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    Wyświetlanie 1-4 z 4
    Tytuł:
    Effect of Solublising Aids on The Entrapment of Loratidine in Pre-Fabricated PVA Filaments Used for FDM Based 3D-Printing
    Autorzy:
    Mahmood, Faisal
    Hussain, Amjad
    Arshad, Muhammad Sohail
    Abbas, Nasir
    Irfan, Muhammad
    Qamar, Nadia
    Hussain, Fahad
    Ghori, Muhammad Usman
    Powiązania:
    https://bibliotekanauki.pl/articles/895332.pdf
    Data publikacji:
    2020-02-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    3D printing
    Plasticizers
    Fused deposition modelling (FDM)
    PVA filaments
    Solubilizers
    Opis:
    Low drug loading efficiency is the limiting factor in the use of pre-fabricated filaments for 3D printing of pharmaceuticals. The aim of present study was to modify the material properties of pre-fabricated filament by incorporating the suitable solubilizing aids in order to enhance the drug loading efficiency. Loratadine was loaded into PVA filaments by using solubilizers (Soluplus®, Sodium lauryl sulphate) and plasticizers (glycerin and Polyethylene glycol-400) and the printability of filaments was investigated. The treated filaments were characterized for morphology and diameter changes, drug content, FTIR and thermal properties and printed into tablets of suitable dimensions. The printed tablets were also characterized for drug assay and drug release. The results have shown that the surface of different drug loaded filaments become rough with almost no change in diameter hence, these filaments remained printable. However, there was 7 to 24 times enhancement in drug content of filaments treated with particularly those pretreated with glycerin and soaked in drug solution containing Soluplus. The printed tablets have also shown almost similar drug content as their precursor filaments and the release followed diffusion mechanism in most of the formulations. The study concludes that the treatment of PVA filament with solubilizer aids has significantly improved the drug loading entrapment without compromising the printability.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 1; 175-182
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    FORMULATION AND EVALUATION OF INDOMETHACIN LOADED NANOSPONGES FOR ORAL DELIVERY
    Autorzy:
    Abbas, Nasir
    Sarwar, Komal
    Irfan, Muhammad
    Hussain, Amjad
    Mehmood, Rabia
    Arshad, Muhammad S.
    Shah, Pervaiz A.
    Powiązania:
    https://bibliotekanauki.pl/articles/895238.pdf
    Data publikacji:
    2018-10-31
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    sustained release
    indomethacin
    Nanosponges
    Emulsion solvent diffusion method
    Franz diffusion cell
    Opis:
    Nanosponges (NS) loaded sustained release tablet formulations of a non-steroidal anti-inflammatory drug; Indomethacin were successfully developed and evaluated for their pharmaceutical properties. Twelve nanosponge formulations were fabricated by solvent diffusion method by using different ratios of drug and polymers (ethyl cellulose and polyvinyl alcohol). Particle size of all the formulations was in the nano range of 221 to 625 nm and it was found dependent on the polymer concentration. Drug loading and entrapment efficiency was ranged in 32.2 to 59.4 % and 30.1 to 64.8 %, respectively. Formulations with equal proportion of drug and polymer resulted in higher values of drug loading and entrapment efficiency. Percent yield was also found dependent on the relative drug polymer ratio with highest value of 51 % was achieved for the formulation having same drug to polymer ratio. SEM results confirmed the formation of spherical and porous structures. Structural analysis by Fourier transform infrared spectroscopy (FTIR), powder x-ray diffraction (PXRD) showed the absence of any interaction between drug and polymer. In comparison to pure drug, NS formulations showed a linear intrinsic dissolution rate (IDR) profile depicting a controlled release profile. Diffusion studies of NS formulations performed by Franz diffusion cell and dialysis bag methods showed comparable results in terms of precision and linearity of diffusion profile. Tablets prepared from the drug loaded NS showed acceptable values for hardness, friability and drug content. Release of drug from NS tablets was confirmed as sustained release behaviour.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 5; 1201-1213
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Image encryption based on Chebyshev chaotic map and S8 S-boxes
    Autorzy:
    Hussain, Iqtadar
    Anees, Amir
    Alkhaldi, Ali Hussain
    Aslam, Muhammad
    Siddiqui, Nasir
    Ahmed, Rehan
    Powiązania:
    https://bibliotekanauki.pl/articles/173918.pdf
    Data publikacji:
    2019
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    image encryption
    chaos
    noise-resistant
    statistical analysis
    key sensitivity
    Opis:
    The encryption of image data is artful as compare to others due to some special characteristics such as entropy, contrast, the correlation between the pixels, intensity, and homogeneity. During encryption process, it is conventionally not easy to manage these characteristics with non-chaotic cryptosystems. Therefore for the sake of strong encryption algorithms, in last decades many cryptographers have presented invulnerable schemes for image encryption based on the chaotic maps. This manuscript aims to propose a strong encryption scheme based on a symmetric group of permutation advanced encryption standard (AES) substitution boxes and modified Chebyshev map. Principally, the secret key depends upon the parameters of Chebyshev map to create confusion in the main image and is encrypted by the scheme made from the S8 AES S-boxes and chaotic map. By this procedure, one can obtain an encrypted image that is entirely twisted. The results of analyses showed that the presented image encryption is strong and invulnerable.
    Źródło:
    Optica Applicata; 2019, 49, 2; 317-330
    0078-5466
    1899-7015
    Pojawia się w:
    Optica Applicata
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Modelling the environmental concerns of constructing the Danube - Morava - Vardar - Thessaloniki Canal using General Morphological Analysis
    Autorzy:
    Hussain, Nasir
    Jovanović Popović, Dejana
    Milinčić, Miroljub
    Powiązania:
    https://bibliotekanauki.pl/articles/2141008.pdf
    Data publikacji:
    2019
    Wydawca:
    Fundacja Centrum Badań Socjologicznych
    Tematy:
    modelling
    canal
    morphological analysis
    Morava-Vardar
    China
    problem structuring method
    Opis:
    The problem structuring method of General Morphological Analysis was used to explore the factors and uncertainties to be considered in the proposed building of a canal linking the Morava and Vardar Rivers, which in recent years has taken on greater importance given its possible link in China’s one belt initiative. Facilitated workshop sessions identified five main factors - investors, risks, the motivation to invest, type of investment and long-term benefits - and 19 conditional states resulting in 1440 unique scenarios. Using specialist software and input from subject matter specialists from the fields of geography, environment and security, 81 scenarios were isolated. Modelling indicated that over two-thirds of scenarios did not feature the impact on environmental damage such as raised pollution and effect on biodiversity. Interestingly, while financial institutions and the EU did feature because of reputational and ethical reasons, non-EU governments, construction firms and some regional governments did not. The implications of these findings warrant additional research but results of this study suggest that strengthening of governance would be required to mitigate impact on the local environment.
    Źródło:
    Journal of Sustainable Development of Transport and Logistics; 2019, 4, 1; 6-16
    2520-2979
    Pojawia się w:
    Journal of Sustainable Development of Transport and Logistics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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