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    Wyświetlanie 1-4 z 4
    Tytuł:
    Aktywność biologiczna pochodnych 2-amino -1H-benzimidazolu. Część I
    Biological activity of 2-amino -1H-benzimidazole derivatives. Part I
    Autorzy:
    Nawrocka, W. P.
    Nowicka, A.
    Liszkiewicz, H.
    Powiązania:
    https://bibliotekanauki.pl/articles/171654.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne 2-aminobenzimidazolu
    aktywność biologiczna
    2-aminobenzimidazole derivatives
    biological activity
    Opis:
    The main goal of this article is to present a various biological activity of 2-aminobenzimidazole derivatives. During the past 20 years the biological activity of 2-aminobenzimidazole have been studied. 2-Aminobenzimidazole occurs in a broad spectrum of drugs and pharmacological agents with anticancer [21], antibacterial [14], antiviral [10], analgesic or antiaggregatory properties. There are 30 drugs, 2-aminobenzimidazole derivatives, registered in the world. Mebendazole represents a big group of antiparasitic drugs [25]. Antihistaminic II-nd generation drug with selective activity towards H1 receptors represents Astemizol [2]. Antiviral drugs are: Enviroksym and its isomer Zinviroksym and Enviraden [3–5]. Synthesized 2-aminobenzimidazole derivatives are active against HCV [7], HIV [8, 9] or HCHV [11]. Selected compounds exhibit antiviral [3–5], antifungal [22–24] and antiparasitic [26–28] activity. Some of them can be used in the treatment of bacterial infections [12–14]. Many of 2-aminobenzimidazole analogues are histamine H1, H2, H3 and also H4 receptor antagonists [30, 33, 35, 39].
    Źródło:
    Wiadomości Chemiczne; 2012, 66, 9-10; 811-838
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wybrane Metody syntezy 2-amino-1H-benzimidazolu
    Selected Methods of the Synthesis of 2-amino-1H-benzimidazole
    Autorzy:
    Nawrocka, W. P.
    Nowicka, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/172251.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    2-amino-1H-benzimidazol
    alkilo i arylo pochodne
    syntezy
    2-amino-1H-benzimidazole
    alkyl and aryl derivatives
    synthesis
    Opis:
    2-Amino-1H-benzimidazoles have attracted much attention due to their varied biological activities toward numerous diseases. 2-Amino-1H-benzimidazole core structures can be found in commercial drugs such as astemizole, mizolastine or carbendazime [1, 2]. 2-(N-substituted)-aminobenzimidazoles are widely used chemical substances in medicinal chemistry. Several compounds from this class have been used as anticancer, antihistamine and antiviral agents [3–5]. An efficient practical method for the synthesis of a diverse collection of 2-aminobenzimidazoles would be of great value for drug discovery. Several synthetic methods have been reported in the literature for the synthesis of 2-aminobenzimidazoles [11]. The synthesis of 2-aminobenzimidazole may be carried out in several ways. The most popular and economical method involves the treatment of various 2-substituted anilines with different cyclising agents to yield 2-aminobenzimidazoles. The cyclocondensation of an appropriate o-phenylenediamine with cyanogen bromide affords high yields of 2-aminobenzimidazoles [12]. Hydrogenation of o-cyanaminonitrobenzene over Raney nickel catalyst gives 2-aminobenzimidazole [34, 35]. Substituted 2-aminobenimidazoles have also been prepared by oxidation of the corresponding substituted thioureas with isothiocyanates using desulfurizing agents such as mercury-(II) oxide or methyl iodide [18–21].
    Źródło:
    Wiadomości Chemiczne; 2013, 67, 7-8; 715-732
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Syntezy wybranych leków pochodnych 2-amino-1H-benzimidazolu
    Synthesis of Selected drugs 2-amino-1H-benzimidazole derivatives
    Autorzy:
    Nowicka, A.
    Nawrocka, W. P.
    Powiązania:
    https://bibliotekanauki.pl/articles/172049.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    synteza leków
    leki przeciwrobacze
    leki przeciwhistaminowe
    leki przeciwwirusowe
    leki przeciwnowotworowe
    Opis:
    2-Amino-1H-benzimidazole fragment occurs in broad spectrum of drugs with anticancer, antiviral, antifungal, anthelmintic and antihistamine properties. There are 30 drugs, 2-amino-1H-benzimidazole derivatives, registered in the world. Mebendazole, Albendazole and another derivatives are antihelmintic drugs which are believed to work by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubes in their intestinal [9, 12, 14]. Astemizole was a second-generation antihistamine drug that has a long duration of action. It has been withdrawn from the market in most countries because of rare but potentially fatal side effects [19]. Mizolastine is non-sedating antihistamine drug [21]. It blocks H1 receptors and doesn’t prevent the actual release of histamine from mast cells, but just prevents it binding to receptors. Enviroksim and its isomer Zinviroksim and Enviraden are antivirial drugs [26, 27]. They inhibit multiplication of 15 different serotypes of rhinovirus. Benomyl is a systemic fungicide that is selectively toxic to microorganisms [29]. Benomyl binds to microtubules, interfering with cell functions, such as meiosis and intracellular transportation. Carbendazim is a widely used, broad-spectrum fungicide and a metabolite of Benomyl [29]. It’s also shown an anticancer activity. Oncodazole shows antifungal, antineoplastic and antihelmintic activities, which exerts its effect in cells by binding to tubulin and interfering with the polymerization of microtubules [33].
    Źródło:
    Wiadomości Chemiczne; 2013, 67, 7-8; 695-714
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Syntezy wybranych, nowych pochodnych 2-amino-1H-benzimidazolu i ich mechanizmy działania biologicznego
    Synthesis of Selected, New 2-amino-1H-benzimidazole derivatives and Their mechanism of biological activity
    Autorzy:
    Nowicka, A.
    Nawrocka, W. P.
    Powiązania:
    https://bibliotekanauki.pl/articles/172102.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne 2-amino-1H-benzimidazolu
    syntezy
    aktywność biologiczna
    2-amino-1H-benzimidazole derivatives
    synthesis
    biological activity
    Opis:
    Many 2-amino-1H-benzimidazole drugs such as antihistaminic mizolastine and norastemizole or antiparasitic mebendazole, albendazole and thiabendazole have been used in clinic [1, 2]. Benomyl and its metabolite Carbendazim are both antifungal and anticancer drugs [4]. Recently, a lot of literature has revealed that 2-amino-1H-benzimidazole derivatives could effectively inhibit the growth of various microorganisms, what suggests that 2-aminobenzimidazole compounds should have large potential as a new type of antibacterial [15] and antifungal [18] agents. A number of 2-aminobenzimidazoles have exhibited antiproliferative in vitro properties [11]. Some new compounds, containing in theirs structures 2-aminobenzimidazole, show interesting and diverse cytotoxic mechanism of action, e.g. induce apoptosis of cancer cells [13]. Some of 2-aminobenzimidazole analogues are histamine and serotonin receptors antagonists [32]. 2-Aminobenzimidazoles derivatives have been frequently found to display a variety of biological activities like anti-inflammatory, antioxidant and anticoagulant [32] properties.
    Źródło:
    Wiadomości Chemiczne; 2013, 67, 3-4; 203-225
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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