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Wyświetlanie 1-15 z 122
Tytuł:
Trypsin-specific Inhibitors from the Macrolepiota procera, Armillaria mellea and Amanita phalloides wild mushrooms
Autorzy:
Lukanc, Tjaša
Brzin, Jože
Kos, Janko
Sabotič, Jerica
Powiązania:
https://bibliotekanauki.pl/articles/1038678.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
basidiomycete
inhibitor
trypsin inhibitor
mushroom
trypsin
thermostable
Opis:
Wild growing mushrooms are a rich source of novel proteins with unique features. We have isolated and characterized trypsin inhibitors from two edible mushrooms, the honey fungus (Armillaria mellea) and the parasol mushroom (Macrolepiota procera), and from the poisonous death cap (Amanita phalloides). The trypsin inhibitors isolated: armespin, macrospin and amphaspin, have similar molecular masses, acidic isoelectric points and are not N-glycosylated. They are very strong trypsin inhibitors and weak chymotrypsin inhibitors. They are resistant to exposure to high temperatures and withstand extreme pH values. These exceptional characteristics are advantageous for their potential use in biotechnology, agriculture and medicine.
Źródło:
Acta Biochimica Polonica; 2017, 64, 1; 21-24
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of proteolysis inhibitors from Ascaris lumbricoides suis on developing chicken embryos
Autorzy:
Blaszkowska, J.
Wojcik, A.
Powiązania:
https://bibliotekanauki.pl/articles/840148.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
Ascaris lumbricoides suis
trypsin inhibitor
proteolysis
chicken
inhibitor
embryo
alpha-chymotrypsin inhibitor
Źródło:
Annals of Parasitology; 1998, 44, 3
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Developmental abnormalities in chicken embryos after injection proteolysis inhibitors from Ascaris suum
Autorzy:
Błaszkowska, J.
Powiązania:
https://bibliotekanauki.pl/articles/2147678.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
Ascaris suum
teratogen
proteolysis inhibitor
developmental abnormality
inhibitor
chicken embryo
injection
Opis:
It bas been found that trypsin and α-chymotrypsin inhibitors isolated from Ascaris suum act embryotoxically and teratogenically on White Leghorn clucken embryos. Mortatity rate for the chicken embryos on day 15 of incubation was 45.0 ± 3.5% after injection of trypsin inbibitor and 44.0 ± 3.5% after adminstration α-chymotrypsin inbibitor. Gross examination of surviving embryos and their dissection revealed pathological changes (abdominal dropsy, umbilical hernia, subcutaneous oedema, hemoperitoneum, hemopericardium), symptoms indicating retardation in growth (lack of down, retarded ossification of long bones, decreased mean body weight) as well as malformations (schistocelia, micrognathia, cyclopia, crossed beak, cranial deformities) after injection of inhibitors from Ascaris. The highest incidence of embryos with pathological changes and malformations was found after administralion of α-chymotrypsin inbibitor. The most commonly occurring abnormality was schistocelia (21.4 ± 3.88%). Growth malformations were not found in the control groups. The trypsin and α-chymotrypsin inhibitors present in Ascaris homogenate have a significant disturbing effect on the development of the chicken embryo.
Źródło:
Wiadomości Parazytologiczne; 2002, 48, 1; 55-64
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Exploring Baltic Sea cyanobacteria for small-molecule inhibitors of microRNA function: a project description
Autorzy:
Brzuzan, P.
Mazur-Marzec, H.
Stefaniak, F.
Woźny, M.
Florczyk, M.
