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Wyświetlanie 1-15 z 20
Tytuł:
The pattern of steroid secretion by perifused preovulatory rat follicles
Autorzy:
Szoltys, M
Powiązania:
https://bibliotekanauki.pl/articles/70002.pdf
Data publikacji:
1995
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
radioimmunoassay
steroid production
progesterone
rat follicle
steroid
endocrinology
steroid analysis
ovulation
androgen
animal physiology
gonadotrophin
hormone free
secretion
estradiol
Źródło:
Journal of Physiology and Pharmacology; 1995, 46, 1
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adrenomyeloneuropathy – a case report
Autorzy:
Leksa, Natalia
Aebisher, David
Galiniak, Sabina
Uberman-Kluz, Dominika
Bartosz, Serweryn
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454995.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
adrenoleukodystrophy
fatty acids
steroid therapy
Opis:
Introduction. Adrenoleukodystrophy is a genetic disorder linked to the X chromosome, in which the peroxisomal beta-oxidation process is disturbed. It is a metabolic disease that results in the accumulation of very long chain fatty acids (VLCFAs - very long chain fatty acids) responsible for the symptoms of damage to the adrenal cortex, gonads and the brain. Aim. A clinical case is reported. Description of case. This article describes the case of a 64-year-old woman who had neurological symptoms for many years, gradually increasing without significant improvement after the treatment (periodic steroid therapy). Conclusion. Based on tests (including the determination of the ABCD1 gene and very long chain fatty acids - VLCFA), adrenoleukodystrophy was suspected.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 3; 274-276
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Molecular basis of mechanisms of steroid resistance in children with nephrotic syndrome
Autorzy:
Świerczewska, Monika
Ostalska-Nowicka, Danuta
Kempisty, Bartosz
Nowicki, Michał
Zabel, Maciej
Powiązania:
https://bibliotekanauki.pl/articles/1039528.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
nephrotic syndrome
glucocorticoid receptor
steroid resistance
polymorphisms
Opis:
Steroid therapy, due to a wide range of anti-inflammatory properties of steroids, is a basic field of treatment in many human diseases including the nephrotic syndrome in children. However, not all patients respond positively to therapy which divides them into steroid sensitive (SS) and steroid resistance (SR) individuals. Many potential factors associated with steroid resistance have been identified so far. It seems that genetic factors associated with glucocorticoid receptor α (GRα), the structure of heterocomplex of GR as well as glycoprotein P or cytochrome P450 may play a role in the induction of glucocorticoid resistance. Here we described several of the molecular mechanisms, which can regulate glucocorticoid sensitivity and resistance. Moreover, we presented genetic defects, which can lead to various effects of treatment and, in a longer perspective, enable clinicians to individualize therapies.
Źródło:
Acta Biochimica Polonica; 2013, 60, 3; 339-344
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Arbutin in Serratula quinquefolia M.B. [Asteraceae]
Autorzy:
Nowak, G
Nawrot, J.
Latowski, K.
Powiązania:
https://bibliotekanauki.pl/articles/58892.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Botaniczne
Tematy:
arbutin
chemotaxonomy
steroid compound
Compositae
Serratula quinquefolia
Opis:
Genus Serratula is known for the presence of steroid compounds which belong to the group of ecdysones. Former phytochemical works from the late sixties and early seventies indicate, in some Serratula species, the occurrence of a phenolic glycoside-arbutin. This has been confirmed in the present work through finding an α,β-arbutin anomer in Serratula quinquefolia M.B. New botanical data concerning the classification of genus Serratula suggest that the species in question should be regarded as belonging to genus Klasea (currently a section of genus Serratula). There has been an attempt to find a key to the chemical division within the taxons.
