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Wyszukujesz frazę "toxin" wg kryterium: Temat


Tytuł:
Toxicity and risks with T-2 and HT-2 toxins in cereals.
Autorzy:
Pettersson, H.
Powiązania:
https://bibliotekanauki.pl/articles/2199611.pdf
Data publikacji:
2011-12-20
Wydawca:
Instytut Hodowli i Aklimatyzacji Roślin
Tematy:
Fusarium langsethiae
HT-2 toxin
oats
T-2 toxin
toxin contamination
toxicity
risk
Opis:
The trichothecenes T-2 and HT-2 toxins have during recent years been found frequently in cereals grown in Europe. They are mainly produced by Fusarium  langsethiae.  High concentrations of the toxins are most commonly found in oats, but they are also detected frequently at lower concentrations in barley. Wheat is only rarely contaminated. Yearly surveys of T-2 and HT-2 toxins in oats from Northern Europe have shown that the occurrence and levels have increased from 2002, with very high levels in 2005-2007, followed by a decrease in 2008-2009. Raw oats delivered to mills for processing to food have also been highly contaminated with T-2 and HT-2 toxins during the period 2006-2009. The processing of oats in the mills by sorting-sieving and dehulling reduce the toxin concentrations in the final food products, flakes and meals, with more than 80 % even at high levels in the raw oat. The concentrations of the toxins in the by-products from the process are instead increased. The by-products are mainly used as feed components. The toxic effects of T-2 and HT-2 toxins in animals and the toxicological information used in the risk evaluations are briefly described. Risk evaluations of the toxins in cereals for human consumption have been conducted by both EU-Scientific Committee on Food and by JECFA in 2001. Both evaluations resulted in the same temporary tolerable daily intake (t-TDI) for the sum of T-2 and HT-2 toxins. The group TDI for T-2 and HT-2 toxins, alone or in combination, became 60 ng/kg bw and day. The intake of T-2 and HT-2 toxins through oats is calculated from median concentrations in oat products and median consumption data from Norway. The intake was found to be 1.5-5.4 % of the t-TDI. The  toxic  effects  studied  or  expected in  farm  animals, horses  and  ruminants, consuming high amounts of oat in their feed are described and discussed.
Źródło:
Plant Breeding and Seed Science; 2011, 64; 65-74
1429-3862
2083-599X
Pojawia się w:
Plant Breeding and Seed Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bacteriological (Biological) and Toxin Weapons as the Source of Endangerment for the Contemporary World and the Reason for the International Law Regulations Being a Subject of Abuse
Autorzy:
Stankiewicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2026745.pdf
Data publikacji:
2006-12-31
Wydawca:
Wydawnictwo Adam Marszałek
Tematy:
international law
toxin weapons
Opis:
Among the kinds of CB Weapons, the chemical one might be considered as the one with the longest history of widespread warfare applicability, whereas the biological one as the developed problem of the recent two centuries but also having its roots in ancient eras. The consequences of the usage of CBs are acknowledged by the international conventions dealing with the CB phenomenon. Although the provisions provide solutions and declarations of the minimised usage of CB weapons as the method of warfare and the limited laboratory testing in accordance to the sake of all mankind, the problem still exists. Nowadays, it is especially discussed after the events of 11.09.2001, which brought about the airborne attack on the the two towers of the World Trade Centre in New York and the proceeding events of the Bacillus anthracis4 intoxication spread across the United States of America.
