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Tytuł:
The renaissance of vitamin D
Autorzy:
Wierzbicka, Justyna
Piotrowska, Anna
Żmijewski, Michał
Powiązania:
https://bibliotekanauki.pl/articles/1039195.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
vitamin D
skin
vitamin D deficiency
vitamin D supplementation
vitamin D analogs
Opis:
There is no doubt that vitamin D plays a crucial role in the maintenance of musculoskeletal system. But the function of this ancient molecule presumably ranges far beyond hormone-like regulation, as it could be generated by simple unicellular organisms. First, we are going to discuss the role of vitamin D as a global regulator of homeostasis from a historical perspective, but later we will focus on current views and its relevance to human physiology and pathology. Three milestones are defining the impact of vitamin D on science and humanity. Firstly, discovery that vitamin D is the cure for rickets, brought us supplementation programs and rapid irradiation of this devastating disease. Secondly, detail description of photoproduction of vitamin D, its subsequent metabolism and interaction with vitamin D receptor VDR, provided mechanistic background for future discoveries. Finally, recent large epidemiological studies provided indirect, but strong evidence that optimal level of vitamin D in serum has beneficial effects on our health and protects us from multiple diseases, including cancer. Furthermore, existence of alternative pathways of vitamin D metabolism and multiple intracellular targets broadens our understanding of its physiological activities and offers new and very promising tools for prophylactics and treatment of many diseases of civilization. Although vitamin D (and its derivatives) should not be regarded as a cure-all for every human disease, its beneficial effects on the human health have to be taken under consideration.
Źródło:
Acta Biochimica Polonica; 2014, 61, 4; 679-686
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Knowledge of vitamin D and its supplementation among students of northern Poland
Autorzy:
Waszak, Przemysław M
Mędza, Aleksandra
Springer, Janusz
Zgłobicka, Martyna
Ogrodnik, Paula
Kalinowska, Paulina
Kmieć, Piotr
Lizakowska-Kmieć, Maria
Sworczak, Krzysztof
Żmijewski, Michał
Powiązania:
https://bibliotekanauki.pl/articles/895781.pdf
Data publikacji:
2018-10-01
Wydawca:
Gdański Uniwersytet Medyczny
Tematy:
knowledge
vitamin D
vitamin D deficiency
students
Opis:
Introduction: Vitamin D deficiency is a worldwide public health problem. The objective of this survey was to assess the undergraduate students’ vitamin D status and knowledge about this vitamin. Materials and methods: An online multi-choice survey was designed and launched in Northern Poland (Gdańsk region). The first part of the survey assessed diet, supplementation, UV radiation exposure (UVE) and general health of respondents. The second part was a vitamin D knowledge test (vitamin D optimal level, deficiency-related diseases). 1766 student volunteers responded to the survey: 369 male and 1397 female. Data was divided according to the respondents’ sex and university affiliation. Appropriate parametric or non-parametric statistical tests were used with statistical significance set at p<0.05. Results: Regular consumption of vitamin D-rich food was high, except for fish (only 18; 22%). High number of participants did not declare any type of supplementation (43; 44%) and only occasionally were exposed to UV (77%; 80%). The most frequently recognized disease linked to vitamin D was osteoporosis. Medical University students obtained higher test scores (4,55), however this did not correlate with healthy vitamin D habits. Conclusion: Undergraduate medical and non-medical students have unsatisfactory vitamin D status and poor understanding of its function and impact on health, which implies the need for changes in the educational program.
Źródło:
European Journal of Translational and Clinical Medicine; 2018, 1, 1; 48-56
2657-3148
2657-3156
Pojawia się w:
European Journal of Translational and Clinical Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Vitamin D in the skin physiology and pathology
Autorzy:
Piotrowska, Anna
Wierzbicka, Justyna
Żmijewski, Michał
Powiązania:
https://bibliotekanauki.pl/articles/1038837.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
vitamin D
cancer
skin
keratinocytes
vitamin D analogues
Opis:
Vitamin D plays important, pleiotropic role in the maintenance of global homeostasis. Its influence goes far beyond the regulation of calcium and phosphorus balance, as diverse activities of vitamin D and its natural metabolites assure proper functioning of major human organs, including skin. Recently, we reviewed the current understanding of vitamin D impact on human health from historical perspective (Wierzbicka et al. (2014) The renaissance of vitamin D. Acta Biochim Pol 61: 679-686). This article focuses on its functions in the skin. The skin and its appendages, creates a platform connecting and protecting internal organs against, usually harmful, external environment. It uppermost layer - epidermis in order to maintain a protective barrier undergoes a constant exchange of cornified keratinocytes layer. Its disturbance leads to development of serious skin disorders including psoriasis, vitiligo, atopic dermatitis and skin cancer. All of those dermatopathologies have a huge impact on modern societies, affecting not only the physical, but also mental state of patients as well as their social status. Furthermore, multiple human systemic diseases (autoimmune, blood and digestive diseases) have skin manifestation, thus "condition of the skin" often reflects the condition and pathological changes within the internal organs. In humans, the skin is the natural source of vitamin D, which is produced locally from 7-dehydrocholesterol in photoreaction induced by ultraviolet B (UVB) radiation from the sun. It is also well established, that the process of proliferation and differentiation of keratinocytes is tightly regulated by calcium and the active form of vitamin D (1,25(OH)2D3). Thus, the skin physiology is inseparably connected with vitamin D production and activity. Unfortunately, UVB, which is required for vitamin D production, is also known as the main cause of a skin cancer, including melanoma. Here, we are going to review benefits of vitamin D and its analogues in the maintenance of epidermal barrier and its potential use in the treatment of common skin diseases.
