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Wyświetlanie 1-15 z 141
Tytuł:
Development trends of the international derivatives market
Autorzy:
Motorniuk, U.
Terebukh, M.
Kharchuk, V.
Powiązania:
https://bibliotekanauki.pl/articles/410758.pdf
Data publikacji:
2016
Wydawca:
Polska Akademia Nauk. Oddział w Lublinie PAN
Tematy:
derivatives
interest rate derivatives
foreign exchange derivatives
commodity derivatives
equity derivatives
credit derivatives
futures
options
Opis:
The factors forming international derivatives market trends are researched in this article. The history of the formation of the global derivatives market was analyzed, in particular, events which have led to the growth of the derivatives market. Global derivatives market has revealed major changes in its trends and witnessed the gradual transformation of its structure, observed in recent years. Global derivatives market has revealed major changes in its trends and witnessed the gradual transformation of its structure, observed in recent years. Derivative risks were considered. Benefits of derivatives make them indispensable to the global financial system and the economy The essence, purpose and benefits of the use of derivatives and their role in the modern global financial markets analyzed. The classification of derivatives considered. The main uses for derivatives were single out. The dynamics of global exchange and OTC derivatives markets were analyze. Volatility of the economic environment was significantly improved, leading to a significant increase in financial risks and caused both the professional market and to institutional investors in dire need of new types of derivatives that would enable to effectively hedge to reduce losses in the event of unfavorable changes market and receive additional income from speculative transactions in the market. Possibility of exchange trading for OTC derivatives was emphasized. Courtesy comparative description of the scope and structure of the exchange and OTC derivatives markets were provided. The dynamics of world markets, interest rate derivatives and currency derivatives and studied their structure. The main trends and prospects of the modern international derivatives market are determined.
Źródło:
ECONTECHMOD : An International Quarterly Journal on Economics of Technology and Modelling Processes; 2016, 5, 1; 63-71
2084-5715
Pojawia się w:
ECONTECHMOD : An International Quarterly Journal on Economics of Technology and Modelling Processes
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and in vitro antibacterial and antifungal evaluation of quinoline analogue azetidin and thiazolidin derivatives
Autorzy:
Prajapati, S. M
Vekariya, R. H.
Patel, K. D.
Panchal, S. N.
Patel, H. D.
Rajani, D. P.
Rajani, S.
Powiązania:
https://bibliotekanauki.pl/articles/412324.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
antibacterial
antifungal
quinoline
azetidin derivatives
thiazolidin derivatives
Opis:
A library of quinoline analog two novel series of azetidin (SH1-5) and thiazolidin (SHa-e) derivatives were designed and synthesized with simple and eco-friendly methodologies. The structures of the compounds were elucidated with the aid of elemental analysis, IR, 1H-NMR and mass spectral data. These novel synthesized compounds were evaluated for antibacterial activity against two gram-positive bacteria (Staphylococcus aureus, Staphylococcus pyogenus) and two gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli). The title compounds were also studied for their antifungal activity with Candida albicans, Aspergillus niger, Aspergillus clavatus using the broth dilution technique. Most of the compounds were the best bio-active desired antibacterial analog with less MIC value against different tested strains.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 20, 2; 195-210
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Credit Swaps as Instruments Securing from the Risk
Swapy kredytowe jako instrumenty zabezpieczające przed ryzykiem
Autorzy:
Szczukocka, Agata
Powiązania:
https://bibliotekanauki.pl/articles/905674.pdf
Data publikacji:
2006
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
swaps
risk
derivatives.
Opis:
The interest in the problem of credit risk has significantly increased within the last few dozen years. Scientific literature presents a lot of methods of the credit risk limitation whereas banks try, with various results, to bring proposed methods into effect. Credit derivatives have been ones of the most important innovations of the last years in the world financial system. Their innovation causes that they become objects of the interest of researchers as well as business entities. This paper pays attention to the definition and types of credit derivatives. The author makes also an attempt at indicating the application of these instruments.