Źródło:
Polish Political Science Yearbook; 2006, 35; 16-32
0208-7375
Pojawia się w:
Polish Political Science Yearbook
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Therapeutic possibilities of botulinum toxin in neurological disorders – treatment of limb spasticity in the course of brain damage
Autorzy:
Nowak, Przemysław
Balicka-Adamik, Luiza
Stybel, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/454985.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
botulinum toxin
neurology
spasticity
Opis:
Introduction. Botulinum toxin is produced by the anaerobic bacterium Clostridium botulinum. The sporulation form of the C. botulinum is widely found in the environment (in soil) and may develop in inappropriately stored food. The symptoms of poisoning occur 18-36 hours after consumption of contaminated food. Aim. The aim of this study is to present the benefits of using botulinum toxin in the treatment of spasticity of the upper and lower limbs in both adults and children. Material and methods. A literature review of the following databases was carried out: PubMed, UpToDate. Results. Botulinum toxin interferes with neural transmission by blocking the release of acetylcholine and causes muscle paralysis. The typical symptoms are diplopia, xerostomia, enteroparesis, speaking and swallowing disorders, as well as paralysis of respiratory muscles which leads to death. However, botulinum toxin is also a very potent medication. The biggest application is found in the field of neurology, inter alia, in the treatment of spasticity. Conclusion. The study provides current evidence regarding the safety and efficacy of botulinum toxin injection for spasticity of the upper and lower limbs. Botulinum toxin injections are applicable in the treatment of many neurological disorders and the list of indications will certainly become wider.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 3; 256-261
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Role of cholera toxin in Vibrio cholerae infection in humans - a review
Autorzy:
Pal, P.
Powiązania:
https://bibliotekanauki.pl/articles/10765.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
cholera
toxin
Vibrio cholerae
human infection
bacteriophage
Opis:
Vibrio cholerae, the causative agent of Asiatic cholera, is a gram-negative motile bacterial species acquired via oral ingestion of contaminated food or water sources. Cholera has spread from the Indian subcontinent where it is endemic to involve nearly the whole world seven times during the past 185 years. V. cholerae serogroup O1, biotype El Tor, has moved from Asia to cause pandemic disease in Africa and South America during the past 35 years. A new serogroup, O139, appeared in south Asia in 1992, has become endemic there, and threatens to start the next pandemic. The facultative human pathogen V. cholerae represents a paradigm that evolved from environmental non-pathogenic strains by acquisition of virulence genes. The major virulence factors of V. cholerae, cholera toxin (CTX) encoded by the ctxAB genes residing in the genome of filamentous lysogenic bacteriophage (CTXɸ) and toxin coregulated pilus (TCP) encoded by vibrio pathogenicity island (VPI). CTX, a potent stimulator of adenylate cyclase, causes the intestine to secrete watery fluid rich in sodium, bicarbonate, and potassium, in volumes far exceeding the intestinal absorptive capacity, by ADP-ribosylation of the alpha subunit of the GTP-binding protein. Thus intestinal infection with V. cholerae results in the loss of large volumes of watery stool, leading to severe and rapidly progressing dehydration and shock. Without adequate and appropriate rehydration therapy, severe cholera kills about half of affected individuals. Today, cholera still remains a burden mainly for underdeveloped countries, which cannot afford to establish or to maintain necessary hygienic and medical facilities. During the last three decades, intensive research has been undertaken to unravel the virulence properties and to study the epidemiology of this significant human pathogen. This review provides an overview of the role of CTX in the occurrence of this disease in humans.
Źródło:
International Letters of Natural Sciences; 2014, 17
2300-9675
Pojawia się w:
International Letters of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The occurrence of killer activity in yeasts isolated from natural habitats
Autorzy:
Wójcik, Monika
Kordowska-Wiater, Monika
Powiązania:
https://bibliotekanauki.pl/articles/1038925.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
killer yeast
killer toxin
natural environments
Opis:
Yeast's ability to restrict the growth and kill other yeasts, fungi and bacteria has been known for over 50 years. Killer activity was detected in yeasts deposited in the world collections or isolated from natural habitats. In this study, isolates from the forest environment, leaves of fruit trees, flower petals, cereals and frozen fruit have been screened in terms of their killer activities. Killer activity was tested on strains belonging to six yeast species: Candida, Rhodotorula, Pichia, Pachysolen, Yarrowia, Trichosporon. The reference strains were Kluyveromyces lactis Y-6682 and Kluyveromyces marxinanus Y-8281, well-known to be sensitive to yeast killer toxins. Among one hundred and two tested strains, 24 (23.5% of isolates) showed positive killer action, and 10 (9.8% of the isolates) a weak killer action against at least one sensitive reference strain. The highest killer activity was observed among isolates from forest soil and flowers.
