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Tytuł:
Aluminum Oxide Formation On Fecral Catalyst Support By Electro-Chemical Coating
Powstawanie tlenku glinu na nośniku katalizatora FeCrAl przez osadzanie elektrochemiczne
Autorzy:
Yang, H. S.
Jang, D. H.
Lee, K. J.
Powiązania:
https://bibliotekanauki.pl/articles/355942.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
FeCrAl
catalyst support
aluminum oxide formation
PEO
plasma electrolytic oxidation
electrochemical coating
nośnik katalizatora
tlenek glinu
plazmowe utlenianie elektrolityczne
elektrochemiczne osadzanie
Opis:
FeCrAl is comprised essentially of Fe, Cr, Al and generally considered as metallic substrates for catalyst support because of its advantage in the high-temperature corrosion resistance, high mechanical strength, and ductility. Oxidation film and its adhesion on FeCrAl surface with aluminum are important for catalyst life. Therefore various appropriate surface treatments such as thermal oxidation, Sol, PVD, CVD has studied. In this research, PEO (plasma electrolytic oxidation) process was applied to form the aluminum oxide on FeCrAl surface, and the formed oxide particle according to process conditions such as electric energy and oxidation time were investigated. Microstructure and aluminum oxide particle on FeCrAl surface after PEO process was observed by FE-SEM and EDS with element mapping analysis. The study presents possibility of aluminum oxide formation by electro-chemical coating process without any pretreatment of FeCrAl.
Źródło:
Archives of Metallurgy and Materials; 2015, 60, 2B; 1503-1506
1733-3490
Pojawia się w:
Archives of Metallurgy and Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Studying the effect of some parameters on the stability of shallow tunnels
Autorzy:
Abdellah, W. R.
Ali, M. A.
Yang, H.-S.
Powiązania:
https://bibliotekanauki.pl/articles/92102.pdf
Data publikacji:
2018
Wydawca:
Główny Instytut Górnictwa
Tematy:
tunnel shape
rock joint
numerical modelling
stability indicator
kształt tunelu
przełom skał
modelowanie numeryczne
wskaźnik stabilności
Opis:
Several factors have crucial impact on the serviceability of underground openings including: the quality of rock mass; the presence of rock joints and their geometrical properties; the state of in-situ stress ratio; the depth below surface and opening geometry. This paper only investigates the effect of two parameters on the stability of underground shallow tunnels, namely: the presence of rock joints in the rock mass matrix and the shape of the excavation. A series of two-dimensional elasto-plastic finite-element models has been constructed using rock-soil, RS2D, software. Consequently, parametric stability analysis has been conducted for three different tunnel shapes (e.g. circular, square and horseshoe) with/without joint inclusion. Four reference points have been assigned in the tunnel perimeter (e.g. back, sidewalls and floor) to monitor the state of stress-displacement in the rock mass around them. The results indicate that the weak performance of a tunnel opening occurs with a square-shaped opening and when joints exist in the rock mass. In addition, the normal stress along joints sharply drops in the vicinity of a tunnel opening. Moreover, the direction of shear stress is reversed. Thus, it causes inward shear displacement.
Źródło:
Journal of Sustainable Mining; 2018, 17, 1; 20-33
2300-1364
2300-3960
Pojawia się w:
Journal of Sustainable Mining
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Optimization of photonic crystal filter based on slack variables
Autorzy:
Yang, H.
Peng, S.
Meng, S.
Powiązania:
https://bibliotekanauki.pl/articles/173949.pdf
Data publikacji:
2017
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
photonic crystal filter
slack variables
optimization
Opis:
The improved model based on slack variables is designed to optimize a photonic crystal filter. An optimization model of the filter is established, with the transmission quantity in a stop-band as the objective function and the transmission quantity outside a stop-band as the constraint condition. The improved model is obtained by introducing slack variables in the infeasible region. With the treatment of objective and constraint functions, the optimization problem and the improved model are solved by sequential linear programming. Then the convergent solution satisfying the constraints can be found. The change of the objective function and design variables with iteration steps is presented by numerical examples, and the influence of by the constraints on the central frequency of the stop-band is discussed, indicating that the improved model is available and effective for optimization of a photonic crystal filter.
