Wszystkie pola: Blebbing - Katalog OPAC zbiorów

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Tytuł:: Alteration of Cytomorphology of Peritoneal Macrophages of Albino Rat Exposed to Mercuric Compound
Autorzy:: Srikanta, Guria
Powiązania:: https://bibliotekanauki.pl/articles/1158129.pdf
Data publikacji:: 2018
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:: Apoptosis
Blebbing
Macrophage
Mercury
Rat
Opis:: Mercury is among the heavy metals that have been reported to cause devastating health problems worldwide. The present work was aimed at investigating the effects of mercury chloride on the cytomorphology of the peritoneal macrophages of rat. The current study characterizes the mechanism by which mercury, a toxic metal, induces death in rat macrophages. In mercury treated group significant numbers of peritoneal macrophages were found to be pyknotic. The cellular death was confirmed by membrane blebbing and membrane rupture. Percentages of cells showing membrane blebbing was increased significantly after treatment. The result indicated mercury induced toxicity may affect macrophage mediated immunity. So macrophage activation during heavy metal mediated reaction is an interesting area to be explored in future researches.
Źródło:: World Scientific News; 2018, 92, 2; 392-399
2392-2192
Pojawia się w:: World Scientific News
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Triggering of erythrocyte membrane blebbing by ciprofloxacin
Autorzy:: Shabir, Kashif
Jilani, Kashif
Zbidah, Mohanad
Riaz, Muhammad
Bibi, Ismat
Asghar, Asma
Powiązania:: https://bibliotekanauki.pl/articles/895372.pdf
Data publikacji:: 2019-10-30
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Tematy:: oxidative stress
calcium
cell size
Opis:: An extensively used fluoroquinolone antibiotic ciprofloxacin shows a broad-spectrum antibacterial activity against both gram-positive and gram-negative strains. It works mainly by the inhibition of DNA gyrase and topoisomerase IV which results in impaired DNA replication leading towards microbial cell death. Eryptosis is an alternative term used for suicidal erythrocyte death. In current study, eryptotic effect of ciprofloxacin was investigated by exposing erythrocytes for 48 hours to the different concentrations (45-90µM) of ciprofloxacin. The experimental work related to the investigation of eryptosis was done by cell size measurement and confirmation of calcium role in membrane blebbing. As a possible mechanism of eryptosis, oxidative stress induced by ciprofloxacin was determined by catalase, glutathion peroxidase and superoxide dismutase activities measurement. Similarly, necrotic effect of ciprofloxacin was also illustrated by hemolysis measurement. Results of our study revealed that the therapeutical doses of ciprofloxacin may induce oxidative stress by significant decrease in superoxide dismutase, catalase and glutathione peroxidase activities as well as induce eryptosis, featured by erythrocytes membrane blebbing and hemolysis.
Źródło:: Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 901-906
0001-6837
2353-5288
Pojawia się w:: Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:: Biblioteka Nauki

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