Źródło:
Acta Biochimica Polonica; 2015, 62, 4; 821-824
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characteristic and Antimicrobial Resistance of Bacillus cereus Group Isolated from Food in Poland
Autorzy:
Kowalska, Joanna
Maćkiw, Elżbieta
Korsak, Dorota
Postupolski, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/2159267.pdf
Data publikacji:
2022-09-05
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
pastry
food safety
toxin
retail food
food control
Opis:
Bacillus cereus is a foodborne pathogen causing food safety issues due to the formation of difficult to eliminate spores and biofilms. The objective of this study was to investigate the occurrence of B. cereus (conducted as part of monitoring in 2017-2018) and the presence of a toxin gene in strains isolated from retail products (pastries/cakes; vegetables, spices, delicatessen products) in Poland, and to determine the susceptibility of these microorganisms to different antimicrobial agents. A total of 267 B. cereus isolates from food products were examined, of which 95.51% were found positive for the presence of at least one toxin gene, with the highest frequency of the nhe gene (91.39%). The hbl and cytK genes were detected in 53.56% and 44.19% of B. cereus strains, respectively. The lowest frequency was found for the ces gene (2.62%). The susceptibility of B. cereus isolates to 16 antimicrobials was investigated. Ampicillin and penicillin resistance was the most common resistance phenotype and was identified in 100% of the B. cereus isolates. In addition, the tested isolates exhibited resistance to: amoxicillin-clavulanic acid (96.25%), cephalothin (67.79%), ceftriaxone (64.42%), rifampicin (46.82%), trimethoprim-sulfamethoxazole (5.62%), quinupristin/dalfopristin (4.87%), chloramphenicol (3.75%), clindamycin (2.62%), teicoplanin (1.87%), erythromycin (1.87%), ciprofloxacin (0.75%), imipenem (0.75%), tetracycline (0.37%), and gentamicin (0.37%). The study results contribute to characterizing the diversity of B. cereus isolated from various food products in Poland and their impact on food safety and public health. This study delivers practical information on antibiotic resistance and the frequency of toxin genes among strains isolated from food.
Źródło:
Polish Journal of Food and Nutrition Sciences; 2022, 72, 3; 297-304
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fusarium mycotoxins and human health. Review.
Autorzy:
Shephard, Gordon S.
Powiązania:
https://bibliotekanauki.pl/articles/2199623.pdf
Data publikacji:
2011-12-20
Wydawca:
Instytut Hodowli i Aklimatyzacji Roślin
Tematy:
cancer
deoxynivalenol
Fumonisin
T-2 toxin
trichothecenes zearalenone
Opis:
Species within the genus Fusarium produce a diverse range of mycotoxins, many of which have signifi- cant impacts on human health. Of the five generally recognised major mycotoxins, three (fumonisins, de- oxynivalenol (DON) and zearalenone (ZON)) are produced by Fusaria. Apart from DON, other trichothecenes such as T-2 toxin, have received considerable international attention due to their impact on human health. The fumonisins, which occur ubiquitously in maize and its products, have been linked to oesophageal cancer, liver cancer and neural tube defects. DON, a frequent contaminant of maize, wheat and their products, although showing no carcinogenic potential, is immunomodulatory and produces emesis and growth retardation in animals. ZON is a naturally occurring endocrine disrupting chemical. Acute exposure to these mycotoxins has in each case been linked to outbreaks of human disease – gastro-intestinal effects in the case of fumonisins and DON, and precocious pubertal changes in the case of ZON. Concern over their toxicological effects has led to risk assessments by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which has set maximum tolerable daily intakes (TDI) of 2 µg/ kg body weight (bw) for fumonisins and 0.5 µg/kg bw for ZON. The initial TDI set for DON, namely 1 µg/kg bw has recently been updated by JECFA to include both 3- and 15-acetylDON. Apart from the above mycotoxins, a number of other secondary metabolites (moniliformin, beauvericin and fusaproliferin) are produced by different Fusaria and their effects on human health, either alone or in combination with other mycotoxins, is largely unexplored.
