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Wyświetlanie 1-15 z 21
Tytuł:
Electrospinning Production of PLLA Fibrous Scaffolds for Tissue Engineering
Autorzy:
Wojasiński, M.
Faliszewski, K.
Ciach, T.
Powiązania:
https://bibliotekanauki.pl/articles/115815.pdf
Data publikacji:
2013
Wydawca:
Fundacja na Rzecz Młodych Naukowców
Tematy:
nanofibre
electrospinning
poly(L-lactic acid)
tissue engineering
biomaterial
degradation
Opis:
Nonwoven fibrous mats were produced in the process of solution electrospinning. Polymeric fibres generated in this process consist of poly(L-lactic) acid (PLLA), biodegradable and biocompatible polymer. Produced fibrous mats were examined by scanning electron microscopy and additionally degradation rate of fibrous material was investigated. Obtained fibres exhibit porous surface and fibre diameter varied from 200 nm to 1,2 ım, depending on the process parameters. Low degradation rate of scaffold material was designed for long-term scaffold usage. The influence of solvent type and solution concentration as well as the solution flow rate, applied voltage and the setup geometry on the fibres morphology and diameter were examined and presented. The influence of polymer concentration on the solution viscosity was also evaluated. Further, the degradation rate of obtained fibres was investigated, as well as the influence of degradation process on surrounding environment. Materials produced in electrospinning process have potential application as long-term biodegradable scaffold for tissue engineering, especially in bone tissue, vascular tissue or cartilage tissue engineering.
Źródło:
Challenges of Modern Technology; 2013, 4, 1; 9-15
2082-2863
2353-4419
Pojawia się w:
Challenges of Modern Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preparation of psyllium husk powder based microporous composite scaffolds for tissue engineering
Autorzy:
Poddar, S.
Agarwal, P. S.
Mahto, S. K.
Powiązania:
https://bibliotekanauki.pl/articles/284676.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
composites
tissue engineering
regeneration
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 48
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Highly porous polurethane-based gradient scaffolds for tissue engineering of osteochondral defects
Autorzy:
Domalik-Pyzik, Patrycja
Kosowska, Karolina
Hunger, Martyna
Pielichowska, Kinga
Chłopek, Jan
Powiązania:
https://bibliotekanauki.pl/articles/1844966.pdf
Data publikacji:
2020
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
tissue engineering
polyurethanes
properties
inżynieria tkankowa
poliuretany
właściwości
Źródło:
Engineering of Biomaterials; 2020, 23, 158 spec. iss.; 66
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preparation of psyllium husk powder based microporous composite scaffolds for tissue engineering
Autorzy:
Poddar, S.
Agarwal, P. S.
Mahto, S. K.
Powiązania:
https://bibliotekanauki.pl/articles/285978.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
psyllium husk powder
EDC-NHS coupling reaction
microporous scaffolds
hydrogel
freeze-drying
vacuum desiccation
Opis:
This study demonstrates the comparison in the method of fabrication and thus evaluates the potential of psyllium husk powder and gelatin-based composite microporous scaffolds for tissue engineering applications. The scaffold is being prepared in three different ratios of 50:50, 75:25 and 100 (w/w of psyllium husk powder and gelatin, respectively) by employing a suitable cross-linking agent, EDC-NHS, followed drying. We have demonstrated the use and outcomes of two different methods of scaffold drying, i.e., vacuum desiccation along with liquid nitrogen dip and lyophilization. It was concluded from the SEM micrographs that the scaffolds dried under vacuum accompanied with liquid nitrogen exposure exhibited less porous architecture when compared to those prepared using a lyophilizer, that resulted in pores in the range of 60-110 μm. Scaffolds fabricated using the former technique lost porosity and sponge-like characteristics of a scaffold. In spite of the above fact, water retaining capacity and stability in the cell culture of such scaffolds is significant, nearly 40-50% of its initial dry weight. Cell culture experiments support the potential of the scaffolds prepared from different methods of fabrication for its cytocompatibility and suitability for cell growth and proliferation for a substantial duration. Erosion in the porous design of the scaffolds was observed after 14 days via SEM micrographs. It was inferred that freeze-drying is a better technique than vacuum desiccation for scaffold preparation. The present investigation has been conducted keeping in mind the importance of drying a scaffold. Scaffold drying is a necessary step to increase its shelf-life, makes it easy to transport and much importantly, controlling the pore size of the scaffold.