W ostatnich kilkudziesięciu latach znacznie wzrosło zainteresowanie problemem ryzyka kredytowego. Literatura naukowa podaje wiele metod i sposobów ograniczania ryzyka kredytowego. Banki natomiast próbują z różnym skutkiem wprowadzać w życie proponowane metody. Jedną z ważniejszych innowacji w światowym systemie finansowym ostatnich lat są pochodne instrumenty kredytowe. Ich innowacyjność sprawia, że są one przedmiotem zainteresowania zarówno badaczy, jak i podmiotów gospodarczych. W artykule zwrócono uwagę na definicję i rodzaje pochodnych instrumentów kredytowych, a także ich zastosowanie.
Źródło:
Acta Universitatis Lodziensis. Folia Oeconomica; 2006, 196
0208-6018
2353-7663
Pojawia się w:
Acta Universitatis Lodziensis. Folia Oeconomica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Infrared study of copper(II) complexes with pyridine-3-carboxamide derivatives in chloride media
Autorzy:
Borowiak-Resterna, A.
Olszanowski, A.
Powiązania:
https://bibliotekanauki.pl/articles/346901.pdf
Data publikacji:
2004
Wydawca:
Politechnika Bydgoska im. Jana i Jędrzeja Śniadeckich. Wydział Technologii i Inżynierii Chemicznej
Tematy:
infrared spectra
solvent extraction
copper(II)
pyridine-3-carboxamide derivatives
benzamide derivatives
Opis:
The extraction studies for copper(II) from chloride solutions by mono- and dialkyl derivatives of benzamide and pyridine-3-carboxamide show that the coordination of copper by amide groups is very weak, weaker than by chloride ions. N,N-dialkyl derivative of benzamide does not extract copper from chloride media but N-alkylbenzamide eliminates a small amount of copper (a great deal smaller than pyridine-3-carboxamide derivatives) only from diluted chloride aqueous solutions ([Cl-] < 0.1 M). Infrared studies of copper complexes with mono- and dialkylpyridine-3-carboxamides show that coordination of the ligand molecules to copper(II) ions takes place mainly by the pyridine nitrogen. More stable monoalkylpyridinecarboxamides complexes with CuCl2 are formed probably by intermolecular hydrogen bonds between monomeric molecules of CuCl2L2 complex (L – the amide). However, weak coordination of copper(II) by the amide group may take place.
Źródło:
Ars Separatoria Acta; 2004, 3; 105-113
1731-6340
Pojawia się w:
Ars Separatoria Acta
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of oil derivatives on the ability of entomopathogenic nematode Steinernema feltiae to find host
Wpływ ropopochodnych na zdolność nicienia Steinernema feltiae do odnajdywania żywiciela
Autorzy:
Ropek, D.
Gospodarek, J.
Powiązania:
https://bibliotekanauki.pl/articles/388827.pdf
Data publikacji:
2013
Wydawca:
Towarzystwo Chemii i Inżynierii Ekologicznej
Tematy:
Steinernema feltiae
oil derivatives
ropopochodne
Opis:
The aim of the research was to evaluate the effect of oil derivatives on entomopatogenic nematode Steinernema feltiae. The effect of unleaded petrol, diesel oil and used engine oil on the ability of S. feltiae infective juveniles to locate test insect was investigated. The experiments were carried out in laboratory conditions in four replications. In the first experiment the effect of oil derivatives on behavior of infective juveniles on agar medium in the presence of test insects was investigated. Oil derivatives were added to the medium at the rate of : 2000, 4000, 6000 and 8000 mm3 dm–3. Infective juveniles did not dispersed towards test insects on agar medium contaminated with oil derivatives. The application of high doses of oil derivatives had also negative effect on nematodes activity and mortality. In the second experiment infective juveniles were applied into contaminated soil. Soil was polluted with following oil derivatives: unleaded petrol, diesel oil and used engine oil at the rate of : 2000, 4000, 6000 i 8000 mg kg–1. In soil contaminated with oil derivatives test insect mortality was significantly lower than in uncontaminated control. It was also revealed that less extensive infestation of test insects with nematodes was observed in contaminated soil. Reaction of S. feltiae to particular oil derivatives was diverse. The most toxic effect on nematode ability to find host was observed in soil polluted with unleaded petrol. The applied oil derivatives had also an adverse effect on the female/male ratio of nematodes infesting host insect.
