- Tytuł:
-
Nadtlenoazotyn - silny biologiczny utleniacz
Peroxynitrite a strong biological oxidant - Autorzy:
-
Bijak, M.
Ponczek, M. B.
Saluk, J.
Chabielska, M.
Stępniak, J.
Nowak, P. - Powiązania:
- https://bibliotekanauki.pl/articles/172573.pdf
- Data publikacji:
- 2012
- Wydawca:
- Polskie Towarzystwo Chemiczne
- Tematy:
-
nadtlenoazotyn
stres oksydacyjny
3-nitrotyrozyna
peroxynitrite
oxidative stress
3-nitrotyrosine - Opis:
- As demonstrated in recent years, one of the major factors of oxidative stress, generated in the circulatory system, in both acute and chronic pathological conditions, is peroxynitrite (ONOO –) [4]. Peroxynitrite is a strong biological oxidant and nitrating compound, generated in vivo from a rapid reaction of two relatively less reactive, but commonly found, of free radicals: nitrogen monoxide (NO ) and superoxide (O2–) [8]. This reaction occurs spontaneously and is not catalyzed by any enzyme. A fundamental reaction of ONOO – in biological systems is its fast reaction with carbon dioxide (k = 5,7 ź 104 M–1 s–1) and yields a short-lived intermediate, nitrosoperoxycarbonate (ONOOCO 2 –), which homolyzes leads to the formation of carbonate (CO 3–) and nitrogen dioxide (NO 2) radicals (yield ~35%) [29, 30] (Fig. 1), which are one-electron oxidants. ONOO – is responsible for oxidative modifications in a wide variety of biomolecules and is capable to induce of nitrative changes in sulfur and aromatic amino acids, especially 3-nitrotyrosine and dityrosine formation [17] (Fig. 2). This article describes the formation, reactivity and biological action of peroxynitrite.
- Źródło:
-
Wiadomości Chemiczne; 2012, 66, 7-8; 623-635
0043-5104
2300-0295 - Pojawia się w:
- Wiadomości Chemiczne
- Dostawca treści:
- Biblioteka Nauki
Artykuł