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    Tytuł:
    Peroxynitrite can affect platelet responses by inhibiting energy production
    Autorzy:
    Rusak, Tomasz
    Tomasiak, Marian
    Ciborowski, Michal
    Powiązania:
    https://bibliotekanauki.pl/articles/1041172.pdf
    Data publikacji:
    2006
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    aggregation
    porcine platelets
    peroxynitrite
    mitochondria
    glycolysis
    secretion
    Opis:
    Peroxynitrite (ONOO-) strongly inhibits agonist-induced platelet responses. However, the mechanisms involved are not completely defined. Using porcine platelets, we tested the hypothesis that ONOO- reduces platelet aggregation and dense granule secretion by inhibiting energy production. It was found that ONOO- (25-300 µM) inhibited collagen-induced dense granule secretion (IC50 = 55 ± 7 µM) more strongly than aggregation (IC50 = 124 ± 16 µM). The antiaggregatory and antisecretory effects of ONOO- were only slightly (5-10%) reduced by 1H-[1,2,4]-oxadiazolo-[4,3-α]quinoxalin-1-one (ODQ), an inhibitor of soluble guanylate cyclase. In resting platelets ONOO- (50-300 µM) enhanced glycolysis rate and reduced oxygen consumption, in a dose dependent manner. The ONOO- effects on glycolysis rate and oxygen consumption were not abolished by ODQ. The extent of glycolysis stimulation exerted by ONOO- was similar to that produced by respiratory chain inhibitors (cyanide and antimycin A) or an uncoupler (2,4-dinitrophenol). Stimulation of platelets by collagen was associated with a rise in mitochondrial oxygen consumption, accelerated lactate production, and unchanged intracellular ATP content. In contrast to resting cells, in collagen-stimulated platelets, ONOO- (200 µM) distinctly decreased the cellular ATP content. The glycolytic activity and oxygen consumption of resting platelets were not affected by 8-bromoguanosine 3',5'-cyclic monophosphate. Blocking of the mitochondrial ATP production by antimycin A slightly reduced collagen-induced aggregation and strongly inhibited dense granule secretion. Treatment of platelets with ONOO- (50-300 µM) resulted in decreased activities of NADH : ubiquinone oxidoreductase, succinate dehydrogenase and cytochrome oxidase. It is concluded that the inhibitory effect of ONOO- on platelet secretion and to a lesser extent on aggregation may be mediated, at least in part, by the reduction of mitochondrial energy production.
    Źródło:
    Acta Biochimica Polonica; 2006, 53, 4; 769-776
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Does the peroxidase-like activity of sodium dodecyl sulphate-modified cytochrome c increase after peroxynitrite or radiation treatment?.
    Autorzy:
    Gębicka, Lidia
    Didik, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1041449.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    cytochrome c
    peroxynitrite; radiation
    SDS
    peroxidatic activity
    Opis:
    The peroxidase-like activity of cytochrome c is considerably increased by unfolding of the protein. The enhancement of the activity is due to the higher reaction rate of unfolded cytochrome c with hydrogen peroxide, which is the rate-determining step in the peroxidase cycle of cytochrome c (Gębicka, L., 2001, Res Chem Intermed 27, 717-23). In this study we checked whether combined action of two unfolding factors, SDS and peroxynitrite or radiation (hydroxyl radicals), increases the peroxidase-like activity of cytochrome c more than any single treatment alone. Peroxynitrite reacts with SDS-modified cytochrome c in the same way as with native cytochrome c, via intermediate radical products, •OH/•NO2, arising from peroxynitrite homolysis. We found that SDS-modified cytochrome c is much more sensitive to oxidative damage than the native protein. Partial unfolding of cytochrome c by SDS causes the peroxide substrate to have a better access to the heme center. On the other hand, the amino acids located in the vicinity of the active site and/or heme group become accessible for oxidizing radicals. The overall effect observed is that the peroxidase-like activity of SDS-modified cytochrome c decreases with an increase of the concentration of the oxidizing species (peroxynitrite or radiolytically generated hydroxyl radicals). The damage of SDS-modified cytochrome c caused by irradiation is much more significant than that observed after peroxynitrite treatment.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 2; 551-555
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mechanism of peroxynitrite interaction with cytochrome c.
