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Tytuł:
Health risk in road transport workers. Part I. Occupational exposure to chemicals, biomarkers of effect
Autorzy:
Gromadzińska, Jolanta
Wąsowicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2161975.pdf
Data publikacji:
2019-06-14
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
drivers
occupational exposure
markers of occupational exposure
inflammation
Oxidative stress
chemicals
Opis:
Motor vehicle emissions constitute a mixture of different chemicals: volatile organic solvents, polycyclic aromatic hydrocarbons, heavy metals, isocyanates, etc. Drivers working in car cabins are exposed to chemicals deriving from incomplete combustion of fuels, exhaust emissions from working engines and fuel evaporation. Concentrations of these substances are rather low and do not exceed the applicable hygiene standards, but some of them pose, or are suspected to pose, carcinogenic risk. The interaction of chemical substances with human cells and tissues can lead to a number of modifications of metabolic pathways at a cellular level. The first biological mechanism of metabolic modulation is an inflammatory state and oxidative stress generation. The aim of this review is to analyze biomarkers of effect and to assess the hazard of occupational exposure of drivers. Int J Occup Med Environ Health. 2019;32(3):267–80
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2019, 32, 3; 267-280
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The distribution and excretion of 1-methylnaphthalene in rats exposed to 1-methylnaphthalene by inhalation
Autorzy:
Świercz, Radosław
Wąsowicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2162034.pdf
Data publikacji:
2018-12-20
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
rats
distribution
inhalation
toxicokinetic
excretion
1-Methylonaphthalene
Opis:
Objectives 1-Methylnaphthalene (1-MN) is a constituent of polycyclic aromatic hydrocarbons, the chemicals that have become ubiquitous in the environment as result of natural and industrial process. This paper reports a study on the distribution and excretion of 1-MN in rats after single and repeated inhalation exposure to 1-MN vapor. Material and Methods Male Wistar rats were exposed to 1-MN vapor at nominal concentrations of 50 mg/m³ or 200 mg/m³ in the dynamic inhalation chambers (TSE Systems Head Nose Only Exposure) for 6 h (single exposure) or 5 days (6 h/day, repeated exposure). Blood, urine and tissue samples were collected during and after the exposure. Blood, urine and tissue concentrations of 1-MN were estimated by gas chromatography using the headspace technique. Results The elimination of 1-MN from blood followed an open 2-compartment model. The concentration in rat tissues was dependent on the magnitude and time of exposure. After repeated exposure, the concentration 1-MN in tissue decreased in comparison to single exposure. The elimination of 1-MN with urine after single and repeated exposure to 1-MN occurred mainly in the samples collected during the first day of collection. Conclusions 1-Methylnaphthalene was rapidly eliminated from the blood and tissues of animals exposed by inhalation to 1-MN. In repeated exposure, there was probably a significant increase of 1-MN metabolism in rats exposed to low and high 1-MN doses. Under conditions of repeated 1-MN exposure, no significant systemic 1-MN accumulation could be observed. Int J Occup Med Environ Health 2018;31(6):763–770
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2018, 31, 6; 763-770
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Reference genes for gene expression studies on non-small cell lung cancer
Autorzy:
Gresner, Peter
Gromadzinska, Jolanta
Wasowicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/1040589.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
non-small cell lung cancer
reference genes
data normalization
real-time PCR
gene expression
Opis:
Study Objective: The aim of this study was to test a panel of 6 reference genes in order to identify and validate the most suitable reference genes for expression studies in paired healthy and non-small cell lung cancer tissues. Method: Quantitative real-time PCR followed by the NormFinder- and geNorm-based analysis was employed. The study involved 21 non-small cell lung cancer patients. Results: The analysis of experimental data revealed HPRT1 as the most stable gene followed by RPLP0 and ESD. In contrast, GAPDH was found to be the least stable gene. HPRT1 together with ESD was revealed as the pair of genes introducing the least systematic error into data normalization. Validation by bootstrap random sampling technique and by normalizing exemplary gene expression data confirmed the results. Conclusion: Although HPRT1 and ESD may by recommended for data normalization in gene expression studies on non-small cell lung cancer, the suitability of selected reference genes must be unconditionally validated prior to each study.