Źródło:
Acta Societatis Botanicorum Poloniae; 2009, 78, 2; 137-140
0001-6977
2083-9480
Pojawia się w:
Acta Societatis Botanicorum Poloniae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The HPV16 E2 transcriptional regulator mode of action depends on the physical state of the viral genome
Autorzy:
Schmidt, Marcin
Olejnik, Agnieszka
Goździcka-Józefiak, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1041324.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
E2
chromatin
transcription
HPV
retinol
steroid hormones
LCR
Opis:
Human papillomavirus (HPV) infection is a major risk factor for the development of cervical cancer. The HPV-induced immortalization of epithelial cell usually requires integration of the viral DNA into the host cell genome. The integration event causes disruption of the E2 gene and this is followed by overexpression of the E6 and E7 oncoproteins. The E2 protein is a transcription factor that regulates expression of the E6 and E7 oncoproteins by binding to four sites within the viral long control region. We used an in vitro cell culture model to explore the role of the E2 protein in the transcriptional control of the HPV16 long control region. Employing transient and stable transfection experiments we simulated the episomal and integrated states of the viral genome, respectively. We show that the E2 protein up-regulates E6/E7 transcription from episomal DNA but represses it in the case of integrated DNA. The activator function of the E2 protein seems to counteract the repressive chromatin structure formed over episomal DNA. Steroid hormones and retinol also modulate oncogene transcription differently depending on the physical structure of the viral DNA. Our data suggest regulatory mechanisms involving interactions between the E2 protein and nuclear hormone receptors.
Źródło:
Acta Biochimica Polonica; 2005, 52, 4; 823-832
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
SOCS3 is epigenetically up-regulated in steroid resistant nephrotic children
Autorzy:
Zaorska, Katarzyna
Zawierucha, Piotr
Ostalska-Nowicka, Danuta
Nowicki, Michał
Powiązania:
https://bibliotekanauki.pl/articles/1038853.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
methylation
nephrotic syndrome
single nucleotide polymorphism
steroid resistance
Opis:
Background. The mechanism of steroid resistance in children with the nephrotic syndrome is yet unknown. About 20% of patients demonstrate steroid unresponsiveness and progress to end stage renal disease. Aberrant SOCS3 and SOCS5 expression in steroid resistant and sensitive patients has previously been demonstrated. Here, we investigate genetic and epigenetic mechanisms of regulation of SOCS3 and SOCS5 transcription in nephrotic children. Methods. 76 patients with the nephrotic syndrome (40 steroid resistant and 36 steroid sensitive) and 33 matched controls were included in this study. We performed genotyping of a total of 34 single nucleotide polymorphisms for SOCS3 and SOCS5 promoters and evaluated their methylation status using MS-PCR and QMSP methods. Results. Steroid resistant patients had a significantly lower methylation of one region of SOCS3 promoter in comparison with steroid sensitive patients and controls (p < 0.0001). However, the relative methylation level in the steroid sensitive patients and controls differed significantly even before the first steroid dose (p = 0.001758). Other SOCS3 and SOCS5 promoter regions displayed no differences in methylation or were fully methylated/unmethylated in all study groups, showing site-specific methylation. The allele and genotype distribution for SOCS3 and SOCS5 markers did not differ statistically between the groups. Conclusions. We demonstrate an epigenetic mechanism of SOCS3 up-regulation in steroid resistant children with the nephrotic syndrome. The assessment of methylation/unmethylation of SOCS3 promoter might be an early marker for steroid responsiveness in NS patients.
Źródło:
Acta Biochimica Polonica; 2016, 63, 1; 131-138
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Exogenous steroid hormones stimulate full development of autonomous endosperm in Arabidopsis thaliana
Autorzy:
Rojek, J.
Pawelko, L.
Kapusta, M.
Naczk, A.
Bohdanowicz, J.
