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    Wyświetlanie 1-6 z 6
    Tytuł:
    Role of iron in pathogenesis of Parkinson disease
    Autorzy:
    Galazka-Friedman, J.
    Friedman, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/80638.pdf
    Data publikacji:
    2011
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    cell membrane
    electron microscopy
    ELISA test
    ferritin
    free radical
    human brain
    iron
    lipid peroxidation
    liver
    neurodegeneration
    oxidative stress
    Parkinson's disease
    pathogenesis
    substantia nigra
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2011, 92, 2
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    T1 and T2 Relaxation Times from Substantia Nigra in Parkinsons Disease and Control
    Autorzy:
    Kuliński, R.
    Szlachta, K.
    Gałązka-Friedman, J.
    Friedman, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/1360221.pdf
    Data publikacji:
    2014-04
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.19.L-
    Opis:
    The diagnosis of Parkinson's disease, and also other neurodegenerative disorders, is based on clinical examination. Many attempts are undertaken to find a test that could confirm this clinical diagnosis. Many hopes were attributed to magnetic resonance imaging but its importance remains obscure. The aim of this study was to compare T1 and T2 relaxation times from substantia nigra of patients with clinical diagnosis of Parkinson's disease and age-matched controls. A decrease of T2 (54.5 ± 1.4 ms vs. 58.0 ± 1.5 ms) in Parkinson's disease vs. control was found with confidence level of 5%. T1 did not differ significantly between Parkinson's disease and control (624 ± 17 ms vs. 614 ± 21 ms).
    Źródło:
    Acta Physica Polonica A; 2014, 125, 4; 869-871
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Different Signals of Magnetic Resonance Imaging and Ultrasound from Substantia Nigra in Parkinsons Disease and Control - Is Iron the Cause?
    Autorzy:
    Szlachta, K.
    Sadowski, K.
    Kuliński, R.
    Gałązka-Friedman, J.
    Friedman, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/1490100.pdf
    Data publikacji:
    2012-02
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.19.L-
    Opis:
    Motor symptoms of Parkinson's disease are caused by a progressive degeneration of substantia nigra, a small structure located deep in the brain. The cause of this process is unknown but may be related to iron mediated oxidative stress. The aim of this study was to understand the mechanism of the change of magnetic resonance and ultrasound signals found in patients with Parkinson's disease, which were attributed by several authors to an important increase of the concentration of iron in substantia nigra. USG and MRI measurements were performed on phantoms simulating human brain to which high amounts of iron were introduced. The USG signal was unaffected by insertion of iron-loaded ferritin, while it was by insertion of glial tissue. Injections of iron-loaded ferritin and iron ions to the phantoms decreased $T_2$ relaxation time. Our results suggest that the observed change of the signal from Parkinsonian brains is probably due to a proliferation of glia and not to an increase of the concentration of iron.
    Źródło:
    Acta Physica Polonica A; 2012, 121, 2; 454-456
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    An example of the application of Mössbauer spectroscopy for determination of concentration of iron in lyophilized brain tissue
    Autorzy:
    Rzepecka, P.
    Duda, P.
    Giebułtowicz, J.
    Sochacka, M.
    Friedman, A.
    Gałązka-Friedman, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/147214.pdf
    Data publikacji:
    2017
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    Mössbauer spectroscopy
    background spectrum
    iron concentration
    brain tissue
    calibration curve
    Opis:
    Mössbauer spectroscopy is not routinely used for the determination of the concentration of iron. However, as this method does not need any pre-treatment of samples before measurements, it may be of extreme importance for the assessment of iron in samples, which can then be used for further investigations. Biological samples are a good example, however, as the concentrations of iron are very low in these, it is important to exclude possible artefacts from the background spectrum related to iron present in the counter and cryostat windows. The aim of this study was to compare two methods of determination of the amounts of iron in investigated sample: one, in which the background spectrum was subtracted from the sample spectrum measured, and the other, in which the obtained non-elaborated spectrum was fitted with two doublets – a doublet for the measured sample and a doublet for the background spectrum. Three samples containing known amounts of natural iron (400, 800 and 1600 µg) and a sample of lyophilized human brain tissue obtained from globus pallidus were assessed. Both methods led to the creation of a very good calibration curve with a correlation coefficient of 0.99. Although both methods gave similar results for the concentration of iron in the sample, the subtraction of the background spectrum had a significantly lower error of the final result.
