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    Wyświetlanie 1-7 z 7
    Tytuł:
    The North-East living quarter of the medieval pilgrim centre in Banganarti. Archaeological research in 2015 and 2016
    Autorzy:
    Dzik, Michał
    Powiązania:
    https://bibliotekanauki.pl/articles/1683707.pdf
    Data publikacji:
    2018-07-09
    Wydawca:
    Uniwersytet Warszawski. Wydawnictwa Uniwersytetu Warszawskiego
    Tematy:
    Banganarti
    medieval architecture
    vaults
    archaeology of dwellings
    Opis:
    Two seasons of fieldwork in the northeastern part of Banganarti site brought significant data on its stratification, as well as the architecture of medieval dwellings. This paper presents a summary of the results. Special attention was focused on the layout of the buildings and on vault usage. Remarks concern the functionality of the explored space, based on an interpretation of the stratigraphy. Evidence of strong water erosion in the early stages of the settlement is also discussed.
    Źródło:
    Polish Archaeology in the Mediterranean; 2017, 26(1); 287-298
    1234-5415
    Pojawia się w:
    Polish Archaeology in the Mediterranean
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Preliminary results of a stratigraphic analysis of late Roman and early Byzantine architecture in the residential quarter of Jiyeh
    Autorzy:
    Dzik, Michał
    Powiązania:
    https://bibliotekanauki.pl/articles/1727685.pdf
    Data publikacji:
    2015
    Wydawca:
    Uniwersytet Warszawski. Wydawnictwa Uniwersytetu Warszawskiego
    Tematy:
    late Roman/early Byzantine architecture
    domestic architecture
    multi-storey house
    village house
    Phoenicia
    Lebanon
    Jiyeh/Porphyreon
    Opis:
    The paper discusses the results of the first season of research undertaken to establish and document the architectural stratification of the residential quarter in Jiyeh (ancient Porphyreon). The research was started on a separate complex of 14 rooms. Three phases of building development in the late Roman and early Byzantine periods were distinguished. Evidence was found of the division of this complex into three houses. Remains of stairways identified in two of the houses proved the existence of double-storey buildings. In the northern house of the complex, the layout of recesses and corbels preserved in the walls suggests the presence of a wooden gallery, communicating at ground level with rooms on the upper floor. This paper presents also some preliminary remarks on the functional division of the houses.
    Źródło:
    Polish Archaeology in the Mediterranean; 2015, 24(1); 475-490
    1234-5415
    Pojawia się w:
    Polish Archaeology in the Mediterranean
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Uwagi o funkcji i symbolice konstrukcji wczesnośredniowiecznych grobów w obudowach kamiennych.
    Remarks on function and symbolic meaning of constructions of Early Medieval graves in stone-settings
    Autorzy:
    Dzik, Michał
    Powiązania:
    https://bibliotekanauki.pl/articles/584795.pdf
    Data publikacji:
    2014
    Wydawca:
    Łódzkie Towarzystwo Naukowe
    Tematy:
    groby w obudowach kamiennych symbolika grobu
    Drohiczyn
    dom zmarłych
    graves in stone-settings
    stone cists
    symbology of the grave
    mortuary house
    Opis:
    This paper discusses the issues of the meaning and function of constructions characteristic for so called ‘groby w obudowach kamiennych’ – early medieval flat boulder- lined graves with cobblestones covering the burials (fig. 1, 4). Burial sites with these kind of cists are quite rare but were discovered in different parts of Europe; in Poland concentrations of them are known from the Mazovia and the basin of the eastern part of the lower Bug river (fig. 2). In the first of the above-mentioned regions, these constructions are dated to the period between the mid 11th century to the beginning of the 13th century. In the second region – from the last third of the 11th century to the mid 14th century. In the literature of the subject, several explanations of the function of the discussed grave constructions were proposed. They were interpreted as structures buttressing the walls of pit-graves or maybe preventing the burials against animals. According to another hypothesis, the idea of building such cists arose in the times of Christianization of funeral customs, when inhumation replaced cremation, and stone constructions were meant to stop the deceased from rising. An opposite proposal recognises in these cists the imitation of Jesus Christ’s grave, peddled by the Church. In the most recent proposition, the discussed cists are depicted as marks of high social position, popular amongst the elites in emerging states. In this article arguments defying the abovementioned hypotheses were presented. In light of comparative studies and new data on the genesis of the aforementioned graves in eastern Poland, it seems, that these cists are the emanations of ideas according to which graves are symbolic houses built for the dead. Another probable function (apotropaic, mark of status) might aktually have had a secondary meaning, which could be given to these constructions in some regions during the evolution of funeral customs.
