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    Wyświetlanie 1-13 z 13
    Tytuł:
    Cytotoxic and anti-cancer activity of the Cistus species of herbal plants
    Autorzy:
    Stępień, Agnieszka Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/454781.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    anti-tumor activity
    Cistus species
    cytotoxic activity
    phytotherapeutics
    Opis:
    Aim. The aim of this paper is to provide an overview of the cytotoxic and anti-cancer properties of the major species of the genus Cistus. Materials and methods. Thirty four papers that discuss the medicinal history and current research of Cistus species as phytotherapeutics were used for this discussion. Literature analysis.The growing popularity of the Cistus species of herbs is mainly due to its anti-inflammatory, antimicrobial, antifungal and antioxidant properties. The results of in vitro studies indicate that the presence of pear extract significantly affects leukemia, leukemia, breast, colon, ovarian, pancreatic, and melanoma carcinomas. The significant growth inhibition of these cells, underlines its valuable anti-tumor properties and allows for the possibility of use as a therapeutic aid.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 165-168
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A simple method for the determination of the cholesterol esterase activity
    Autorzy:
    Stępień, Agnieszka
    Gonchar, Mykhailo
    Powiązania:
    https://bibliotekanauki.pl/articles/1039538.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    cholesterol esterase
    cholesterol
    activity determination
    human serum
    Opis:
    The proposed method determines the activity of cholesterol esterase (CEH) and takes advantage of its ability to catalyze the hydrolysis of cholesterol esters naturally present in human serum. The assay is based on Allain's method of spectrophotometric determination of cholesterol by means of cholesterol oxidase, peroxidase, but using 3,5-dichloro-dihydroxybenzenesulfonic acid (DHBS) as phenolic chromogen and human serum as a source of substrate for the CEH as a novelty. Furthermore, it is characterized by low costs and high precision. It can be employed to control the activity of CE preparations used for the preparation of enzymatic kits for the determination of cholesterol or for screening of potential bacterial enzyme producers.
    Źródło:
    Acta Biochimica Polonica; 2013, 60, 3; 401-403
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cytotoxic and anticancer activity of Moringa oleifera
    Autorzy:
    Szlachetka, Kinga
    Kut, Paulina
    Stepien, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/2038320.pdf
    Data publikacji:
    2020-09-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    anticancer activity
    cytotoxic activity
    Moringa oleifera
    Opis:
    Introduction. Given its very strong antioxidant properties, Moringa oleifera is particularly noteworthy among medicinal plants. The high contents antioxidants in the M. oleifera determining her antioxidant activities deciding for very important anticancer properties. Aim. The aim of the paper is to provide an overview of the cytotoxic and anticancer activity of Moringa oleifera. Material and methods. This review was performed based systematic analysis of literature. Analysis of the literature. The results of scientific research conducted in vitro indicate that extracts from Moringa oleifera significantly affect the development of human cancer cells such as myeloma, leukemia, cervix, breast, colon, lung, liver, neuroblastoma, pancreas, colorectal, epidermoid, oral, ovarian, muscular, prostate, skin. Conclusion. This indicates Moringa oleifera as that they may be used as a therapeutic agent to support oncological therapies.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 3; 214-220
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Anticancer properties of Viburnum
    Autorzy:
    Stępień, Agnieszka
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454949.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    antitumor activity
    Viburnum species
    cytotoxic activity
    Opis:
    Aim. The aim of this paper is to provide an overview of the anticancer properties of different species of Viburnum. Materials and methods. Forty nine papers that discuss the medicinal history and current research of Viburnum species as phytotherapeutic agent were used for this discussion. Literature analysis. The results of scientific research conducted in vitro indicate that the compounds present in the extracts of Viburnum significantly affect the development of cancer cells such as leukemia, cervical cancer, breast, colon, lung, skin and stomach. This indicates that they may be used as a therapeutic agent to support oncological therapies.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 1; 47-52
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Characteristics of the health-promoting properties of Cornus mas
    Autorzy:
    Nawrot, Klaudia
    Polak-Szczybyło, Ewelina
    Stępień, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/2075087.pdf
    Data publikacji:
    2022-06-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    bioactive compounds
    cornelian cherry
    Cornus mas L.
    medicinal plant
    Opis:
    Introduction and aim. The medicinal properties of Cornus mas L. have been used in European and Asian folk medicine for many centuries in the prevention and treatment of many diseases. The high biological activity of the plant results primarily from the presence of valuable ingredients, including anthocyanins, flavonoids and iridoid compounds. The aim of the article is to present the role of bioactive ingredients present in C.mas that determine its health-promoting properties. Material and methods. Review and analysis of the scientific literature. Analysis of the literature. The summarize information about in the field of phytochemical properties and therapeutic effects, among others anticancer, antidiabetic, neuroprotective, cardioprotective and antibacterial. Conclusion. The results of many in vitro and in vivo scientific studies They indicate the possibility of the potential use of Cornelian cherry to obtain valuable nutraceutical and pharmacological substances.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2022, 2; 217-223
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biological properties of Cistus species
    Autorzy:
    Stępień, Agnieszka
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454751.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    biological properties
    Cistus sp.
