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Wyświetlanie 1-15 z 18
Tytuł:
Selected applications of fluorinated MR contrast agents and fluorine-containing drugs in medicine
Autorzy:
Bartusik-Aebisher, Dorota
Bober, Zuzanna
Aebisher, David
Powiązania:
https://bibliotekanauki.pl/articles/895525.pdf
Data publikacji:
2020-06-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
drug delivery
drug design
19F MRI
19F MRS
drug efficacy
Opis:
This review aims to present magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) for applications in cellular therapeutics including descriptions of the use of 19F MRI and 19F MRS in drug tracking and visualization. Both MRI and MRS are often used as diagnostic tools in oncology, are non-invasive, and also can be employed for monitoring non-oncological and oncological therapies. Herin, we provide information pertaining to tracking and visualization of fluorinated drug uptake in cancer tissue in vitro, in vivo and ex vivo. The response of tissue to treatment is also discussed.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 3; 403-410
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Plant medicinal products and drug interactions
Autorzy:
Ożóg, Łukasz
Aebisher, David
Bober, Zuzanna
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454688.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
drug interactions
natural products
drug
therapeutic material
Opis:
Introduction. Some herbal medicinal products may be beneficial in certain respects but many can be dangerous for patients taking doctor-prescribed medications. Plant medicinal products are often taken with conventional drugs by patients. Interactions are possible between herbal medicinal products and conventional medications that can lead to toxicity due to increaseddrug plasma levels or drug treatment failure. Aim. The aim of the study was to review the study of plant medicinal products and drug interactions. Materials and method. Analysis of literature.
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 1; 37-40
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Contrast-enhanced Magnetic Resonance Imaging of lung cell cultures
Autorzy:
Bober, Zuzanna
Pogoda, Katarzyna
Aebisher, David
Tabarkiewcz, Jacek
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/895529.pdf
Data publikacji:
2020-04-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
Lung cancer
cell cultures
magnetic resonance imaging
contrast media
Gadolinium
Opis:
Lung cancer is one of the most common types of cancer diagnosed, and the development of methods to image diseased lung tissue by MRI is of utmost importance. Contrast-Enhanced Magnetic Resonance Imaging (CE-MRI) was used to noninvasively evaluate spin-spin relaxation time, T1, of lung cell cultures infused with various clinical gadolinium-based contrast media for imaging. In this study we used a clinical 1.5 Tesla scanner and the contrast agents: Omniscan, MultiHance, Gadovist and ProHance. A significant five-fold reduction of T1 relaxation time was obtained.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 251-258
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fundamentals of the use of Berberis as a medicinal plant
Autorzy:
Bober, Zuzanna
Stępień, Agnieszka
Aebisher, David
Ożóg, Łukasz
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454712.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
medicinal plants
phythotherapy
Berberis
Opis:
Introduction. The daily use of medicinal plants has increased in recent years. The study of drugs of natural origin as an academic discipline and its applications in healthcare has changed remarkably but still focus on the quality of products and the development of new medicines. Aim. This study covers all fundamental aspects of pharmacognosy as well as topics relating to the therapeutic use of plant drugs known as phythotherapy. The purpose of the study was to review the literature about the use of Berberis. Materials and method. We reviewed the literature regarding the use of Berberis published between 1933 and 2018. We found more than 500 articles studying the properties of Berberis for digestive disorders, antibacterial, antidiabetic, hypotensive effects, anti-inflammatory effects, cholesterol regulation, cardiovascular disease, hyperlipidemia, cerebral ischemia trauma, mental disease, Alzheimer disease and osteoporosis. Our review includes recent studies regarding chemical composition and medicinal outcomes of Berberis
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 1; 41-46
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The potential of phythotherapy in otorhinolaryngology
Autorzy:
Domka, Wojciech
Aebisher, David
Bober, Zuzanna
Ożóg, Łukasz
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454662.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
phytotherapy
medicinal plants
otorhinolaryngology
Opis:
Introduction. The objective of this paper is to review the evidence of the use of herbs in phytotherapy. Aim. To discuss plant properties and applications in otorhinolaryngology. Materials and methods. We analysed literature and collected information of phythotherapy in otorhinolaryngology. Results. The databases were searched using various keywords such as phytotherapy, otorhinolaryngology, and herbs such as: echinacea, eucalyptus, garlic, ginkgo, ginseng, kava, pelargonium sidoides, rosemary, spirulina, St John’s wort, and thyme. Conclusions. Due to the beneficial impact of meicinal plants in medicine there is a growing interest in analytical identification and quantification for clinical medicine and forensic toxicology.