Źródło:
Optica Applicata; 2017, 47, 4; 621-633
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zero-Bias Anomaly in Magnetic Tunnel Junctions
Autorzy:
Yang, H.
Yang, S.
Ilnicki, G.
Martinek, J.
Parkin, S.
Powiązania:
https://bibliotekanauki.pl/articles/1536909.pdf
Data publikacji:
2010-08
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
73.21.La
73.23.-b
73.22.-f
Opis:
We present experimental results, which may indicate the possibility of the coexistence of the Kondo effect and ferromagnetism in macroscopic planar magnetic tunnel junctions with a layer of nanodots inside tunnel barriers. A conductance double peak structure was observed. Magnetic field dependence of the splitting of a conductance peak, and temperature evolution of the conductance curves are well explained from the theoretical point of view according to the predictions of the Kondo physics and cotunneling in the Anderson quantum dot coupled to ferromagnetic leads.
Źródło:
Acta Physica Polonica A; 2010, 118, 2; 316-318
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Study of the characteristics about insulation damage based on the accelerated life tests
Badanie charakterystyk uszkodzeń izolacji w oparciu o testy przyspieszonego starzenia
Autorzy:
Yang, Y. H.
Wang, K.-S.
Powiązania:
https://bibliotekanauki.pl/articles/300857.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Polskie Naukowo-Techniczne Towarzystwo Eksploatacyjne PAN
Tematy:
accelerated life testing
competing failure mode
insulation degradation
Gompertz-type relation shape parameter
Opis:
In this study the Maximum Likelihood Estimator is taken to identify the characteristics of insulation failure about the class-H motors by considering the accelerated life testing data under censored situation from Nelson. Based on the Weibull survival modeling the failure is expressed as the series connection of three modes, namely the turn, phase, and ground, respectively, the so-called competing failure. The main concern in present investigation is about the variation of shape parameters, β with the temperature. The Gompertz-type relation of βi(T) is suggested with the reference temperature, Tri for the i-th failure mode. It is found that the Tri ’s not only distinguish the characteristics of cumulative damage process about the insulation, but also involve the estimation of mean-time-to-failure (MTTF). Physically Tri denotes the turning point of varied βi as the i-th failure mode becomes moderate in a sense of less capability about the accumulation of insulation damage at higher temperature where corresponds the thermal degradation process. The numerical results indicate that the insulation technique used is acceptable as the operation temperature kept in the use condition 363K. According to the predicted lifetime as the temperature rises up to 440K, which still within the allowed range in application, the turn structure needs to be rearranged primarily, then the phase next. The ground mode has only influence on the failure at much higher temperature.
Źródło:
Eksploatacja i Niezawodność; 2013, 15, 4; 325-331
1507-2711
Pojawia się w:
Eksploatacja i Niezawodność
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Multi-objective optimization of dielectric layer photonic crystal filter
Autorzy:
Yang, H.
Huang, C.
Meng, S.
Powiązania:
https://bibliotekanauki.pl/articles/174482.pdf
Data publikacji:
2017
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
filter
photonic crystal
weighting factors method
response surface methodology
RSM
Opis:
The weighting factors method and the response surface methodology are used to achieve multi-objective optimization of a dielectric layer photonic crystal filter. The size of period and the transmission quantity are considered simultaneously and a multi-objective optimization model of filter is established, which takes the size of period and transmission quantity to be minimized in stop-band as objectives. Global approximate expressions of the objective and the constraint functions are found by response surface methodology. Then the weighting factors method is employed to convert the model into a quadratic programming model and the optimal parameters can be obtained using sequence quadratic programming. Examples provide the optimized results in three different weight coefficients. The effect of the weighting factors on the value of the objective function is also discussed. Results show that the present method is precise and efficient for multi-objective optimization of a dielectric layer photonic crystal filter.