Źródło:
Engineering of Biomaterials; 2018, 21, 147; 2-6
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of supercritical foaming conditions on properties of polymer scaffolds for tissue engineering
Autorzy:
Kosowska, K.
Henczka, M.
Powiązania:
https://bibliotekanauki.pl/articles/185451.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
supercritical fluids
supercritical foaming
poly(ε-caprolactone)
tissue engineering
scaffold
płyny nadkrytyczne
pienienie nadkrytyczne
inżynieria tkankowa
szafot
Opis:
The results of experimental investigations into foaming process of poly(ε-caprolactone) using supercritical CO2 are presented. The objective of the study was to explore the aspects of fabrication of biodegradable and biocompatible scaffolds that can be applied as a temporary three-dimensional extracellular matrix analog for cells to grow into a new tissue. The influence of foaming process parameters, which have been proven previously to affect significantly scaffold bioactivity, such as pressure (8-18 MPa), temperature (323-373 K) and time of saturation (1-6 h) on microstructure and mechanical properties of produced polymer porous structures is presented. The morphology and mechanical properties of considered materials were analyzed using a scanning electron microscope (SEM), x-ray microtomography (μ-CT) and a static compression test. A precise control over porosity and morphology of obtained polymer porous structures by adjusting the foaming process parameters has been proved. The obtained poly(ε-caprolactone) solid foams prepared using scCO2 have demonstrated sufficient mechanical strength to be applied as scaffolds in tissue engineering.
Źródło:
Chemical and Process Engineering; 2017, 38, 4; 535-541
0208-6425
2300-1925
Pojawia się w:
Chemical and Process Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
One step 3D printing of surface functionalized composite scaffolds for tissue engineering applications
Autorzy:
Kotlarz, M.
Jordan, R.
Wegner, E.
Dobrzyński, P.
Neunzehn, J.
Lederer, A.
Wolf-Brandstetter, C.
Pamula, E.
Scharnweber, D.
Powiązania:
https://bibliotekanauki.pl/articles/306484.pdf
Data publikacji:
2018
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
druk 3D
PLGA
węglan wapnia
właściwości powierzchniowe
3D printing
calcium carbonate
amphiphilic poly(2-oxazoline)
degradation
surface properties
Opis:
A successful approach widely used in materials science to adapt approved materials to specific applications is to design their surface properties. A main challenge in this area is the development of processing routes enabling for a simple but efficient surface design of complex shaped geometries. Against this background, this work aimed at the implementation of self-assembly principles for surface functionalization of 3D-printed poly(lactic-co-glycolic acid) (PLGA)-based constructs with macro- and microporous geometries via precision extruding deposition. Methods: Three-component melts from PLGA, CaCO3 and amphiphilic polymers (poly(2-oxazoline) block copolymer) were printed and their bulk and surface properties were studied. Results: Melts with up to 30 mass % of CaCO3 could be successfully printed with homogeneously distributed mineral particles. PLGA degradation during the printing process was temperature and time dependent: the molecular weight reached 10 to 15% of the initial values after ca. 120 min of heat exposure. Filament surfaces from melts containing CaCO3 show an increasing microroughness along with increasing CaCO3 content. Surface roughness and amphiphilic polymer content improve scaffold wettability with both factors showing synergistic effects. The CaCO3 content of the melts affected the inner filament structure during in vitro degradation in PBS, resulting in a homogeneous mineral particle-associated microporosity for mineral contents of 20 mass % and above. Conclusions: These results provide novel insights into the behavior of three-component melts from PLGA, CaCO3 and amphiphilic polymers during precision extruding deposition and show for the first time that self-assembly processes can be used to tailor scaffolds surface properties under such processing conditions.
