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Wyszukujesz frazę "Giorgi, M." wg kryterium: Wszystkie pola

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    Wyświetlanie 1-7 z 7
    Tytuł:
    Simulation of road systems and queuing network models
    Autorzy:
    Pasini, L.
    Feliziani, S.
    Giorgi, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1964157.pdf
    Data publikacji:
    2005
    Wydawca:
    Politechnika Gdańska
    Tematy:
    queue systems
    vehicular traffic systems
    computer networks simulation
    Opis:
    The purpose of this paper is to describe the versatility of queuing network systems for modelling vehicular traffic flows in road systems. These techniques are applicable in a simulation context because of the complexity of the resulting models, which can not be solved by mathematical analytical solvers. Moreover, these techniques can be used to model and simulate the behaviour of an automatic control system of vehicular flow in the same frame.
    Źródło:
    TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2005, 9, 4; 397-408
    1428-6394
    Pojawia się w:
    TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pharmacokinetics of tramadol and metabolites after injective administrations in dogs
    Autorzy:
    Giorgi, M.
    Del Carlo, S.
    Lebkowska-Wieruszewska, B.
    Kowalski, C.J.
    Saccomanni, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/30304.pdf
    Data publikacji:
    2010
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    pharmacokinetics
    tramadol
    metabolite
    dog
    bioavailability
    intravenous injection
    intramuscular injection
    plasma
    tramadol concentration
    Opis:
    The aim of this study was to determine the pharmacokinetics of tramadol and its main metabolites after IV and IM injections. The pharmacokinetic cross-over study was carried out on 6 healthy male beagle dogs. Tramadol was administered by intravenous (IV) and intramuscular (IM) injection at 4 mg/kg. Tramadol and its main metabolites O-desmethyl-tramadol (M1), N-,N-didesmethyl-tramadol (M2) and N-,O-didesmethyl-tramadol (M5) concentrations were measured in plasma samples by a HPLC coupled with fluorimetric detection; pharmacokinetic evaluations were carried out with a compartmental and non-compartmental model for tramadol and its metabolites, respectively. The bioavailability of the drug, ranging between 84-102% (mean 92%), was within the generally accepted values for a positive bioequivalence decision of (80-125%). After the IM injection the mean plasma drug concentration peak was reached after a Tmax of 0.34 h with a Cmax of 2.52 μg/mL. No therapeutic relevant differences were observed between IM and IV administration. The minimal effective plasma concentration was reached after a few minutes and maintained for about 6-7 h in both administrations. M1 plasma concentration was low and the amounts of the other metabolites produced were analogous in both routes of administration. In conclusion, tramadol was rapidly and almost completely absorbed after IM administration and its systemic availability was equivalent to the IV injection. The different onset time and duration of action observed were very small and probably therapeutically irrelevant. The IM injection is a useful alternative to IV injection in the dog.
    Źródło:
    Polish Journal of Veterinary Sciences; 2010, 13, 4
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pharmacokinetics and pharmacodynamics (PK/PD) of irbesartan in Beagle dogs after oral administration at two dose rates
    Autorzy:
    Carlucci, L.
    Song, K.H.
    Yun, H.I.
    Park, H.J.
    Seo, K.W.
    Giorgi, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/31017.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    Irbesartan (Irb) is an angiotensin II type 1 receptor antagonist widely used in humans to treat hypertension. Age-related diseases such as hypertension are increasingly being diagnosed in dogs and there is the need for new drugs. The PK/PD of Irb was tested in Beagle dogs. Ten healthy Beagles were orally administered two dose rates (2 and 5 mg/kg), according to a cross over study design. Blood collections for PK analysis and systolic blood pressure (SBP), heart and respiratory rate, mucous membranes colour, capillary refill time and temperature evaluations were performed at scheduled intervals. The drug plasma concentration was dose dependent. The dogs administered 5 mg/kg showed a significant reduction in SBP, while in those receiving 2 mg/kg, this parameter was minimally affected. A counter clockwise hysteresis showed no direct correlation between SBP and plasma concentrations. The minimum effective concentration was theorized to be within the range 550-800 ng/mL. Although further studies are necessary, 5 mg/kg seems to be the more appropriate dose to obtain a hypotensive effect in Beagle dogs.
