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    Wyświetlanie 1-8 z 8
    Tytuł:
    Influence of antlerogenic stem cells on the healing of lesions in the corneal epithelium and corneal stroma in rabbits
    Autorzy:
    Kiełbowicz, M.
    Kuropka, P.
    Cegielski, M.
    Kiełbowicz, Z.
    Trębacz, P.
    Hebel, M.
    Aleksiewicz, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087321.pdf
    Data publikacji:
    2020
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    eye
    stem cells
    cornea
    rabbit
    healing
    lesions
    Źródło:
    Polish Journal of Veterinary Sciences; 2020, 23, 2; 281-290
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A REVIEW ON CYCLAMEN SPECIES: TRANSCRIPTION FACTORS VS. PHARMACOLOGICAL EFFECTS
    Autorzy:
    Cornea-Cipcigan, Mihaiela
    Pamfil, Doru
    Sisea, Cristian R.
    Gavriș, Cornelia P.
    da Graça Ribeiro Campos, Maria
    MĂRGĂOAN, Rodica
    Powiązania:
    https://bibliotekanauki.pl/articles/895434.pdf
    Data publikacji:
    2019-12-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    saponins
    volatile compounds
    ABCDE model
    cyclamin
    MADS-box genes
    medicinal properties
    Opis:
    The mechanism of floral mutation including double flowers in plant species can be explained by the ABCDE model which represents the relationship between MADS-box transcription factor genes and floral morphogenesis. The ornamental importance of Cyclamen led to the creation of double-flowered cultivars caused by the repression of AG-like gene expression in whorl 3. Modifications in these genes also influence the accumulation of different bioactive compounds depending on species and/or variety. In antiquity, cyclamen plants were recognized for their therapeutic qualities and later gained importance due to their content in saponins, which have been reported to exhibit anti-cancer, anti-inflammatory and antibacterial effects, and also to alleviate symptoms in acute rhinosinusitis patients. Furthermore, the extracts and isolated compounds are used as treatments in a wide range of diseases. In this review, we describe the transcription factors and their role in the development and ABCDE model formation of organs which led to the development of double-petal and fragrant varieties. Additionally, we describe the potential mechanisms of action underlying the therapeutic effects of saponin extracts against cancers and inflammatory disorders and their potential as a pharmacological agent in clinical studies.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 6; 919-938
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Three-dimensional biomechanical modeling and simulation of trephine cutting cornea for keratoplasty
    Autorzy:
    Su, P.
    Lu, D.
    Deng, S.
    Zhang, L.
    Hao, Y.
    Yang, Y.
    Powiązania:
    https://bibliotekanauki.pl/articles/307486.pdf
    Data publikacji:
    2018
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    rogówka
    biomechanika
    kryterium wytężeniowe
    FEM
    cornea
    biomechanics
    failure criterion
    finite element simulation
    Opis:
    Trephination is one of the basic operations of keratoplasty, and the biomechanical mechanism of the operation can be revealed based on three-dimensional modeling and simulation of trephine cutting cornea. Methods: Based on the analysis of the physical and biomechanical characteristics of corneal trephination, a three-dimensional numerical model of corneal trephination is built, where the cornea can be simplified to two layers structure including stroma and epithelium, and the trephine cuts the cornea under the vertical motion load and the rotational motion load. A three-dimensional failure criterion of corneal material is proposed based on the yield strength theory. On this basis, trephination simulation is carried out, and the units of corneal material are removed from the model when they meet the defined failure criterion. Results: Under the given parameters including the velocity, the angle and the angular velocity, the trephine force curves, include the linear cutting force and the rotary cutting force are obtained, and show the change of the forces with displacement during the process of trephination simulation. The maps of the equivalent stress show the destruction and deformation of the cornea. Then, the experiment of robotic trephination is carried out under the same parameters and the effectiveness of the simulation is evaluated. Conclusions: Based on mechanics theory and finite element method, the process of trephine cutting cornea has been reproduced, and the interaction mechanism is revealed, which lays the foundation for the development of real-time simulation and virtual system of the corneal surgery.
    Źródło:
    Acta of Bioengineering and Biomechanics; 2018, 20, 2; 23-33
    1509-409X
    2450-6303
    Pojawia się w:
    Acta of Bioengineering and Biomechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biomechanical simulation of needle insertion into cornea based on distortion energy failure criterion
    Autorzy:
    Su, P.