Powiązania:
https://bibliotekanauki.pl/articles/363294.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie
Tematy:
cyanobacteria
luciferase reporter cell line
microRNA
small-molecule inhibitor
cyjanobakteria
inhibitor
Morze Bałtyckie
Opis:
Cyanobacteria constitute a rich source of biologically active and structurally diverse compounds. The pharmacological potential of these compounds resides among others in their ability to control the proliferation and growth of cancer cell lines and potent disease-causing microbial agents. Despite recent scientific advances, the way these compounds interact with the body’s molecular structure are still unclear and science still has to discover how the cyanobacterial metabolites interact with cell structures and how cells react to them. In this project, we will study yet unexamined cyanobacterial metabolites, especially the compounds which act as chemical ligands for microRNA (miRNA) -binding sites, making them promising regulators (inhibitors) of gene networks that are involved in various diseases. We will first develop a stable cell line that constitutively expresses a unique miRNA reporter system. Then, we will conduct a screen on chemical compounds discovered in Baltic cyanobacteria to identify small molecules with inhibitory activity and specificity to MIR92b-3p, which has a significant impact on liver cell behavior in humans. We assume that a successful MIR92b-3p inhibitor will bind to the precursors of MIR92b-3p miRNA, disabling the action of either of the two processing enzymes involved in the biogenesis of any miRNA in a cell (Drosha or Dicer), thus affecting the MIR92b function. The discoveries made with these inhibitory chemical molecules could provide insight into the role of the MIR92 pathway in liver diseases and cancer, and possibly, if promising results appear, they may facilitate a strategy for treating some human diseases in the future.
Źródło:
Environmental Biotechnology; 2018, 14, 1; 1-4
1734-4964
Pojawia się w:
Environmental Biotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Developmental abnormalities in chicken embryos after injection proteolysis inhibitors from Ascaris suum
Autorzy:
Blaszkowska, J
Powiązania:
https://bibliotekanauki.pl/articles/840466.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
Ascaris suum
teratogen
proteolysis inhibitor
developmental abnormality
inhibitor
chicken embryo
injection
Opis:
It bas been found that trypsin and α-chymotrypsin inhibitors isolated from Ascaris suum act embryotoxically and teratogenically on White Leghorn clucken embryos. Mortatity rate for the chicken embryos on day 15 of incubation was 45.0 ± 3.5% after injection of trypsin inbibitor and 44.0 ± 3.5% after adminstration α-chymotrypsin inbibitor. Gross examination of surviving embryos and their dissection revealed pathological changes (abdominal dropsy, umbilical hernia, subcutaneous oedema, hemoperitoneum, hemopericardium), symptoms indicating retardation in growth (lack of down, retarded ossification of long bones, decreased mean body weight) as well as malformations (schistocelia, micrognathia, cyclopia, crossed beak, cranial deformities) after injection of inhibitors from Ascaris. The highest incidence of embryos with pathological changes and malformations was found after administralion of α-chymotrypsin inbibitor. The most commonly occurring abnormality was schistocelia (21.4 ± 3.88%). Growth malformations were not found in the control groups. The trypsin and α-chymotrypsin inhibitors present in Ascaris homogenate have a significant disturbing effect on the development of the chicken embryo.
Źródło:
Annals of Parasitology; 2002, 48, 1
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Photochemical screening and corrosion inhibition of Poupartia birrea back extracts as a potential green inhibitor for mild steel in 0.5 M H2SO4 medium
Autorzy:
Louis, H.
Japari, J.
Sadia, A.
Philip, M.
Bamanga, A.
Powiązania:
https://bibliotekanauki.pl/articles/1118151.pdf
Data publikacji:
2017
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Poupartia birrea
corrosion
inhibitor
mild steel
Opis:
Corrosion of metals is a serious environmental problem and has been given much attention in the oil and gas industries. In several industrial processes (acid cleaning and etching, removal of rust and scale), metal surfaces are often made to come in contact with acids. In the present study, an attempt was made to examine Poupartia birrea (P. birres) back extract as a potential green corrosion inhibitor for mild steel in a 0.5 M H2SO4 medium, using the weight loss determination method. The results of our work indicate that highest inhibition efficiency exhibited by Poupartia birrea is 70%. The inhibiting effect of the studied extract could be attributed to the presence of phytochemical constituents present in the extract that are adsorbed on the surface of the mild steel. The plant extract can, hence, be considered as being eco-friendly and an effective green corrosion inhibitor for mild steel exposed to an acid medium.