Źródło:
Acta Biochimica Polonica; 2009, 56, 2; 307-316
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Health risk in transport workers. Part II. Dietary compounds as modulators of occupational exposure to chemicals
Autorzy:
Kozłowska, Lucyna
Gromadzińska, Jolanta
Wąsowicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2161959.pdf
Data publikacji:
2019-07-15
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
diet
heavy metals
benzene
dietary supplements
transport workers
Benzo(a)pyrene
Opis:
Professional drivers are exposed to a number of factors that have a negative influence on their health status. These include vibrations, noise, the lack of fresh air in the car cabin, shift work (frequently at night), monotony resulting from permanent repetition of certain actions, static loads due to immobilization in a sitting position, stress resulting from the need to ensure safety in heavy traffic, as well as air pollution (dust, volatile organic substances, nitrogen and sulfur oxides, polycyclic aromatic hydrocarbons, heavy metals, dioxins, furans and others). Factors associated with the specificity of the profession of a driver, including exposure to chemical substances, result in an increased risk of the development of many diseases, i.e., obesity, diabetes, heart disease, hypertension, extensive genitourinary pathology experienced by taxi drivers, lung cancer and other forms of cancer. In the case of drivers, especially those covering long distances, there are also actual difficulties related to ensuring a proper diet. Although attempts at interventional research that would change the principles of nutrition, as well as ensure physical activity and weight reduction, have been made, their results have not been satisfactory. The paper focuses on the discussion on the role of a diet and dietary phytochemicals in the prevention of adverse health effects of such chemicals as a mix of chemicals in the polluted air, benzo(a)pyrene, benzene and metals (lead, cadmium, chromium, nickel), which are the main sources of exposure in the case of transport workers. Int J Occup Med Environ Health. 2019;32(4):441–64
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2019, 32, 4; 441-464
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hemimellitene (1,2,3-trimethylbenzene) in the liver, lung, kidney, and blood, and dimethylbenzoic acid isomers in the liver, lung, kidney and urine of rats after single and repeated inhalation exposure to hemimellitene
Autorzy:
Świercz, Radosław
Majcherek, Wanda
Wąsowicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2177094.pdf
Data publikacji:
2015-10-08
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
rats
hemimellitene
pseudocumene
mesitylene
inhalation
toxicokinetic
Opis:
Objectives The aim of the study has been to explore hemimellitene distribution in blood, liver, lung and kidney as well as toxicokinetics of its elimination from blood of rats after single and repeated inhalation exposure to this compound. Tissue distribution and excretion with urine of 2-dimethylbenzoic acids (2,3-DMBA and 2,6-DMBA) were also evaluated. Material and Methods Male outbred IMP:WIST rats were used in the experiment. The animals were exposed to hemimellitene vapors at the nominal concentration of 25 ppm, 100 ppm, and 250 ppm in the dynamic inhalation chambers for 6 h for single exposure purpose and for 4 weeks (6 h/day for 5 day/week) for repeated exposure purposes. Results Significantly lower concentrations of hemimellitene were detected in the blood and tissues of animals after repeated inhalation exposure of animals to hemimellitene vapors, which points to reduced retention of the chemical in the lungs of the experimental rats. The trend of hemimellitene elimination from the blood depended solely on exposure intensity, irrespective of exposure time, both after single and repeated exposure. As regards the 2 determined hemimellitene metabolites, the major trend of the metabolic transformation involved formation of 2,3-DMBA. Conclusions The significantly higher urinary 2,3-DMBA concentration after repeated exposure shows that hemimellitene induces enzymatic processes in the rat.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2016, 29, 1; 113-128
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Lipidomic profiles as a tool to search for new biomarkers
Autorzy:
Pisarska, Anna
Wąsowicz, Wojciech
Gromadzińska, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/2084885.pdf
Data publikacji:
2022-04-11
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
cancer
biomarkers
lipids
lipidomics
kidney disease
metabolomic disease
Opis:
Lipidomics belongs to the family of the so-called omics domains, which, based on modern chemical technologies, strive to explain the biological principles of the organism’s functioning. Main biological functions of lipids include energy storage, the formation of cell membranes, and participation in the transmission of biological signals, and their dysregulation is responsible for the development of pathological states. Thanks to lipid profiling, potential biomarkers for disease diagnosis and prognosis can be identified. This paper discusses selected examples of the use of lipidomic tests in the diagnosis of the kidney, metabolic and neoplastic diseases based on research papers published over the last few years (since 2016). Only works based on the study of human biological material by mass spectrometry methods were taken into account. The examples of lipidomics application presented in this publication are only a few of the possibilities of this technique. As potential possibilities have already been discovered, the next step for the research community is to work on standardization of the approach to lipidomic research and to develop bioinformatics methods that allow efficient processing and analysis of large amounts of data generated in this technique.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2022, 35, 2; 111-126