Źródło:
Plant Breeding and Seed Science; 2011, 64; 113-122
1429-3862
2083-599X
Pojawia się w:
Plant Breeding and Seed Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
QUINOLINIC ACID DOES NOT INFLUENCE COAGULATION PROFILE, NOR FIBRINOLYTIC ACTIVITY, UNDER PHYSIOLOGICAL CONDITIONS IN RATS.
Autorzy:
Leszczyńska, Agnieszka
Kamiński, Tomasz W.
Misztal, Tomasz
Cylwik, Bogdan
Pawlak, Dariusz
Powiązania:
https://bibliotekanauki.pl/articles/895276.pdf
Data publikacji:
2019-10-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
rats
coagulation
platelets
fibrinolysis
Quinolinic acid (QA)
uremic toxin
Opis:
Disturbances of hemostatic system are commonly observed in chronic kidney disease (CKD) patients. Along with CKD progression, the levels of tryptophan-derived uremic toxins increase, including quinolinic acid (QA). Objective of the study was to evaluate the effect of QA, a representative of tryptophan metabolites, on coagulation and fibrinolytic activity in male Wistar rats in vivo and platelet activity in vitro. Rats received QA dissolved in drinking water in doses of 3, 10, and 30 mg/kg (or water, VEH) for 14 days. Next, the following parameters were measured in the rat‘s whole blood or plasma ex vivo: thromboelastometric (ROTEM) parameters, standard coagulation parameters and fibrinolytic parameters. To evaluate the direct effect of QA on coagulation and platelet activity, blood from control rats was drawn and analyzed in vitro in the following scheme: samples of whole blood were incubated with QA (100µM) before thromboelastometric (ROTEM) analysis and collagen-induced platelet aggregation, or samples of platelet rich plasma (PRP) were incubated with QA (100µM, 1 and 2mM) 10 minutes before collagen (1µg/ml) or ADP (10µM)-induced platelet aggregation. QA administrated for 14 days in drinking water had no effect per se on activation of coagulation and fibrinolytic parameters in rats ex vivo. Similarly, no changes were observed in a whole blood incubated directly with QA regarding coagulation parameters or collagen-induced platelet aggregation. QA inhibited ADP-induced platelets aggregation in PRP only at higher concentrations of 1 and 2 mM and when aggregation was initiated by the addition of 10µM ADP in vitro.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 863-871
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characterization of Bacillus subtilis clones surviving overproduction of Zeta, a pSM19035 plasmid-encoded toxin.
Autorzy:
Nowakowska, Beata
Kern-Zdanowicz, Izabela
Zielenkiewicz, Urszula
Cegłowski, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1041467.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
toxin
Gram positive bacteria
postsegregational killing
plasmid stable maintenance
Opis:
The postsegregational killing system of pSM19035 plasmid consists of the proteins Zeta and Epsilon, a toxin and an antidote, respectively. Zeta mutants were isolated with the use of Bacillus subtilis strain with the ζ gene under control of an inducible promoter integrated into the chromosome. Results of mutant analysis point to the amino terminal part of the Zeta protein as being responsible for the toxicity.
Źródło:
Acta Biochimica Polonica; 2005, 52, 1; 99-107
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Distinct role of clathrin-mediated endocytosis in the functional uptake of cholera toxin
Autorzy:
Broeck, Davy
Lagrou, Albert
De Wolf, Marc
Powiązania:
https://bibliotekanauki.pl/articles/1040864.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
clathrin-mediated endocytosis
internalization
chlorpromazine
Cholera toxin
siRNA
Opis:
The involvement of the clathrin-mediated endocytic internalization route in the uptake of cholera toxin (CT) was investigated using different cell lines, including the human intestinal Caco-2 and T84 cell lines, green monkey Vero cells, SH-SY5Y neuroblastoma cells and Madin-Darby canine kidney cells. Suppression of the clathrin-mediated endocytic pathway by classical biochemical procedures, like intracellular acidification and potassium depletion, inhibited cholera toxin uptake by up to about 50% as well as its ability to raise intracellular levels of cAMP. Also prior exposure of these cell types to the cationic amphiphilic drug chlorpromazine reduced the functional uptake of cholera toxin, even to a greater extent. These effects were dose- and cell type-dependent, suggesting an involvement of clathrin-mediated endocytosis in the functional uptake of cholera toxin. For a more straightforward approach to study the role of the clathrin-mediated uptake in the internalization of cholera toxin, a Caco-2eps- cell line was exploited. These Caco-2eps- cells constitutively suppress the expression of epsin, an essential accessory protein of clathrin-mediated endocytosis, thereby selectively blocking this internalization route. CT uptake was found to be reduced by over 60% in Caco-2eps- paralleled by a diminished ability of CT to raise the level of cAMP. The data presented suggest that the clathrin-mediated uptake route fulfils an important role in the functional internalization of cholera toxin in several cell types.