Źródło:
Acta of Bioengineering and Biomechanics; 2018, 20, 2; 35-45
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Double crosslinking of chitosan/vanillin hydrogels as a basis for mechanically strong gradient scaffolds for tissue engineering
Autorzy:
Hunger, Martyna
Domalik-Pyzik, Patrycja
Reczyńska, Katarzyna
Chłopek, Jan
Powiązania:
https://bibliotekanauki.pl/articles/1844976.pdf
Data publikacji:
2020
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
hydrogel
chitosan
vanillin
tripolyphosphate
tissue engineering
Opis:
Polysaccharides, such as chitosan (CS), are widely used in many biomedical applications. However, they require crosslinking agents to achieve chemical stability and appropriate mechanical properties. In this work, chitosan-based hydrogels were crosslinked using vanillin and/or sodium tripolyphosphate, as chemical and physical crosslinking agents, respectively. Microstructural (digital microscope, SEM), structural (FTIR-ATR), mechanical (static compression test), and in vitro biological (chemical stability and swelling ratio in PBS, cytotoxicity) properties of the obtained materials were evaluated to assess materials potential as biomedical scaffolds. The optimal ratio of vanillin to chitosan (DD = 89%) to crosslink the polymer was found to be 1.2:1. Moreover, the double crosslinking with vanillin caused a two-time increase in the compression strength of the samples and led to the slower biodegradability. Cytotoxicity studies showed that the cells prefer double vanillin crosslinked hydrogels over those treated with TPP. Further studies, such as bioactivity are required to determine the specific functionality of the hydrogels and the specific tissue which may be treated with the tested materials. The optimal material was chosen to the next step of the study, which may be obtaining composite hydrogels with hydroxyapatite and/or graphene oxide to tailor or improve properties towards specific tissue regeneration.
Źródło:
Engineering of Biomaterials; 2020, 23, 155; 2-11
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bioactive hydroxyapatite ceramics as scaffolds for bone tissue engineering – a preliminary study
Autorzy:
Soukup, D.
Horakova, D.
Sumberova, H.
Andertova, J.
Bacakova, M.
Bacakova, L.
Powiązania:
https://bibliotekanauki.pl/articles/285204.pdf
Data publikacji:
2011
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
hydroxyapatite
tissue engineering
scaffolds
Źródło:
Engineering of Biomaterials; 2011, 14, no. 106-108; 13-16
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of 3D hybrid microfiber/nanofiber scaffolds for bone tissue engineering
Autorzy:
Ostrowska, B.
Jaroszewicz, J.
Zaczyńska, E.
Tomaszewski, W.
Swieszkowski, W.
Kurzydłowski, K. J.
Powiązania:
https://bibliotekanauki.pl/articles/200803.pdf
Data publikacji:
2014
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
rapid prototyping
RP
Electrospinning
ESP
Hybrid scaffolds
Opis:
Fabrication of scaffolds for tissue engineering (TE) applications becomes a very important research topic in present days. The aim of the study was to create and evaluate a hybrid polymeric 3D scaffold consisted of nano and microfibers, which could be used for bone tissue engineering. Hybrid structures were fabricated using rapid prototyping (RP) and electrospinning (ES) methods. Electrospun nanofibrous mats were incorporated between the microfibrous layers produced by RP technology. The nanofibers were made of poly(L-lactid) and polycaprolactone was used to fabricate microfibers. The micro- and nanostructures of the hybrid scaffolds were examined using scanning electron microscopy (SEM). X-ray microtomographical (μCT) analysis and the mechanical testing of the porous hybrid structures were performed using SkyScan 1172 machine, equipped with a material testing stage. The scanning electron microscopy and micro-tomography analyses showed that obtained scaffolds are hybrid nanofibers/microfibers structures with high porosity and interconnected pores ranging from 10 to 500um. Although, connection between microfibrous layers and electrospun mats remained consistent under compression tests, addition of the nanofibrous mats affected the mechanical properties of the scaffold, particularly its elastic modulus. The results of the biocompatibility tests didn’t show any cytotoxic effects and no fibroblast after contact with the scaffold showed any damage of the cell body, the cells had proper morphologies and showed good proliferation. Summarizing, using RP technology and electrospinning method it is possible to fabricate biocompatible scaffolds with controllable geometrical parameters and good mechanical properties.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2014, 62, 3; 551-556
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of cellulose/hydroxyapatite scaffolds for bone tissue engineering: studies in vitro and in vivo
Autorzy:
Liesiene, J.
Baniukaitiene, O.
Daugela, P.
Pranskunas, M.
Juodzbalys, G.
Babenko, N.