Powiązania:
https://bibliotekanauki.pl/articles/59176.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Botaniczne
Tematy:
steroid hormone
endosperm
Arabidopsis thaliana
apomixis
DNA methylation
Opis:
Most flowering plants, including important crops, require double fertilization to form an embryo and endosperm, which nourishes it. Independence from fertilization is a feature of apomictic plants that produce seeds, from which the plants that are clones of the mother plant arise. The phenomenon of apomixis occurs in some sexual plants under specific circumstances. Since the launch of a fertilization-independent mechanism is considered a useful tool for plant breeding, there have been efforts to artificially induce apomixis. We have been able to produce fertilization-independent endosperm in vitro in Arabidopsis over the last few years. This paper demonstrates the methods of improving the quality of the endosperm obtained using plant and mammalian steroid hormones. Additionally, it shows the study on the autonomous endosperm (AE) formation mechanism in vitro. This paper examines the effect of exogenous steroid hormones on unfertilized egg and central cell divisions in culture of unpollinated pistils of Arabidopsis Col-0 wild-type andfie-1 mutant. All media with hormones used (estrone, androsterone, progesterone, and epibrassinolide) stimulated central cell divisions and fertilization-independent endosperm development. The stages of AE development followed the pattern of Arabidopsis thaliana wild type after fertilization. Subsequent stages of AE were observed from 2-nuclear up to cellular with the most advanced occurring on medium with 24-epibrassinolide and progesterone. The significant influence of mammalian sex hormones on speed of AE development and differentiation was noticed. Using restriction analysis, the changes in methylation of FIE gene was established under in vitro condition. The authors of this paper showed that Arabidopsis thaliana has a high potency to fertilization-independent development.
Źródło:
Acta Societatis Botanicorum Poloniae; 2015, 84, 2
0001-6977
2083-9480
Pojawia się w:
Acta Societatis Botanicorum Poloniae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prenatal glucocorticoids can programme postnatal development
Autorzy:
Tomaszewska, E.
Dobrowolski, P.
Powiązania:
https://bibliotekanauki.pl/articles/3123.pdf
Data publikacji:
2011
Wydawca:
Instytut Medycyny Wsi
Tematy:
prenatal glucocorticoid
glucocorticoid
postnatal development
bone
dexamethasone
steroid hormone
Źródło:
Journal of Pre-Clinical and Clinical Research; 2011, 05, 1
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Qa-SNARE protein SYP22 negatively regulates brassinosteroid signaling in the dark
Autorzy:
Yao, T.S.
Zhu, X.F.
Jung, J.H.
Xuan, Y.H.
Powiązania:
https://bibliotekanauki.pl/articles/19201.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
SNARE protein
SYP22 gene
brassinosteroid
steroid hormone
signalling
dark
Arabidopsis
Źródło:
Acta Biologica Cracoviensia. Series Botanica; 2015, 57, 2
0001-5296
Pojawia się w:
Acta Biologica Cracoviensia. Series Botanica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
O-GlcNAcylation, steroid hormone receptors and cancer
O-GlcNAcylacja, receptory dla steroidów i nowotwory
Autorzy:
Wilkosz, Jacek
Różański, Waldemar
Bryś, Magdalena
Forma, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/1032739.pdf
Data publikacji:
2013
Wydawca:
Łódzkie Towarzystwo Naukowe
Tematy:
o-glcnacylation
steroid hormone receptors
cancer
o-glcnacylacja
receptory dla steroidów
nowotwór
Opis:
The addition of a single residue of O-linked N-acetylglucosamine (O-GlcNAc) to serine or threonine is a post-translational modification (O-GlcNAcylation) of proteins found in the cytoplasm or the nucleus. This dynamic modification is dependent on the environmental glucose concentration. O-GlcNAc modification is catalysed by a glycosyltransferase named O-linked N-acetylglucosaminyltransferase (OGT), and O-GlcNAc residue is removed by the antagonistic enzyme β-N-acetylglucosaminidase (O-GlcNAcase; OGA). Cytosolic O-GlcNAcylation is important for the proper transduction of signalling cascades, whereas nuclear O-GlcNAc is crucial for the transcriptional regulation. O-GlcNAcylation is also important in the regulation of the transcriptional activity of steroid hormone receptors. Both O-GlcNAc transferase and O-GlcNAcase are found in all tissues and have been shown to be essential for development in vertebrates, which underscores their fundamental roles in vital processes as well as in pathological conditions such as neoplastic transformation.