Źródło:
Optica Applicata; 2017, 47, 1; 29-40
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nonlinear piezo-thermoelastic shell theory applied to control of variable-geometry shells
Autorzy:
Tzou, H. S.
Yang, R. J.
Powiązania:
https://bibliotekanauki.pl/articles/279711.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Mechaniki Teoretycznej i Stosowanej
Tematy:
geometric nonlinearity
smart structures
structronics
von Karman nonlinearity
Opis:
Complexity of multi-field opto-electromechanical coupling always poses many challenging research issues. Recently due to a rapid development in smart structures and structronic systems, multi-field coupling and control of distributed structronic systems also raises variety of new research, development, and system integration issues. This paper presents a generic nonlinear piezo(electric) -thermoelectromechanical shell theory for a piezoelectric double-curvature shell continuum with admissible boundary cinditions. Applications of the generic theory to other shell and non-shell continua based on four system parameters are also demonstrated. Detailed sensing and control electromechanical characteristics are further investigated in a series of shell of various curvatures. The results show that the membrane sensing/control component dominates the lower natutal modes of deep shells and the bending sensing/control component dominates the natural modes of shallow shell. Electromechanical characteristics and effectiveness of distributed sensors and actuators are evaluated.
Zastosowanie nieliniowej piezo-termosprężystej teorii powłok do sterowania powłok o zmiennej geometrii. W pracy przedstawiono zastosowanie ogólnej nieliniowej piezo-termoelektromechanicznej teorii do piezoelektrycznych powłok o podwójnej krzywiźnie oraz czteroparametrowego kontinuum niepowłokowego. Szczegółowo zbadano elektromechaniczne charakterystyki rozłożonego układu pomiarowego i wykonawczego w ciągu powłok o różnej geometrii. Wyniki wskazują, że membranowe elementy pomiarowe i wykonawcze panują nad dynamiką niskich częstości głębokich powłok, a giętne elementy pomiarowe i wykonawcze nadają się do sterowania powłok małowyniosłych. Zbadano elekromechaniczne charakterystyki i efektywność rozłożonych elementów pomiarowych i wykonawczych.
Źródło:
Journal of Theoretical and Applied Mechanics; 2000, 38, 3; 623-644
1429-2955
Pojawia się w:
Journal of Theoretical and Applied Mechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Quantitative analysis of the relationship between shear strength and fractal dimension of solidified dredger fill with different fly ash content under monotonic shear
Autorzy:
Yang, S.
Liu, W.
Liu, H.
Powiązania:
https://bibliotekanauki.pl/articles/258498.pdf
Data publikacji:
2018
Wydawca:
Politechnika Gdańska. Wydział Inżynierii Mechanicznej i Okrętownictwa
Tematy:
curing agent
fly ash
shear strength
fractal dimension
SEM
Opis:
The dredger fill of Shanghai Hengsha Island Dongtan is solidified by curing agents with different fly ash content, and the shear strength index of solidified dredger fill is measured by the direct shear test. The microscopic images of solidified dredger fill are obtained by using SEM. The microscopic images are processed and analyzed by using IPP, and the fractal dimension including particle size fractal dimension Dps, aperture fractal dimension Dbs and particle surface fractal dimension Dpr is calculated by fractal theory. The quantitative analysis of the relationship between shear strength index and fractal dimension of solidified dredger fill is done. The research results show that the internal friction angle and the cohesion are closely related to the fly ash content λ and the curing period T, and the addition of fly ash can improve the effect of curing agent; There is no obvious linear relationship between the internal friction angle and the three fractal dimensions; The smaller particle surface fractal dimension Dpr and particle size fractal dimension Dps, the larger aperture fractal dimension Dbs, the greater the cohesion, and the cohesion has a good linear relationship with three fractal dimensions, and the correlation coefficient R2 is above 0.91.
Źródło:
Polish Maritime Research; 2018, S 2; 132-138
1233-2585
Pojawia się w:
Polish Maritime Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fabrication of Mo-Si-B Intermetallic Compound Powders Under Different Heat Treatment Conditions
Autorzy:
Park, J. H.