    Źródło:
    Nukleonika; 2017, 62, 2; 159-163
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mössbauer Studies of Pathological Brain Tissues Affected by PSP Disease
    Autorzy:
    Gałązka-Friedman, J.
    Bauminger, E.
    Szlachta, K.
    Schweitzer, K.
    Wszolek, Z.
    Dickson, D.
    Friedman, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/1809541.pdf
    Data publikacji:
    2009-02
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.64.kx
    Opis:
    Progressive supranuclear palsy (PSP) is a neurological disease leading to the damage of two brain structures: globus pallidus and substantia nigra. The pathomechanism of this disease is still unknown. One of the hypotheses is oxidative stress. Oxidative stress is an overproduction of free radicals in which iron may be involved. To verify the hypothesis that iron may play a role in PSP we performed the Mössbauer comparative studies of pathological and control tissues. Ten samples of PSP globus pallidus, ten samples of PSP substantia nigra, twelve control samples of globus pallidus and nine control samples of substantia nigra were measured in a conventional Mössbauer spectrometer at 90 K. The Mössbauer spectra obtained for all samples showed well resolved doublets with an isomer shift of 0.46±0.01 mm/s and a quadruple splitting of 0.70±0.02 mm/s. The main difference in these preliminary studies was in the concentration of iron. The concentration in PSP samples in globus pallidus was found to be 257±19 ng/mg tissue, compared to 183±22 ng/mg in control samples and 301±26 ng/mg in substantia nigra compared to 188±22 ng/mg in control samples. Taking into consideration that we did not notice any substantial increase in iron concentration in Parkinsonian substantia nigra compared to control substantia nigra, but a substantial increase in both substantia nigra and globus pallidus in PSP, may suggest that iron plays a different role in the pathomechanisms of PSP and of Parkinson's disease.
    Źródło:
    Acta Physica Polonica A; 2009, 115, 2; 545-547
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Iron in Alzheimers and Control Hippocampi - Mössbauer, Atomic Absorption and ELISA Studies
    Autorzy:
    Gałązka-Friedman, J.
    Bauminger, E.
    Szlachta, K.
    Koziorowski, D.
    Tomasiuk, R.
    Jaklewicz, A.
    Wszołek, Z.
    Dickson, D.
    Kaplińska, K.
    Friedman, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/1506657.pdf
    Data publikacji:
    2011-01
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.64.kx
    Opis:
    Alzheimer disease is a neurodegenerative process of unknown mechanism taking place in a part of the brain - hippocampus. Oxidative stress and the role of iron in it is one of the suggested mechanisms of cells death. In this study several methods were used to assess iron and iron binding compounds in human hippocampus tissues. Mössbauer spectroscopy was used for identification of the iron binding compound and determination of total iron concentration in 12 control and one Alzheimer disease sample of hippocampus. Mössbauer parameters obtained for all samples suggest that most of the iron is ferritin-like iron. The average concentration of iron determined by Mössbauer spectroscopy in control hippocampus was 45±10 ng/mg wet tissue. The average concentration of iron in 10 Alzheimer disease samples determined by atomic absorption was 66±13 ng/mg wet tissue. The concentration of H and L chains of ferritin in 20 control and 10 AD hippocampi was assessed with enzyme-linked immuno-absorbent assay. The concentration of H and L ferritin was higher in Alzheimer disease compared to control (19.36±1.51 vs. 5.84±0.55 ng/μg protein for H, and 1.39±0.25 vs. 0.55±0.10 for L). This 3-fold increase of the concentration of ferritin is accompanied by a small increase of the total iron concentration.
    Źródło:
    Acta Physica Polonica A; 2011, 119, 1; 81-83
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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