Glikozylacja polegająca na przyłączeniu pojedynczych reszt β-N-acetylo- D-glukozaminy do reszt seryny lub treoniny polipeptydu wiązaniem O-glikozydowym (O-GlcNAc), jest powszechną modyfikacją białek jądrowych i cytoplazmatycznych. Modyfikacja ta pozostaje w ścisłym związku z dostępnością glukozy. β-N-acetyloglukozaminylotransferaza (O-GlcNAc transferaza, OGT) jest enzymem odpowiedzialnym za katalityczne przyłączenie reszt O-GlcNAc, natomiast β-N-acetylo-D-glukozaminidaza (OGA) reszty te odłącza. Proces O-GlcNAcylacji zachodzący w cytozolu jest istotny z punktu widzenia transmisji sygnału komórkowego, natomiast przyłączanie reszt O-GlcNAc na terenie jądra wpływa na proces transkrypcji. Wykazano, że proces O-GlcNAcylacji moduluje regulację aktywności transkrypcyjnej receptorów hormonów steroidowych. Oba enzymy, O-GlcNAc transferaza i β-N-acetylo- D-glukozaminidaza wykrywane są we wszystkich tkankach i jak wykazano, niezbędne są dla prawidłowego rozwoju organizmu, jak również mogą uczestniczyć w procesie transformacji nowotworowej.
Źródło:
Folia Medica Lodziensia; 2013, 40, 1; 133-149
0071-6731
Pojawia się w:
Folia Medica Lodziensia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polymorphic variants of MIF gene and prognosis in steroid therapy in children with idiopathic nephrotic syndrome
Autorzy:
Świerczewska, Monika
Ostalska-Nowicka, Danuta
Kempisty, Bartosz
Szczepankiewicz, Aleksandra
Nowicki, Michał
Powiązania:
https://bibliotekanauki.pl/articles/1039333.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
nephrotic syndrome
steroid resistance
MIF gene
single nucleotide polymorphism
short tandem repeat
Opis:
Nephrotic syndrome (NS) is the most common reason of proteinuria in children and can be caused by the pathology of renal glomeruli. Steroid therapy is typically used in this disorder. It has been shown that MIF is a cytokine which counteracts the immunosuppressive properties of glucocorticoids. The aim of this study was looking for a correlation between MIF polymorphisms and genetic susceptibility to steroid resistance in children with INS (Idiopathic NS). Methods: The study was performed in 71 patients with INS including SRNS (steroid resistance nephrotic syndrome) (41) and SSNS (steroid sensitive nephrotic syndrome) (30) and in 30 control subjects. We employed Sanger sequencing and capillary electrophoresis. Linkage disequilibrium was made using Haploview and PHASE. Results: We didn't observe a statistical significance between SNPs detected in patients with INS and controls. Our studies revealed statistical significance for two polymorphisms: rs2070767C > T and rs2000466T > G between patients with SRNS and SSNS. The results for rs34383331T > A are close to being statistically significant. Statistical significance was revealed for CATT5/CATT6 genotype in SRNS group vs SSNS group (OR=4.604, 95%CI=1.356-15.632, p=0.0168). We found that the frequency of 5/X-CATT genotype compared with X/X-CATT genotype was significantly higher in SRNS patients vs SSNS (OR=3.167, 95%CI=1.046-9.585, p=0.0426). In linkage disequilibrium analysis we didn't show involvement in susceptibility to INS and steroid sensitive phenotype. Conclusions: Our results suggest that the role of MIF polymorphisms in the susceptibility to positive response to steroid therapy is still unresolved. It indicates that MIF may be involved in indirect and complex molecular mechanisms of steroid activity in hormone-dependent metabolic pathways in children with INS. Because of ambiguous findings, pleiotropic features of this cytokine require that more research should be undertaken.