    Źródło:
    Acta Archaeologica Lodziensia; 2014, 60; 87-101
    0065-0986
    2451-0300
    Pojawia się w:
    Acta Archaeologica Lodziensia
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Zabytki z wczesnośredniowiecznych cmentarzysk z grobami w obudowach kamiennych pochodzące z badań Nikolaja P. Awenariusa
    Artefacts from the Early Medieval burial grounds with graves in stone-settings coming from the research of Nikolai P. Avenarius
    Autorzy:
    Dzik, Michał
    Powiązania:
    https://bibliotekanauki.pl/articles/567514.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Instytut Archeologii Uniwersytetu Rzeszowskiego. Muzeum Okręgowe w Rzeszowie
    Tematy:
    Nikolai Avenarius
    graves in stone-settings
    early medieval Polish-Rus’ borderland
    Opis:
    The aim of this paper is putting into scientific circulation archaeological finds from eight early medieval burial grounds with graves in stone-settings, from the area of Podlaskie Voivodeship (norh-eastern Poland). The finds come from excavations conducted by Russian researcher Nikolai Avenarius in 1887 and 1888. For a long time his collection, which is kept in the State Historical Museum in Moscow, has been considered to be lost. This is the reason why despite of that 130 years had passed since N. Avenarius’ excavations, hardly any information about his collection can be found in archaeological literature.
    Źródło:
    Materiały i Sprawozdania Rzeszowskiego Ośrodka Archeologicznego; 2017, 38; 185-196
    0137-5725
    Pojawia się w:
    Materiały i Sprawozdania Rzeszowskiego Ośrodka Archeologicznego
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Sulfamide antifolates inhibiting thymidylate synthase: synthesis, enzyme inhibition and cytotoxicity.
    Autorzy:
    Pawełczak, Krzysztof
    Makowski, Maciej
    Kempny, Michał
    Dzik, Jolanta
    Gołos, Barbara
    Rode, Wojciech
    Rzeszotarska, Barbara
    Powiązania:
    https://bibliotekanauki.pl/articles/1043769.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    thymidylate synthase inhibitors
    antifolate analogues
    antifolates
    p-aminobenzenesulfonic acid
    Opis:
    Synthesis and biological evaluation are described of seven new analogues (3-9) of two potent thymidylate synthase inhibitors, 10-propargyl-5,8-dideazafolate (1) and its 2-methyl-2-deamino congener ICI 198583 (2). While the new compunds 3 and 4 were analogues of 1 and 2, respectively, containing a p-aminobenzenesulfonyl residue in place of the p-aminobenzoic acid residue, the remaining 5 new compounds were analogues of 4 with the L-glutamic acid residue replaced by glycine (5), L-valine (6), L-alanine (7), L-phenylglycine (8) or L-norvaline (9). The new analogues were tested as inhibitors of thymidylate synthases isolated from tumour (Ehrlich carcinoma), parasite (Hymenolepis diminuta) and normal tissue (regenerating rat liver) and found to be weaker inhibitors than the parent 10-propargyl-5,8-dideazafolic acid. Selected new analogues, tested as inhibitors of growth of mouse leukemia L 5178Y cells, were less potent than the parent 10-propargyl-5,8-dideazafolic acid. Substitution of the glutamyl residue in compound 4 with l-norvaline (9) resulted in only a 5-fold stronger thymidylate synthase inhibitor, but a 40-fold weaker cell growth inhibitor.
    Źródło:
    Acta Biochimica Polonica; 2002, 49, 2; 407-420
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Comparative analysis of combustion of qualified composite fuel for the transitional period in the household and communal sector in Poland
    Autorzy:
    Bembenek, Michał
    Dzik, Tomasz
    Smyła, Jarosław
    Kozłowski, Artur
    Wojtas, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/27315551.pdf
    Data publikacji:
    2022
    Wydawca:
    STE GROUP
    Tematy:
    microbriquette
    environmentally friendly fuel
    solid fuel
    composite solid fuel
    qualified solid fuel
    roller press
    Opis:
    The article presents the results of laboratory combustion tests of the microbriquette obtained from useless coal (grain class of < 5 mm) generated in the production of “eco-pea” (eko-groszek) coal. The briquettes of 1.5 and 2.5 cm3 were made in a roller press of crushed coal granulation down to 2 mm, mixed with a binder and/or catalytic additives and sorbents, then dried to final moisture of about 7%. The tests were carried out on a specially designed stand enabling to determine the differential curve of the weight loss of samples heated to the ignition temperature and then burnt with laminar airflow by natural chimney draft. Comparative tests were carried out with ecopea coal from the “ZG Sobieski” mine. The results indicate that composite fuels, in the form of microbriquette, ignite faster, burn at a higher temperature and leave less ash when burned than lump coal. The greater reactivity of the briquette concerning the lump coal allows for minimizing the air rate by about 10%, which also reduces the exhaust gas volume by the same amount and the stack losses. It reduces the velocity of dust lifting, which leads to the reduction of their emission.