Celem badań było poznanie wpływu wybranych substancji ropopochodnych na owadobójczego nicienia Steinernema feltiae. Badano wpływ benzyny bezołowiowej, oleju napędowego i zużytego oleju silnikowego na zdolność larw inwazyjnych S. feltiae do odnajdywania potencjalnego żywiciela. Doświadczenia zostały przeprowadzone w warunkach laboratoryjnych. W pierwszym doświadczeniu badano wpływ ropopochodnych na zachowanie się larw inwazyjnych nicienia na zanieczyszczonym podłożu agarowym w obecności owadów testowych. Substancje ropopochodne zastosowano w następujących stężeniach: 2000, 4000, 6000 i 8000 mm3 dm–3. Na podłożu agarowym silnie zanieczyszczonym substancjami ropopochodnymi larwy inwazyjne nicienia nie kierowały się w stronę owada testowego, pozostając w miejscu aplikacji. Zastosowanie wysokich stężeń ropopochodnych powodowało również wysoką śmiertelność larw inwazyjnych. W drugim doświadczeniu larwy inwazyjne wprowadzono do skażonego podłoża glebowego. Zastosowano następujące stężenia substancji ropopochodnych: 2000, 4000, 6000 i 8000 mg kg–1 s.m. W glebie skażonej ropopochodnymi śmiertelność owadów testowych była istotnie mniejsza niż w niezanieczyszczonej kontroli. Stwierdzono także, że owady testowe były w mniejszym stopniu infekowane przez nicienie w glebie skażonej. Reakcja nicienia S. feltiae zależała od rodzaju substancji ropopochodnej. Zdolność nicieni do odnajdywania żywiciela była najsilniej ograniczana przez skażenie podłoża benzyną bezołowiową. Ropopochodne wpłynęły również na strukturę płciową nicieni, które zdołały wniknąć na owadów testowych.
Źródło:
Ecological Chemistry and Engineering. A; 2013, 20, 7-8; 857-865
1898-6188
2084-4530
Pojawia się w:
Ecological Chemistry and Engineering. A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oxytocin analogues with amide groups substituted by tetrazole groups in position 4, 5 or 9
Autorzy:
Manturewicz, Michał
Grzonka, Zbigniew
Borovičková, Lenka
Slaninová, Jiřina
Powiązania:
https://bibliotekanauki.pl/articles/1040873.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
oxytocin analogues
SAR
tetrazole derivatives
Opis:
Eleven oxytocin analogues substituted in position 4, 5 or 9 by tetrazole analogues of amino acids were prepared using solid-phase peptide synthesis method and tested for rat uterotonic in vitro and pressor activities, as well as for their affinity to human oxytocin receptor. The tetrazolic group has been used as a bioisosteric substitution of carboxylic, ester or amide groups in structure-activity relationship studies of biologically active compounds. Replacement of the amide groups of Gln4 and Asn5 in oxytocin by tetrazole analogues of aspartic, glutamic and α-aminoadipic acids containing the tetrazole moiety in the side chains leads to analogues with decreased biological activities. Oxytocin analogues in which the glycine amide residue in position 9 was substituted by tetrazole analogues of glycine had diminished activities as well. The analysis of differences in rat uterotonic activity and in the affinity to human oxytocin receptors of analogues containing either an acidic 5-substituted tetrazolic group or a neutral 1,5- or 2,5-tetrazole nucleus makes it possible to draw some new conclusions concerning the role of the amide group of amino acids in positions 4, 5 and 9 of oxytocin for its activity. The data suggest that the interaction of the side chain of Gln4 with the oxytocin receptor is influenced mainly by electronic effects and the hydrogen bonding capacity of the amide group. Steric effects of the side chain are minor. Substitution of Asn5 by its tetrazole derivative gave an analogue of very low activity. The result suggests that in the interaction between the amide group of Asn5 and the binding sites of oxytocic receptor hydrogen bonds are of less importance than the spatial requirements for this group.