Źródło:
Acta Biochimica Polonica; 2014, 61, 1; 67-75
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Steroid signal transduction activated at the cell membrane: from plants to animals.
Autorzy:
Marcinkowska, Ewa
Więdłocha, Antoni
Powiązania:
https://bibliotekanauki.pl/articles/1043743.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
signal transduction pathways
membrane receptors
nuclear receptors
transcription factors
translocation
steroid hormones
Opis:
Steroid hormones in plants and in animals are very important for physiological and developmental regulation. In animals steroid hormones are recognized by nuclear receptors, which transcriptionally regulate specific target genes following binding of the ligand. In addition, numerous rapid effects generated by steroids appear to be mediated by a mechanism not depending on the activation of nuclear receptors. Although the existence of separate membrane receptors was postulated many years ago and hundreds of reports supporting this hypothesis have been published, no animal membrane steroid receptor has been cloned to date. Meanwhile, a plant steroid receptor from Arabidopsis thaliana has been identified and cloned. It is a transmembrane protein which specifically recognizes plant steroids (brassinosteroids) at the cell surface and has a serine/threonine protein kinase activity. It seems that plants have no intracellular steroid receptors, since there are no genes homologous to the family of animal nuclear steroid receptors in the genome of A. thaliana. Since the reason of the rapid responses to steroid hormones in animal cells still remains obscure we show in this article two possible explanations of this phenomenon. Using 1,25-dihydroxyvitamin D3 as an example of animal steroid hormone, we review results of our and of other groups concordant with the hypothesis of membrane steroid receptors. We also review the results of experiments performed with ovarian hormones, that led their authors to the hypothesis explaining rapid steroid actions without distinct membrane steroid receptors. Finally, examples of polypeptide growth factor that similarly to steroids exhibit a dual mode of action, activating not only cell surface receptors, but also intracellular targets, are discussed.
Źródło:
Acta Biochimica Polonica; 2002, 49, 3; 735-745
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Roux-en-Y gastric bypass as a cure of iatrogenic steroid-induced diabetes
Autorzy:
Poznanska, Grazyna
Hogendorf, Piotr
Czupryniak, Leszek
Smolewski, Piotr
Grząsiak, Oliwia
Szmiel, Aneta
Kasiarz, Anna
Strzelczyk, Janusz
Durczyński, Adam
Powiązania:
https://bibliotekanauki.pl/articles/1392077.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
bariatric surgery
cure
iatrogenic diabetes
Roux-en-Y gastric bypass
steroid induced diabetes
treatment
Opis:
Background: Steroid-induced diabetes (SIDM) is a frequently found clinical condition since steroid-based therapies continue to be widely used in hospital and ambulatory care. Recommended optimal treatment of SIDM includes similar glucose lowering strategies as in type 2 diabetes. This typical management cannot cure the disease, it can only control blood glucose. Recently, bariatric surgery has emerged as an effective treatment for type 2 diabetes mellitus. However, up to now, the usefulness of bariatric surgery in treatment of SIDM has not been evaluated. Case report: A 49-year-old female oncologic patient with steroid induced diabetes was referred for surgical treatment to the Department of General and Transplant Surgery in November 2009. Six years earlier, she underwent successful oncologic treatment with cladribine and high doses of steroids due to hairy cell leukemia. Finally complete hematologic remission with normalization of morphology and reduction of spleen size has been obtained. Prior to steroid treatment, blood glucose and urine examinations were within normal range. The patient was non-obese and had no family history of diabetes. Nevertheless, the patient developed diabetes secondary to corticosteroid therapy, poorly controlled by oral hypoglycemic agent (acarbosum), successfully converted to insulin therapy. Upon admission to the Department of General and Transplant Surgery, the patient was treated with 58 units of insulin per day. The patient was scheduled for Roux-en-Y gastric bypass (RYGB). Insulin was withdrawn immediately after the surgery and within six months after the surgery, plasma glucose and glycated hemoglobin (HbA1c-5.5%) levels reached and remained within normal range. Currently, eight years after surgery, body weight and BMI are 80 kg and 27.68 kg/m2, respectively. Plasma glucose and glycated hemoglobin are also normal. Importantly, from an oncological point of view, the patient has remained in continuous complete remission since October 2003. Conclusions: Our report is the first to our knowledge describing the effect of gastric bypass surgery on SIDM in a patient with prior hematologic malignancy. It proves that surgically altered anatomy of the small intestine improves glucose homeostasis previously disturbed with pro-diabetic medication.
