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    Wyświetlanie 1-15 z 15
    Tytuł:
    Cyclic enkephalin-deltorphin hybrids containing a carbonyl bridge: structure and opioid activity
    Autorzy:
    Ciszewska, Małgorzata
    Ruszczyńska, Katarzyna
    Oleszczuk, Marta
    Chung, Nga
    Witkowska, Ewa
    Schiller, Peter
    Wójcik, Jacek
    Izdebski, Jan
    Powiązania:
    https://bibliotekanauki.pl/articles/1039922.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    cyclic opioid peptides
    conformation
    NMR
    N-(ureidoethyl)amides
    side-chain to side-chain cyclization
    structure-activity relationship
    Opis:
    Six hybrid N-ureidoethylamides of octapeptides in which an N-terminal cyclic structure related to enkephalin was elongated by a C-terminal fragment of deltorphin were synthesized on MBHA resin. The synthetic procedure involved deprotection of Boc groups with HCl/dioxane and cleavage of the peptide resin with 45 % TFA in DCM. d-Lys and d-Orn were incorporated in position 2, and Lys, Orn, Dab, or Dap in position 5. The side chains of the dibasic amino function were protected with the Fmoc group. This protection was removed by treatment with 55 % piperidine in DMF, and cyclization was achieved by treatment with bis-(4-nitrophenyl)carbonate. Using various combinations of dibasic amino acids, peptides containing a 17-, 18-, 19- or 20-membered ring structure were obtained. The peptides were tested in the guinea-pig ileum (GPI) and mouse vas deferens (MVD) assays. Diverse opioid activities were observed, depending on the size of the ring. Extension of the enkephalin sequence at the C-terminus by a deltorphin fragment resulted in a change of receptor selectivity in favor of the δ receptor. The conformational propensities of selected peptides were determined using the EDMC method in conjunction with data derived from NMR experiments carried out in water. This approach allowed proper examination of the dynamical behavior of these small peptides. The results were compared with those obtained earlier with corresponding N-(ureidoethyl)pentapeptide amides.
    Źródło:
    Acta Biochimica Polonica; 2011, 58, 2; 225-230
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Light conditions alter accumulation of long chain polyprenols in leaves of trees and shrubs throughout the vegetation season.
    Autorzy:
    Bajda, Agnieszka
    Chojnacki, Tadeusz
    Hertel, Józefina
    Swiezewska, Ewa
    Wójcik, Jacek
    Kaczkowska, Alicja
    Marczewski, Andrzej
    Bojarczuk, Tomasz
    Karolewski, Piotr
    Oleksyn, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/1041482.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    plant polyprenols
    SLA
    Opis:
    In many plants belonging to angiosperms and gymnosperms the accumulation in leaves of long chain polyprenols and polyprenyl esters during growth in natural habitats depends on the light intensity. The amount of polyprenols in leaves is also positively correlated with the thickness of the leaf blade (SLA, specific leaf area). The polyprenol content of leaves shows seasonal changes with a maximum in autumn and a minimum in early summer with the difference between poorly and well illuminated plants persisting throughout the vegetation season.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 1; 233-241
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Health in the context of martial arts practice
    Autorzy:
    Wąsik, Jacek
    Wójcik, Agata
    Powiązania:
    https://bibliotekanauki.pl/articles/1031741.pdf
    Data publikacji:
    2017
    Wydawca:
    PPHU Projack Jacek Wąsik
    Tematy:
    health
    martial arts
    quality of life
    Opis:
    One of the manifestations of physical activity are martial arts. Modern research also concerns the problem of treating martial arts not only as a means of self defence, sport or how one spends their free time, but also as a therapy. Therapy throu gh traditional martial arts can help treat many medical disorders. It was acclaimed that participation in the traditional martial arts promotes mental health. It was noted that the sense of self - worth and self - esteem of competence is directly related to th e time spent doing training. Current studies show that the traditional martial arts are largely effective, complementary strategy of medical care and rehabilitation of chronic diseases. By watching yet another MMA event on the TV, seeing players’ faces bei ng hit and blood flowing on their bodies, it is worth to be aware that it’s just a spectacular event. The everyday life of people concerned with martial arts is different. Often times they undertake these exercises to improve their physical fitness and the quality of life. It is followed by taking responsibility for their health and not giving it exclusively to the doctor. This results in an active and rational fight agains any disease.
