Wszystkie pola: Domańska, Daria - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Uveal melanoma - a review of treatment methods
Autorzy:: Domańska, Aleksandra
Piekarz, Daria
Pieniążek, Barbara
Pijas, Natalia
Piecewicz-Szczęsna, Halina
Powiązania:: https://bibliotekanauki.pl/articles/51789543.pdf
Data publikacji:: 2023-12-31
Wydawca:: Medical Education
Tematy:: ocular melanoma
uveal melanoma
treatment methods
Opis:: Uveal melanoma is the most common primary intraocular malignancy. In Europe, the incidence of uveal melanoma is approximately 8 cases per million people per year. In about 50% of cases, uveal melanoma metastasizes. Scientific papers on uveal melanoma published between 1 January 2018 and 1 March 2023, available in the PubMed database were analyzed. Currently, methods such as enucleation, transpupillary thermotherapy, photodynamic therapy, eye plaque brachytherapy, proton beam therapy and stereotactic surgery are used to treat this cancer. In this paper we summarize the current knowledge about the classic treatment methods and the promising novel ones.
Źródło:: OphthaTherapy; 2023, 10, 4; 245-252
2353-7175
2543-9987
Pojawia się w:: OphthaTherapy
Dostawca treści:: Biblioteka Nauki

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Tytuł:: CTLA-4 polymorphisms (+49 A/G and -318 C/T) are important genetic determinants of AITD susceptibility and predisposition to high levels of thyroid autoantibodies in Polish children - preliminary study
Autorzy:: Pastuszak-Lewandoska, Dorota
Domańska, Daria
Rudzińska, Magdalena
Bossowski, Artur
Kucharska, Anna
Sewerynek, Ewa
Czarnecka, Karolina
Migdalska-Sęk, Monika
Czarnocka, Barbara
Powiązania:: https://bibliotekanauki.pl/articles/1039459.pdf
Data publikacji:: 2013
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: Graves' disease
Hashimoto's thyroiditis
autoimmune thyroid disease
CTLA-4
single nucleotide polymorphism
TAb production
Opis:: Autoimmune thyroid diseases (AITDs), including Hashimoto' s thyroiditis (HT) and Graves' disease (GD), are related to environmental and genetic factors. We analyzed the association of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) gene two polymorphisms (+49 A/G, -318 C/T) with HT and GD development in Polish children, and correlated both polymorphisms with the production of thyroid autoantibodies (TPOAb and TgAb). The study involved 49 AITD patients (age 10-19) with HT (n=25) or GD (n=24) and 69 healthy controls. SNP genotyping was performed using genomic DNA and TaqMan® probes. The obtained results indicated that CTLA-4 +49 GG genotype was significantly more frequent in both HT and GD patients, whereas the AA genotype was more common in controls. CTLA-4-318 CT genotype was significantly more frequent in AITD, and the CC genotype more often occurred in controls. Significantly higher median TPOAb and TgAb values were associated with G allele in HT, and with T allele in GD patients. Concluding, both studied polymorphisms seem to be important genetic determinants of the risk of HT and GD, and appear to be associated with a predisposition to high levels of TAbs and clinical AITD. The obtained results give more information on the distribution of the CTLA-4 polymorphism in Polish AITD children, and further support the proposal that the CTLA-4 gene plays an important role in a TAb production.
Źródło:: Acta Biochimica Polonica; 2013, 60, 4; 641-646
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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