Źródło:
World News of Natural Sciences; 2017, 10; 95-100
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Study on flotation behavior and mechanism of separating chalcopyrite and Molybdenite with ethyl mercaptoglycolate as inhibitor
Autorzy:
Yang, Xiao-Feng
Xu-Zhao
Liu, Yao-Yao
Powiązania:
https://bibliotekanauki.pl/articles/24085868.pdf
Data publikacji:
2023
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
ethyl thioglycolate
chalcopyrite
molybdenite
inhibitor
separation
Opis:
The effect of ethyl thioglycolate organic small molecule inhibitors on chalcopyrite molybdenite flotation behaviour is investigated via single mineral micro-flotation tests, zeta potential tests, and X-ray photoelectron spectroscopy (XPS) analysis. Results of the flotation test indicate that ethyl thioglycolate organic small-molecule inhibitors can effectively separate Cu and Mo and selectively inhibit chalcopyrite under weak alkaline conditions. Infrared spectroscopy and XPS analysis show that hydrophilic functional groups C=O and -COOH in the ethyl thioglycolate organic small molecules can chemically adsorb onto the chalcopyrite surface. Moreover, ethyl thioglycolate has no obvious effect on zeta potential of molybdenite. Therefore, ethyl thioglycolate can effectively separate chalcopyrite and molybdenite.
Źródło:
Physicochemical Problems of Mineral Processing; 2023, 59, 2; art. no. 162824
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The first line therapy for intermediate/ high risk patients with advanced renal cell carcinoma according to therapeutic program B.10
Autorzy:
Żołnierek, Jakub
Powiązania:
https://bibliotekanauki.pl/articles/22792533.pdf
Data publikacji:
2023-08-19
Wydawca:
Medical Education
Tematy:
renal cell carcinoma
intermediate risk group
unfavourable risk group
tyrosine kinases inhibitor
immune check-point inhibitor
Opis:
The purpose of this article is to discuss the use of therapeutic options for the first-line systemic treatment of patients with advanced renal cell carcinoma under the B.10 drug program effective in Poland as of May 2022 - with a focus on intermediate and high-risk patient populations according to the IMDC. The specific situation created by reimbursement conditions with the exclusion of regimens combined with a tyrosine kinase inhibitor and immune checkpoint inhibitors along with the marginalisation of the use of an mTOr inhibitor necessitates a choice between two-drug immunotherapy or an antian giogenic drug in monotherapy. In this context, choosing the right treatment in the context of specific clinical situations is a challenge.
Źródło:
OncoReview; 2023, 13, 2; 48-57
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Proteolytic activity in the midgut of the crimson speckled moth Utethesia pulchella L. (lepidoptera: arctiidae)
Autorzy:
Ajamhassani, M.
Zibaee, A.
Sendi, J.J.
Askary, H.
Farrar, N.
Powiązania:
https://bibliotekanauki.pl/articles/961656.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
utethesia pulchalle
midgut
protease
inhibitor
Opis:
Samples were prepared from the midgut of 4th instar larvae of the crimson speckled moth Utethesia pulchella L. to find proteolytic activity and properties. Result revealed the presence of high proteolytic activity in the midgut when taking into account specific proteinases including trypsin-like, chymotrypsin-like, elastase and two exopeptidase (aminopeptidase and carboxipeptidase). The optimal pH of general protease was 8 and 7 when using azocasein and hemoglobin as general substrates, respectively. The optimal temperature of the total proteolytic activity in the midgut of U. pulchella was 25°C and 30°C when using azocasein and hemoglobin, respectively. Proteolytic activity was inhibited significantly by soybean trypsin inhibitor (SBTI), phenylmethylsulfonyl fluoride (PMSF), trypsin inhibitor (TLCK), chymotrypsin inhibitor (TPCK) and Phenanthroline. These results provide evidences for the presence of serine proteinases as the major proteases in the midgut of U. pulchella; a key rangeland pest in warm climates. The interaction between digestive proteases and protease inhibitors have potentially important consequences for pest management programs.
Źródło:
Journal of Plant Protection Research; 2012, 52, 3
1427-4345
Pojawia się w:
Journal of Plant Protection Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Investigation of the inhibitory-bactericidal effect of amidoamine-based inorganic complexes against microbiological and atmospheric corrosion
Autorzy:
Aghazada, Y.J.
Abbasov, V.M.
Mursalov, N.I.
Abdullayev, S.E.