    Źródło:
    Physical Activity Review; 2017, 5; 91-94
    2300-5076
    Pojawia się w:
    Physical Activity Review
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Rup Driven Development of Social Learning Platform
    Zastosowanie metodyki RUP w działaniach analityczno-projektowych przy rozwoju platformy nauczania społecznościowego
    Autorzy:
    Jakieła, Jacek
    Wójcik, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/588235.pdf
    Data publikacji:
    2014
    Wydawca:
    Uniwersytet Ekonomiczny w Katowicach
    Tematy:
    Bezpieczeństwo danych
    Rynek informatyczny
    Systemy informatyczne
    Zabezpieczenie systemów informatycznych
    Computer system
    Data security
    Information technology (IT) market
    Security of information systems
    Opis:
    Celem prac, których częściowe rezultaty przedstawiono w niniejszym artykule, było zaprojektowanie i zaimplementowanie platformy nauczania społecznościowego WeLearning na poziomie szkolnictwa wyższego, uwzględniającej mechanizmy grywalizacji. Działania analityczno-projektowe zrealizowano z wykorzystaniem metodyki RUP. W artykule wyjaśniono, dlaczego wybór metodyki RUP był właściwą decyzją podczas projektowania platformy, oraz przedstawiono szczegółowo kolejne fazy cyklu życia projektu platformy, tj. fazę rozpoczęcia, opracowywania, konstrukcji oraz przekazania systemu.
    Źródło:
    Studia Ekonomiczne; 2014, 188; 65-83
    2083-8611
    Pojawia się w:
    Studia Ekonomiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Role of biochemical factors in the pathogenesis of keratoconus
    Autorzy:
    Wojcik, Katarzyna
    Blasiak, Janusz
    Szaflik, Jerzy
    Szaflik, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/1039330.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    keratoconus
    cornea
    collagen
    proteinases
    proinflammatory markers
    antioxidants
    Opis:
    Keratoconus (KC) is a corneal disease associated with structural abnormalities in the corneal epithelium, Bowman's layer and stroma and altered concentration of tear components. KC corneas show a different pattern of collagen lamellae than their normal counterparts. Also, a reduction of several collagen types in KC epithelium and stroma was observed. Altered expression and/or activity of lysyl oxidase, a critical enzyme of the biogenesis of connective tissue detected in KC corneas, may weaken covalent bonds between collagen and elastin fibrils, what may lead to biomechanical deterioration of the cornea. Increased activity of matrix metalloproteinases observed in KC may induce the degradation of the extracellular matrix causing damage to the cornea. Oxidative and nitrative stress play an important role in KC pathogenesis and KC corneas are characterized by the disturbed lipid peroxidation and nitric oxide pathways. Malfunctioning of these pathways may lead to accumulation of their toxic by-products inducing several detrimental effects, along with apoptosis of the corneal cells, which may result from the loss of β-actin or increased levels of cytokines, including interleukin-1 and -6. Change in the expression of genes associated with wound healing, including the nerve growth factor and the visual system homeobox 1, may contribute to increased susceptibility of KC corneas to injury. Consequently, biochemical changes may play an important role in KC pathophysiology and, therefore, can be considered in prevention, diagnosis, prognosis and in the therapy of this disease as well.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 1; 55-62
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prevalence of tick-borne pathogens at various workplaces in forest exploitation environment
    Występowanie patogenów przenoszonych przez kleszcze na różnych stanowiskach pracy w środowisku eksploatacji lasu
    Autorzy:
    Cisak, Ewa
    Wójcik-Fatla, Angelina
    Zając, Violetta
    Dutkiewicz, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/2166205.pdf
    Data publikacji:
    2014-12-05
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    Anaplasma phagocytophilum
    Babesia microti
    Borrelia burgdorferi
    kleszcze Ixodes ricinus
    leśnictwo
    miejsca pracy
    Ixodes ricinus ticks
    forestry
    workplaces
    Opis:
    Background: The objective of the study was the evaluation of the infection of ticks with pathogenic microorganisms at various workplaces (timber acquisition, forest growing, forest cultivation, forest protection). Material and Methods: Eight hundred sixty one Ixodes ricinus ticks collected from 4 workplaces were examined for the presence of Borrelia burgdorferi, Anaplasma phagocytophilum and Babesia microti by polymerase chain reaction (PCR). Then, a comparative analysis of the relative density and infection of ticks at individual workplaces was done. In the statistical analysis, Chi² test, and Pearson’s test for correlation were applied. Results: The differences in infection (15.9–50%) of ticks with B. burgdorferi between the examined workplaces were highly significant, with the highest percentage observed at forest growing. The percentages of infection of ticks with A. phagocytophilum at individual workplaces ranged from 1.1–3.7%, and differences were statistically insignificant. The percentages of infections of ticks with Babesia microti at individual workplaces fluctuated from 3.6–4.4% and differences were also insignificant. Co-infections of ticks with 2 or 3 pathogens were rare. Conclusions: Co-infections with B. burgdorferi and B. microti showed a significant relationship with the workplaces, while those with B. burgdorferi and A. phagocytophilum did not show such a dependence. No significant positive correlation was found between the relative density of ticks and the frequencies of infections with B. burgdorferi, A. phagocytophilum and B. microti. Med. Pr. 2014;65(5):575–581
    Wstęp: Celem badań była ocena zakażenia kleszczy występujących na różnych miejscach i stanowiskach pracy w leśnictwie (uzyskiwanie drewna, hodowla lasu, uprawa lasu, ochrona lasu) patogenami przenoszonymi przez kleszcze. Materiał i metody: Z 4 miejsc pracy zebrano 861 kleszczy Ixodes ricinus, które zbadano na obecność Borrelia burgdorferi, Anaplasma phagocytophilum i Babesia microti przy pomocy łańcuchowej reakcji polimerazy (polymerase chain reaction – PCR). Następnie przeprowadzono analizę porównawczą względnej gęstości kleszczy i ich zakażenia w poszczególnych miejscach pracy. W analizie statystycznej zastosowano test Chi² i test korelacji Pearsona. Wyniki: Różnice w zakażeniach kleszczy B. burgdorferi (15,9–50%) zebranych z różnych miejsc pracy były statystycznie wysoce istotne, a najwyższe zakażenie kleszczy zaobserwowano w miejscu hodowli lasu. Odsetki zakażeń kleszczy A. phagocytophilum i B. microti na poszczególnych miejscach pracy wahały się odpowiednio od 1,1% do 3,7% i od 3,6% do 4,4%, a różnice były nieistotne statystycznie. Współzakażenia kleszczy 2 lub 3 patogenami występowały rzadko. Wnioski: Wykazano istotną zależność koinfekcji B. burgdorferi i B. microti od stanowiska pracy, natomiast nie stwierdzono jej dla współwystępowania B. burgdorferi i A. phagocytophilum. Nie wykazano korelacji między względną aktywnością a zakażeniem kleszczy B. burgdorferi, A. phagocytophilum i B. microti. Med Pr 2014;65(5):575–581
    Źródło:
    Medycyna Pracy; 2014, 65, 5; 575-581
    0465-5893
    2353-1339
    Pojawia się w:
    Medycyna Pracy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Comparison of the efficiency of two commercial kits - ELFA and Western blot in estimating the phase of Toxoplasma gondii infection in pregnant women
    Autorzy:
    Sroka, Jacek
    Wójcik-Fatla, Angelina
    Zając, Violetta
    Sawczyn, Anna
    Cisak, Ewa
    Karamon, Jacek
    Dutkiewicz, Jacek
    Bojar, Iwona
    Powiązania:
    https://bibliotekanauki.pl/articles/991156.pdf
    Data publikacji:
    2016
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    toxoplasmosis
    pregnant women
    seroprevalence
    antibodies
    igg
    igm
    elfa
    western blot
    avidity
    correlation of serologic tests
    Opis:
    Sera of 89 pregnant women were selected according to the results of ELFA IgM, IgG and avidity IgG, and tested with commercial tests IgM, IgG and avidity IgG Western Blot (WB) to compare the efficacy of both techniques in determining the phase of T. gondii infection. In total, 81 of 89 tested sera (91.0%) were classified as positive, both in the ELFA and WB tests for the presence of anti-Toxoplasma antibodies of class IgG, indicating a past infection, while the prevalence of anti-Toxoplasma positive reactions associated with the antibodies of class IgM indicating a recent infection was much lower – 31.5% and 20.2%, respectively. Sera of 81 women were also tested in the ELFA and WB tests for avidity, e.g. ability of forming high-molecular IgG antibody complexes. Low or medium results in these tests (in this study all classified as low), indicating a recent infection, were detected by ELFA and WB in 22.2% and 45.7% of the total examined samples, respectively. The Spearman’s rank test for correlation, performed for recognition of quantitative data of the ELFA and WB tests (index, units or points), revealed a highly significant correlation between the ELFA and WB tests for homologous classes of antibodies, both for IgM and IgG (p<0.00001). In contrast, the ELFA and WB tests for detection of anti-Toxoplasma IgM antibodies were not correlated with the ELFA and WB tests for detection of anti-Toxoplasma IgG antibodies (p>0.05), except for the WB test for IgM antibodies, which showed a significant correlation with the ELFA test for IgG antibodies (p<0.01). A highly significant negative correlation between the ELFA and WB test for IgM antibodies and ELFA and WB tests for IgG avidity was demonstrated (p<0.01), except for a relationship between the WB test for IgM and WB for avidity, which was not significant. Such negative correlations are theoretically expected, as strong complexes with the participation of IgG antibodies are absent in the early phase of toxoplasmosis when early antibodies of IgM class are present. Summarizing, this study indicates the high usefulness of the commercial ELFA and WB tests in serodiagnostics of toxoplasmosis in pregnant women. Special attention should be paid to parallel detection of IgM antibodies and low values in the ELFA and WB tests for IgG avidity, which indicates a recent infection which may be associated with a clinical form of congenital toxoplasmosis and damage to the foetus.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2016, 23, 4
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Microbiological characterization of vegetables and their rhizosphere soil in Eastern Poland
    Autorzy:
    Kłapeć, Teresa
    Cholewa, Alicja
    Cholewa, Grażyna
    Dutkiewicz, Jacek
    Wójcik-Fatla, Angelina
    Powiązania:
    https://bibliotekanauki.pl/articles/989616.pdf
    Data publikacji:
    2016
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    microbiological quality
    vegetables
    soil
    aerobic bacteria
    enterobacteriaceae
    coliform bacteria
    salmonella
    clostridium
    perfringens
    Opis:
    The aim of this study was to investigate the bacteriological quality of 5 kinds of vegetables (lettuce, dill, radish, beetroot, carrot) and their rhizosphere soil, originating from conventional farms located in the Lublin Province of Eastern Poland. A total number of 35 samples of fresh vegetables (FV) taken immediately from soil, 35 samples of soil from rhizosphere of these vegetables (SR) and 35 samples of vegetables sold at retail in the markets in Lublin (VR) were examined. The samples were analysed for the content of: aerobic mesophilic bacteria (AMB) grown at 30 °C and 37 °C, Gram-negative bacteria of Enterobacteriaceae family, faecal coliform (FC) bacteria, Salmonella spp., and Clostridium perfringens. Median AMB values determined at 30 °C for FV, SR and VR were 5.27, 5.00, and 5.00 log10 CFU g-1, respectively, being significantly greater compared to those recorded at 37 °C. The exceeding of the threshold value of 6.0 log10 CFU g-1 proposed by Gelosa (1998) was noted only in 5 FV samples grown at 30 °C (14.3%), and in 3 FV samples grown at 37 °C (8.6%). The threshold value was never exceeded in SR and VR samples. Median concentrations of Enterobacteriaceae determined for FV, SR and VR were 4.03, 3.87, and 3.04 log10 CFU g-1, respectively. Eleven species of Enterobacteriaceae were identified in the FV, SR and VR samples. The percent of samples containing Escherichia coli was greatest for VR (22.9%), smaller for FV (17.1%) and smallest for SR (5.7%). The median concentrations of the faecal coliform bacteria (FC), determined by culture at 44oC, were low, amounting to 1.000 log10 CFU g-1 for FV and SR and 0.00 for VR. All examined vegetable and soil samples tested negative for the presence of Salmonella. The median concentrations of Clostridium perfringens were low, amounting to 0.00 log10 CFU g-1 for all categories of samples. This bacterium was relatively common in soil samples with the prevalence of 40.0%, but very rare in vegetable samples (occurring in 5.7% of FV and in none of VR samples). In conclusion, the results of the present study generally indicate that the microbiological quality of Polish vegetables grown on conventional farms is satisfactory and safe for consumers.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2016, 23, 4
