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Wyszukujesz frazę "African swine fever virus (ASFV)" wg kryterium: Wszystkie pola

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    Wyświetlanie 1-5 z 5
    Tytuł:
    Virucidal effect of chosen disinfectants against African swine fever virus (ASFV) – preliminary studies
    Autorzy:
    Juszkiewicz, M.
    Walczak, M.
    Mazur-Panasiuk, N.
    Woźniakowski, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087427.pdf
    Data publikacji:
    2019
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    African swine fever (ASF)
    African swine fever virus (ASFV)
    disinfection
    biosecurity
    virucidal effects
    Źródło:
    Polish Journal of Veterinary Sciences; 2019, 4; 777-780
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Comparative analysis of CpG islands in two genotypes of African swine fever virus
    Autorzy:
    Yu, Y.-Y.
    X, M.-S.
    Liu, Q.
    Powiązania:
    https://bibliotekanauki.pl/articles/16539329.pdf
    Data publikacji:
    2022
    Wydawca:
    Polska Akademia Nauk. Czasopisma i Monografie PAN
    Tematy:
    African Swine Fever Virus (ASFV)
    genotype
    DNA methylation
    CpG island
    Opis:
    African swine fever (ASF) is an acute, hemorrhagic, and devastating viral infectious disease that causes important economic losses to the swine industry. Currently, there are no effective vaccines or drugs available. Epigenetic mechanisms, especially cytosine methylation of cytosine-phosphate-guanine (CpG) islands, have a significant impact on the life cycle of several viruses. Hence, drugs targeting DNA methylation may potentially be used for the treatment of ASF. Here, we selected the inner core, core shell, inner membrane, capsid, and external envelope membrane, to analyze the characteristics of CpG islands in the ASF virus (ASFV) genomes. Furthermore, we analyzed the promoters and CpG islands in the upstream regions of these genes. Results showed that the CpG islands of seven genes were conserved in the genomes of two genotype of ASFV strains, whereas the CpG islands of other genes were relatively conserved (ASFV strains differed mainly in the quantity of CpG islands). The different distribution of CpG islands in the genomes of different ASFV strains may affect their methylation status, which may in turn affect the regulation of viral gene expression, leading to different clinical outcomes. In addition, the predicted promoter regions based on the upstream sequences of most genes overlapped with CpG island positions. Methylation of the binding sites of the promoter regions inhibits the binding of the transcription factors to the promoters, thus inhibiting the activation of the promoters and limiting the synthesis of viral proteins. The results of this study provide a basis for exploring new antiviral therapeutic strategies from an epigenetic perspective.
    Źródło:
    Polish Journal of Veterinary Sciences; 2022, 25, 3; 455-462
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pathomorphology of the brain in the acute form of African swine fever
    Autorzy:
    Karalyan, Zaven A.
    Sargsyan, Mariam A.
    Arzumanyan, Hranush H.
    Kotsinyan, Armen A.
    Hakobyan, Lina H.
    Karalova, Elena M.
    Voskanyan, Henrih E.
    Powiązania:
    https://bibliotekanauki.pl/articles/972144.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    African swine fever virus (ASFV)
    subdural hematomas
    cerebral edema
    lymphocytic infiltration
    viremia
    Opis:
    The brains of 10 infected pigs were examined for histopathology and presence of African swine fever virus (ASFV) DNA ASFV infection induces inflamed meninges, cerebral edema and vascular thrombosis, as well as subdural hematomas. Slight tension in the dura mater, flattening of the gyri and narrowing of the sulci were also observed at four days post infection (dpi). Enlarged perivascular spaces were detected for most vessels of the brain after three to four dpi. Considerable lymphocytic infiltration of the brain tissue was observed at the terminal stage of disease. ASFV was present in all investigated areas of brain beginning from three to four dpi. The isolated virus do not differ from the used in present study Georgia 2007 strain.
    Źródło:
    Annals of Parasitology; 2017, 63, 4; 347-352
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    MGF360-12L of ASFV-SY18 is an immune-evasion protein that inhibits host type I IFN, NF-κB, and JAK/STAT pathways
    Autorzy:
    Chen, Q.