Źródło:
Acta Biochimica Polonica; 2016, 63, 1; 17-29
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
ROLA WITAMINY D W CHOROBACH NOWOTWOROWYCH I NEURODEGENERACYJNYCH – PRZEGLĄD LITERATURY
THE ROLE OF VITAMIN D IN NEOPLASMS AND NEURODEGENERATION DISEASES - A REVIEW OF THE LITERATURE
Autorzy:
Waszyk-Nowaczyk, Magdalena
Główka, Eliza
Powiązania:
https://bibliotekanauki.pl/articles/762677.pdf
Data publikacji:
2020-04-27
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
witamina D
suplementacja
kalcytriol
plejotropowe działanie witaminy D
vitamin D
Calcitriol
vitamin D supplementation
pleiotropic action of vitamin D
Opis:
In recent years, a significant increase in the incidence of cancer and neurodegenerative diseases has been observed. This is mainly because of the higher life expectancy and thus prolonged contact with risk factors, inadequate diet and lack of physical activity. Along with aging processes, the prevalence and incidence of many diseases rise dramatically. New drugs and solutions are constantly being sought that would help in particular preventing. One way could be the use of vitamin D or its analogues, which through their proven pleiotropic action, have become the focus of the interest of many scientists in the last decade. One might think that the problem of vitamin D deficiency should affect a small part of the population, due to health campaigns carried out and the availability of many OTC preparations with vitamin D in various forms. Research, however, confirms that the need for vitamin D supplementation is overlooked by healthcare professionals, and its deficiencies are widespread worldwide and affect all ages. It is very meaningful problem. It is important to check the concentration of this vitamin in the blood, which in the case of low levels can be correlated with potential health problems. The influence of vitamin D on physiological processes, confirmed by numerous studies and scientific publications, and thus also the prevention of numerous diseases, is an important argument indicating the need for patient education on how to take it regularly. For this reason, preventive actions carried out by professional medical staff, including pharmacists in community pharmacies, regarding awareness of the important role of vitamin D and its impact on our health are important. Patient counseling may have a significant effect on improving quality of life. This article discusses some mechanisms of antiproliferative, neuroprotective and immunomodulatory activity of active vitamin D derivatives on the example of selected cancers, Alzheimer's disease, and multiple sclerosis.
W ostatnich latach obserwuje się znaczny wzrost zachorowań na nowotwory i choroby neurodegeneracyjne. Wciąż poszukuje się nowych leków i rozwiązań, które pomogłyby zwłaszcza w zapobieganiu tym chorobom. Jednym ze sposobów może być stosowanie witaminy D lub jej analogów, które poprzez swoje udowodnione wielokierunkowe działanie, stały się w ostatniej dekadzie przedmiotem zainteresowania wielu naukowców. Można by pomyśleć, że problem niedoboru witaminy D powinien dotyczyć niewielkiej części populacji, ze względu na przeprowadzane kampanie zdrowotne i dostępność wielu preparatów OTC z witaminą D w różnej postaci. Badania potwierdzają jednak, że potrzeba suplementacji witaminy D jest pomijana przez pracowników służby zdrowia, a jej niedobory są powszechne na całym świecie i dotykają wszystkich grup wiekowych. Duże znaczenie ma sprawdzanie stężenia tej witaminy we krwi, co w przypadku niskiego poziomu można skorelować z potencjalnymi problemami zdrowotnymi. Potwierdzony w licznych badaniach i publikacjach naukowych wpływ witaminy D na procesy fizjologiczne, a przez to także na zapobieganie licznym chorobom, jest istotnym argumentem wskazującym na potrzebę edukacji pacjentów na temat jej regularnego przyjmowania. Z tego powodu istotne są akcje profilaktyczne prowadzone przez fachowy personel medyczny, w tym także przez farmaceutów w aptekach ogólnodostępnych, dotyczące uświadamiania pacjentom ważnej roli witamy D i jej wpływu na nasze zdrowie. W niniejszym artykule omówiono niektóre mechanizmy działania antyproliferacyjnego, neuroprotekcyjnego i immunomodulującego aktywnych pochodnych witaminy D na przykładzie wybranych chorób nowotworowych, choroby Alzheimera oraz stwardnienia rozsianego.