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Streptococcus suis: a re-emerging pathogen associated with occupational exposure to pigs or pork products. Part I - epidemiology
    Autorzy:
    Dutkiewicz, Jacek
    Sroka, Jacek
    Zając, Violetta
    Wasiński, Bernard
    Cisak, Ewa
    Sawczyn, Anna
    Kloc, Anna
    Wójcik-Fatla, Angelina
    Powiązania:
    https://bibliotekanauki.pl/articles/991187.pdf
    Data publikacji:
    2017
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    streptococcus suis
    pigs
    humans
    carriage
    disease
    epidemiology
    treatment
    prevention
    Opis:
    Streptococcus suis (ex Elliot 1966, Kilpper-Bälz & Schleifer 1987) is a facultatively anaerobic Gram-positive ovoid or coccal bacterium surrounded by a polysaccharide capsule. Based on the antigenic diversity of the capsule, S. suis strains are classified serologically into 35 serotypes. Streptococcus suis is a commensal of pigs, commonly colonizing their tonsils and nasal cavities, mostly in weaning piglets between 4–10 weeks of age. This species occurs also in cattle and other mammals, in birds and in humans. Some strains, mostly those belonging to serotype 2, are also pathogenic for pigs, as well as for other animals and humans. Meningitis is the primary disease syndrome caused by S. suis, both in pigs and in humans. It is estimated that meningitis accounted for 68.0% of all cases of human disease reported until the end of 2012, followed by septicaemia (including life-threatening condition described as ‘streptococcal toxic shock-like syndrome’ – STSLS), arthritis, endocarditis, and endophthalmitis. Hearing loss and/or vestibular dysfunction are the most common sequelae after recovery from meningitis caused by S. suis, occurring in more than 50% of patients. In the last two decades, the number of reported human cases due to S. suis has dramatically increased, mostly due to epidemics recorded in China in 1998 and 2005, and the fulminant increase in morbidity in the countries of south-eastern Asia, mostly Vietnam and Thailand. Out of 1,642 cases of S. suis infections identified between 2002–2013 worldwide in humans, 90.2% occurred in Asia, 8.5% in Europe and 1.3% in other parts of the globe. The human disease has mostly a zoonotic and occupational origin and occurs in pig breeders, abattoir workers, butchers and workers of meat processing facilities, veterinarians and meat inspectors. Bacteria are transmitted to workers by close contact with pigs or pig products, usually through contamination of minor cuts or abrasions on skin of hands and/or arms, or by pig bite. A different epidemiologic situation occurs in the Southeast Asian countries where most people become infected by habitual consumption of raw or undercooked pork, blood and offal products in the form of traditional dishes. Prevention of S. suis infections in pigs includes vaccination, improvement in pig-raising conditions, disinfection and/or fumigation of animal houses, and isolation of sick animals at the outbreak of disease. Prevention of human infections comprises: protection of skin from pig bite or injury with sharp tools by people occupationally exposed to pigs and pig products, prompt disinfection and dressing of wounds and abrasions at work, protection of the respiratory tract by wearing appropriate masks or repirators, consulting a doctor in the case of febrile illness after exposure to pigs or pork meat, avoidance of occupations associated with exposure to pigs and pork by immunocompomised people, avoidance of consumption of raw pork or pig blood, adequate cooking of pork, and health education.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2017, 24, 4
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Social councils and committees as (not quite) present in local decision-making processes