Lee, S.
Kim, D.
Kim, Y.
Yang, S. H.
Lee, S. H.
Powiązania:
https://bibliotekanauki.pl/articles/353369.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Mo-Si-B alloys
intermetallic compounds
reitveld refinement
T2 phase
A15 phase
Opis:
In this research, we investigated the effects of reduction atmospheres on the creation of the Mo-Si-B intermetallic compounds (IMC) during the heat treatments. For outstanding anti-oxidation and elevated mechanical strength at the ultrahigh temperature, we fabricated the uniformly dispersed IMC powders such as Mo5SiB2 (T2) and Mo3Si (A15) phases using the two steps of chemical reactions. Especially, in the second procedure, we studied the influence of the atmospheres (e.g. vacuum, argon, and hydrogen) on the synthesis of IMCs during the reduction. Furthermore, the newly produced IMCs were observed by SEM, XRD, and EDS to identify the phase of the compounds. We also calculated an amount of IMCs in the reduced powders depending on the atmosphere using the Reitveld refinement method. Consequently, it is found that hydrogen atmosphere was suitable for fabrication of IMC without other IMC phases.
Źródło:
Archives of Metallurgy and Materials; 2018, 63, 3; 1509-1512
1733-3490
Pojawia się w:
Archives of Metallurgy and Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Preparation and Microstructure of Semi-Solid 7075 Alloy Slurry
Autorzy:
Gan, G.
Yang, B.
Bei, S.
Mei, H.
Powiązania:
https://bibliotekanauki.pl/articles/1418959.pdf
Data publikacji:
2012-09
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
81.05.Bx
82.40.-g
98.20.Gm
Opis:
A novel technique, with which in situ $TiB_2$ particles and serpentine channels are introduced to prepare wrought aluminum alloy with higher strength, has been successfully applied to produce semi-solid 7075 alloy slurry. The effects of in situ $TiB_2$ particles and serpentine channels on the microstructure of the 7075 alloy including the grain growth behavior in the semi-solid state of the 7075 alloy were investigated. The experimental results showed that the in situ $TiB_2$ particles and serpentine channels are beneficial to increase the number of solidification nuclei and to promote uniform distribution of α-Al nuclei. As a result, the semi-solid 7075 alloy slurry with globular-like grains has been successfully produced.
Źródło:
Acta Physica Polonica A; 2012, 122, 3; 565-568
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The optimization of the dielectric layer photonic crystal filter by the quadratic response surface methodology
Autorzy:
Yang, H.
Meng, S
Wang, G.
Huang, C.
Powiązania:
https://bibliotekanauki.pl/articles/174592.pdf
Data publikacji:
2015
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
optimization
photonic crystal filter
response surface methodology
Opis:
Dielectric layer photonic crystal filter structures in waveguide are optimized by the quadratic response surface methodology. The optimization model of the filter is established on the basis of the analysis which is conducted with the aid of the response surface methodology. The model is solved using sequential quadratic programming and the optimal parameters are obtained. Examples demonstrate it is effective.
Źródło:
Optica Applicata; 2015, 45, 3; 369-379
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Manipulation of the supercontinuum energy distribution based on the positive chirp in photonic crystal fiber
Autorzy:
Yang, H.
Tong, X.
Zhao, S.
Huang, Y.
Powiązania:
https://bibliotekanauki.pl/articles/174604.pdf
Data publikacji:
2018
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
chirp
dispersive waves
solitons
Opis:
The effect of initial frequency chirp is numerically investigated to obtain high-efficient supercontinuum radiation in photonic crystal fibers with two closely spaced zero-dispersion wavelengths. Our results show that the positive chirp can significantly improve the probability of energy transferred from the soliton to the dispersive wave. And with the increase of the chirp, the energy increases obviously. At the same time, the intensity of the dispersive wave is proportional to the chirp value. Especially, solitons will not appear when the chirp value exceeds 3.9. Therefore, choosing an appropriate positive chirp, we can regulate the energy of the dispersive wave and solitons in photonic crystal fibers.