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 4; 359-365
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The usefulness of relaxation time using MRI measurements
Autorzy:
Bober, Zuzanna
Aebisher, David
Truszkiewicz, Adrian
Ożóg, Łukasz
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454698.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
Magnetic Resonance Imaging
T1 relaxation
field strength 1.5 Tesla
Opis:
Introduction. Magnetic Resonance Imaging methods are now frequently used for the analysis of the diseased tissue. These methods are based on the fact that the spin-lattice, T1 , and the spin-spin, T2 , relaxation times are different in diseased tissue as compared to that of normal tissue. Aim. Here we present measurements of spin-lattice relaxation time T1 on a Magnetic Resonance Imaging scaner with field strength 1.5 Tesla. Material and methods. Measurements of T1 relaxation time and analysis of literature. Results. We provide procedure for measurements of T1 relaxation time with field strength 1.5 Tesla and present a discussion of current applications.
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 3; 224-227
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Medicinal benefits from the use of Black pepper, Curcuma and Ginger
Autorzy:
Bober, Zuzanna
Stępień, Agnieszka
Aebisher, David
Ożog, Łukasz
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454723.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
medicinal plants
phythotherapy
Black pepper
Curcuma
Ginger
Opis:
Introduction. Black pepper, Curcuma and Ginger are three of the most popular and most frequently used spices. Due to their beneficial medical and pharmacological properties, they are increasingly appreciated phytotheraputic plants. Most of their actions are attributed to their biochemical compositions. Aim. Our intention is to equip the reader with the information and knowledge necessary to understand the role of natural products in the drug discovery process and to enable the assessment of potential benefits and harms of plant-based medicines when advising patients who wish to use them. Material and methods. Analysis of literature. Results. In this paper, we reviewed the use of Black pepper, Curcuma and Ginger documented in the treatment of colds and flu,
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 2; 133-145
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Radio Frequency MRI coils
Autorzy:
Truszkiewicz, Adrian
Aebisher, David
Bober, Zuzanna
Ożóg, Łukasz
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454860.pdf
Data publikacji:
2020-03-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
field strength 1.5 Tesla
magnetic resonance imaging
radio frequency coil
Opis:
Introduction. Magnetic Resonance Imaging (MRI) coils technology is a powerful improvement for clinical diagnostics. This includes opportunities for mathematical and physical research into coil design. Aim. Here we present the method applied to MRI coil array designs. Material and methods. Analysis of literature and self-research. Results. The coils that emit the radiofrequency pulses are designed similarly. As much as possible, they deliver the same strength of radiofrequency to all voxels within their imaging volume. Surface coils on the other hand are usually not embedded in cylindrical surfaces relatively close to the surface of the body. Conclusion. The presented here results relates to the art of magnetic resonance imaging (MRI) and RF coils design. It finds particular application of RF coils in conjunction with bore type MRI scanners.
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 1; 24-27
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Plants – a source of therapeutic material?
Autorzy:
Bober, Zuzanna
Stępień, Agnieszka
Aebisher, David
Ożóg, Łukasz
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454997.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
plants
natural products
drug
therapeutic material
Opis:
Introduction. The use of plants with therapeutic or medicinal properties is as ancient as human civilization and for many years prior to the 20th century, plants and animal products were the main source of therapeutic medicinal drugs. Aim. The discovery of new plant-derived drugs continues to be an active field of research in medical science today. The aim of this article is to describe several main classes of natural products currently under investigation. Material and methods. Analysis of literature.