    Społeczne rady i komisje jako (nie)obecny uczestnik lokalnego procesu decyzyjnego
    Autorzy:
    Pawłowska, Agnieszka
    Kmieciak, Robert
    Kołomycew, Anna
    Radzik-Maruszak, Katarzyna
    Antkowiak, Paweł
    Wójcik, Bartosz
    Sroka, Jacek
    Wojnicki, Jacek
    Powiązania:
    https://bibliotekanauki.pl/books/19233495.pdf
    Data publikacji:
    2021
    Wydawca:
    Wydawnictwo Naukowe Scholar
    Opis:
    Social councils and committees (SCs), the topic of this volume, cannot yet be called a well-researched matter, and – whether in Poland or internationally – very few analyses have focused on them, or have done so in a more than fragmentary fashion. Although they constitute a challenging subject, among other things due to their sometimes non-obligatory character, term limits, the availability of members, and diversity, we believe they deserve academic interest as well as the attention of the public and the third sector. SCs have the potential to become an important actor of the local decision-making process. This thread was the crucial element of our research, whose aim was primarily to define the impact of SCs on decision-making, as well as to describe the character of these entities, which in our view show features of participatory and deliberative solutions. Another major objective of our research was to identify the advantages of the participation of these bodies in the local decision-making process as well as to indicate the factors that hinder or prevent their potential as the participants of this process. From the Introduction
    Dostawca treści:
    Biblioteka Nauki
    Książka
    Tytuł:
    Early and late results of direct superior approach versus direct lateral approach in total hip arthroplasty – single-center, prospective study
    Wczesne i odległe wyniki endoprotezoplastyki stawu biodrowego z dostępu bezpośredniego górnego oraz bezpośredniego bocznego. Badania prospektywne z jednego ośrodka
    Autorzy:
    Markiewicz, Tomasz
    Bałonika, Andrzej
    Wójcik, Paulina
    Buliński, Patryk
    Chodór, Paweł
    Kruczyński, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/12665808.pdf
    Data publikacji:
    2023-09-20
    Wydawca:
    Wydawnictwo Exemplum
    Tematy:
    minimally invasive hip arthroplasty
    direct superior approach
    postoperative pain
    mini inwazyjna endoprotezoplastyka stawu biodrowego
    dostęp bezpośredni górny
    ból pooperacyjny
    Opis:
    Introduction. Total hip arthroplasty (THA) is an established treatment for severe hip osteoarthritis (OA). Traditionally, surgical approaches involved extensive soft tissue damage. New, less invasive approaches were introduced, facilitating fast recovery, reducing postoperative pain and incision length. Aim. Comparative analysis of postoperative pain and long-term results in patients undergoing total hip arthroplasty (THA) utilizing direct superior approach (DSA) and direct lateral approach (DLA). Materials and methods. Sixty-one patients scheduled for primary THA were included in the study. THA was performed utilizing the approach chosen by experienced orthopedic surgeons. After the procedure, pain intensity and use of analgesics were recorded daily. Patients were contacted 18 months following surgery to collect data on SF-36 score, pain intensity and complications (dislocations, infections, periprosthetic fractures, and revision surgeries). Fifty-two patients were included in the final analysis. Group A (DSA) consisted of 27 patients, whereas group B (DLA) consisted of 25 patients. Results. There were no significant differences between groups in terms of demographic parameters, preoperative pain intensity, Harris Hip Score, and SF-36 score. Significant differences were observed in pain intensity during the first three days post-operation. The use of non-opioid analgesics did not differ; however, the use of tramadol was lower in group A on the 1st and 2nd day post-operation. No significant differences were found in SF-36 score and pain intensity after 18 months post-surgery. Conclusions. DSA approach in THA is superior in comparison with the direct lateral approach in terms of early postoperative pain intensity and use of analgesic drugs. Late results of both approaches are comparable.