    medicinal plants
    Opis:
    Aim. This paper presents a review of scientific studies analyzing the biological properties of different species of Cistus sp. Materials and methods. Forty papers that discuss the current research of Cistus sp. as phytotherapeutic agent were used for this discussion. Literature analysis. The results of scientific research indicate that extracts from various species of Cistus sp. exhibit antioxidant, antibacterial, antifungal, anti-inflammatory, antiviral, cytotoxic and anticancer properties. These properties give rise to the possibility of using Cistus sp. as a therapeutic agent supporting many therapies
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 2; 27-132
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Medicinal benefits from the use of Black pepper, Curcuma and Ginger
    Autorzy:
    Bober, Zuzanna
    Stępień, Agnieszka
    Aebisher, David
    Ożog, Łukasz
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454723.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    medicinal plants
    phythotherapy
    Black pepper
    Curcuma
    Ginger
    Opis:
    Introduction. Black pepper, Curcuma and Ginger are three of the most popular and most frequently used spices. Due to their beneficial medical and pharmacological properties, they are increasingly appreciated phytotheraputic plants. Most of their actions are attributed to their biochemical compositions. Aim. Our intention is to equip the reader with the information and knowledge necessary to understand the role of natural products in the drug discovery process and to enable the assessment of potential benefits and harms of plant-based medicines when advising patients who wish to use them. Material and methods. Analysis of literature. Results. In this paper, we reviewed the use of Black pepper, Curcuma and Ginger documented in the treatment of colds and flu,
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 2; 133-145
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Plants – a source of therapeutic material?
    Autorzy:
    Bober, Zuzanna
    Stępień, Agnieszka
    Aebisher, David
    Ożóg, Łukasz
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454997.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    plants
    natural products
    drug
    therapeutic material
    Opis:
    Introduction. The use of plants with therapeutic or medicinal properties is as ancient as human civilization and for many years prior to the 20th century, plants and animal products were the main source of therapeutic medicinal drugs. Aim. The discovery of new plant-derived drugs continues to be an active field of research in medical science today. The aim of this article is to describe several main classes of natural products currently under investigation. Material and methods. Analysis of literature.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 1; 34-36
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Fundamentals of the use of Berberis as a medicinal plant
    Autorzy:
    Bober, Zuzanna
    Stępień, Agnieszka
    Aebisher, David
    Ożóg, Łukasz
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454712.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    medicinal plants
    phythotherapy
    Berberis
    Opis:
    Introduction. The daily use of medicinal plants has increased in recent years. The study of drugs of natural origin as an academic discipline and its applications in healthcare has changed remarkably but still focus on the quality of products and the development of new medicines. Aim. This study covers all fundamental aspects of pharmacognosy as well as topics relating to the therapeutic use of plant drugs known as phythotherapy. The purpose of the study was to review the literature about the use of Berberis. Materials and method. We reviewed the literature regarding the use of Berberis published between 1933 and 2018. We found more than 500 articles studying the properties of Berberis for digestive disorders, antibacterial, antidiabetic, hypotensive effects, anti-inflammatory effects, cholesterol regulation, cardiovascular disease, hyperlipidemia, cerebral ischemia trauma, mental disease, Alzheimer disease and osteoporosis. Our review includes recent studies regarding chemical composition and medicinal outcomes of Berberis
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 1; 41-46
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Factors Associated with Physical Activity in People with Diabetes
    Autorzy:
    Sieńko-Awieraniów, Elżbieta
    Stępień-Słodkowska, Marta
    Latkowska, Agnieszka
    Głowacka, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1054668.pdf
    Data publikacji:
    2015
    Wydawca:
    Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
    Tematy:
    Body Mass Index
    diabetes mellitus
    lifestyle
    physical activity
    Opis:
    Background: Diabetes mellitus is a chronic disease related to the occurrence of numerous metabolic disorders. Their common feature is hyperglycaemia, caused by insufficient insulin secretion or its malfunction. The World Health Organization states that 346 million people worldwide have diabetes. The studies in adults with type 2 diabetes clearly demonstrate that the change of lifestyle behaviours effectively improves glycemic control. The modifications of lifestyle habits, such as regular physical activity and healthier dietary habits prove to be beneficial for patients. The aim of this study was to determine the factors affecting the level of physical activity in people with diabetes mellitus. Methods: Research material consisted of the data gathered from a diagnostic survey, which was conducted in a form of a questionnaire. The study included 60 people with type 1 or type 2 diabetes. Results: Unfortunately, the results show that not all of them were active enough, which is so crucial for stabilizing the disease. Conclusions: The diagnosis of diabetes in the respondents resulted in more time being spent by them on physical activity, which resulted in the improvement of diabetes control and the normalization of body weight according to BMI, thus increasing the effectiveness of diabetes treatment and reducing complications. The frequency of the physical activity undertaken by the respondents prior to the disease was not related to gender, however, after the diagnosis, it was dependent on gender