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Revision of reciprocal action of mercury and selenium
Autorzy:
Kuraś, Renata
Janasik, Beata
Wąsowicz, Wojciech
Stanisławska, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/2162011.pdf
Data publikacji:
2018-10-23
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
gene expression
polymorphism
mercury
selenium
antagonism
interaction
Opis:
Diverse forms of mercury (Hg) have various effects on animals and humans because of a variety of routes of administration. Inorganic mercury (iHg) binds to thiol groups of proteins and enzymes in one’s body or is methylated by microorganisms. Organic form of Hg, contrary to the iHg, is more stable but may be demethylated to Hg2+ in the tissue of intestinal flora. Selenium (Se) also occurs in a variety of chemical forms in one’s body but both of these elements behave very differently from one another. Mercury binding to selenide or Se-containing ligands is a primary molecular mechanism that reduces toxicity of Hg. Complexes formed in such a way are irreversible, and thus, biologically inactive. Se deficiency in a human body may impair normal synthesis of selenoproteins and its expression because expression of mRNA may be potentially regulated by the Se status. This paper provides a comprehensive review concerning Hg–Se reciprocal action as a potential mechanism of protective action of Se against Hg toxicity as well as a potential detoxification mechanism. Although interactions between Hg–Se have been presented in numerous studies concerning animals and humans, we have focused mainly on animal models so as to understand molecular mechanisms responsible for antagonism better. The review also investigates what conclusions have been drawn by researchers with respect to the chemical species of Se and Hg (and their relationship) in biological systems as well as genetic variations and expression and/or activity of selenoproteins related to the thioredoxin (thioredoxin Trx/TrxR) system and glutathione metabolism. Int J Occup Med Environ Health 2018;31(5):575–592
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2018, 31, 5; 575-592
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Red blood cell and plasma glutathione peroxidase activities and selenium concentration in patients with chronic kidney disease: A review
Autorzy:
Zachara, Bronisław
Gromadzińska, Jolanta
Wąsowicz, Wojciech
Zbróg, Zbigniew
Powiązania:
https://bibliotekanauki.pl/articles/1041155.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
hemodialysis
selenium
kidney transplantation
glutathione peroxidase
chronic kidney disease
antioxidants
plasma
Opis:
The metabolism of oxygen in aerobic organisms leads to generation of reactive oxygen species (ROS). These entities are able to oxidize almost all classes of macromolecules, including proteins, lipids and nucleic acids. The physiological level of ROS is usually regulated by antioxidant defense mechanisms. There are at least three groups of antioxidant enzymes: superoxide dismutases, catalases and glutathione peroxidases (GSH-Pxs) which neutralize ROS. The trace elements (copper, zinc and selenium) bound to the active sites of the above listed enzymes play an important role in the antioxidant defense system. In mammals, a major function of selenium (Se) and Se-dependent GSH-Pxs is to protect cells from oxidative stress. Selenium concentrations and GSH-Px activities are altered in blood components of chronic kidney disease (CKD) patients. The Se level is frequently lower than in healthy subjects and the concentration very often decreases gradually with advancing stage of the disease. Studies on red cell GSH-Px activity in CKD patients reported its values significantly lower, significantly higher and lower or higher, but not significantly as compared with healthy subjects. On the other hand, all authors who studied plasma GSH-Px activity have shown significantly lower values than in healthy subjects. The degree of the reduction decreases gradually with the progression of the disease. High inverse correlations were seen between plasma GSH-Px activity and creatinine level. A gradual decrease in plasma GSH-Px activity in CKD patients is due to the fact that this enzyme is synthesized predominantly in the kidney and thus the impairment of this organ is the cause of the enzyme's lower activity. Se supplementation to CKD patients has a slightly positive effect in the incipient stage of the disease, but usually no effect was observed in end-stage CKD. Presently, kidney transplantation is the only treatment that may restore plasma Se level and GSH-Px activity in patients suffering from end-stage CKD. A few studies have shown that in kidney recipients, plasma Se concentration and GSH-Px activity are restored to normal values within a period of 2 weeks to 3 months following surgery and thus it can be acknowledged that Se supplementation to those patients has a positive effect on plasma GSH-Px activity.