    Wstęp. Endoprotezoplastyka stawu biodrowego jest uznaną metodą leczenia zaawansowanej koksartrozy. Tradycyjne dostępy operacyjne wiązały się z istotną traumatyzacją tkanek miękkich, co było powodem wprowadzenia nowych, mało inwazyjnych dostępów operacyjnych. Umożliwiają one szybki powrót do sprawności, zmniejszają ból pooperacyjny oraz niejednokrotnie wiążą się z mniejszym cięciem. Cel. Porównawcza analiza bólu pooperacyjnego i wyników odległych u pacjentów zakwalifikowanych do endoprotezoplastyki stawu biodrowego z wykorzystaniem dostępu bezpośredniego górnego (DSA) i bezpośredniego bocznego (DLA). Materiał i metody. Do badania rekrutowano kolejnych chorych zakwalifikowanych do endoprotezoplastyki stawu biodrowego. Operacje wykonywane były przez doświadczonych ortopedów. Po operacji mierzono nasilenie bólu pooperacyjnego i zużycie leków przeciwbólowych. Po 18 miesiącach kontaktowano się z pacjentami w celu oceny jakości życia za pomocą kwestionariusza SF-36, nasilenia bólu (w skali NRS), satysfakcji oraz ewentualnych powikłań (zwichnięć, infekcji, złamań okołoprotezowych i operacji rewizyjnych). Do ostatecznej analizy włączono 52 chorych. Grupę A (27 osób) stanowili chorzy operowanie z dostępu DSA, natomiast grupę B chorzy operowani z dostępu DLA (25 osób). Wyniki. Nie zaobserwowano różnic w zakresie parametrów demograficznych, bólu przedoperacyjnego, wyników kwestionariusza Harris Hip Score czy SF-36. Wykazano istotne różnice w zakresie wczesnego bólu pooperacyjnego w pierwszych trzech dobach. Zapotrzebowanie na nieopioidowe leki przeciwbólowe nie różniło się między grupami, natomiast zużycie tramadolu było istotnie niższe w grupie A w I i II dobie. Po 18 miesiącach nie wykazano różnic między grupami w zakresie SF-36, satysfakcji oraz nasilenia bólu. Wnioski. Dostęp DSA wykazuje przewagę nad dostępem DLA w zakresie wczesnego bólu pooperacyjnego i zapotrzebowania na leki przeciwbólowe. Zastosowanie obu dostępów daje porównywalne, znakomite wyniki odległe.
    Źródło:
    Chirurgia Narządów Ruchu i Ortopedia Polska; 2023, 88, 3; 99-102
    0009-479X
    2956-4719
    Pojawia się w:
    Chirurgia Narządów Ruchu i Ortopedia Polska
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Implementation of the integrated hydrocarbon reservoir management system by the example of exploiting Polish Lowland’s natural gas reservoirs
    Implementacja zintegrowanego systemu zarządzania złożem węglowodorów na przykładzie eksploatowanych złóż gazu ziemnego na Niżu Polskim
    Autorzy:
    Dudek, Jacek
    Podsobiński, Daniel
    Potera, Krzysztof
    Kawecki, Bartłomiej
    Paliborek, Grzegorz
    Pietrzyk, Krzysztof
    Wójcik, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/298773.pdf
    Data publikacji:
    2019
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
    Tematy:
    data integration
    optimization
    field management
    production forecasts
    economic efficiency
    integracja danych
    optymalizacja
    zarządzanie złożami
    prognozy produkcji
    efektywność ekonomiczna
    Opis:
    Nowadays, because of the smaller and smaller chances of discovering new hydrocarbon deposits with abundant resources as well as significant technological advance, the proper strategy of reservoir management connected with simultaneous optimization of its production parameters is the key element in the process of development the most economically advantageous variant of reservoir management and field development. In Polish Oil and Gas Company, the project called as “Digital reservoir” based on the interactive IAM platform was initiated, thanks to which the work of all upstream segments was integrated, starting from geophysics, geology through reservoir engineering, production engineering, process engineering ending with the economic model that allows for verification of the economic efficiency of the investment. This paper presents the methodology of integration all of the above elements and the results of the IAM system implementation with further production forecasts, on the example of selected natural gas reservoirs in the Polish Lowlands being PGNiG S.A. assets.
