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Wyświetlanie 1-4 z 4
Tytuł:
A practical approach to the assessment of waterjet propulsion performance: the case of a waterjet-propelled trimaran
Autorzy:
Zhang, Lei
Zhang, Jia-ning
Shang, Yu-chen
Dong, Guo-xiang
Chen, Wei-min
Powiązania:
https://bibliotekanauki.pl/articles/963425.pdf
Data publikacji:
2019
Wydawca:
Politechnika Gdańska. Wydział Inżynierii Mechanicznej i Okrętownictwa
Tematy:
waterjet propulsion thrust
pressure jump method
boundary element method
trimaran
negative thrust deduction
Opis:
To obtain a reasonable evaluation of the performance of waterjet propulsion at the design stage, a semi-theoretical and semi-empirical method is used to calculate the fundamental parameters of waterjet propulsion performance using an iterative approach. To calculate the ship’s resistance, a boundary element method based on three-dimensional potential flow theory is used to solve the wave-making resistance, and an empirical approach is used to evaluate the viscous resistance. Finally, the velocity and pressure of the capture area of the waterjet propulsion control volume are solved based on turbulent boundary layer theory. The iteration equation is established based on the waterjet-hull force-balance equation, and the change in the ship’s attitude and the local loss of the intake duct are considered. The performance parameters of waterjet propulsion, such as resistance, waterjet thrust, thrust deduction, and the physical quantity of the control volume, are solved by iteration. In addition, a PID-controlled free-running ship model is simulated using the RANS CFD method as a comparison. We apply the proposed approach and the RANS CFD method to a waterjetpropelled trimaran model, and the simulation process and the results are presented and discussed. Although there are some differences between the two methods in terms of the local pressure distribution and thrust deduction, the relative error in the evaluation results for the waterjet propulsion performance is generally reasonable and acceptable. This indicates that the present method can be used at the early stages of ship design without partial information about the waterjet propulsion system, and especially in the absence of a physical model of the pump.
Źródło:
Polish Maritime Research; 2019, 4; 27-38
1233-2585
Pojawia się w:
Polish Maritime Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Vps41, a protein involved in lysosomal trafficking, interacts with caspase-8
Autorzy:
Wang, Lu
Pan, Xiao
He, Liangqiang
Zhang, Rong
Chen, Wei
Zhang, Jing
Lu, Min
Hua, Zi-Chun
Powiązania:
https://bibliotekanauki.pl/articles/1039602.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
caspase-8
yeast two-hybrid
Vps41
protein interaction
apoptosis
Opis:
Caspase-8 is a member of the cysteine-aspartic acid protease (caspase) family which plays a central role in apoptosis and development. We screened caspase-8 interacting proteins from mouse T-cell lymphoma and 7.5-day embryo cDNA libraries by yeast two-hybrid system and obtained eleven positive clones, including Vacuolar protein sorting 41 (Vps41), a protein involved in trafficking of proteins from the late Golgi to the vacuole. The interaction of Vps41 with caspase-8 was confirmed by co-immunoprecipitation (co-IP) and co-localization studies in HEK293T cells. Co-IP experiments also showed that Vps41 binds to the p18 subunit of caspase-8 through its WD40 region and RING-finger motif. Furthermore, we found that overexpression of Vps41 promotes Fas-induced apoptosis in A549 human lung adenocarcinoma cells. The cleavage of caspase-3, a caspase-8 downstream effector, was increased when cells were transfected with Vps41-overexpressing plasmid. Together, these results suggest a novel interaction of caspase-8 with Vps41 and provide a potential role of Vps41 beyond lysosomal trafficking.
Źródło:
Acta Biochimica Polonica; 2013, 60, 1; 37-42
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Removal of chromium and strontium from aqueous solutions by adsorption on laterite
Autorzy:
He, Yong
Chen, Yong-Gui
Zhang, Ke-Neng
Ye, Wei-Min
Wu, Dong-Yu
Powiązania:
https://bibliotekanauki.pl/articles/204768.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
adsorption
isotherms
chromium
strontium
laterite
Opis:
To investigate the adsorptive properties of a local laterite deposited in Chenzhou, Hunan province, China, the adsorptive properties of the natural laterite were investigated by batch technique in this study. The effects of contact time, pH, ionic strength, temperature, and the concentration on adsorption properties were also analyzed. The obtained experimental results show that the main mineral composition of laterite is kaolinite and montmorillonite. The adsorption process achieved equilibrium within 60 minutes and 90 minutes for Sr(II) and Cr(VI), respectively. The adsorption capacities for Cr(VI) and Sr(II) by the laterite were about 7.25 mg·g-1 and 8.35 mg·g-1 under the given experimental conditions, respectively. The equilibrium adsorption data were fitted to the second-order kinetic equation. The adsorption capacity for Sr(II) onto the laterite increased with increasing pH from 3–11 but decreased with increasing ionic strength from 0.001 to 1.0 M NaCl. The Sr(II) adsorption reaction on laterite was endothermic and the process of adsorption was favored at high temperature. Similarly, the adsorption capacity for Cr(VI) onto the laterite increased with increasing pH from 3–11, however, the ionic strength and temperature had an insignificant effect on Cr(VI) adsorption. The adsorption of Cr(VI) and Sr(II) was dominated by ion exchange and surface complexation in this work. Furthermore, the Langmuir and Freundlich adsorption isotherm model was used for the description of the adsorption process. The results suggest that the studied laterite samples can be effectively used for the treatment of contaminated wastewaters.
Źródło:
Archives of Environmental Protection; 2019, 45, 3; 11-20
2083-4772
2083-4810
Pojawia się w:
Archives of Environmental Protection
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Two Gln187 mutants of human soluble APRIL inhibit proliferation of lung carcinoma A549 cells
Autorzy:
Dai, Shuangshuang
Zheng, Yingru
Chen, Bin
Gao, Min
Zhang, Yan
Zhang, Li
Gong, Wei
He, Fengtain
Powiązania:
https://bibliotekanauki.pl/articles/1040492.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
APRIL
Gln187 mutant of sAPRIL
anti-tumor activity
Opis:
Soluble APRIL (sAPRIL), the active form of a proliferation-inducing ligand (APRIL), is implicated in the proliferation of tumor cells. Suppressing APRIL function has been considered as a potential strategy for the therapy of APRIL-associated tumors. In the present study, we generated human sAPRIL and its two mutants, Gln187-D-sAPRIL (Gln187 deleted) and Gly187-sAPRIL (Gln187 replaced by Gly). In vitro experiments showed that the two mutants had similar specific binding capacity to lung carcinoma A549 cells compared to the wild-type sAPRIL, and both, especially Gly187-sAPRIL, exhibited significant antagonistic effect on sAPRIL-induced tumor cell proliferation in a dose-dependent manner, which might be predominantly mediated by blocking sAPRIL-induced MEK and ERK phosphorylation but not p38MAPK or JNK signaling. In vivo experiments with nude mice bearing A549 cell-derived xenograft tumor showed that only the Gly187-sAPRIL mutant could significantly suppress the tumor growth. These results suggest that Gln187 may be a crucial amino acid in APRIL-mediated tumor cell proliferation via the MEK-ERK signaling pathway and that the sAPRIL mutants may serve as novel potential antagonists of APRIL for the therapy of APRIL-associated cancers.
Źródło:
Acta Biochimica Polonica; 2009, 56, 4; 703-710
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-4 z 4

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