Źródło:
Acta Biochimica Polonica; 2006, 53, 4; 663-677
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Can the effects of chromium compounds exposure be modulated by vitamins and microelements?
Autorzy:
Sijko, Monika
Janasik, Beata
Wąsowicz, Wojciech
Kozłowska, Lucyna
Powiązania:
https://bibliotekanauki.pl/articles/2086573.pdf
Data publikacji:
2021-08-05
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
zinc
folic acid
selenium
hexavalent chromium
vitamin E
vitamin C
Opis:
Chromium (Cr) is a very common element. It occurs in 2 oxidation states, Cr(III) and Cr(VI). Although Cr(III) is not considered an element essential for mammals, it raises lots of controversy due to its role in the body. While Cr(III) action should be considered an effect of pharmacological action, Cr(VI) is included in the first group of carcinogens for humans. Moreover, it induces numerous pathological changes in the respiratory, urinary, reproductive and digestive systems. In addition, Cr(VI) is used in many industry branches, causing millions of workers all over the world to be exposed to Cr(VI) compounds. A considerable number of the occupationally exposed individuals are in favor of a deep analysis of the mechanisms of Cr(VI) action and a search for a way to reduce its negative impact on the human body. Numerous reactive oxygen species inducing oxidative stress and causing various damage are produced during Cr(VI) reduction in the cells. A good balance between antioxidants and pro-oxidants can reduce Cr(VI)-induced damage. The influence of vitamins and microelements on the adverse Cr(VI) effects has no systematic research results summary. Therefore, this work focuses on the role of dietary antioxidants such as vitamins and microelements in the prevention of Cr(VI) adverse health effects. Numerous studies have revealed a protective influence of vitamins (mainly vitamins E and C) as well as microelements (especially selenium) on the reduction of Cr(VI)-induced adverse changes. A potential protective effect of these ingredients may be useful in occupational groups that are particularly exposed to Cr(VI). However, more research in this area is required.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2021, 34, 4; 461-490
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Faster health deterioration among nail technicians occupationally exposed to low levels of volatile organic compounds
Autorzy:
Grešner, Peter
Świercz, Radosław
Wąsowicz, Wojciech
Gromadzińska, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/2167475.pdf
Data publikacji:
2017-05-08
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
occupational exposure
volatile organic compounds
survival analysis
case-control study
adverse health effects
nail technicians
Opis:
Objectives The study has aimed at investigating the subjective assessment of an individual’s health status and comparing the prevalence of selected work-related symptoms among nail technicians occupationally exposed to volatile organic compounds (VOCs) to the one among control subjects. Associations between occupational exposure to VOCs and the incidence of adverse health effects were also analyzed. Material and Methods The study involved 145 female nail technicians and 152 control subjects. Data on the prevalence of adverse health effects was collected using the researcher- made questionnaire and then analyzed by means of survival analysis methods. Results Only 22% of nail technicians as compared to 45% of control subjects described their current health status as “excellent” or “very good” (odds ratio (OR) = 0.4, 95% confidence interval (CI): 0.2–0.6, p < 0.00005). In general, 61% of nail technicians confirmed to have experienced any out of all symptoms considered in the study since the commencement of the job, which was significantly higher as compared to 17% of control subjects (adjusted OR = 2.8, 95% CI: 2.1–3.7, p < 0.0001). Estimated median length of the employment period free of investigated symptoms was significantly shorter among nail technicians as compared to controls (12 years vs. 33 years, p < 0.0001), consistent with almost 4-times increased hazard of the occurrence of such symptoms among the technicians (hazard ratio (HR) = 3.9, 95% CI: 2.7–5.7, p < 0.0001). Cox proportional hazard regression modeling revealed almost 5-times increased hazard of the occurrence of any symptoms among nail technicians exposed to higher levels of the mixture of VOCs as compared to those exposed to lower levels (HR = 4.9, 95% CI: 1–24.1, p = 0.05). Conclusions All outcomes combined together indicate that nail technicians are subject to faster health deterioration, which may be assumed to be caused by occupational exposure to low levels of VOCs. Int J Occup Med Environ Health 2017;30(3):469–483