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 1; 34-36
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Investigation of pharmaceuticals by nuclear magnetic resonance imaging and spectroscopy
Autorzy:
Bober, Zuzanna
Aebisher, David
Tabarkiewicz, Jacek
Guz, Wiesław
Tutka, Piotr
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454783.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
drug delivery systems
drug forms
magnetic resonance imaging pharmaceuticals
Opis:
Currently, new and easier ways of analyzing pharmaceutical drug forms and drug delivery mechanisms are being sought. Magnetic resonance imaging (MRI) is a non-invasive imaging technique that images drug forms such as tablets, liquids and topicals and drug form behavior in living organisms on both the tissue and cellular scale. The advantages of MRI include noninvasiveness, variable sample capacity and ease of transfer of phantom results to in vitro and in vivo studies. This review concerns the usefulness of clinical MRI that cannot be understated as this technique provides non-invasive and non-destructive insight into the properties of drug delivery systems. The research discussed here concerns the use of magnetic resonance, spectroscopy and chromatography to investigate selected pharmaceuticals and covers work of selecting drugs and antibodies for modification by synthesis for evaluation by MRI. Modifications have been aimed at improving therapeutic efficacy, delivery, and MRI. Modification conditions such as (pH, concentration, temperature, and the influence of other components present in the solutions) will be discussed to understand drug delivery system improvements and the reliability and repeatability of the results obtained. We hope to explore and expand the scope of pharmaceutical imaging with MRI for application in clinical medicine.
Źródło:
European Journal of Clinical and Experimental Medicine; 2017, 2; 110-119
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
19F MRI As a tool for imaging drug delivery to tissue and individual cells
Autorzy:
Bober, Zuzanna
Aebisher, David
Ożóg, Łukasz
Tabarkiewicz, Jacek
Tutka, Piotr
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454941.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
drug delivery
drug tracking
fluorine
magnetic resonance imaging
Opis:
Over the past few decades, magnetic resonance imaging (MRI) has proven to be extremely successful in medical applications. More recently, the biomedical applications of MRI have been gaining more use in the field of clinical pharmacy. In 1977, perfluorocarbon compounds (PFC), which form emulsions that can carry drugs, were analyzed by 19F MRI and emulsified PFC compounds have been investigated as potential blood substitutes since the early 1960s and now a wide variety of PFC compounds are currently available as 19F MRI biomarkers. Molecules with 19F substituents are particularly attractive for use in drug tracking by 19F MRI due to 100% 19F abundance, high 19F MRI sensitivity (0.83 relative to 1H MRI) and an impressively large chemical shift range (400 ppm). Another benefit in the use of 19F MRI is a zero background signal in biological samples due to lack of endogenous fluorine. Therefore, drugs containing fluorine atom have potential for 19F MRI imaging drug delivery to tissue. This article will review recent developments in the use of 19F MRI in imaging drug delivery to tissue and individual cells.
Źródło:
European Journal of Clinical and Experimental Medicine; 2017, 2; 99-109
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Magnetic Resonance Elastography – noninvasive method to assess liver disease
Autorzy:
Ożóg, Łukasz
Aebisher, David
Bober, Zuzanna
Bartusik-Aebisher, Dorota
Guz, Wiesław
Cholewa, Marian
Powiązania:
https://bibliotekanauki.pl/articles/454714.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
fibrosis
liver stiffness
MRE
magnetic resonance imaging
Opis:
Currently, liver disease is widespread and the awareness of these diseases is low. Early symptoms of liver disease do not necessarily indicate problems with this organ and patients are usually informed of their problems when the stage of the disease is already advanced. Invasive biopsies are the clinical diagnostic method most commonly used in the evaluation of liver disease. A biopsy is associated with a high risk of false results and additional complications. Finding new non-invasive imaging methods has led to the discovery of a new method called Magnetic Resonance Elastography (MRE). This technique allows one to evaluate the mechanical properties of tissues and to distinguish between pathological states. Testing using this technique can be performed on a conventional magnetic resonance system by using few additional components and properly prepared software. Studies have shown that there is a strong correlation between MRE-measured liver stiffness and the degree of fibrosis. MRE is also useful in characterizing liver tumors. Studies show that this technique is highly credible in both health volunteers and patients with liver fibrosis. MRE has tremendous diagnostic potential. The described technique is not currently widely used and has the 127-132potential to serve as a safe and accurate alternative in clinical diagnostics in the future.