Źródło:
Acta Biochimica Polonica; 2007, 54, 4; 757-767
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A systematic investigation of the stability of green fluorescent protein fusion proteins
Autorzy:
Janczak, Monika
Bukowski, Michał
Górecki, Andrzej
Dubin, Grzegorz
Dubin, Adam
Wladyka, Benedykt
Powiązania:
https://bibliotekanauki.pl/articles/1038973.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
crystallography
fusion protein
recombinant protein
toxin-antitoxin system
Opis:
X-ray crystallography provides important insights into structure-function relationship in biomolecules. However, protein crystals are usually hard to obtain which hinders our understanding of multiple important processes. Crystallization requires large amount of protein sample, whereas recombinant proteins are often unstable or insoluble. Green fluorescent protein (GFP) fusion is one of the approaches to increase protein synthesis, solubility and stability, facilitating crystallization. In this study we analyze the influence of the linker length, composition and the position of GFP relative to the fusion partner on the fusion protein production and stability. To this end, multiple constructs of enzymatically impaired variant of PemKSa toxin from Staphylococcus aureus CH91 fused to GFP were generated. Fusion protein production in Escherichia coli was evaluated. The proteins were purified and their stability tested. PemKSa-α14aa-GFP fusion provided best production and stability. Obtained results demonstrate the importance of optimization of fusion protein construct, including linker selection and the order of fusion partners, in obtaining high quantities of stable protein for crystallization.
Źródło:
Acta Biochimica Polonica; 2015, 62, 3; 407-411
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Molecular aspects of effect of Shiga toxin in humans - a Review
Autorzy:
Pal, P.
Powiązania:
https://bibliotekanauki.pl/articles/10966.pdf
Data publikacji:
2015
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
molecular aspect
Shiga toxin
apoptosis
Shigella dysenteriae
man
Opis:
Shiga toxins belonging to a family of structurally and functionally related protein toxins serve as the key virulence factors for pathogenecity of the virulent enteric bacterial strains namely Shigella dysenteriae serotype 1 including Shiga toxin-producing Escherichia coli (STEC). S. dysenteriae type 1 isolates remain major public health concerns due to their widespread outbreaks and the severity of extra-intestinal diseases, including acute renal failure and also affects the central nervous system. Despite practicing improved hygienic conditions and regulating food and drinking water safety, the enteric pathogens are imposing a major threat in the well being of the human society. Shiga toxin on entry into host cells’ endoplasmic reticulum (ER) activates the stress response in ER and inhibits protein synthesis by catalytic inactivation of eukaryotic ribosomes. In many cell types shiga toxins trigger apoptosis. Recent studies have shown that shiga toxins induce autophagy which activates different signaling pathways in toxin-sensitive and toxin-resistant human cells. In this review the molecular basis of Shiga toxins’ effect on host cell leading to manifestation of the infection in affected individuals are discussed with an emphasis on recent findings.
Źródło:
International Letters of Natural Sciences; 2015, 07
2300-9675
Pojawia się w:
International Letters of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of botulinum toxin type A (BTX) on the immunohistochemical characteristics of noradrenergic and cholinergic nerve fibres supplying the porcine urinary bladder wall
Autorzy:
Lepiarczyk, E.
Bossowska, A.
Kaleczyc, J.
Majewski, M.