    Obecnie, ze względu na to, że zarówno szanse na odkrycie nowych złóż węglowodorów o znaczących zasobach są coraz mniejsze, jak i postęp technologiczny jest znaczący, kluczowym elementem staje się właściwa strategia zarządzania pracą złoża wraz z jednoczesną optymalizacją parametrów jego produkcji, w celu opracowania najkorzystniejszego ekonomicznie wariantu zagospodarowania złoża i pracy kopalni. W Polskim Górnictwie Naftowym i Gazownictwie S.A. zainicjowano projekt „Cyfrowe złoża” oparty na interaktywnej platformie IAM, dzięki której zintegrowana została praca wszystkich segmentów wydobywczych, począwszy od geofizyki, geologii, inżynierii złożowej, produkcji oraz inżynierii procesowej, a kończąc na modelu ekonomicznym, pozwalającym na weryfikację efektywności ekonomicznej inwestycji. W artykule zaprezentowana została metodyka integracji powyższych elementów oraz wyniki implementacji systemu IAM wraz z prognozami produkcji, na przykładzie wybranych złóż gazu ziemnego na Niżu Polskim, których operatorem jest firma PGNiG S.A.
    Źródło:
    AGH Drilling, Oil, Gas; 2019, 36, 1; 31-44
    2299-4157
    2300-7052
    Pojawia się w:
    AGH Drilling, Oil, Gas
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prevalence of infections and co-infections with 6 pathogens in Dermacentor reticulatus ticks collected in eastern Poland
    Autorzy:
    Zając, Violetta
    Wójcik-Fatla, Angelina
    Sawczyn, Anna
    Cisak, Ewa
    Sroka, Jacek
    Kloc, Anna
    Zając, Zbigniew
    Buczek, Alicja
    Dutkiewicz, Jacek
    Bartosik, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/989947.pdf
    Data publikacji:
    2017
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    dermacentor reticulatus
    co-infections
    tbe virus
    anaplasma phagocytophilum
    rickettsia raoultii
    borrelia burgdorferi sensu
    lato
    babesia spp.
    toxoplasma gondii
    Opis:
    Occurrence of co-infections with various pathogens in ixodid ticks creates a risk of increased severity of tick-borne diseases in humans and animals exposed to bite of the ticks carrying multiple pathogens. Accordingly, co-infections in ticks were subject of numerous analyses, but almost exclusively with regard to Ixodes ricinus complex whereas potential tick vectors belonging to other genera were much less studied. Taking into consideration the role of Dermacentor reticulatus in the transmission of various pathogens, we carried out for the first time the comprehensive statistical analysis of co-infections occurring in this tick species. An attempt was made to determine the significance of the associations between 6 different pathogens occurring in D. reticulatus (Tick-borne encephalitis virus = TBEV, Anaplasma phagocytophilum, Rickettsia raoultii, Borrelia burgdorferi s. l., Babesia spp., Toxoplasma gondii), using 2 statistical methods: determination of Odds Ratios (ORs) and the Fisher’s exact test. 634 questing Dermacentor reticulatus ticks (370 females and 264 males) were collected in 2011–2013 by flagging the lower vegetation in 3 localities in the area of Łęczyńsko-Włodawskie Lakeland, situated in the Lublin region of eastern Poland. The presence of individual pathogens was detected by PCR. Ticks were infected most often with Rickettsia raoultii (43.8%), less with TBEV (8.5%), and much less with Babesia spp., Toxoplasma gondii, Borrelia burgdorferi s.l., and Anaplasma phagocytophilum (2.5%, 2.1%, 1.6% and 1.1%, respectively). The locality-dependent variability proved to be significant for TBEV (c2=11.063; P=0.004) and Toxoplasma gondii (c2=11.298; P=0.0035), but not for other pathogens. Two hundred seventy (42.6%) of the examined ticks were infected only with a single pathogen, and 54 (8.5%) showed the presence of dual co-infections, each with 2 pathogens. The most common were dual infections with participation of Rickettsia raoultii (7.41%); next, those with participation of the TBEV (5.21%), Toxoplasma gondii (1.58%), Borrelia burgdorferi s.l. (1.26%), Anaplasma phagocytophilum (0.95%), and Babesia spp. (0.63%). On the total number of 15 possible associations, in 9 cases co-infections occurred whereas in 6 cases they were not detected. The most noteworthy were positive co-infections with the participation of TBEV, which proved to be weakly significant (0.05
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2017, 24, 1
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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