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2017, 30, 3; 469-483
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Today’s oxidative stress markers
Współczesne markery stresu oksydacyjnego
Autorzy:
Czerska, Marta
Mikołajewska, Karolina
Zieliński, Marek
Gromadzińska, Jolanta
Wąsowicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2165384.pdf
Data publikacji:
2015-07-09
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
izoprostany
stres oksydacyjny
markery stresu oksydacyjnego
alantoina
metabolity izoprostanów
isoprostanes
Oxidative stress
oxidative stress markers
allantoin
metabolites of isoprostanes
Opis:
Oxidative stress represents a situation where there is an imbalance between the reactive oxygen species (ROS) and the availability and the activity of antioxidants. This balance is disturbed by increased generation of free radicals or decreased antioxidant activity. It is very important to develop methods and find appropriate biomarkers that may be used to assess oxidative stress in vivo. It is significant because appropriate measurement of such stress is necessary in identifying its role in lifestyle-related diseases. Previously used markers of oxidative stress, such as thiobarbituric acid reactive substances (TBARS) or malondialdehyde (MDA), are progressively being supplemented by new ones, such as isoprostanes (IsoPs) and their metabolites or allantoin. This paper is focusing on the presentation of new ones, promising markers of oxidative stress (IsoPs, their metabolites and allantoin), taking into account the advantage of those markers over markers used previously. Med Pr 2015;66(3):393–405
Stres oksydacyjny jest stanem braku równowagi między działaniem reaktywnych form tlenu (RFT) a działaniem antyoksydantów. Równowaga ta może być zakłócona w wyniku zwiększonego działania wolnych rodników lub spadku aktywności antyoksydacyjnej. Zaburzenia te mogą występować zarówno na poziomie komórkowym, jak i całego organizmu. Ponieważ stres oksydacyjny może być podłożem wielu zespołów chorobowych, niezwykle istotne jest znalezienie odpowiednich markerów, które mogą być wykorzystane do oceny jego poziomu in vivo. Stosowane od wielu lat markery – ocenę stężenia aldehyd dimalonowy (MDA) i substancji reagujących z kwasem tiobarbiturowym (thiobarbituric acid reactive substances – TBARS) – stopniowo uzupełnia się nowymi, takimi jak alantoina czy izoprostany (IzoP) wraz z ich metabolitami (IzoP-M). W niniejszej pracy skupiono się na zaprezentowaniu nowych, obiecujących markerów stresu oksydacyjnego (alantoina, IzoP, IzoP-M), ukazując korzyści wynikające z ich stosowania i prognozując dalsze kierunki badań nad ich zastosowaniem. Med. Pr. 2015;66(3):393–405
Źródło:
Medycyna Pracy; 2015, 66, 3; 393-405
0465-5893
2353-1339
Pojawia się w:
Medycyna Pracy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
4-Week inhalation toxicity of 2-methylnaphthalene in experimental animals
Autorzy:
Świercz, Radosław
Wąsowicz, Wojciech
Stetkiewicz, Jan
Gromadzińska, Jolanta
Majcherek, Wanda
Powiązania:
https://bibliotekanauki.pl/articles/2185378.pdf
Data publikacji:
2011-12-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
2-Methylnaphthalene
rats
inhalation
NOAEL
LOAEL
Opis:
Objectives: This paper presents toxic effects of 2-MN in laboratory animals under conditions of 4-week inhalation exposure to 2-methylnaphthalene (2-MN) vapors. Materials and Methods: Male Wistar rats were exposed to 2-MN vapors at a nominal concentration of 0, 2, 10 or 50 mg/m³ in dynamic inhalation chambers for 4 weeks (6 h/day, 5 days/week). After 4 weeks of inhalation exposure the animals were necropsied. Blood samples were collected and selected organs were weighted and prepared for histological examinations. Results: The effects of the increased levels of exposure to 2-MN experienced by the experimental rats were as follows: a) increasing γ-glutamylotransferase activity, b) stimulation of the hematopoietic system, c) lower cholesterol concentrations, d) higher number of goblet cells in lobar bronchi, e) hyperplasia of hepatic bile ducts. Conclusion: Four-week exposure of the animals to 2-MN at 2 mg/m³ proved to be the no-observed-adverse-effect-level (NOAEL), while 10 mg/m³ appeared to represent the lowest-observed-adverseeffect- level (LOAEL).
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2011, 24, 4; 399-408
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fertility and developmental toxicity studies of diethylene glycol monobutyl ether (DGBE) in rats
Autorzy:
Sitarek, Krystyna
Gromadzińska, Jolanta
Lutz, Piotr
Stetkiewicz, Jan
Świercz, Radosław
Wąsowicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2180019.pdf
Data publikacji:
2012-09-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
dimethylene glycol monobutyl ether (DGBE)
CAS No. 112-34-5
female and male rats
fertility
Opis:
Objectives The solvent, dimethylene glycol monobutyl ether (DGBE), is a component of latex paints, inks; it is used as a degreasing agent, industrial detergent. The aim of the study was evaluating the effects of DGBE administered by gavage on the estrous cycle and given with drinking water on fertility in rats and early development of their progeny. Materials and Methods Female rats were exposed to DGBE by gavage during 8 weeks at 250, 500 or 1000 mg/kg/day. Vaginal smears were collected during the exposure and 4 weeks after its cessation. Fertility studies were performed in male and female animals exposed to in drinking water. Males were exposed for 10 weeks and then mated with females exposed before mating, during pregnancy and lactation. Young animals were observed during 3 weeks after birth. Results DGBE does not cause disturbances of the menstrual cycle in females. Parameters used to assess the general toxicity indicate that males receiving DGBE in drinking water are more sensitive to this compound than females: significantly greater, dose-dependent relative spleen weight, significant decrease in hematological parameters from 8% to 15% depending on the dose, were observed. Clinical chemistry parameters (HDL-cholesterol, BUN) and some markers of oxidative stress differ between the exposed groups and the control one, but without adverse health effect. The microscopic examination of internal organs did not reveal morphological changes in male and female rats. Conclusion The results of our study on the impact of exposure to DGBE on fertility in rats indicate that the substance administered for 9–10 weeks to females and males at a limit dose of 1000 mg/kg did not impair fertility or viability of their offspring during the first three weeks of life.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2012, 25, 4; 404-417
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clara cells protein, prolactin and transcription factors of protein NF-ĸB and c-Jun/AP-1 levels in rats inhaled to stainless steel welding dust and its soluble form
Autorzy:
Hałatek, Tadeusz
Stanisławska, Magdalena
Świercz, Radosław
Domeradzka-Gajda, Katarzyna
Kuraś, Renata
Wąsowicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2162014.pdf
Data publikacji:
2018-10-23
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
prolactin
stainless welding
Clara cells protein
NF-kB
c-Jun/AP-1
LA-ICP-MS
Opis:
