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    Wyświetlanie 1-6 z 6
    Tytuł:
    Application of chitosan in the formulation of hydrogels applied on skin
    Autorzy:
    Meler, Jan
    Powiązania:
    https://bibliotekanauki.pl/articles/1035198.pdf
    Data publikacji:
    2013
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    hydrocortisone
    hydrogels
    pharmaceutical availability
    Opis:
    These studies concerned the effect of composition on the substrate physicochemical parameters of hydrogels for use on skin. Hydrogels containing 1% of hydrocortisone and 1% of chitosan addition was made on the basis of methylcellulose, sodium carboxymethylcellulose and Carbopol 934 P. The release proceeds according to first-order kinetics. Depending on the type and composition of the polymer gels were obtained with various pharmaceutical availability of hydrocortisone. Addition of 1% chitosan affects the acceleration of the release in any given case.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 181-186
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Application of chitosan in the formulation of methyl cellulose-based hydrogels
    Autorzy:
    Szcześniak, Maria
    Grimling, Bożena
    Meler, Jan
    Pluta, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1035190.pdf
    Data publikacji:
    2014
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    methylcellulose
    pharmaceutical availability
    rheological parameters
    Opis:
    The aim of this work was to study the properties of methylcellulose hydrogels with supplements containing chitosan and 1% hydrocortisone. Depending on the composition of the substrate, gels are characterised by a variety of pharmaceutical availabilities. Increasing the concentration of chitosan has an influence on increasing the viscosity, hardness, and cohesiveness of the tested gels.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 139-144
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of chitosan on the rheological properties of hydrogels based on sodium carboxymethylcellulose
    Autorzy:
    Szcześniak, Maria
    Grimling, Bożena
    Pluta, Janusz
    Meler, Jan
    Powiązania:
    https://bibliotekanauki.pl/articles/1034876.pdf
    Data publikacji:
    2015
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    pharmaceutical availability
    rheological parameters
    sodium carboxymethylcellulose
    Opis:
    The aim of the study was to evaluate the effect of changing the concentrations of chitosan on the rheological properties of the obtained formulation. Hydrogels were prepared with 1% hydrocortisone containing 4% sodium carboxymethylcellulose with the addition of chitosan, propylene glycol-1,2 or polyethylene glycol 400 and glycerol or paraffin. The concentration of chitosan and excipients affects the rheological properties of gels and the pharmaceutical availability of hydrocortisone. Increasing the concentration of chitosan have influence on increasing the viscosity, hardness, and cohesiveness of the tested gels.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 254-259
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of selected polymers on the rheological properties of hydrogels with chitosan applied on the skin
    Autorzy:
    Szcześniak, Maria
    Grimling, Bożena
    Meler, Jan
    Karolewicz, Bożena
    Powiązania:
    https://bibliotekanauki.pl/articles/1034591.pdf
    Data publikacji:
    2017
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    hydrogels
    pharmaceutical availability
    rheological parameters
    Opis:
    The aim of the study was to evaluate the effect of methylcellulose and carboxymethylcellulose on the rheological properties of hydrogels applied to skin on chitosan in the presence of the additives propylene glycol and glycerol. Rheological studies showed that the tested gels are non-newtonian systems, and have thixotropic properties. Substrates made of methylcellulose and chitosan are characterised by higher shear values than those obtained with carboxymethylcellulose. The addition of polymers had a positive influence on the dispersion of hydrogels, and the addition of excipients increased firmness, consistency and cohesiveness of the gels. Larger increases were observed with the addition of 10% of glycol propylene and glycerol contents for methylcellulose and of 20% of carboxymethylcellulose.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 201-206
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of substrate composition on the physicochemical properties of hydrogels with chitosan
    Autorzy:
    Szcześniak, Maria
    Grimling, Bożena
    Meler, Jan
    Pluta, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1034687.pdf
    Data publikacji:
    2016
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    Carbopl 934P
    PVP
    chitosane
    hydrogels
    pharmaceutical availability
    rheological parameters
    Opis:
    The aim of the study was to evaluate the effect of Carbopol 934 P and PVP K 90 on the rheological properties of chitosan gels. Hydrogels were prepared with hydrocortisone containing chitosan, Carbopl 934P, PVP, propylene glycol-1,2 or polyethyleneglycol 400 and glycerol. Addition of polymers had positive influence on the dispersion of hydrogels. The studied gels have thixotropic properties, their viscosity increases with the increase of the concentration of polymers. Increase of the content of polyvinylpyrrolidone K 90 and Carbopol 934 P increases the consistence, gels are more firm and cohesive. Gels with 5 % chitosane, 15% polyvinylpyrrolidone K 90 and Carbopol 934 P in the presence of additives have prolonged half release period of hydrocortisone.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 187-191
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of a dental formulation prepared with chitosan on the pharmaceutical availability of clotrimazole
    Autorzy:
    Grimling, Bożena
    Meler, Jan
    Szcześniak, Maria
    Kocoń, Martyna
    Karolewicz, Bożena
    Złocińska, Adrianna
    Górniak, Agata
    Powiązania:
    https://bibliotekanauki.pl/articles/1034568.pdf
    Data publikacji:
    2017
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    FTIR
    carrier XRPD
    chitosan
    clotrimazole
    hydrogel
    solid dispersion
    Opis:
    The present work involves the development of a dental gel composition obtained on the basis of clotrimazole incorporated into chitosan in order to improve drug solubility. Solid dispersions were prepared by using two methods: grinding and kneading. The solid dispersion varied the ratio of chitosan to drug to increase the volume of the drug; the ratios were 5:5, 3:7, 2:8, 1:9. The mixtures were subjected to the dissolution rate of clotrimazole. The presence of chitosan improved the drug solubility; a better solubility from the solid dispersion prepared by the grinding method was obtained from the ratio of drug to polymer of 1+9. The rate of dissolution of clotrimazole was improved 17 times compared to the pure drug. Fourier transform infrared spectroscopy (both infrared and X-ray diffraction) revealed no new chemical structure of the tested connections and concluded that there was no interaction between the drug and the polymer in the test diffractions. Solid dispersions with the best parameters were used to prepare hydrogels, and the pharmaceutical availability of clotrimazole was analysed. The best properties were characterized by a hydrogel that was composed of the ratio of the amount of drug to polymer 5:5. The study demonstrated the availability of a pharmaceutical drug release at a therapeutic concentration in the first hour of the study. The use of the appropriate balance between clotrimazole and chitosan and the development of the hydrogel composition may affect the improvement of the drug solubility and may create the possibility of obtaining sustained or controlled release of the drug substance.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 42-53
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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