Powiązania:
https://bibliotekanauki.pl/articles/32489.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
botulinic toxin type A
immunohistochemistry
noradrenergic nerve fibre
cholinergic nerve fibre
nerve fibre
pig
urinary bladder
bladder wall
botulinum toxin
neurotoxin
autonomic neuron
Opis:
Botulinum toxin (BTX) belongs to a family of neurotoxins which strongly influence the function of autonomic neurons supplying the urinary bladder. Accordingly, BTX has been used as an effective drug in experimental therapies of a range of neurogenic bladder disorders. However, there is no detailed information dealing with the influence of BTX on the morphological and chemical properties of nerve fibres supplying the urinary bladder wall. Therefore, the present study investigated, using double-labeling immunohistochemistry, the distribution, relative frequency and chemical coding of cholinergic and noradrenergic nerve fibers supplying the wall of the urinary bladder in normal female pigs (n=6) and in the pigs (n=6) after intravesical BTX injections. In the pigs injected with BTX, the number of adrenergic (DβH-positive) nerve fibers distributed in the bladder wall (urothelium, submucosa and muscle coat) was distinctly higher while the number of cholinergic (VAChT-positive) nerve terminals was lower than that found in the control animals. Moreover, the injections of BTX resulted in some changes dealing with the chemical coding of the adrenergic nerve fibers. In contrast to the normal pigs, in BTX injected animals the number of DβH/NPY- or DβH/CGRP-positive axons was higher in the muscle coat, and some fibres distributed in the urothelium and submucosa expressed immunoreactivity to CGRP. The results obtained suggest that the therapeutic effects of BTX on the urinary bladder might be dependent on changes in the distribution and chemical coding of nerve fibers supplying this organ.
Źródło:
Polish Journal of Veterinary Sciences; 2011, 14, 2
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prokaryotic toxin-antitoxin systems - the role in bacterial physiology and application in molecular biology
Autorzy:
Bukowski, Michal
Rojowska, Anna
Wladyka, Benedykt
Powiązania:
https://bibliotekanauki.pl/articles/1039939.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
bacteria physiology
toxin-antitoxin systems
environmental stress conditions
antibiotic resistance
Opis:
Bacteria have developed multiple complex mechanisms ensuring an adequate response to environmental changes. In this context, bacterial cell division and growth are subject to strict control to ensure metabolic balance and cell survival. A plethora of studies cast light on toxin-antitoxin (TA) systems as metabolism regulators acting in response to environmental stress conditions. Many of those studies suggest direct relations between the TA systems and the pathogenic potential or antibiotic resistance of relevant bacteria. Other studies point out that TA systems play a significant role in ensuring stability of mobile genetic material. The evolutionary origin and relations between various TA systems are still a subject of a debate. The impact of toxin-antitoxin systems on bacteria physiology prompted their application in molecular biology as tools allowing cloning of some hard-to-maintain genes, plasmid maintenance and production of recombinant proteins.
Źródło:
Acta Biochimica Polonica; 2011, 58, 1; 1-9
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preoperative treatment with botulinum toxin A: a tool for giant groin hernia repair? Case report
Autorzy:
Avellana, Rocio
Peña, Maria Jesus
Saez, Patricia
Cabeza, Juan
Torres, Antonio
Powiązania:
https://bibliotekanauki.pl/articles/1391555.pdf
Data publikacji:
2021
Wydawca:
Index Copernicus International
Tematy:
botulinum toxin A
giant groin hernia
loss of domain
Opis:
Introduction: Giant groin hernia is an unusual disease nowadays and its management can be a challenge for surgeons. The application of botulinum toxin A as a preoperative therapy could decrease the thickness of the lateral wall muscles, increase their length and increase the volume of the abdominal cavity facilitating the surgical repair. Morbidity and mortality due to high intra-abdominal pressure would decrease, allowing a minimal tension closure after reduction of the herniated viscera. Case report: We present the repair of two cases of massive inguinal hernia with loss of domain using preoperative abdominal wall injection of botulinum toxin.
Źródło:
Polish Journal of Surgery; 2021, 93, 4; 70-73
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł

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