Źródło:
Farmacja Polska; 2020, 76, 3; 149-155
0014-8261
2544-8552
Pojawia się w:
Farmacja Polska
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of correlation between vitamin D level and prevalence of preterm births in the population of pregnant women in Poland
Autorzy:
Baczyńska-Strzecha, Marta
Kalinka, Jarosław
Powiązania:
https://bibliotekanauki.pl/articles/2161845.pdf
Data publikacji:
2017-10-06
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
pregnancy
vitamin D
preterm delivery
vitamin D deficiency
preterm birth
preterm labor
Opis:
Objectives Aim of this project is determination of the correlation between the level of vitamin D in blood serum and duration of pregnancy in population in central Poland. Material and Methods 25-Hydroxyvitamin D (25(OH)D) level was determined in blood serum, using enzyme-linked immunosorbent assay (ELISA). Standardized history of each patient was recorded. The history included: general medical history, data regarding the course of pregnancy and information about health-related behavior that could influence vitamin D concentration. Two hundred-and-one Caucasian women at childbirth were qualified into the study. The study group was divided into 2 parts: 100 patients who had a spontaneous premature birth and 101 patients who had birth at full term. Results Vitamin D deficiency (< 30 ng/ml) was very common for both groups (69.6% of patients in the premature group and 72% – in the control group). Patients who had a premature birth had severe vitamin D deficiency (less than 10 ng/ml) more often than in the control group (34% vs. 14.2%, p = 0.001). Severe vitamin D deficiency increased the risk of premature birth but the association was not statistically significant in the multivariate regression model (odds ratio (OR) = 2.47, 95% confidence interval (CI): 0.86–7.15, p = 0.094). Conclusions Severe vitamin D deficiency (< 10 ng/ml) may be the factor increasing the risk of preterm birth. Int J Occup Med Environ Health 2017;30(6):933–941
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2017, 30, 6; 933-941
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Vitamin D – dietary intake, supplementation and metabolic status of Polish adults
Autorzy:
Kamińska, Sylwia
Pikala, Małgorzata
Dziankowska-Zaborszczyk, Elżbieta
Bielecki, Wojciech
Rębowska, Ewa
Kozakiewicz, Krystyna
Nadrowski, Paweł
Drygas, Wojciech
Kwaśniewska, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/2116712.pdf
Data publikacji:
2020-01-17
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
adults
abdominal obesity
metabolic disorders
Polish
vitamin D supplementation
vitamin D intake
Opis:
ObjectivesContrary to popular opinion on the preventive properties of vitamin D, results of previous studies have been inconclusive. The aim of this research was to evaluate the associations between the intake of vitamin D and metabolic abnormalities in a representative sample of Polish adults.Material and MethodsWithin the framework of the Multi-Center National Population Health Examination Survey (referred to as WOBASZ), a random sample of 2381 adult residents of Poland (53.8% of whom were women) was examined. All the study subjects were extensively reviewed, including 24-h dietary recall. The intake of vitamin D was assessed on the basis of dietary and supplements reviews. Metabolic abnormalities were evaluated using measurements of waist circumference (WC), blood pressure (BP), serum triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and fasting glycemia. Metabolic syndrome was defined according to the International Diabetes Federation.ResultsOf all the study participants, about 4.4 % of women and 2.6% of men declared a regular supplementation of vitamin D. Among women, a significant inverse correlation between vitamin D supplementation and the mean systolic BP was found (p < 0.01). A more substantial relationship was noted after dividing the study subjects according to their body mass. Among obese men, there was a significant inverse relationship between vitamin D intake and the mean systolic BP (p < 0.01) and diastolic BP (p < 0.05), as well as a positive correlation with HDL-C (p < 0.05). Among obese women, a negative correlation was found between vitamin D supplementation and the mean systolic BP (p < 0.01) and diastolic BP (p < 0.05), and a positive correlation with TG (p < 0.05). Among non-obese male subjects, a negative correlation between vitamin D intake and WC was observed.ConclusionsThe obtained findings suggest that the correlation between vitamin D intake and metabolic abnormalities may depend on the obesity status. A higher vitamin D intake may reduce BP and increase HDL-C in obese subjects. The positive relationship between vitamin D intake and TG concentration in women needs further investigation.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2020, 33, 1; 107-118
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Serum levels of vitamin D and tumour necrosis factor-alpha in adults with metabolic syndrome
Autorzy:
Rahamon, Sheu Kadiri
Arinola, Olatunbosun Ganiyu
Charles-Davies, Mabel Ayebatonyo
Akinlade, Kehinde Sola
Olaniyi, John Ayodele
Fasanmade, Adesoji Adedipe
Oyewole, Oyediran Emmanuel
Owolabi, Mayowa Ojo
Adebusuyi, Jane Roli
Hassan, Olufunke Olayemi
Ajobo, Muhammed Babatunde
Adigun, Kehinde
Ebesunun, Maria Onomaghuan
Popoola, Omolara Olutosin
Omiyale, Wemimo
Agbedana, Emmanuel Oluyemi
Powiązania:
https://bibliotekanauki.pl/articles/2040233.pdf
Data publikacji:
2021-12-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
metabolic syndrome
vitamin D
inflammation
Opis:
Introduction. Reports continue to show that a significant association exists between serum vitamin D level and metabolic syndrome (MS)-associated inflammation. However, information on the serum levels of vitamin D and alterations in inflammation in different vitamin D status is presently lacking. Aim. To determine the serum levels of vitamin D and TNF-α, and assess their possible relationship with gender in individuals with MS. Material and methods. Sixty adults with MS and 40 controls were enrolled into this case-control study. Serum vitamin D and TNF-α levels were measured and participants stratified into different vitamin D status. Results. None of the participants had vitamin D deficiency and the mean vitamin D level was similar in MS compared with the controls. However, TNF-α level was significantly higher in MS compared with the controls. Serum vitamin D level had significant inverse correlation with serum TNF-α level in MS. Also vitamin D level was significantly lower while TNF-α level was significantly higher in female-MS compared with the male-MS. Conclusion. Adults with MS have elevated TNF-α level which appears to be associated with the serum level of vitamin D. Also, females with MS have low vitamin D level and this may exacerbate the MS-associated inflammation in them.
Źródło:
European Journal of Clinical and Experimental Medicine; 2021, 4; 306-312
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Determinants of vitamin D status among Jordanian employees: Focus on the night shift effect
Autorzy:
Alefishat, Eman
Abu Farha, Rana
Powiązania:
https://bibliotekanauki.pl/articles/2168364.pdf
Data publikacji:
2016-07-22
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
vitamin D
vitamin D deficiency
night shift work
Jordan
working conditions
risk assessment
Opis:
Objectives To assess the association between night work and 25-hydroxy vitamin D (25OHD) levels, and to evaluate effect of potential risk factors on 25OHD levels. Material and Methods A total of 140 adult Jordanian employees were recruited. Demographic, lifestyle and working patterns data were documented through a well-structured questionnaire. Vitamin D status was assessed by measuring circulating concentrations of 25OHD. Results Mean 25OHD level was 23.8 ng/ml. No significant difference was found in 25OHD levels between the summer and winter (p = 0.46), or between males and females (p = 0.35). The female night workers had significantly lower serum 25OHD levels compared to the female day workers (p = 0.01). No significant difference in serum 25OHD levels was found between the night and day male workers (p = 0.25). The number of night shifts/month was negatively correlated with 25OHD levels in both the males and females (p = 0.01 and p = 0.007, respectively). Age was positively correlated with 25OHD levels in both the males and females (p = 0.02 and p = 0.001, respectively). Body mass index was negatively associated with 25OHD levels in the whole sample (p = 0.03), but not within each gender group (p = 0.21 for the males and p = 0.09 for the females). Smoking had no significant association with 25OHD levels (p = 0.99 for the males and p = 0.22 for the females). Conclusions Our results suggest that women working night shifts are at higher risk of 25OHD deficiency, and, consequently, of other health problems linked to 25OHD deficiency. Int J Occup Med Environ Health 2016;29(5):859–870
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2016, 29, 5; 859-870
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hypovitaminosis D and adipose tissue – cause and effect relationships in obesity
Autorzy:
Pelczyńska, Marta
Grzelak, Teresa
Sperling, Marcelina
Czyżewska, Krystyna
Powiązania:
https://bibliotekanauki.pl/articles/989098.pdf
Data publikacji:
2016
Wydawca:
Instytut Medycyny Wsi
Tematy:
vitamin d
adipose tissue
obesity
Opis:
In recent years, attention has been focused on pleiotropic directions of effects exerted by vitamin D. Epidemiological data indicate that deficiency of vitamin D in various population groups represents an increasingly widespread phenomenon, while a decreased serum concentration of calcitriol correlates with manifestation of civilization-linked diseases, including visceral obesity. This study aims at a review and synthesis of data linked to relationships between lowered vitamin D concentrations in blood and manifestation of obesity, and potential mechanisms which affect the concentration of the vitamin in conditions of an excessive accumulation of adipose tissue. Several variables are distinguished which can affect the status of vitamin D in obesity, but the key role in this respect is ascribed to the metabolic activity of visceral adipose tissue. Among others, the activity favours sequestration and modulation of calcitriol turnover. On the other hand, the effects of vitamin D on the process of adipogenesis and its involvement in remodelling of adipose tissue are pointed out. Also, several factors of an environmental nature (e.g. time of year/day, dietetic supply of vitamin D), genetic nature (e.g. genetic polymorphisms) and other conditioning (e.g. coexisting diseases, age, content of melanin in skin) cannot be bypassed as they may affect the concentration of vitamin D. Nevertheless, it still remains unresolved to what extent hypovitaminosis D represents the cause and to which it is the effect of obesity.