Źródło:
Acta Biochimica Polonica; 2007, 54, 4; 805-811
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and antimicrobial activity of new adamantane derivatives I.
Autorzy:
Orzeszko, Andrzej
Gralewska, Renata
Starościak, Bohdan
Kazimierczuk, Zygmunt
Powiązania:
https://bibliotekanauki.pl/articles/1044397.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
imides
antimicrobial activity
adamantane derivatives
Opis:
A series of fourteen derivatives of adamantane was synthesised. The new compound 4-(adamant-1-ylmethoxycarbonyl)phthalanhydride obtained from 1-adamantane- methanol and trimellitic anhydride chloride appeared very useful for preparation of a number of N-substituted phthalimides. Antimicrobial activity of the newly obtained derivatives such as, for example, 4-(adamant-1-ylmethoxycarbonyl)-N-(5-carboxypentamethylene)phthalimide or 4-(adamant-1-ylmethoxycarbonyl)-N-(L-alanyl)phthalimide was tested against Staphylococcus aureus, Bacillus sp., Micrococcus flavus and Enterococcus faecium. The minimal inhibitory concentration (MIC) for these compounds against S. aureus were 0.022 and 0.05 μg/ml, respectively.
Źródło:
Acta Biochimica Polonica; 2000, 47, 1; 87-94
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of a boundary perforation on the Dirichlet energy
Autorzy:
Dambrine, M.
Vial, G.
Powiązania:
https://bibliotekanauki.pl/articles/970142.pdf
Data publikacji:
2005
Wydawca:
Polska Akademia Nauk. Instytut Badań Systemowych PAN
Tematy:
pochodna kształtu
pochodna topologiczna
singular shape perturbation
shape derivatives
topological derivatives
multi-scale asymptotic expansion
Opis:
We consider some singular perturbations of the boundary of a smooth domain. Such domain variations are not differentiable within the classical theory of shape calculus. We mimic the topological asymptotic and we derive an asymptotic expansion of the shape function in terms of a size parameter. The two-dimensional case of the Dirichlet energy is treated in detail. We give a full theoretical proof as well as a numerical confirmation of the results.
Źródło:
Control and Cybernetics; 2005, 34, 1; 117-136
0324-8569
Pojawia się w:
Control and Cybernetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Selected nonapeptides in terahertz light
Autorzy:
Fuglewicz, B.
Pliński, E. F.
Jarząb, P. P.
Plińska, S.
Cebrat, M.
Nowak, K.
Augustyn, L.
Walczakowski, M. J.
Mikulics, M.
Pałka, N.
Szustakowski, M.
Powiązania:
https://bibliotekanauki.pl/articles/173420.pdf
Data publikacji:
2014
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
terahertz spectroscopy
peptides
oxytocin
vasopressin
derivatives
Opis:
Eight synthetic histidine analogues of oxytocin and vasopressin are subject of investigations. The spectra of the peptides have been investigated in the terahertz band. The results are obtained in the terahertz time-domain spectroscopy arrangement.
Źródło:
Optica Applicata; 2014, 44, 1; 159-171
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Green synthesis of pyrimidine derivative
Autorzy:
Sonawane, R. P.