    Yang, Y.
    Huang, L.
    Powiązania:
    https://bibliotekanauki.pl/articles/306549.pdf
    Data publikacji:
    2016
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    rogówka
    biomechanika
    symulacja matematyczna
    cornea
    biomechanics
    insertion force
    suture
    mathematical simulation
    Opis:
    Purpose: This paper is mainly about biomechanical behavior of needle insertion into cornea, and proposes a failure criterion to simulate the insertion process which has attracted considerable attention due to its importance for the minimally invasive treatment. Methods: In the process of needle insertion into cornea, tiny and complex insertion force is generated due to contact between needle and soft tissue. Based on the distortion energy theory, there is proposed a failure criterion of corneal material that can solve contact problem between rigid body and biological tissue in insertion simulation, where Cauchy stress of corneal material is the key to numerical calculation. A finite element model of in vivo cornea is built, and the cornea constrained by sclera is simplified to two layers containing epithelium and stroma. Considering the hyper-viscoelastic property of corneal material, insertion simulation is carried out. Results: By insertion experiment, the insertion force increases with insertion depth accompanying obvious fluctuations. Different insertion forces are generated at different speeds. The punctured locations are obvious in the force-displacement curves. The results of insertion simulation are generally consistent with experimental data. Maps of von Mises stress reflect the tissue injury of the cornea during insertion process, and punctured status corresponds to the point in the curves. Conclusions: The ability of this study to reproduce the behavior of needle insertion into cornea opens a promising perspective for the control of robotic surgery operation as well as the real-time simulation of corneal suture surgery.
    Źródło:
    Acta of Bioengineering and Biomechanics; 2016, 18, 1; 65-75
    1509-409X
    2450-6303
    Pojawia się w:
    Acta of Bioengineering and Biomechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Corneal hyper-viscoelastic model: derivations, experiments, and simulations
    Autorzy:
    Su, P.
    Yang, Y.
    Song, Y
    Powiązania:
    https://bibliotekanauki.pl/articles/307042.pdf
    Data publikacji:
    2015
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    rogówka
    biomechanika
    hiperelastyczność
    lepkosprężystość
    cornea
    biomechanics
    constitutive model
    hyperelastic
    viscoelastic
    Opis:
    Purpose: The aim of this study is to propose a method to construct corneal biomechanical model which is the foundation for simulation of corneal microsurgery. Methods: Corneal material has two significant characteristics: hyperelastic and viscoelastic. Firstly, Mooney–Rivlin hyperelastic model of cornea obtained based on stored-energy function can be simplified as a linear equation with two unknown parameters. Then, modified Maxwell viscoelastic model of the cornea, whose analytical form is consistent with the generalized Prony-series model, is proposed from the perspective of material mechanics. Results: Parameters of the model are determined by the uniaxial tensile tests and the stress-relaxation tests. Corneal material properties are simulated to verify the hyper-viscoelastic model and measure the effectiveness of the model in the finite element simulation. On this basis, an in vivo model of the corneal is built. And the simulation of extrusion in vivo cornea shows that the force is roughly nonlinearly increasing with displacement, and it is consistent with the results obtained by extrusion experiment of in vivo cornea. Conlusions: This paper derives a corneal hyper-viscoelastic model to describe the material properties more accurately, and explains the mathematical method for determination of the model parameters. The model is an effective biomechanical model, which can be directly used for simulation of trephine and suture in keratoplasty. Although the corneal hyper-viscoelastic model is taken as the object of study, the method has certain adaptability in biomechanical research of ophthalmology.
    Źródło:
    Acta of Bioengineering and Biomechanics; 2015, 17, 2; 73-84
    1509-409X
    2450-6303
    Pojawia się w:
    Acta of Bioengineering and Biomechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    In vitro evaluation of the effect of tobacco smoke on rat cornea function
    Autorzy:
    Marzec, E.
    Olszewski, J.
    Piatek, J.
    Samborski, W.
    Sosnowski, P.
    Oleskow, B.
    Zawadzinski, J.