Źródło:
Annals of Agricultural and Environmental Medicine; 2016, 23, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dietary Pattern and its Relationship Between Bone Mineral Density in Girls and Boys with Cystic Fibrosis – preliminary report
Sposób żywienia i jego związek z gęstością mineralną kości u dziewcząt i chłopców z mukowiscydozą
Autorzy:
Sands, Dorota
Mielus, Monika
Umławska, Wioleta
Lipowicz, Anna
Oralewska, Beata
Walkowiak, Jarosław
Powiązania:
https://bibliotekanauki.pl/articles/1032977.pdf
Data publikacji:
2015
Wydawca:
Wydawnictwo ALUNA
Tematy:
adolescents
calcium
densitometry
nutrition
vitamin D
Opis:
Background: Nutrition influence on cystic fibrosis (CF) patients survival is well documented and dietary therapy is one of basic elements of their treatment. Prolonged survival of CF patients might yet emerge comorbidities, which include bone mineral disease. The aim: The assessment of the dietary pattern and its relationship between bone density in boys and girls with cystic fibrosis. Material and methods: 89 patients aged 10-18 years from 3 Polish CF Centres were included into the study. To obtain a knowledge about quality of diet, a 3-day food record was assessed and percent of recommended for CF patients intake of energy, protein, carbohydrates, fat, vitamin D3, calcium, phosphorus was counted. Bone mineral density (BMD) in lumbar spine (L1-L4) was measured and expressed as a Z-score. To assess nutritional status, anthropometric measurements was evaluated (body weight, height and BMI). Descriptive methods, Mann-Whitney test, T-Student test, Spearman correlation and one-way ANOVA were used for statistical analyses. Results: The patients with cystic fibrosis did not meet specific for CF nutritional guidelines. A deficiency in recommended intake was observed in energy (88%), protein (82%), calcium (78%) and vitamin D3 (71%). The intake of phosphorus was higher than recommended (142%). A nutritional status was significantly reduced, as compared with the reference group (p<0.001). Boys characterized significantly lower body weight (p=0.019) and height (p=0.036) than girls as well as worse caloric (p=0.023) and carbohydrates intake (p=0.005). However, girls had reduced vitamin D3 content in their diet (p<0.001). The bone mineral density in the whole group was reduced and Z-score amounted to -0.95±1.17. Tendency to decreasing of BMD with age was observed. BMI showed important correlation with bone mineral density both in girls (p<0.001) and in boys (p=0.020). Conclusion: CF patients do not follow specific for them dietary recommendations and essential differences were observed between girls and boys. Nutritional status (BMI) showed correlation with bone mineral density in CF patients. Therefore intensive nutritional therapy according to recommendations is needed.