Powiązania:
https://bibliotekanauki.pl/articles/412470.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
dihydropyrimidine derivatives
Biginelli reaction
Grindstone chemistry
Opis:
The majority of the drugs on the market today are entirely chemically synthesized in the laboratory. Several scientists had synthesized dihydropyrimidine (DHPMs) derivatives showing a wide spectrum of biological actions as antibacterials, antivirals as well as antitumor agents. This activity is principally due to presence of steriogenic carbon C4 in their structure. The current investigation is study and synthesis of dihydropyrimidinones efficiently and in high yields under mild, solvent free and eco-friendly conditions by using “Grindstone Chemistry Technique” catalyzed by CuCl2•2H2O and Conc. HCl. The obtained products have been identified by comparison with spectral data & their melting points. The synthesis of DHPMs derivative involves a multicomponent reaction (aldehyde derivative, urea /thiourea and 1,3-dicarbonyl compounds) in presence of HCl / NH4Cl as a catalyst. 3,4-dihydropyrimidin-2-(1H)-ones was synthesized and characterized using IR. The melting points was obtained 203 °C.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 2; 64-68
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparative Study of Chemical Synthesis of Pyrimidine Derivatives by Using Grindstone Chemistry Technique and Conventional Metod
Autorzy:
Sonawane, R. P.
Powiązania:
https://bibliotekanauki.pl/articles/412505.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
dihydropyrimidine derivatives
Biginelli reaction
Grindstone chemistry
Opis:
The majority of the drugs on the market today are entirely chemically synthesized in the laboratory. Several scientists had synthesized dihydropyrimidine (DHPMs) derivatives showing a wide spectrum of biological actions as antibacterials, antivirals as well as antitumor agents. This activity is principally due to presence of steriogenic carbon C4 in their structure. The current investigation is comparative study of chemically synthesis of two DHPMs derivatives by Biginelli Reaction using conventional method and grindstone chemistry technique. The synthesis of DHPMs derivative involves a multicomponent reaction (aldehyde derivative, urea /thiourea and 1,3-dicarbonyl compounds) in presence of HCl / NH4Cl as a catalyst. Two derivative viz. 3,4-dihydropyrimidin-2-(1H)-ones and 3,4-dihydropyrimidin-2-(1H)-thiones were synthesized and characterized using IR. The melting points were obtained are 208 °C and 210 °C respectively. “Grindstone Chemistry Technique” catalyzed by CuCl2•2H2O and Conc. HCl. gave more yield, solvent free and ecofriendly. The obtained products have been identified by comparison with spectral data & their melting points. This study will help to develop easy protocol for the synthesis of many more DHPMs derivative with high field.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 14, 1; 22-27
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and structure of new modified derivatives based on the quinine molecule and their biological activity
Autorzy:
Mukusheva, Gulim
Zhasymbekova, Aigerym
Nurmaganbetov, Zhangeldy
Powiązania:
https://bibliotekanauki.pl/articles/2204140.pdf
Data publikacji:
2023
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
Quinine derivatives
antimalarial drug
chloroquine
hydroxychloroquine
Opis:
The relevance of the subject matter is conditioned by the constantly growing need to meet human needs in the field of medicine, in particular, the search, study, and further introduction of new types of medicines into practical use. The purpose of this study is to investigate the synthesis of modified quinine alkaloid derivatives, and their structure, to identify the properties and biological activity of antimalarial drugs based on quinine molecules, and to structure the general data of these substances. The leading approach is the analysis of the synthesis of quinine derivatives, their chemical and physical properties, and their ability to exert a medicinal effect. The abstracting method allows structuring alkaloid derivatives and establishing a general relationship between the structural configuration of molecules and their impact on human health in a number of related derivatives. The study identifies the main antimalarial drugs based on quinine molecules, including a comparative analysis of their effectiveness and overall biological activity.
Źródło:
Polish Journal of Chemical Technology; 2023, 25, 1; 28--34
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Electron capture negative ion mass spectra of some freon derivatives
Autorzy:
Asfandiarov, N.
Pshenichnyuk, S.
Fal’ko, V.
Wnorowska, J.
Wnorowski, K.
Szamrej-Foryś, I.