    Florek, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/49713.pdf
    Data publikacji:
    2012
    Wydawca:
    Instytut Medycyny Wsi
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2012, 19, 4
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    "Indolent ulcer" in Boxer
    Trudnogojacy sie wrzód rogówki y psa rasy bokser
    Autorzy:
    Bryla, P.K.
    Powiązania:
    https://bibliotekanauki.pl/articles/9940.pdf
    Data publikacji:
    2011
    Wydawca:
    Okulistyka Weterynaryjna
    Tematy:
    indolent ulcer
    ulcer
    animal disease
    dog
    eye
    cornea
    keratotomy
    keratectomy
    refractory ulcer
    Boxer breed
    Opis:
    Artykuł przedstawia przypadek leczenia wrzodu rogówki u psa rasy bokser. Wrzód ten określany jest terminem "trudnogojący się" lub "indolent ulcer". Wrzody tego typu są predylekcyjne dla niektórych ras psów. Powstają często spontanicznie i niestety często mogą nawracać. istota choroby polega na oddzielaniu się nabłonka rogówki od jej istoty właściwej. Przyczyną tego może być wada hemidesmosomów, które odpowiadają za przyleganie nabłonka do stromy lub też procesy zwyrodnieniowe stromy rogówki. W obrazie klinicznym, po wybarwieniu rogówki za pomocą fluoresceiny, widoczne jest podciekanie barwnika pod warstwy rogówki. Istnieje kilka metod leczenia tego typu owrzodzenia. wymienić należy; keratotomię, powierzchowną keratektomię, chirurgiczne usunięcie martwego nabłonka rogówki. Leczeniu chirurgicznemu zawsze towarzyszy leczenie farmakologiczne. W naszym przypadku u psa zastosowaliśmy leczenie za pomocą keratotomii kratkowej skojarzonej z leczeniem farmakologicznym.
    A case of indolent ulcer in a Boxer is described. An indolent ulcer is a ulcer which fails to heal in the expected time. These ulcers are often breed-related, develop spontaneously and may be considered to represent a primary corneal epithelial or superficial stroma dystrophy. It is caused by a failure of attachment between the basal epithelium to the underlying membrane. There are several methods that will facilitate healing; debridement, keratotomy, superficial keratectomy and medical treatment.
    Źródło:
    Okulistyka Weterynaryjna. e-kwartalnik dla lekarzy i studentów weterynarii; 2011, 3
    2082-9256
    Pojawia się w:
    Okulistyka Weterynaryjna. e-kwartalnik dla lekarzy i studentów weterynarii
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Phenotypic and Marker Assisted Evaluation for Pathogenicity and Aggressiveness of Romanian Fusarium Isolates Vs. Wheat
    Autorzy:
    Ittu, M.
    Cana, L.
    Ciuca, M.
    Voaides, C.
    Cornea, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/2199565.pdf
    Data publikacji:
    2011-06-21
    Wydawca:
    Instytut Hodowli i Aklimatyzacji Roślin
    Tematy:
    aggressiveness
    Fusarium graminearum
    F. culmorum
    molecular polymorphism
    TRI 5 gene
    Opis:
    Pathogenicity and aggressiveness vs. wheat of 30 new Fusarium accessions, primarily F. graminearum, obtained  from random naturally infected grain samples of bread wheat, durum wheat and triticale collected across Romania,  phenotypically and by molecular tools has been investigated. A large variation of this trait, expressed as reduction of  coleoptiles length (% of control), in seedling stage, on average over three varieties, ranging from 2.1 to 30.9 % was  registered. Point field inoculations at anthesis of 90 Fusarium isolate x wheat varieties combinations, revealed also  the variability of several components of aggressiveness: severity (14.4-64.8%), AUDPC (104.9-527.1), and FDK 8.1-43.7%, respectively.Molecular techniques allowed identification of Fusarium species and the analysis of polymorphism within fungal  isolates. Moreover, the presence of TRI 5 gene involved in DON biosynthesis was detected in the majority of isolates.Similarity between records obtained in seedling and adult stage for the most aggressive of Fusarium isolates,  suggests that phenotypic selection in conjunction with molecular tools could be a reliable method to select the appropriate pathogen strains for breeding of resistance.
    Źródło:
    Plant Breeding and Seed Science; 2011, 63; 77-86
    1429-3862
    2083-599X
    Pojawia się w:
    Plant Breeding and Seed Science
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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