    Źródło:
    Central European Journal of Sport Sciences and Medicine; 2015, 12, 4; 73-81
    2300-9705
    2353-2807
    Pojawia się w:
    Central European Journal of Sport Sciences and Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Yeast nuclear PET127 gene can suppress deletions of the SUV3 or DSS1 genes: An indication of a functional interaction between 3' and 5' ends of mitochondrial mRNAs
    Autorzy:
    Węgierski, Tomasz
    Dmochowska, Aleksandra
    Jabłonowska, Agnieszka
    Dziembowski, Andrzej
    Bartnik, Ewa
    Stępień, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1044752.pdf
    Data publikacji:
    1998
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Źródło:
    Acta Biochimica Polonica; 1998, 45, 4; 935-940
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Human SUV3 helicase regulates growth rate of the HeLa cells and can localize in the nucleoli
    Autorzy:
    Szewczyk, Maciej
    Fedoryszak-Kuśka, Natalia
    Tkaczuk, Katarzyna
    Dobrucki, Jurek
    Waligórska, Agnieszka
    Stępień, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1038704.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    SUV3 helicase
    SUPV3L1
    dual targeting
    nucleolus
    mitochondria
    cell cycle
    Opis:
    The human SUV3 helicase (SUV3, hSUV3, SUPV3L1) is a DNA/RNA unwinding enzyme belonging to the class of DexH-box helicases. It localizes predominantly in the mitochondria, where it forms an RNA-degrading complex called mitochondrial degradosome with exonuclease PNP (polynucleotide phosphorylase). Association of this complex with the polyA polymerase can modulate mitochondrial polyA tails. Silencing of the SUV3 gene was shown to inhibit the cell cycle and to induce apoptosis in human cell lines. However, since small amounts of the SUV3 helicase were found in the cell nuclei, it was not clear whether the observed phenotypes of SUV3 depletion were of mitochondrial or nuclear origin. In order to answer this question we have designed gene constructs able to inhibit the SUV3 activity exclusively in the cell nuclei. The results indicate that the observed growth rate impairment upon SUV3 depletion is due to its nuclear function(s). Unexpectedly, overexpression of the nuclear-targeted wild-type copies of the SUV3 gene resulted in a higher growth rate. In addition, we demonstrate that the SUV3 helicase can be found in the HeLa cell nucleoli, but it is not detectable in the DNA-repair foci. Our results indicate that the nucleolar-associated human SUV3 protein is an important factor in regulation of the cell cycle.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 1; 177-181
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Hepatitis C virus epidemiology and prevention in Polish and Swiss population – similar and contrasting experiences
    Autorzy:
    Sakem, Benjamin
    Madaliński, Kazimierz
    Nydegger, Urs
    Stępień, Małgorzata
    Godzik, Paulina
    Kołakowska, Agnieszka
    Risch, Lorenz
    Risch, Martin
    Zakrzewska, Karolina
    Rosińska, Magdalena
    Powiązania:
    https://bibliotekanauki.pl/articles/990971.pdf
    Data publikacji:
    2016
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    hepatitis c
    acute and chronic hcv infection
    epidemiological data
    poland and switzerland
    consequences of infection
    access to treatment
    Opis:
    Objective. The aim of the study was to review available data on HCV in Poland and Switzerland, in order to compare the two European countries with respect to epidemiological situation and efficiency of the response systems. Materials and method. A search of registries, published and grey literature was performed to assemble data on prevalence, rate of detection of new cases, identified risk factors for transmission, mortality due to HCV, prevalence of HCC and the consequent liver transplantations, as well as data on treatment in Poland and Switzerland. Results. Overall, the prevalence of anti-HCV antibodies was similar, not exceeding 1%. However, the major transmission routes of HCV infections were different: medical procedures in Poland and drug injections in Switzerland. By combining the available information it was also possible to demonstrate important differences in efficiency of the response systems. There was approximately 1 new diagnosis per 100 estimated undiagnosed cases in the population in Poland per year, compared to 6 in Switzerland, and the treatment rate per 100 estimated active infections was 2 and 4, respectively. Conclusions. Scaling up of the diagnosis and treatment is necessary in both countries; however, the means to achieve this might differ, taking into account the higher concentration of the infections in risk groups in Switzerland than in Poland.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2016, 23, 3
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-13 z 13

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