Powiązania:
https://bibliotekanauki.pl/articles/284014.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
bone tissue engineering
hydroxyapatite
cellulose
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 73
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A tubular polycaprolactone/hyaluronic acid scaffolds for nasal cartilage tissue engineering
Autorzy:
Jatteau, S.
Kurowska, A.
Ziąbka, M.
Rajzer, I.
Powiązania:
https://bibliotekanauki.pl/articles/285184.pdf
Data publikacji:
2017
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
electrospinning
tissue engineering scaffolds
nasal cartilages
hyaluronic acid
PCL
Opis:
In this preliminary study, 3D nanofibrous porous scaffolds in the form of spiral tubes for future application as nasal cartilages implants were fabricated by combining polycaprolactone electrospun fibers with drug modified hyaluronic acid gel. It is expected that the spiral form of the scaffold with open geometries, large surface area, and distance between the scaffold walls will be helpful for improving future cell penetration into the scaffolds, nutrient transport and metabolic waste removal, which are otherwise limited in conventional electrospun tissue-engineered scaffolds. The tubular scaffolds structure, its porosity and fibers’ diameter were assessed via scanning electron microscopy, and biological properties of the scaffolds were evaluated in an in vitro study using Simulated Body Fluid (SBF). SEM results showed that apatite formed within a short period on tubular scaffolds after its immersion in SBF, demonstrating high in vitro bioactivity of the scaffolds.
Źródło:
Engineering of Biomaterials; 2017, 20, 141; 8-12
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Investigation of influence of internal architecture on mechanical properties of 3D printed scaffolds for bone tissue engineering
Autorzy:
Ostrowska, B.
Święszkowski, W.
Kurzydlowski, K.J.
Powiązania:
https://bibliotekanauki.pl/articles/285974.pdf
Data publikacji:
2012
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
scaffolds
internal architecture
polycaprolactone
Opis:
The aim of the study was to investigate the influence of internal architecture of 3D printed scaffolds on their mechanical properties. The polycaprolactone scaffolds with four different geometries produced by rapid prototyping were tested in this study. The 3D samples were manufactured with different internal architecture. The scaffolds were plotted using a 330 ym dispensing needle, layer by layer with lay-down pattern of the fibers: 00/450/900, 0P/60°/120°, 00/900/1800 and 00/600/1200 with shifted layers. Scanning electron mic¬roscopy analyses and mechanical properties examinations were performed. The mechanical test showed that the highest Young's modulus was obtained for the samples with 0P/6CP/12CP lay-down pattern, especially after layers shifting. The SEM analyzes didn't show any defects or layers delamination in the scaffolds. All the samples were characterized by appropriate 3D architecture and good layers connections. The obtained results confirmed the hypothesis that scaffolds with 00/60°/120l0 lay-down pattern of the fibers and with shifted layers have the highest mechanically properties of the investigated samples and therefore, show high potential to be used in bone tissue engineering application.
Źródło:
Engineering of Biomaterials; 2012, 15, no. 116-117 spec. iss.; 8-9
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Double crosslinking of chitosan/vanillin as a basis to mechanically strong gradient hydrogel scaffolds for cartilage tissue engineering
Autorzy:
Hunger, Martyna
Domalik-Pyzik, Patrycja
Chłopek, Jan
Powiązania:
https://bibliotekanauki.pl/articles/283882.pdf
Data publikacji:
2019
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Źródło:
Engineering of Biomaterials; 2019, 22, no.153; 70
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of pre-coarsening on architectural and mechanical properties of highly porous titanium dioxide scaffolds for bone tissue engineering
Autorzy:
Reczyńska, K.
Rumian, Ł.
Pamuła, E.
Haugen, H. J.
Tiainen, H.