Wprowadzenie: Wpływ żywienia na długość życia chorych z mukowiscydozą (ang. Cystic Fibrosis − CF) jest dobrze udokumentowany, a postępowanie dietetyczne jest jednym z podstawowych elementów leczenia pacjentów z CF. Systematyczne wydłużanie się wieku przeżycia chorych może powodować ujawienie się niedoborów żywieniowych prowadzących do chorób towarzyszących, jakimi są m.in. zaburzenia w gospodarce mineralnej kości. Cel: Celem pracy była ocena sposobu żywienia dziewcząt i chłopców z mukowiscydozą i jego związku z gęstością mineralną kości. Materiał imetody: Do badania włączono 89 pacjentów wwieku 10-18 lat. Wcelu ustalenia jakości diety, oceniono sposób żywienia za pomocą zapisu 3-dniowych jadłospisów, obliczając procent realizacji zapotrzebowania zgodnie z rekomendacjami opracowanymi dla pacjentów z mukowiscydozą. Dotyczyło to pokrycia zapotrzebowania kalorycznego, białka, tłuszczu, węglowodanów, witaminy D3, wapnia i fosforu. Oceniono gęstość mineralną kości (Bone Mineral Density − BMD) w odcinku lędźwiowym (L1-L4). Wynik wyrażono, jako wartość standaryzowaną Z-score. W celu określenia stanu odżywienia dokonano pomiarów antropometrycznych (masa i wysokość ciała oraz BMI). Wykonano następujące obliczenia statystyczne: analizy opisowe, test Manna-Whitneya, test t-Studenta, korelację Spearmana, oraz jednoczynnikową analizę wariancji ANOVA. Wyniki: Badani pacjenci nie spełniali opracowanych dla chorych na mukowiscydozę zaleceń żywieniowych. W diecie zaobserwowano niedobory energii (88% normy), białka (82%), wapnia (78%) oraz witaminy D3 (71%). Wykazano nadmierne spożycie fosforu (142%). Stan odżywienia (parametry antropometryczne) badanej grupy był obniżony i w sposób statystycznie istotny różnił się od grupy referencyjnej (p<0,001). Chłopcy charakteryzowali się znacznie niższą masą ciała (p=0,019) iwysokością (p=0,036) niż dziewczęta, a także niższą kalorycznością diety (p=0,023) oraz zawartością węglowodanów (p=0,005). Dietę dziewcząt cechowała mniejsza zawartość witaminy D3 w diecie (p<0,001) w porównaniu do chłopców. Średnia wartość gęstości mineralnej kości w całej grupie była obniżona i wynosiła -0,95±1,17. Zaobserwowano tendencję do obniżania się BMD wraz z wiekiem. Stan odżywienia wyrażony jako BMI wykazał statystycznie istotną korelację z gęstością mineralną kości, zarówno u dziewcząt (p<0,001), jak i u chłopców (p=0,020). Wnioski: Pacjenci z CF nie przestrzegali opracowanych dla nich zaleceń dietetycznych. Zaobserwowano istotne różnice między dziewczętami i chłopcami. Stan odżywienia (BMI), wykazał korelację z gęstością mineralną kości (BMD), co wymaga intensywnej terapii żywieniowej, zgodnie z opracowanymi rekomendacjami.
Źródło:
Developmental Period Medicine; 2015, 1; 105-113
1428-345X
Pojawia się w:
Developmental Period Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Protein and Vitamin D supplementation in Sarcopenia: A review
Autorzy:
Colonetti, Tamy
Rosa, Maria Ines
Powiązania:
https://bibliotekanauki.pl/articles/1197968.pdf
Data publikacji:
2018-02-01
Wydawca:
Akademia Ignatianum w Krakowie
Tematy:
Aging
Sarcopenia
Vitamin D
Dietary Supplements
Opis:
RESEARCH OBJECTIVE: Perform a review of protein and vitamin D supplementation in Sarcopenia. THE RESEARCH PROBLEM AND METHODS: Demographic change implies new demands for public health, with health promotion and prevention activities seeking to delay the appearance of common diseases in elderly population. We performed a review of protein and vitamin D supplementation in Sarcopenia. THE PROCESS OF ARGUMENTATION: Changes in body composition occur during the aging process, resulting in increased body fat and reduced muscle mass and also bone mass. Sarcopenia is defined by a syndrome characterized by generalized and progressive loss of muscle mass and strength. After 50 years, there is a reduction between approximately 1% and 2% of muscle mass per year. RESEARCH RESULTS: Currently progressive resistance training is the most well-established intervention, and dietary interventions such as protein and vitamin D also mentioned in literature. Leucine is a branched chain amino acid knows as key role in muscle protein synthesis. The consumption of leucine-enriched amino acids showed beneficial effects in the elderly contributing to the conservation of skeletal muscle mass. Vitamin D has pre-hormone functions, vitamin D deficiency is related with diffuse musculoskeletal pain, myopathy, sarcopenia and falls. Vitamin D supplementation of 800 to 1000 IU/day is associated with increased muscle strength in the elderly. CONCLUSIONS, INNOVATIONS AND RECOMMENDATIONS: The protein and vitamin D supplementation are strategies that are proving to be important for the prevention and treatment of sarcopenia, especially when associated with resistance training.
Źródło:
Horyzonty Wychowania; 2017, 16, 40; 25-35
1643-9171
2391-9485
Pojawia się w:
Horyzonty Wychowania
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Thyroid functioning, adipocytokines, bone turnover and vitamin D - review of literature
Autorzy:
Koszowska, A.
Brończyk-Puzoń, A.
Dittfeld, A.
Nowak, J.
Kulik-Kupka, K.
Zubelewicz-Szkodzińska, B.