Objectives Welding processes that generate fumes containing toxic metals, such as hexavalent chromium (Cr(VI)), manganese, and nickel (Ni), have been implicated in lung injury, inflammation, and lung tumor promotion in animal models. Bronchiolar epithelium Clara cells/club cells, coordinate these inflammatory responses. Clara cells secretory protein (CC16) with ant-inflammatory role. Material and Methods The pulmonary toxicity of welding dust (WD) was assessed for Wistar rats exposed to 60 mg/m³ of respirable-size welding dust (mean diameter 1.17 μm for 1 and 2 weeks (6 h/day, 5 days/week)) or the aerosols of soluble form (SWD) in the nose-only exposure chambers. Additionally the effect of antiinflammatory betaine supplementation was assessed. Clara cells secretory protein, differential cell counts, total protein concentrations and cellular enzyme (lactate dehydrogenase – LDH) activities were determined in bronchoalveolar lavage fluid, and corticosterone and thiobarbituric acid reactive substances (TBARS) and prolactin concentrations were assessed in serum. Histopathology examination of lung, brain, liver, kidney, spleen was done. Additionally slices of brain and lung were exanimated in laser ablation inductively coupled plasma mass spectrometry. Results Both WD and SWD exposure evoked large bronchiolar infiltration shoved in histopathology examination. In this study, TBARS inversely correlated with a significant decrease of CC16 concentration that occurred after instillation of both WD and SWD indicating decreased anti- inflammatory potential in the lung. In WD exposed rats prolactin correlated with nuclear factor-kappa B (NF-κB), LDH, TBARS and serum levels Cr, Ni and inversely with c-Jun. In SWD exposed rats prolactin correlated with CC16 indicated effect of prolactin on the population of epithelial cells. Conclusions In the current study, deleterious effects of repeated inhalation stainless steel welding dust form on club (Clara) cell secretory protein (CC16) were demonstrated. Clara cells secretory protein relation with prolactin in exposed rats to welding dust were shown and explored whether the NF-κB and c-Jun/activator protein 1 related pathway was involved. Int J Occup Med Environ Health 2018;31(5):613–632
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2018, 31, 5; 613-632
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Partial protection from organophosphate-induced cholinesterase inhibition by metyrapone treatment
Autorzy:
Świercz, Radosław
Lutz, Piotr
Gralewicz, Sławomir
Grzelińska, Zofia
Piasecka-Zelga, Joanna
Wąsowicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2179137.pdf
Data publikacji:
2013-08-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
chlorfenvinphos
metyrapone
cholinesterase
corticosterone
Opis:
Background: Organophosphates are cholinesterase (ChE) inhibitors with worldwide use as insecticides. Stress response, evidenced by a dramatic and relatively long-lasting (several hours) rise in the plasma glucocorticoid concentration is an integral element of the organophosphate (OP) poisoning symptomatology. In rodents, corticosterone (CORT) is the main glucocorticoid. There are several reports suggesting a relationship between the stressor-induced rise in CORT concentraion (the CORT response) and the activity of the cerebral and peripheral ChE. Thus, it seems reasonable to presume that, in OP intoxication, the rise in plasma CORT concentration may somehow affect the magnitude of the OP-induced ChE inhibition. Metyrapone (MET) [2-methyl-1,2-di(pyridin-3-yl)propan-1-one] blocks CORT synthesis by inhibiting steoid 11β-hydroxylase, thereby preventing the CORT response. Chlorfenvinphos (CVP) [2-chloro-1-(2,4-dichlorophenyl) ethenyl diethyl phosphate] is an organophosphate insecticide still in use in some countries. Material and Methods: The purose of the present work was to compare the CVP-induced effects - the rise of the plasma CORT concentration and the reduction in ChE activity - in MET-treated and MET-untreated rats. Chlorfenvinphos was administered once at 0.0, 0.5, 1.0 and 3.0 mg/kg i.p. Metyrapone, at 100 mg/kg i.p., was administered five times, at 24-h intervals. The first MET dose was given two hours before CVP. Conclusion: The following was observed in the MET-treated rats: i) no rise in plasma CORT concentration after the CVP administration, ii) a reduced inhibition and a faster restitution of blood and brain ChE activities. The results suggest that MET treatment may confer significant protection against at least some effects of OP poisoning. The likely mechanism of the protective MET action has been discussed.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2013, 26, 4; 636-646
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
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