    Źródło:
    Management Systems in Production Engineering; 2022, 4 (30); Bibliogr. 40 poz., rys., tab.
    2299-0461
    Pojawia się w:
    Management Systems in Production Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of perphenazine and prochlorperazine on viability of human astrocytes
    Wpływ perfenazyny i prochlorperazyny na przeżywalność ludzkich astrocytów
    Autorzy:
    Otręba, Michał
    Rzepecka-Stojko, Anna
    Stojko, Jerzy
    Kabała-Dzik, Agata
    Kleczka, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/33297601.pdf
    Data publikacji:
    2024-06-28
    Wydawca:
    Śląski Uniwersytet Medyczny w Katowicach
    Tematy:
    perphenazine
    prochlorperazine
    DMSO
    human astrocytes
    viability
    WST-1
    perfenazyna
    prochlorperazyna
    ludzkie astrocyty
    przeżywalność
    Opis:
    Phenothiazine derivatives are well-known anti-psychotic drugs that possess several biological activities including anticancer activity. Much research provides data about its anticancer activity against human glioblastoma cell lines. Unfortunately, to date in vitro studies analyzing the impact of phenothiazines on the viability of human astrocytes have not been performed. However, it is possible to find one study about the viability of neurons and neurons with glia after incubation with perphenazine. Thus, in this study we measured the viability of human astrocytes after 24-, 48-, and 72-hour incubation with perphenazine and prochlorperazine dimaleate using the WST-1 assay. The obtained results suggest that perphenazine is safer for human astrocytes than prochlorperazine dimaleate. Moreover, 24-hour incubation with perphenazine or prochlorperazine did not significantly reduce cellular viability. It is a very important finding since previously we proved that in similar concentrations both drugs reduce the viability of the human glioblastoma U-87 MG cell line by approximately 50%. Therefore, the results suggest that phenothiazines can be used in glioblastoma treatment in concentrations that do not impact human astrocyte viability.
    Pochodne fenotiazyny należą do dobrze znanej grupy leków przeciwpsychotycznych, posiadających wiele nowych aktywności biologicznych, w tym działanie przeciwnowotworowe. Istnieje wiele doniesień naukowych na temat działania przeciwnowotworowego wobec ludzkich linii komórkowych glejaka wielopostaciowego. Niestety, jak dotąd nie przeprowadzono badań in vitro oceniających wpływ fenotiazyn na żywotność ludzkich astrocytów. Można jednak znaleźć badanie dotyczące żywotności neuronów i neuronów z komórkami glejowymi po inkubacji z perfenazyną. Dlatego też w niniejszym badaniu z użyciem testu WST-1 oznaczono żywotność ludzkich astrocytów po 24-, 48- i 72--godzinnej inkubacji z perfenazyną lub dimaleinianem prochlorperazyny. Uzyskane wyniki sugerują, że perfenazyna jest bezpieczniejsza dla ludzkich astrocytów niż dimaleinian prochlorperazyny. Co więcej, 24-godzinna inkubacja z perfenazyną lub prochlorperazyną nie zmniejszyła znacząco żywotności komórek. Jest to o tyle istotne, że już wcześniej wykazano, iż oba leki w podobnym stężeniu zmniejszają żywotność ludzkiego glejaka wielopostaciowego U-87 MG o około 50%. Wyniki sugerują zatem, że fenotiazyny mogą mieć zastosowanie w leczeniu glejaka wie-lopostaciowego w stężeniu, które nie wpływa na żywotność ludzkich astrocytów.
    Źródło:
    Annales Academiae Medicae Silesiensis; 2024, 78; 167-172
    1734-025X
    Pojawia się w:
    Annales Academiae Medicae Silesiensis
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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