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    Wyświetlanie 1-3 z 3
    Tytuł:
    Effects of gelatine-coated vascular grafts on human neutrophils
    Autorzy:
    Mayer, Frank
    Buerger, Thomas
    Halloul, Zuhir
    Lippert, Hans
    König, Brigitte
    Tautenhahn, Joert
    Powiązania:
    https://bibliotekanauki.pl/articles/1394409.pdf
    Data publikacji:
    2015
    Wydawca:
    Index Copernicus International
    Tematy:
    biocompatibility
    gelatine
    vascular grafts
    human neutrophils
    Opis:
    The aim of the study was to investigate the immune-modulatory potential of commercially available PTFE and polyester vascular grafts with and without gelatine-coating. The biomaterial-cell-interaction was characterized by changes of established parameters such as PMN-related receptors/mediators, phagocytosis potential and capacity as well as the effect of an additional plasma-dependent modulation. Material and methods. By means of a standardized experimental in vitro model, various vascular graft material (PTFE/polyester/uncoated/gelatine-coated) was used for incubation with or without plasma and co-culturing with human neutrophile granulocytes (PMN) followed by analysis of representative receptors and mediators (CD62L, CD11b, CXCR2, fMLP-R, IL-8, Elastase, LTB4 ). Oxidative burst assessed phagocytosis capacity. Results. Comparing the vascular grafts, un-coated PTFE induced the lowest magnitude of cell stimulation whereas in case of gelatine-coating, cell response exceeded those of the other vascular grafts. This was also found comparing the polyester-based prosthetic material. Gelatine-coated polyester led to a more pronounced release of elastase than gelatine- coated PTFE and the uncoated materials. The results of oxidative burst indicated a reduced phagocytosis capacity in case of gelatine-coated polyester. Plasma incubation did also provide an impact on the cellular response. While in case of gelatinecoating, PMN-related receptor stimulation became lower, it increased by native polyester. The latter one did also induce more mediators such as IL-8 and LTB4 than gelatine-coated material. Conclusions. There have been no extensive data on cell-cell interactions, cytokines and general histo-/hemocompatibility of human cells by the new generation of vascular grafts. It remains still open whether healing process and infectious resistance can be compromised by material-dependent overstimulation or reduced phagocytosis potential of the immune cells of the primary unspecific immune response induced by gelatine-coated materials.
    Źródło:
    Polish Journal of Surgery; 2015, 87, 9; 443-452
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Relevance of Primitive Carotidobasilar Anastomosis for Internal Carotid Artery Stenosis
    Autorzy:
    Udelnow, Andrej
    Goertler, Michael
    Meyer, Frank
    Halloul, Zuhir
    Powiązania:
    https://bibliotekanauki.pl/articles/1395747.pdf
    Data publikacji:
    2014-04-01
    Wydawca:
    Index Copernicus International
    Tematy:
    internal crotid artery stenosis
    primitive carotidobasilar anastomosis
    Opis:
    Primitive carotido-basilar anastomoses (PCA) are persistent fetal vessels. The aim of the study was to compare the clinical characteristics of patients operated on for internal carotid artery (ICA) stenosis with or without PCA in order to evaluate the impact of PCA on the treatment. Material and methods. Consecutive patients operated on for ICA stenosis at our university hospital were included. Surgical treatment consisted in carotid endarterectomy (CEA) with patch plastic. Results. Of the 380 CEA performed between 2006 and 2012, PCA were found in six patients (1.6%). All patients with PCA were symptomatic vs. 54% of patients without PCA (p=0.035). Significantly less posterior collateral flow was present in patients with PCA (33%) compared to those without PCA (85%, p=0.01). Only two of the six patients with PCA were diagnosed prior to surgery, none was ligated intraoperatively. PCA was not associated with stroke and restenosis at long-term follow up. Conclusions. PCA are rarely diagnosed prior to surgery in patients with ICA stenosis and need not to be ligated during CEA
    Źródło:
    Polish Journal of Surgery; 2014, 86, 4; 166-171
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    In Vitro Chemo-Sensitivity Assay Guided Chemotherapy is Associated with Prolonged Overall Survival in Cancer Patients
    Autorzy:
    Udelnow, Andrej
    Schönfelder, Manfred
    Würl, Peter
    Halloul, Zuhir
    Meyer, Frank
    Lippert, Hans
    Mroczkowski, Paweł
    Powiązania:
    https://bibliotekanauki.pl/articles/1396300.pdf
    Data publikacji:
    2013-06-01
    Wydawca:
    Index Copernicus International
    Tematy:
    chemo-sensivity in vitro
    survival prediction
    chemotherapy
    drug sensivity
    cancer
    Opis:
    The overall survival (OS) of patients suffering From various tumour entities was correlated with the results of in vitro-chemosensitivity assay (CSA) of the in vivo applied drugs. Material and methods. Tumour specimen (n=611) were dissected in 514 patients and incubated for primary tumour cell culture. The histocytological regression assay was performed 5 days after adding chemotherapeutic substances to the cell cultures. n=329 patients undergoing chemotherapy were included in the in vitro/in vivo associations. OS was assessed and in vitro response groups compared using survival analysis. Furthermore Cox-regression analysis was performed on OS including CSA, age, TNM classification and treatment course. Results. The growth rate of the primary was 73-96% depending on tumour entity. The in-vitro response rate varied with histology and drugs (e.g. 8-18% for methotrexate and 33-83% for epirubicine). OS was significantly prolonged for patients treated with in vitro effective drugs compared to empiric therapy (log-rank-test, p=0.0435). Cox-regression revealed that application of in vitro effective drugs, residual tumour and postoperative radiotherapy determined the death risk independently. Conclusions. When patients were treated with drugs effective in our CSA, OS was significantly prolonged compared to empiric therapy. CSA guided chemotherapy should be compared to empiric treatment by a prospective randomized trial.
    Źródło:
    Polish Journal of Surgery; 2013, 85, 6; 340-347
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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