Powiązania:
https://bibliotekanauki.pl/articles/284566.pdf
Data publikacji:
2014
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
bone tissue engineering
porous titanium
biomaterials
Źródło:
Engineering of Biomaterials; 2014, 17, no. 128-129; 96-98
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bioactive Scaffolds for Skin Tissue Engineering Doped with Gold Nanoparticles Prepared from Waste Biomass
Bioaktywne rusztowania do inżynierii tkanek skóry domieszkowane złotymi nanocząstkami przygotowanymi z biomasy odpadowej
Autorzy:
Radwan-Pragłowska, Julia
Janus, Łukasz
Piątkowski, Marek
Sierakowska, Aleksandra
Bogdał, Dariusz
Powiązania:
https://bibliotekanauki.pl/articles/319093.pdf
Data publikacji:
2020
Wydawca:
Polskie Towarzystwo Przeróbki Kopalin
Tematy:
waste biomass
gold nanoparticles
chitosan
biomaterials
Green Chemistry
odpady biomasy
nanocząstki złota
chitozan
biomateriały
Zielona Chemia
Opis:
Skin is the first barrier against pathogens and harmful external factors. Each damage of this tissue may cause microbial infection and danger to internal organs. Burns which may be a result of the exposure to radiation, chemicals or high temperature leads to the significant disruption of skin functions. The most promising method for this tissue recovery is regenerative medicine which requires application of three-dimensional biocompatible scaffolds. The biomaterials enable skin cells proliferation and new tissue formation under in vitro conditions. They can be prepared from synthetic and natural polymers and their combination. The application of additional components such as nanoparticles may enhance their mechanical properties and have a positive impact on fibroblasts divisions and extra cellular formation. One of the most promising raw materials for scaffolds is chitosan -a chitin derivative. It may be obtained from waste biomass such as crabs, shrimps and lobsters exoskeletons. Chitosan is non-toxic, biodegradable and have antibacterial properties. The aim of the following study was to obtain novel chitosan derivatives doped with the gold nanoparticles using only natural components such as orange peels and fatty acid derivative. Proposed modification strategy resulted in the preparation of the novel, biodegradable and biocompatible material with interesting properties. The products were analysed by UV-Vis and FT-IR methods. The scaffolds were investigated over their susceptibility to enzymatic degradation. Finally, the biomaterials were verified over their cyto-compability with human dermal fibroblasts. The results showed that the proposed synthesis pathway resulted in the obtained of the chitosan biomaterials with high potential in medicine.
Skóra jest pierwszą barierą przed patogenami i szkodliwymi czynnikami zewnętrznymi. Każde uszkodzenie tej tkanki może powodować zakażenie drobnoustrojami i zagrożenie dla narządów wewnętrznych. Oparzenia, które mogą być wynikiem narażenia na promieniowanie, chemikalia lub wysoką temperaturę, prowadzą do znacznego zakłócenia funkcji skóry. Najbardziej obiecującą metodą tego odzyskiwania tkanki jest medycyna regeneracyjna, która wymaga zastosowania trójwymiarowych biokompatybilnych rusztowań. Biomateriały umożliwiają namnażanie komórek skóry i tworzenie nowych tkanek w warunkach in vitro. Można je wytwarzać z polimerów syntetycznych i naturalnych oraz ich kombinacji. Zastosowanie dodatkowych składników, takich jak nanocząstki, może poprawić ich właściwości mechaniczne i mieć pozytywny wpływ na podziały fibroblastów i tworzenie się komórek. Jednym z najbardziej obiecujących surowców na rusztowania jest chitozan - pochodna chityny.Można go uzyskać z biomasy odpadowej, takiej jak egzoszkielety krabów, krewetek i homarów. Chitozan jest nietoksyczny, biodegradowalny i ma właściwości antybakteryjne. Celem przedstawionych badań było uzyskanie nowych pochodnych chitozanu domieszkowanych nanocząstkami złota przy użyciu wyłącznie naturalnych składników, takich jak skórki pomarańczy i pochodna kwasu tłuszczowego. Proponowana strategia modyfikacji zaowocowała przygotowaniem nowego, biodegradowalnego i biokompatybilnego materiału o interesujących właściwościach. Produkty analizowano metodami UV-Vis i FT-IR. Rusztowania badano pod kątem ich podatności na degradację enzymatyczną. Na koniec biomateriały zweryfikowano pod kątem ich zgodności cytologicznej z ludzkimi fibroblastami skórnymi. Wyniki wykazały, że proponowany szlak syntezy zaowocował uzyskaniem biomateriałów chitozanu o wysokim potencjale w medycynie.
Źródło:
Inżynieria Mineralna; 2020, 2, 1; 169-173
1640-4920
Pojawia się w:
Inżynieria Mineralna
Dostawca treści:
Biblioteka Nauki
Artykuł
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