Źródło:
Optica Applicata; 2018, 48, 1; 75-85
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of the influence of the transducer and its coupling layer on round window stimulation
Autorzy:
Liu, H.
Xu, D.
Yang, J.
Yang, S.
Cheng, G.
Huang, X.
Powiązania:
https://bibliotekanauki.pl/articles/306655.pdf
Data publikacji:
2017
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
słuch
stymulacja
przetwornik
RW
FEM
implantable middle ear hearing device
round window stimulation
transducer
coupling layer
finite element analysis
Opis:
Purpose: In this work, a finite element study is proposed to evaluate the effects of the transducer and its coupling layer on the performance of round window (RW) stimulation. Methods: Based on a set of micro-computer tomography images of a healthy adult’s right ear and reverse engineering technique, a coupled finite-element model of the human ear and the transducer was constructed and verified. Then, the effect of the cross-section of the transducer, the elastic modulus of the coupling layer, the mass of the transducer, and the preload of the transducer were studied. Results: The increase of the transducer’s cross-section area deteriorates the RW stimulation, especially at the lower frequencies. This adverse effect of the cross-section area’s increase of the transducer can be reduced by adding a coupling layer between the transducer and the RW. However, the coupling layer’s improvement on the RW stimulation is reduced with the increase of its elastic modulus. Moreover, the mass loading of the transducer decreases the RW stimulation’s performance mainly at higher frequencies and applying a static preload on the transducer enhances its hearing compensating performance at higher frequencies. Conclusions: The influence of the transducer’s mass, the mass of the transducer, the applied static preload and the properties of the coupling layer must be taken into account in the design of the RW stimulation type implantable middle ear hearing device.
Źródło:
Acta of Bioengineering and Biomechanics; 2017, 19, 2; 103-111
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
An integrated treatment technology for ground fissures of shallow coal seam mining in the mountainous area of southwestern China: a typical case study
Zintegrowana technologia zapobiegania pęknięciom gruntu w procesie wydobywania płytkich pokładów węgla w górzystym obszarze południowo-zachodnich Chin: typowe studium przypadku
Autorzy:
Zhu, H.
He, F.
Zhang, S.
Yang, Z.
Powiązania:
https://bibliotekanauki.pl/articles/215969.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Instytut Gospodarki Surowcami Mineralnymi i Energią PAN
Tematy:
wydobywanie węgla
płytki pokład węgla
pęknięcia gruntu
zapadlisko górnicze
zintegrowana technologia zapobiegania
ochrona środowiska
shallow coal seam mining
ground fissures
surface sinkhole
integrated treatment technology
environmental protection
Opis:
This article is the result of treatments on ground fissures for environmental protection and scientific shallow coal seam mining. In the southwestern mining area of China, the traditional longwall mining method has caused a large area of surface sinkhole, ground fissures, vegetation deterioration and disorderly coal gangue. To solve these problems, an integrated treatment technology that includes ground fissure treatment technology and underground backfilled technology was proposed as a solution. The technical principle and technical process were explained in detail; the ground fissure treatment technology involves a “three-step treatment method”, and the underground backfilled technology adopted a strip mining method with backfilling technology. The compression mechanical behavior of backfilled material, including coal gangue, fly ash and ordinary Portland cement, was studied; the mixed ratio of 1:0.3:0.18 was selected. In addition, the vertical stress, vertical displacement and plastic zone of the coal pillar were determined by FLAC3D numerical simulation, and a rational mining scheme of “11 m mining width, 2 m coal pillar width” was determined to be appropriate because of the lower vertical stress, smaller vertical displacement and better supporting capacity of the coal pillar. The monitoring results of ground sinkhole indicated that the maximal ground sinkhole deformation was 17.3 cm, and the deformation showed few changes after this technology was implemented. The treatment capacity of coal gangue and fly ash reached 821.150 t per year, and the vegetation survival rate of the ground fissure treatment area reached 85%. This integrated treatment technology could effectively control ground fissures and surface sinkhole as well as protect the environment.