Powiązania:
https://bibliotekanauki.pl/articles/1917694.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Thyroid gland
obesity
adipokines
vitamin D
Opis:
The most common public health problems include, among others, overweight, obesity, and cardiovascular diseases. In addition, the number of people with thyroid disturbances is still growing. Thyroid abnormalities can lead to many metabolic dysfunctions, including secondary osteoporosis, alterations in body mass, lipid profile, and insulin resistance. Recently, the studies have been focused on the connections between thyroid gland function, obesity, metabolic syndrome and cardiovascular diseases, as well as bone turnover. Fatty tissue plays an important role in whole body homeostasis. Adipose tissue hormones, such as leptin, resistin and adiponectin are proteins having immunomodulatory lproperties, and their balance is needed to control immune response, as well as inflammation processes. The following article constitutes a review of literature concerning thyroid function with regard to adipocytokines and vitamin D, as well as the influence of this gland on the skeletal system. For this purpose, Medline Pub Med base and Google Scholar were used. All the citied studies in this review article underline how much should be done to achieve more efficient treatment of thyroid disorders, specifically, how to prevent its complications, for instance, osteoporosis, over-weight, obesity or cardiovascular diseases.
Źródło:
Progress in Health Sciences; 2016, 6(1); 188-196
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Correlation of vitamin D deficiency with mortality in critically ill patients admitted to the intensive care unit
Autorzy:
Joshi, Vidit Maheshkumar
Wasnik, Seema Balkrishna
Yadav, Amlendu
Yadav, Rupesh
Powiązania:
https://bibliotekanauki.pl/articles/29432042.pdf
Data publikacji:
2024-03-31
Wydawca:
Towarzystwo Pomocy Doraźnej
Tematy:
Intensive care unit
mortality
vitamin D
Opis:
INTRODUCTION: Vitamin D, which is a fat-soluble vitamin, plays a key role in enhancing the intestinal absorption of calcium, magnesium and phosphate. In severely ill patients, vitamin D can adversely affect immune and metabolic functions, contributing to poorer outcomes. The aim of this study was to correlate vitamin D with mortality in critically ill patients. MATERIALS AND METHODS: prospective observational study was conducted, involving 162 patients in an intensive care unit (ICU). 162 patients were divided into two groups according to vitamin D Deficiency Group levels ≤ 20 ng/ml and Non vitamin D deficiency group levels <20 ng / ml and non-vitamin D deficiency group B levels > 20ng/ml. Data collected during the study included the APACHE II (acute physiology and chronic health evaluation) score at ICU admission, SOFA (sequential organ failure assessment) scores throughout the ICU stay, the need for mechanical ventilation, inotropic support, length of stay in ICU, and ICU outcomes, which were classified as either discharge or mortality. RESULTS: Of the 162 patient admitted to ICU, the prevalence of vitamin D deficiency in this study was 140 (86.4%) and nondeficient 22 (13.6%). The mortality rate in the vitamin D deficient group was 40% compared to 18.18% in the nondeficient group. The difference in mortality in both groups for mortality was statistically significant (p-value < 0.05). Vitamin D deficiency was not associated as an independent risk factor for ICU mortality [Odds ratio (OR) 1.220, 95% CI (0.825- 1.805) (p-value -0.320)]. CONCLUSIONS: The vitamin D-deficient group had a significantly higher mortality rate compared to the patient in the nondeficient group. But vitamin D deficiency was not found to be an independent risk factor for mortality.
Źródło:
Critical Care Innovations; 2024, 7, 1; 1-11
2545-2533
Pojawia się w:
Critical Care Innovations
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pain involving the motor system and serum vitamin D concentration in postmenopausal women working in agriculture
Autorzy:
Raczkiewicz, Dorota
Owoc, Alfred
Sarecka-Hujar, Beata
Bojar, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/989974.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
menopause
vitamin d
pain
motor system
Opis:
Introduction and objective. Since the role of vitamin D is essential in numerous biological processes its deficiency was suggested to be a risk factor for e.g. osteoporosis, musculoskeletal pain and spine pain. The purpose of the study was to analyse whether serum vitamin D concentration is related to pain involving the motor system in Polish postmenopausal women working in agriculture. Material and methods. The study group consisted of 1,751 post-menopausal women, aged 45–65, at least 12 months from the last menstrual period, living in rural areas and working in agriculture. The research method was self-assessment of pain involving the motor system using VAS, laboratory test of serum vitamin D concentration and a medical interview. Statistical methods included generalized linear models, analysis of variance, t test for two means in two independents, χ2 test of stochastic independence. Results. Postmenopausal women working in agriculture and suffering from pain in at least one part of the motor system were younger and lower educated, they also had higher abdominal obesity and lower serum vitamin D, compared to those without pain in any part of the motor system. Decreased serum vitamin D concentration in postmenopausal women working in agriculture is important from the aspect of a higher prevalence of pain in the thoracic spine and more severe pain in the neck spine, but not for severity of pain in the lumbar spine; higher occurrence of pain in both hands or wrists; higher prevalence and more severe pain in at least one knee; and no prevalence or severity of pain in the shoulders and elbows. Conclusion. Serum vitamin D concentration is important for the prevalence and severity of pain in the neck and thoracic spine, knees and hands or wrists, but not for the lumbar spine, shoulders and elbows.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 1
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Health outcomes of vitamin D. Part I. Characteristics and classic role
Autorzy:
Wranicz, J.