    Autorzy:
    Gębicka, Lidia
    Didik, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1043459.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    cytochrome c
    radiolysis
    peroxynitrite
    stopped-flow spectrophotometry
    Opis:
    Kinetics of the reaction of peroxynitrite with ferric cytochrome c in the absence and presence of bicarbonate was studied. It was found that the heme iron in ferric cytochrome c does not react directly with peroxynitrite. The rates of the absorbance changes in the Soret region of cytochrome c spectrum caused by peroxynitrite or peroxynitrite/bicarbonate were the same as the rate of spontaneous isomerization of peroxynitrite or as the rate of the reaction of peroxynitrite with bicarbonate, respectively. This means that intermediate products of peroxynitrite decomposition, ·OH/·NO2 or, in the presence of bicarbonate, CO3-·/·NO2, are the species responsible for the absorbance changes in the Soret band of cytochrome c. Modifications of the heme center of cytochrome c by radiolytically produced radicals, ·OH, ·NO2 or CO3-·, were also studied. The absorbance changes in the Soret band caused by radiolytically produced ·OH or CO3-· were much more significant that those observed after peroxynitrite treatment, compared under similar concentrations of radicals. ·NO2 produced radiolytically did not interact with the heme center of cytochrome c. Cytochrome c exhibited an increased peroxidase-like activity after reaction with peroxynitrite as well as with radiolytically produced ·OH, ·NO2 or CO3-· radicals. This means that modification of protein structure: oxidation of amino acids and/or tyrosine nitration, facilitates reaction of H2O2 with the heme iron of cytochrome c, followed by reaction with the second substrate.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 3; 815-823
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Nadtlenoazotyn - silny biologiczny utleniacz
    Peroxynitrite a strong biological oxidant
    Autorzy:
    Bijak, M.
    Ponczek, M. B.
    Saluk, J.
    Chabielska, M.
    Stępniak, J.
    Nowak, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/172573.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    nadtlenoazotyn
    stres oksydacyjny
    3-nitrotyrozyna
    peroxynitrite
    oxidative stress
    3-nitrotyrosine
    Opis:
    As demonstrated in recent years, one of the major factors of oxidative stress, generated in the circulatory system, in both acute and chronic pathological conditions, is peroxynitrite (ONOO –) [4]. Peroxynitrite is a strong biological oxidant and nitrating compound, generated in vivo from a rapid reaction of two relatively less reactive, but commonly found, of free radicals: nitrogen monoxide (NO ) and superoxide (O2–) [8]. This reaction occurs spontaneously and is not catalyzed by any enzyme. A fundamental reaction of ONOO – in biological systems is its fast reaction with carbon dioxide (k = 5,7 ź 104 M–1 s–1) and yields a short-lived intermediate, nitrosoperoxycarbonate (ONOOCO 2 –), which homolyzes leads to the formation of carbonate (CO 3–) and nitrogen dioxide (NO 2) radicals (yield ~35%) [29, 30] (Fig. 1), which are one-electron oxidants. ONOO – is responsible for oxidative modifications in a wide variety of biomolecules and is capable to induce of nitrative changes in sulfur and aromatic amino acids, especially 3-nitrotyrosine and dityrosine formation [17] (Fig. 2). This article describes the formation, reactivity and biological action of peroxynitrite.
    Źródło:
    Wiadomości Chemiczne; 2012, 66, 7-8; 623-635
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Antioxidant properties of PF9601N, a novel MAO-B inhibitor: assessment of its ability to interact with reactive nitrogen species
    Autorzy:
    Bellik, Lydia
    Dragoni, Stefania
    Pessina, Federica
    Sanz, Elisenda
    Unzeta, Mercedes
    Valoti, Massimo
    Powiązania:
    https://bibliotekanauki.pl/articles/1040409.pdf
    Data publikacji:
    2010
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    MAO-B inhibitors
    peroxynitrite
    l-deprenyl
    nitric oxide
    Parkinson's disease
    Opis:
    The novel MAO-B inhibitor PF9601N, its cytochrome P450-dependent metabolite FA72 and l-deprenyl were studied as potential peroxynitrite (ONOO-) scavengers and nitric oxide synthase (NOS) inhibitors. The scavenging activity of these compounds was evaluated by measuring the oxygen consumption through peroxynitrite-mediated oxidation of both linoleic acid and brain homogenate. FA72, PF9601N and l-deprenyl caused a concentration-dependent inhibition of ONOO--induced linoleic acid oxidation with an IC50 value of 60.2 µM, 82.8 µM and 235.8 µM, respectively. FA72 was the most potent also in inhibiting ONOO--induced brain homogenate oxidation with an IC50 value of 99.4 µM, while PF9601N and l-deprenyl resulted weaker inhibitors in the same experimental model, showing an IC50 value of 164.8 and 112.0 µM, respectively. Furthermore, both the novel MAO-B inhibitor as well as its metabolite were able to strongly inhibit rat brain neuronal NOS (IC50 of 183 µM and 192 µM, respectively), while l-deprenyl at the highest concentration used (3 mM), caused only a slight decrease of the enzyme activity. Moreover, inducible NOS was strongly inhibited by FA72 only. All these results suggest that PF9601N could be a promising therapeutic agent in neurodegenerative disorders such as Parkinson's disease.