Źródło:
Polish Journal of Surgery; 2019, 91, 5; 52-54
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Phytopharmacological study of red, white and black variety of Abrus precatorius L.
Autorzy:
Garaniya, N.H.
Bapodra, A.H.
Ladva, K.D.
Powiązania:
https://bibliotekanauki.pl/articles/11319.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
phytopharmacology
red variety
white variety
black variety
Abrus precatorius
medicinal plant
flavonoids
steroid
Opis:
Abrus precatorius L. is a leguminous plant of family fabaceae. Plant parts are widely used for medicinal purpose in different region of the world. Seed behavior and phytochemical evaluation of different solvent extracts (i.e. Petroleum ether, Ethyl acetate, Methanol & Water) of leaf and seed of red, white and black varieties of Abrus precatorius L. is carried out in the present study. This study indicates presence of different phytoconstituents i.e. alkaloids, steroids, glycosides, proteins, etc. the present study concludes that the plant parts can be used as very good natural remedy to diagnosed variety of dieses.
Źródło:
International Letters of Natural Sciences; 2014, 09
2300-9675
Pojawia się w:
International Letters of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Relationship between receptors for insulin-like growth factor - I, steroid hormones and apoptosis-associated proteins in canine mammary tumors
Autorzy:
Dolka, I.
Motyl, T.
Malicka, E.
Sapierzynski, R.
Fabisiak, M.
Powiązania:
https://bibliotekanauki.pl/articles/32455.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
relationship
receptor
insulin-like growth factor
steroid hormone
apoptosis-associated protein
dog
mammary tumour
cancer
Opis:
In the veterinary literature there are few data concerning the expression of insulin-like growth factor type I (IGF-IR) in the canine mammary gland tumors. The aim of the present study was the evaluation of IGF-IR expression and its correlation to the expression of estrogen receptor α (ERα) and progesterone receptor (PR), proteins: Bcl-2, Bax, p53 in canine mammary gland tumors, and also a correlation with other features: bitch’s age, tumor diameter, histologic type of tumor, degree of histologic malignancy, proliferate activity. The study was done on 112 epithelial neoplasms: 21 (19%) were adenoma, 38 (34%) complex carcinoma (adenocarcinoma), 47 (42%) simple carcinoma (adenocarcinoma) and 6 (5%) solid carcinoma. Histochemistry and immunohistochemistry methods were employed. It was shown that more common and/or higher IGF-IR expression in cells of canine mammary gland tumors was related to the histologic type of cancer of worse prognostic (solid and simple carcinoma), high histologic degree of malignancy (IIIo) but the statistical analysis did not reveal any significant differences. We observed the high degree of IGF-IR expression in tumors which displayed the high ERα and PR expression. These results suggest the involvement of IGF-IR in the development of hormonosensitive canine mammary tumors. Additionally, the significant positive correlation between expression of IGF-IR and p53, Bax was found. Our study provides some evidence that interactions exist between the IGF-IR and these apoptosis-associated proteins may contribute to the development and progression of canine mammary gland tumors. These results require further investigations.
Źródło:
Polish Journal of Veterinary Sciences; 2011, 14, 2
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
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