Powiązania:
https://bibliotekanauki.pl/articles/148517.pdf
Data publikacji:
2003
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
negative ions
electron capture
freon derivatives
Opis:
The temperature dependence of dissociative attachment has been investigated in the temperature range 350-575 K for two freon derivatives 1,1,1-C2H3F2Cl and C2F5Cl using Electron Capture Negative Ion Mass Spectra (ECNI MS). The temperature dependence for 1,1,1-C2H3F2Cl is similar to that observed in the case of CF3Cl reported by Illenberger et al. In contrast, C2F5Cl exhibits quite a different spectrum and its temperature behavior. It has been suggested that sigma*C-Cl delocalization onto two empty orbital leads to Cl- ion formation in two different resonance states.
Źródło:
Nukleonika; 2003, 48, 2; 83-88
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hybrid derivatives in contemporary Korean
Autorzy:
Borowiak, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1047576.pdf
Data publikacji:
2020-12-08
Wydawca:
Uniwersytet im. Adama Mickiewicza w Poznaniu
Tematy:
hybrid derivatives
Korean
adjectivization
verbification
nominification
Opis:
The advances in international and intercultural communication resulting in the multilingualism of native communicative communities and ultimately leading to the creation of the global communicative community, is well reflected in the lexical subsystem of many languages all around the world. This subsystem is continuously being enriched not only with numerous borrowings but also with the formations of hybrid type. As far as the Korean language is concerned, opening of the Korean borders to the world in 1876, also opened ‘the lexicon borders’ to the considerable number of Western loanwords, which, with time, started to be used in morpheme-based word-formation processes such as derivation and composition, as well as in new word-formation processes – among them blending and reanalysis. Despite the fact that there are two types of hybrid derivatives distinguished according to the origin of their counterparts (roots and affixes), which are coined and used in contemporary Korean, this article, given its scope, focuses only on the derivatives having the Koreanized bases of European provenance.
Źródło:
Scripta Neophilologica Posnaniensia; 2020, 20; 59-80
1509-4146
Pojawia się w:
Scripta Neophilologica Posnaniensia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
SYNTHESIS AND ANTICONVULSANT PROPERTIES OF SOME N-ARYL AND N-ARYLAMINOMETHYL DERIVATIVES OF 3-P-ISOPROPOXYPHENYLPYRROLIDINE-2,5-DIONE
Autorzy:
Kocharov, Sergey L.
Panosyan, Henry
Chmielewski, Jaroslaw
Gworek, Barbara
Łuszczki, Jarogniew J.
Powiązania:
https://bibliotekanauki.pl/articles/895346.pdf
Data publikacji:
2019-04-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
maximal electroshock-induced seizures
3-p-Isopropoxyphenylpyrrolidine-2
5-dione
N-aryl derivatives
N-arylaminomethyl derivatives
Opis:
Introduction: Anticonvulsant properties of newly synthesized compounds and potential antiepileptic drugs are usually assessed in screen tests in experimental animals. One of the most commonly used screen tests in mice is the maximal electroshock-induced seizure test that reflects tonic-clonic seizures in humans. Materials and Method: A series of 3-p-isopropoxyphenylpyrrolidine-2,5-dione derivatives, including N-aryl and N-arylaminomethyl analogs, were characterized for their anticonvulsant properties in the maximal electroshock-induced seizure test in mice. Electroconvulsions (tonic-clonic seizures) were evoked in adult Albino Swiss mice by a current (sine-wave, 25mA, 50Hz, 500V, 0.2s stimulus duration) delivered via auricular electrodes. Results: N-aryl derivatives did not show any anticonvulsant activity, whereas some representatives of N-arylaminomethyl derivatives, i.e. N-Mannich bases, exhibited a distinct protective action against maximal electroshock-induced (MES) convulsions in mice. Conclusions: Several N-arylaminomethyl derivatives of 3-p-isopropoxyphenylpyrrolidine-2,5-dione may become in future new antiepileptic drugs, or they could serve as valuable supporting materials for obtaining new derivatives with stronger anticonvulsant activities than their maternal compounds.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 2; 265-273
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
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