    Źródło:
    Acta Biochimica Polonica; 2010, 57, 2; 235-239
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Endothelial NADH/NADPH-dependent enzymatic sources of superoxide production: relationship to endothelial dysfunction.
    Autorzy:
    Kalinowski, Leszek
    Malinski, Tadeusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1043282.pdf
    Data publikacji:
    2004
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    peroxynitrite
    endothelial dysfunction
    NAD(P)H oxidase
    nitric oxide
    superoxide
    eNOS
    Opis:
    There is growing evidence that endothelial dysfunction, which is often defined as the decreased endothelial-derived nitric oxide (NO) bioavailability, is a crucial factor leading to vascular disease states such as hypertension, diabetes, atherosclerosis, heart failure and cigarette smoking. This is due to the fact that the lack of NO in endothelium-dependent vascular disorders contributes to impaired vascular relaxation, platelet aggregation, increased vascular smooth muscle proliferation, and enhanced leukocyte adhesion to the endothelium. During the last several years, it has become clear that reduction of NO bioavailability in the endothelium-impaired function disorders is associated with an increase in endothelial production of superoxide (O2̇̄). Because O2̇̄ rapidly scavenges NO within the endothelium, a reduction of bioactive NO might occur despite an increased NO generation. Among many enzymatic systems that are capable of producing O2̇̄, NAD(P)H oxidase and uncoupled endothelial NO synthase (eNOS) apparently are the main sources of O2̇̄ in the endothelial cells. It seems that O2̇̄ generated by NAD(P)H oxidase may trigger eNOS uncoupling and contribute to the endothelial balance between NO and O2̇̄. That is maintained at diverse levels.
    Źródło:
    Acta Biochimica Polonica; 2004, 51, 2; 459-469
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Stres oksydacyjny – reaktywne formy tlenu i azotu w patogenezie zaburzeń układu krążenia
    Oxidative stress – reactive oxygen and nitrogen species in the pathogenesis of cardiovascular disorders
    Autorzy:
    Kołodziejczyk, Joanna
    Saluk, Joanna
    Wachowicz, Barbara
    Powiązania:
    https://bibliotekanauki.pl/articles/1038430.pdf
    Data publikacji:
    2011
    Wydawca:
    Śląski Uniwersytet Medyczny w Katowicach
    Tematy:
    stres oksydacyjny
    choroby układu krążenia
    nadtlenoazotyn
    oxidative stress
    cardiovascular diseases
    peroxynitrite
    Opis:
    The generation of reactive oxygen and nitrogen species is a part of normal metabolism and under physiological conditions undergoes a strict control by a variety of enzymatic and non-enzymatic anti-oxidative mechanisms. However, under pathological conditions, the enhanced production of free radicals and non-radical oxidants may be overwhelm the anti-oxidative defence, leading to oxidative stress and irreversible damage of cells and tissues. It has been established, that increased production of reactive oxygen and nitrogen species has been implicated in the development of cardiovascular system-related disorders, including hypertension, atherosclerosis, diabetes, and ischemia-reperfusion injury. The presented review is a brief insight on the role of oxidative stress in the pathogenesis and progression of cardiovascular diseases, related to haemostasis disturbances and endothelium dysfunction.
    Powstawanie reaktywnych form tlenu i azotu jest częścią prawidłowych przemian biochemicznych i w warunkach fizjologicznych podlega ścisłej kontroli przez system licznych mechanizmów antyoksydacyjnych. W warunkach patologicznych dochodzi jednak do zwiększenia generowania zarówno wolnych rodników, jak i nierodnikowych czynników utleniających, co przewyższa możliwości obrony antoksydacyjnej organizmu. Pojawiający się stres oksydacyjny prowadzi do nieodwracalnych uszkodzeń komórek i tkanek. Wiadomo, że reaktywne formy tlenu i azotu są zaangażowane w rozwój wielu zaburzeń związanych z układem sercowo-naczyniowym, takich jak miażdżyca, nadciśnienie, cukrzyca czy uszkodzenia związane z niedokrwieniem serca i reperfuzją. Prezentowana praca stanowi krótki przegląd dostępnych danych, dotyczących biochemicznych podstaw udziału stresu oksydacyjnego w patogenezie i rozwoju wybranych chorób układu sercowo-naczyniowego.