    Źródło:
    Polish Journal of Veterinary Sciences; 2013, 16, 3
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pharmacokinetic profiles of 5 mg/kg ibudilast, a phosphodiesterase inhibitor, orally administered to dogs in fasted and non-fasted states. A preliminary study.
    Autorzy:
    Łebkowska-Wieruszewska, B.
    De Vito, V.
    Kowalski, C.J.
    Owen, H.
    Poapolathep, A.
    Lisowski, A.
    Giorgi, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087742.pdf
    Data publikacji:
    2018
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    pharmacokinetics
    ibudilast
    dog
    non-selective cyclic nucleotide phosphodiesterase inhibitor
    Źródło:
    Polish Journal of Veterinary Sciences; 2018, 21, 2; 281-285
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Plasma profile of cimicoxib in sheep after oral administration at two different rates
    Autorzy:
    Di Salvo, A.
    Giorgi, M.
    Lee, H.K.
    Vercelli, C.
    Rueca, F.
    Trabalza Marinucci, M.
    della Rocca, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087920.pdf
    Data publikacji:
    2017
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Źródło:
    Polish Journal of Veterinary Sciences; 2017, 3; 535-538
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A remark on sensitivity in linear programming and Gale-Samuelson nonsubstitution theorem
    Autorzy:
    De Giuli, M. E.
    Giorgi, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/969906.pdf
    Data publikacji:
    2010
    Wydawca:
    Polska Akademia Nauk. Instytut Badań Systemowych PAN
    Tematy:
    linear programming
    sensitivity analysis
    nonsubstitution theorem
    Opis:
    The main purpose of this paper is to show that David Gale's result (1960, Lemma 9.3 on sensitivity in linear programming) is not generally valid. In this lemma, additional assumptions, that are instead required, are not made. We give some correct versions of the above mentioned lemma, and with these an elementary proof of the Gale-Samuelson nonsubstitution theorem.
    Źródło:
    Control and Cybernetics; 2010, 39, 3; 827-838
    0324-8569
    Pojawia się w:
    Control and Cybernetics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Return to work after coronary revascularization procedures and a patient’s job satisfaction: A prospective study
    Autorzy:
    Fiabane, Elena
    Giorgi, Ines
    Candura, Stefano M.
    Argentero, Piergiorgio
    Powiązania:
    https://bibliotekanauki.pl/articles/2177011.pdf
    Data publikacji:
    2015-02-24
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    depression
    job satisfaction
    work stress
    return to work
    cardiac rehabilitation
    Opis:
    Introduction Research into work reintegration following invasive cardiac procedures is limited. The aim of this prospective study was to explore predictors of job satisfaction among cardiac patients who have returned to work after cardiac rehabilitation (CR). Material and methods The study population consisted of 90 cardiac patients who have recently been treated with coronary angioplasty or heart surgery. They were evaluated during their CR and 12 months after the discharge using validated self-report questionnaires measuring job satisfaction, work stress-related factors, emotional distress and illness perception. Information on socio-demographic, medical and occupational factors has also been collected. Results After adjusting for demographic, occupational and medical variables, baseline job satisfaction (p < 0.001), depression (p < 0.01) and ambition (p < 0.05) turned out to be independent, significant predictors of job satisfaction following return to work (RTW). Patients who had a partial RTW were more satisfied with their job than those who had a full RTW, controlling for baseline job satisfaction. Conclusions These findings recommend an early assessment of patients’ psychosocial work environment and emotional distress, with particular emphasis on job satisfaction and depressive symptoms, in order to promote satisfying and healthy RTW after cardiac interventions.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2015, 28, 1; 52-61
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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