Yolchuyeva, U.J.
Powiązania:
https://bibliotekanauki.pl/articles/778541.pdf
Data publikacji:
2020
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
corrosion
inhibitor
bactericide
adsorption
amidoamine
Opis:
In the process, inorganic complexes of amidoamines obtained from the interaction of natural petroleum acid and oleic acids with diethylenetriamine have been developed and their effectiveness as inhibitor-bactericides has been investigated. The effect of the synthesized reagents on the kinetics of the corrosion process of steel and the activity of sulphate-reducing bacteria in 3% NaCl solution saturated with CO2 and in the biphasic water–isopropyl alcohol medium with H2S dissolved has been analyzed. The thermodynamic and kinetic parameters of the corrosion process were calculated. The adsorption of the complexes was investigated using the Langmuir isotherm and the correlation constant was determined. State of the metal surface was investigated by SEM method in CO2 and H2S media, with and without inhibitors, and the metal surface contact of complexes was studied by computer molecular simulation.
Źródło:
Polish Journal of Chemical Technology; 2020, 22, 3; 29-37
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Tadalafil alters energy metabolism in C2C12 skeletal muscle cells
Autorzy:
Sabatini, Stefania
Sgrò, Paolo
Duranti, Guglielmo
Ceci, Roberta
Di Luigi, Luigi
Powiązania:
https://bibliotekanauki.pl/articles/1039925.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
phosphodiesterase type 5 inhibitor
lactate
aerobic enzymes
Opis:
Phosphodiesterases (PDEs) are a family of enzymes that hydrolyze cyclic nucleotides, thereby modulating cell functions. Three highly selective PDE5 inhibitors (PDE5i), sildenafil, vardenafil and tadalafil, have been developed for treatment of erectile dysfunction (ED). Experimental evidence showed that chronic treatment with sildenafil PDE5i in a mouse model of diet-induced obesity and insulin resistance improved insulin action and decreased circulating fatty acid levels. It has recently been shown that healthy athletes use PDE5i as performance enhancers, hence in the present study we investigated whether the long-lasting PDE5i tadalafil influences energy metabolism in C2C12 skeletal muscle cells by evaluating lactate production, glucose consumption, and citrate synthase and 3-OH acyl CoA dehydrogenase activities. Our data demonstrate that tadalafil is able to modulate energy homeostasis in mouse skeletal muscle cells, depending on the treatment length and dose.
Źródło:
Acta Biochimica Polonica; 2011, 58, 2; 237-242
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Defense against own arms: staphylococcal cysteine proteases and their inhibitors.
Autorzy:
Dubin, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1043443.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
staphostatin
staphylococcus
ssp
proteinase
protease inhibitor
staphopain
Opis:
Staphylococcus aureus is a human pathogen causing a wide range of diseases. Most staphylococcal infections, unlike those caused by other bacteria are not toxigenic and very little is known about their pathogenesis. It has been proposed that a core of secreted proteins common to many infectious strains is responsible for colonization and infection. Among those proteins several proteases are present and over the years many different functions in the infection process have been attributed to them. However, little direct, in vivo data has been presented. Two cysteine proteases, staphopain A (ScpA) and staphopain B (SspB) are important members of this group of enzymes. Recently, two cysteine protease inhibitors, staphostatin A and staphostatin B (ScpB and SspC, respectively) were described in S. aureus shedding new light on the complexity of the processes involving the two proteases. The scope of this review is to summarize current knowledge on the network of staphylococcal cysteine proteases and their inhibitors in view of their possible role as virulence factors.
Źródło:
Acta Biochimica Polonica; 2003, 50, 3; 715-724
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Inter-α-inhibitor, hyaluronan and inflammation.