    Wang, X.X.
    Jiang, S.W.
    Gao, X.T.
    Huang, S.Y.
    Liang, Y.
    Jia, H.
    Zhu, H.F.
    Powiązania:
    https://bibliotekanauki.pl/articles/16647496.pdf
    Data publikacji:
    2023
    Wydawca:
    Polska Akademia Nauk. Czasopisma i Monografie PAN
    Tematy:
    African swine fever virus
    MGF360-12L
    type I IFN
    NF-κB
    JAK/STAT
    Opis:
    African swine fever virus (ASFV) causes feverous and hemorrhagic disease of domestic pigs and European wild boars with high mortality, yet no commercial vaccine is currently available. Several ASFV strains with natural deletion or gene-targeted knockout of multiple MGF360 and MGF505 genes are attenuated in vitro and in vivo, and can offer full protection against homologous challenge. However, the mechanisms underlying the protection are not fully understood. This study aims to investigate the effects of MGF360-12L of ASFV-SY18 on the cGAS-STING signaling pathway and explore the potential mechanisms. We identified that ASFV-SY18 MGF360-12L could inhibit cGAS-STING, TBK1, or IRF3-5D-stimulated IFN-β expression and ISRE activation. Specifically, MGF360-12L inhibits both the activation of PRD(III-I) in a dose-dependent manner, and suppresses the exogenous expression of TBK1 and IRF3-5D. MGF360-12L could block NF-κB activation induced by overexpression of cGAS-STING, TBK1, IKKβ. Downstream of the IFN-β signaling, MGF360-12L blocks the ISRE promoter activation by reducing total protein level of IRF9. Moreover, MGF360-12L protein can inhibit IFN-β-mediated antiviral effects. In conclusion, our findings suggest that MGF360-12L is a multifunctional immune-evasion protein that inhibits both the expression and effect of IFN-β, which could partially explain the attenuation of relevant gene-deleted ASFV strains, and shed light on the development of efficient ASFV live attenuated vaccines in the future.
    Źródło:
    Polish Journal of Veterinary Sciences; 2023, 26, 1; 119-130
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wild boar as the most important reservoir and vector of transmission of the African swine fever virus; why do we have to restrict their population
    Autorzy:
    Pejsak, Zygmunt
    Truszczyński, Marian
    Powiązania:
    https://bibliotekanauki.pl/articles/704203.pdf
    Data publikacji:
    2019
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    African swine fever
    wild boar
    reservoir of ASFV
    control of ASF transmission
    Opis:
    Basing on Polish experience of about 5 years (since the presence of the African swine fever (ASF) in this country, starting from February 17th, 2014) and in accordance with literature the importance of the disease in wild boar is charaterised. ASF belongs to the most dangerous, very contagious diseases occurring in domestic swine and wild boar in Eurasia. In Europe, including Russia, Ukraine, Belarus, Lithuania, Latvia, Estonia, Poland, Romania, Hungary, Bulgaria, Czech Republic and Belgium ASF is existing at present and was diagnosed for short time in the frame of the Eurasian pandemy. There is a serious concern of spreading of the virus of ASF (ASFV) to other countries of Europe, not only by wild boar. However the reservoir of ASFV in this animal is playing a very important role in the maintenance of the virus and infection of pigs. Long lasting existence of ASFV in the environmnent is connected with the very high resistance to antiviral environmental factors. Following the lack of an effective immunogenic vaccine against ASF the disease can only be controlled by administrative measures. Additionally the important and recommended procedure is the significant reduction of the wild boar population. Probability of eradication of ASFV from wild boar is increased after adding quick carcass removal simultaneously by respecting biosecurity rules. If effectively implemented, fencing is more useful to delineating zones rather than adding substantially to increased efficiency of ASF control. However, segments of fencing will be particularly usefull in theses areas, where carcasses removal or intensive hunting is difficult to implement.
    Źródło:
    Nauka; 2019, 1
    1231-8515
    Pojawia się w:
    Nauka
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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