustained by appropriate and regular exercise. The aim of this article is to recommend such a program of exercises focused on strengthening the muscles and improving stabilization of the lumbar spine.
Źródło:: European Journal of Translational and Clinical Medicine; 2023, 6, 2; 78-84
2657-3148
2657-3156
Pojawia się w:: European Journal of Translational and Clinical Medicine
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Zastosowanie modeli wnioskowania rozmytego w projektowaniu struktury interfejsu systemu rekomendującego
Application of fuzzy inference models in the web recommending interface design
Autorzy:: Jankowski, Jarosław
Janiak, Maciej
Powiązania:: https://bibliotekanauki.pl/articles/432091.pdf
Data publikacji:: 2014
Wydawca:: Wydawnictwo Uniwersytetu Ekonomicznego we Wrocławiu
Tematy:: web recommending systems
fuzzy modeling
fuzzy inference
Opis:: Features of web-based recommending systems can be considered both from the perspective of providing access to certain options or from the commercial applications and marketing. Due to different applications different objectives and criteria for their evaluation, and application areas can be distinguished here. In the case of online platforms focused on business goals recommending interfaces play an important role that provide matching products to customer preference. Research areas related to recommending systems have usually focused on algorithmic layer and mechanisms of selection of offers. More and more often, attention is also drawn to the way of visualization offers and presentation layer. The article examines the design of recommending interfaces focused on certain acquisition-oriented interaction with a receiver, and the use of mechanisms of selection of the level of influence and persuasion. The solution enables the selection of design options, and multi-criteria assessment of the effects, which is meant to take into account both business purpose and customer satisfaction level.
Źródło:: Informatyka Ekonomiczna; 2014, 2(32); 86-94
1507-3858
Pojawia się w:: Informatyka Ekonomiczna
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Acute methoxetamine and amphetamine poisoning with fatal outcome: A case report
Autorzy:: Wiergowski, Marek
Anand, Jacek
Krzyżanowski, Maciej
Jankowski, Zbigniew
Powiązania:: https://bibliotekanauki.pl/articles/2178876.pdf
Data publikacji:: 2014-08-06
Wydawca:: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:: acute poisoning
methoxetamine (MXE)
amphetamine
fatal new drug intoxication
gas chromatography
mass spectrometry
Opis:: Methoxetamine (MXE) is a psychoactive substance distributed mostly via the Internet and is not liable to legal regulation in Poland. MXE has a toxicity profile similar to that of ketamine but longer-lasting effects. The paper describes a case of acute poisoning that resulted from recreational use of MXE and amphetamine and ended in death. In mid-July 2012, a 31-year old man was admitted to the clinical toxicology unit in Gdańsk because of poisoning with an unknown psychoactive substance. The patient was transported to the emergency department (ED) at 5:15 a.m. in a very poor general condition, in a deep coma, with acute respiratory failure, hyperthermia (> 39°C) and generalized seizures. Laboratory tests showed marked leukocytosis, signs of massive rhabdomyolysis, hepatic failure and beginning of acute renal failure. Despite intensive therapy, the patient died 4 weeks after the poisoning in the course of multi-organ dysfunction syndrome. Chemical and toxicological studies of serum and urine samples collected on the poisoning day at 1:40 p.m. confirmed that amphetamine and MXE had been taken earlier that day. Concentration of amphetamine in the serum (0.06 μg/ml) was within the non-toxic range, while MXE (0.32 μg/ml) was within the toxic range of concentrations. Amphetamine was also detected in the patient's hair, which suggested a possibility of its use within the last dozen weeks or so. The serious clinical course of intoxication and co-existence of amphetamine and MXE in the patient's blood and urine suggest the possibility of adverse interactions between them.
Źródło:: International Journal of Occupational Medicine and Environmental Health; 2014, 27, 4; 683-690
1232-1087
1896-494X
Pojawia się w:: International Journal of Occupational Medicine and Environmental Health
Dostawca treści:: Biblioteka Nauki