    Źródło:
    Annales Academiae Medicae Silesiensis; 2011, 65, 4; 63-69
    1734-025X
    Pojawia się w:
    Annales Academiae Medicae Silesiensis
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Nitric oxide (NO) : a universal regulator of an organism’s vital processes at the cellular level
    Tlenek azotu (NO) : uniwersalny regulator procesów życiowych organizmu na poziomie komórkowym
    Autorzy:
    Pedrycz, A.
    Siermontowski, P.
    Ciechan, A.
    Orłowski, M.
    Zając, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/366117.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Medycyny i Techniki Hiperbarycznej
    Tematy:
    nitric oxide
    peroxynitrite
    cell
    L-arginine
    tlenek azotu
    nadtlenek azotu
    komórki
    L-arginina
    Opis:
    At the present time, seven types of nitrogen oxide have been discovered and defined: Nitrogen oxide (I) (N2O) – nitrous oxide, also known as a laughing gas, Nitric oxide (II) (NO) – nitrogen monoxide, Nitrogen oxide (III) (N2O3), Nitrogen oxide (IV) (NO2) – nitrogen dioxide which may produce a dimer – N2O4 – dinitrogen tetroxide, Nitrogen oxide (V) (N2O5) – dinitrogen pentoxide, Nitrogen oxide (VI) (NO3) nitrogen trioxide – nitrate radical of a strong oxidizing effect, Nitrogen oxide (VII) (N2O6) – dinitrogen hexoxide – an unstable compound with a peroxide bond O2N-O-ONO2. Of the above compounds the one that is of the greatest significance from the point of view of medicine is nitric oxide (NO), hence it is the main focus of this work.
    Do chwili obecnej odkryto i opisano 7 tlenków azotu: Tlenek azotu (I) (N2O)- podtlenek azotu, tlenek di azotu, inaczej zwany gazem rozweselającym, Tlenek azotu (II) (NO) - monotlenek azotu, Tlenek azotu (III) (N2O3), Tlenek azotu IV (NO2) - dwutlenek azotu, który może tworzyć dimer- N2O 4 - czterotlenek azotu, Tlenek azotu (V) (N2O5) pięciotlenek di azotu, Tlenek azotu (VI) (NO3) trójtlenek azotu- rodnik azotanowy o silnym działaniu utleniającym, Tlenek azotu (VII) (N2O6)- sześciotlenek azotu - nietrwały związek z wiązaniem nadtlenkowym O2N-O-O-NO2. W medycynie największe znaczenie ma monotlenek azotu (NO) i jemu poświęcona jest niniejsza praca.
    Źródło:
    Polish Hyperbaric Research; 2013, 2(43); 93-103
    1734-7009
    2084-0535
    Pojawia się w:
    Polish Hyperbaric Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The reactive nitrogen species affect potato immunity to Phytophthora infestans
    Autorzy:
    Arasimowicz-Jelonek, M.
    Floryszak-Wieczorek, J.
    Abramowski, D.
    Izbianska, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/81084.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    reactive nitrogen species
    nitric oxide
    peroxynitrite
    potato
    Phytophthora infestans
    gene coding
    thioredoxin peroxidase
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Peroxynitrite mediated linoleic acid oxidation and tyrosine nitration in the presence of synthetic neuromelanins.
    Autorzy:
    Stępień, Krystyna
    Wilczok, Adam
    Zajdel, Alicja
    Dzierżęga-Lęcznar, Anna
    Wilczok, Tadeusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1044213.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    3-nitrotyrosine
    DA/CysDA-copolymers
    peroxidation
    peroxynitrite
    CysDA-melanin
    DA-melanin
    nitration
    linoleic acid
    neuromelanin
    Opis:
    Peroxynitrite-mediated linoleic acid oxidation and tyrosine nitration were analysed in the presence of synthetic model neuromelanins: dopamine (DA) -melanin, cysteinyldopamine (CysDA) -melanin and various DA/CysDA copolymers. The presence of melanin significantly decreased the amount of 3-nitrotyrosine formed. This inhibitory effect depended on the type and concentration of melanin polymer. It was found that incorporation of CysDA-derived units into melanin attenuated its protective effect on tyrosine nitration induced by peroxynitrite. In the presence of bicarbonate, the melanins also inhibited 3-nitrotyrosine formation in a concentration dependent manner, although the extent of inhibition was lower than in the absence of bicarbonate. The tested melanins inhibited peroxynitrite-induced formation of linoleic acid hydroperoxides, both in the absence and in the presence of bicarbonate. In the presence of bicarbonate, among the oxidation products appeared 4-hydroxynonenal (HNE). CysDA-melanin inhibited the formation of HNE, while DA-melanin did not affect the aldehyde level. The results of the presented study suggest that neuromelanin can act as a natural scavenger of peroxynitrite.
    Źródło:
    Acta Biochimica Polonica; 2000, 47, 4; 931-940
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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