Autorzy:
Fries, Erik
Kaczmarczyk, Aneta
Powiązania:
https://bibliotekanauki.pl/articles/1043445.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
inflammation
hyaluronan
TSG-6
inter-α-inhibitor
Opis:
Inter-α-inhibitor is an abundant plasma protein whose physiological function is only now beginning to be revealed. It consists of three polypeptides: two heavy chains and one light chain called bikunin. Bikunin, which has antiproteolytic activity, carries a chondroitin sulphate chain to which the heavy chains are covalently linked. The heavy chains can be transferred from inter-α-inhibitor to hyaluronan molecules and become covalently linked. This reaction seems to be mediated by TSG-6, a protein secreted by various cells upon stimulation by inflammatory cytokines. Inter-α-inhibitor has been shown to be required for the stabilization of the cumulus cell-oocyte complex during the expansion that occurs prior to ovulation. Hyaluronan-linked heavy chains in the extracellular matrix of this cellular complex have recently been shown to be tightly bound to TSG-6. Since TSG-6 binds to hyaluronan, its complex with heavy chains could stabilize the extracellular matrix by cross-linking hyaluronan molecules. Heavy chains linked to hyaluronan molecules have also been found in inflamed tissues. The physiological role of these complexes is not known but there are indications that they might protect hyaluronan against fragmentation by reactive oxygen species. TSG-6 also binds to bikunin thereby enhancing its antiplasmin activity. Taken together, these results suggest that inter-α-inhibitor is an anti-inflammatory agent which is activated by TSG-6.
Źródło:
Acta Biochimica Polonica; 2003, 50, 3; 735-742
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Investigation on Corrosion Inhibition of Hura Crepitans for 2101 Duplex Stainless Steel in an Acidic Environment
Autorzy:
Temitayo, Ogunmodede O.
Vawe, Humwapwa
Johnson, Jonathan
Adewole, Ezekie
Ilesanmi, Osasona
Powiązania:
https://bibliotekanauki.pl/articles/2201784.pdf
Data publikacji:
2022
Wydawca:
Stowarzyszenie Inżynierów i Techników Mechaników Polskich
Tematy:
corrosion
steel
Hura crepitans
inhibitor
sulphuric acid
Opis:
Corrosion is a global menace which has imparted the world economy greatly. One of the solutions proffered to these challenges is the use of inhibitors. Several natural inhibitors have been used to protect engineering materials from corroding. This research is focused on investigating the inhibitive properties of Hura crepitans seed (HCS) on Duplex Stainless Steel 2101 (DSS2101) in H2SO4. The selected plant part was subjected to characterization to determine the presence of organic anti-corrosion agents present. From the result, phytochemicals such as saponin, tannins, steroid and flavonoids were observed. The presence of the organic group accounted for the inhibitive efficiency recorded in the environment. The polarization studies revealed that generally the inhibitor produced from seed extract of Hura crepitans, improved the corrosion resistance of DSS2101 in 0.5M H2SO4. The optimum corrosion inhibitor efficiency was observed at 0.2% inhibitors in 0.5M H2SO4 for 2101DSS.
Źródło:
Advances in Science and Technology. Research Journal; 2022, 16, 4; 56--63
2299-8624
Pojawia się w:
Advances in Science and Technology. Research Journal
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Corrosion Inhibition of Mild Steel in Nitric Acid Media by some Schiff Bases Derived from Anisalidine
Autorzy:
Saxena, N.
Kumar, S.
Sharma, M. K.
Mathur, S. P.
Powiązania:
https://bibliotekanauki.pl/articles/779278.pdf
Data publikacji:
2013
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
Schiff base
degradation
inhibitor and mild steel
Opis:
Corrosion inhibition performance of mild steel in nitric acid solution containing different concentration of anisalidine derivative Schiff bases viz. N- (4-nitro phenyl) p-anisalidine (SB1), N- (4-chloro phenyl) p-anisalidine (SB2), N- (4-phenyl) p-anisalidine (SB3), N- (4-methoxy phenyl) p-anisalidine (SB4), N- (4-hydroxy phenyl) p-anisalidine (SB5) has been investigated using mass loss, thermometric and potentiostate polarization technique. Inhibition efficiencies of Schiff bases have been evaluated at different acid strength. The inhibition efficiency was found larger than their parent amines. Inhibition efficiencies of synthesized Schiff bases increase with inhibitor concentration. Inhibition efficiency increases up to 98.32% with ansalidine derivative Schiff base.
Źródło:
Polish Journal of Chemical Technology; 2013, 15, 1; 61-67
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 122

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