Artykuł jest opisem zapobiegania pęknięciom gruntu w celu ochrony środowiska, jak również naukowego podejścia do wydobywania płytko zalegających pokładów węgla. W południowo-zachodniej części górniczej Chin tradycyjna, ścianowa metoda wydobywania węgla, powodowała duży obszar powierzchniowego zapadliska, pęknięcia gruntu, pogorszenie stanu wegetacji roślin. W celu rozwiązania tych problemów zaproponowano zintegrowaną technologię zapobiegania, która obejmuje technologię zapobiegania pęknięciom gruntu i podziemną technologię podsadzki. Zasada i proces techniczny zostały szczegółowo opisane; technologia zapobiegania pęknięciom gruntu obejmuje „trójstopniową metodę zabiegu”, a technologia podsadzki zaadoptowała metodę wydobywania węgla pasami. Badano ściśliwość podsadzki, w tym odpadów węglowych, popiołu lotnego i zwykłego cementu portlandzkiego; wybrano mieszaninę o stosunku 1: 0,3: 0,18. Ponadto pionowe naprężenie, pionowe przemieszczenie i strefa plastyczności filaru węglowego zostały określone za pomocą symulacji numerycznej FLAC 3D. Racjonalny schemat wydobycia „szerokość wydobycia 11 m, szerokość filaru węglowego 2 m” był odpowiedni ze względu na niższą wartość naprężenia pionowego, mniejsze pionowe przemieszczenie i lepszą nośność filaru węglowego. Wyniki monitoringu pęknięć gruntu wskazują, że maksymalna deformacja gruntu wynosiła 17,3 cm i wykazała kilka zmian po wdrożeniu tej technologii. Ilość zagospodarowanych odpadów węglowych i popiołu lotnego wynosiła 821 150 Mg na rok, a wskaźnik przeżycia roślinności w obszarze zapobiegania pęknięciom gruntu osiągnął poziom 85%. Ta zintegrowana technologia zapobiegania może skutecznie kontrolować pęknięcia gruntu i deformację powierzchni, a także chronić środowisko.
Źródło:
Gospodarka Surowcami Mineralnymi; 2018, 34, 1; 119-138
0860-0953
Pojawia się w:
Gospodarka Surowcami Mineralnymi
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Genetic algorithm combined with a local search method for identifying susceptibility genes
Autorzy:
Yang, C -H.
Moi, S. -H.
Lin, Y. -D.
Chuang, L. -Y.
Powiązania:
https://bibliotekanauki.pl/articles/91586.pdf
Data publikacji:
2016
Wydawca:
Społeczna Akademia Nauk w Łodzi. Polskie Towarzystwo Sieci Neuronowych
Tematy:
genetic algorithms
identifying susceptibility genes
local search algorithm
Opis:
Detecting genetic association models between single nucleotide polymorphisms (SNPs) in various disease-related genes can help to understand susceptibility to disease. Statistical tools have been widely used to detect significant genetic association models, according to their related statistical values, including odds ratio (OR), chi-square test (χ2), p-value, etc. However, the high number of computations entailed in such operations may limit the capacity of such statistical tools to detect high-order genetic associations. In this study, we propose lsGA algorithm, a genetic algorithm based on local search method, to detect significant genetic association models amongst large numbers of SNP combinations. We used two disease models to simulate the large data sets considering the minor allele frequency (MAF), number of SNPs, and number of samples. The three-order epistasis models were evaluated by chi-square test (χ2) to evaluate the significance (P-value < 0.05). Analysis results showed that lsGA provided higher chi-square test values than that of GA. Simple linear regression indicated that lsGA provides a significant advantage over GA, providing the highest β values and significant p-value.
Źródło:
Journal of Artificial Intelligence and Soft Computing Research; 2016, 6, 3; 203-212
2083-2567
2449-6499
Pojawia się w:
Journal of Artificial Intelligence and Soft Computing Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 42

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