- Tytuł:
- Synthesis, characterization and antifungal activity of some fluorine containing 1,3,5-trisubstituted pyrazoline derivatives
- Autorzy:
-
Manivannan, C.
Santhi, N. - Powiązania:
- https://bibliotekanauki.pl/articles/1118150.pdf
- Data publikacji:
- 2017
- Wydawca:
- Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
- Tematy:
-
antifungal activity
chalcone
disc diffusion method
pyrazoline
ultrasonic irradiation - Opis:
- A series of (E)-1-(4-fluorophenyl)-3-substitutedphenylprop-2-en-1-one (3-7) were ultrasonically prepared by the reaction of 4-fluoroacetophenone with different aromatic aldehydes in the presence of alkali . Reaction of the prepared chalcones (3-7) with 3,4,5-trimethoxybenzohydrazide (8) afforded the corresponding substituted pyrazoline (9-13). Ultrasonic irradiation method provides several advantages over current reaction methodologies, including a simple work-up procedure, shorter reaction times and good yields. All the prepared compounds have been characterized by FT-IR and 1H-NMR spectra. These compounds were screened for their antifungal activity using disc diffusion method. Compound 10 and 11 was found to exhibit the most potent in-vitro anti-fungal activity with against all the fungal strains.
- Źródło:
-
World News of Natural Sciences; 2017, 10; 86-94
2543-5426 - Pojawia się w:
- World News of Natural Sciences
- Dostawca treści:
- Biblioteka Nauki
Artykuł