Szostak-Wegierek, D.
Powiązania:
https://bibliotekanauki.pl/articles/873318.pdf
Data publikacji:
2014
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
health outcome
vitamin D
vitamin D3
mineral homeostasis
homeostasis
vitamin deficiency
pleiotrophic effect
calcium deficiency
phosphate deficiency
Opis:
Vitamin D is a compound responsible for maintaining mineral homeostasis. It protects against calcium and phosphate deficiency through the effects on the intestine, kidney, parathyroid gland and bone. All mechanisms that help maintain mineral homeostasis of the body are regulated by the vitamin D hormonal form - calcitriol. Synthesis of vitamin D starts in the skin as a non-enzymatic process, which begins during exposure to sunlight, when the absorption of ultraviolet B (UVB) radiation results in convertion of 7-dehydrocholesterol, a metabolite of cholesterol that is stored in the skin, to precholecalciferol (previtamin-D3) that is immediately converted into cholecalciferol (vitamin D3). After the skin synthesis cholecalciferol is transported to the liver where it undergoes hydroxylation, what results in formation of calcidiol (25(OH) D3). The second metabolic process takes place in the kidney, where calcidiol undergoes hydroxylation at the C-1 position to the hormonal, the most active metabolite - 1,25-dihydroxyvitamin D (calcitriol). Vitamin D deficiency may result in bone diseases, such as rickets in children and osteomalacia and osteoporosis in adults. Symptoms of osteomalacia affect mainly the skeletal system and are similar to that observed in rickets. It concerns thoracic kyphosis, pelvis deformities and also the varus knee. Osteoporosis is another condition that is related to abnormalities of mineral homeostasis. It is characterized by the progressive loss of bone mass, impaired bone microarchitecture, and consequently increased fragility and susceptibility to fracture. For the last several years other, non-classic actions of vitamin D3 have been discussed. It was engendered by the discovery of vitamin D3 receptor (VDR) in the most of body tissues and cells. Hence, there are many hypotheses which suggest the inverse relationship between vitamin D status and various diseases, such as cancer, autoimmune diseases, diabetes mellitus and others.
Witamina D jest związkiem chemicznym odpowiedzialnym za utrzymanie homeostazy mineralnej organizmu. Poprzez wpływ na jelita, nerki, przytarczyce i kości zapobiega niedoborowi wapnia i fosforanów. Aktywną formą witaminy D3 o właściwościach hormonalnych jest kalcytriol, który odpowiada za utrzymanie homeostazy mineralnej organizmu. Pierwszy etap syntezy witaminy D zachodzi w skórze, pod wpływem ekspozycji na światło słoneczne (UVB). Polega on na nieenzymatycznej przemianie 7-dehydrocholesterolu do prowitaminy D (pre-D3), która natychmiast ulega przekształceniu do cholekalcyferolu (witaminy D3). Wyprodukowana w skórze witamina D3 jest następnie transportowana do wątroby, gdzie ulega hydroksylacji, w wyniku której powstaje kalcydiol (25(OH)D3). Drugi proces metaboliczny zachodzi w nerkach, gdzie kalcydiol ulega hydroksylacji w pozycji C-1 do hormonalnie najbardziej aktywnego metabolitu witaminy D - 1,25-dihydroksywitaminy D (kalcytriol). Niedobór witaminy D może prowadzić do chorób kości, takich jak krzywica u dzieci oraz osteomalacja i osteoporoza u osób dorosłych. Objawy osteomalacji dotyczą głównie układu kostnego i są zbliżone do tych obserwowanych w krzywicy. Są to m.in.: kifoza piersiowa, deformacje miednicy i szpotawość kolan. Osteoporoza to choroba, która także związane jest z zaburzeniem homeostazy mineralnej. Charakteryzuje się postępującą utratą masy kostnej, uszkodzeniami mikroarchitektury kości, i w konsekwencji zwiększoną ich kruchością i podatnością na złamania. Na przestrzeni ostatnich lat pojawiły się doniesienia dotyczące innych, nieklasycznych działań witaminy D3. Stwierdzono obecność receptora witaminy D (VDR) w wielu tkankach organizmu, które nie biorą udziału w utrzymaniu homeostazy wapniowo-fosforanowej. Świadczy to o wielokierunkowym działaniu tego związku. Pojawiło się wiele hipotez sugerujących związek między niedoborem witaminy D a występowaniem wielu różnych chorób, takich jak: nowotwory, choroby autoimmunologiczne, cukrzyca i inne.
Źródło:
Roczniki Państwowego Zakładu Higieny; 2014, 65, 3
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 84

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