Źródło:
European Journal of Clinical and Experimental Medicine; 2017, 2; 127-132
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Infliximab MRI relaxation time in solution
Autorzy:
Bober, Zuzanna
Bar, Piotr
Pasternak, Grzegorz
Galiniak, Sabina
Bartusik-Aebisher, Dorota
Filip, Rafał
Aebisher, David
Powiązania:
https://bibliotekanauki.pl/articles/454757.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
infliximab
magnetic resonance imaging relaxation time
Opis:
Introduction. The use of Quantitative Magnetic Resonance Imaging to drug monitoring in vitro or in vivo can provides a powerful means to map the effects of drugs on tissue activity. Aim. The purpose of this study was to measure relaxation time of antibody phantom. For this purpose, infliximab sample was used. Material and methods. The selected methods to detect relaxation time of antibody was Magnetic Resonance Imaging technique. We detected spin-lattice (T1 ) relaxation time and discuss differences where compare to water. Results. The measurements ofspin-lattice (T1 ) relaxation time showed significant differences. The results obtained in phantom indicate that we can use this result for measurements of relaxation time in vitro. Conclusion. Infliximab is approved for severe cases of rheumatoid arthritis, together with methotrexate, for pronounced psoriasis and psoriasis-arthritis, ankylosing spondylitis as well as for chronic inflammatory bowel disease. We conclude, that Quantitative Magnetic Resonance Imaging can be used to monitor drug effects
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 1; 22-25
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Lycopene activity on lung and kidney cancer cells by T2 relaxation time 1 H Magnetic Resonance Imaging in vitro
Autorzy:
Pogoda, Katarzyna
Pucka, Maria
Tabarkiewicz, Jacek
Bober, Zuzanna
Aebisher, David
Galiniak, Sabina
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454731.pdf
Data publikacji:
2020-03-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
cell cultures
lung cancer
lycopene
kidney cancer
magnetic resonance imaging relaxation times
Opis:
Introduction. The paper presents the results of a study of cell cultures of lung cancer and kidney cancer using lycopene performed using clinical magnetic resonance imaging. Aim. The aim of the study was to evaluate lycopene activity on tumor cell cultures. Material and methods. For this purpose, MR tests were performed using the technique of determining transverse relaxation. Results. Described here studies demonstrated that lycopene may inhibit the growth of A549 and ACHN cell lines. Conclusion. We determine changes in spin lattice relaxavity T2 to monitor treatment of lung cancer cell line A549 and kidney cancer cell line ACHN cells treatment with lycopene.
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 1; 5-9
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Applications of cytisine extraction and detection in biological materials for clinical medicine
Autorzy:
Bartusik-Aebisher, Dorota
Aebisher, David
Courtney, Ryan
Sobczak, Andrzej
Bober, Zuzanna
Podgórski, Rafał
Kołodziejczyk, Patrycjusz
Tutka, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/895314.pdf
Data publikacji:
2019-10-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
smoking cessation
chromatography
Biomedicine
cytisine extraction
biopharmacy
Opis:
Tobacco use is a leading cause of preventable mortality worldwide. New cost-effective smoking cessation treatments are needed especially in some low-to-middle income countries where smoking rates are rising, and current pharmacotherapy treatments remain cost-prohibitive. Since the 1960’s, cytisine has been used as an effective nicotine substitution agent to aid in smoking cessation albeit limited to a selected few Eastern/Central Europe and Central Asian countries. Cytisine is a biologically active alkaloid of plant origin and is known to be a ligand of nicotinic acetylcholinergic receptors (nAChRs). For several decades, the properties of cytisine have been investigated and reported in the biomedical and pharmaceutical literature. Due to the beneficial impact of cytisine on smoking cessation and its costly multistep synthesis, there is a growing interest in extraction from natural sources as well as in analytical identification and quantification for clinical medicine and forensic toxicology. In this paper, we present several current analytical approaches to cytisine extraction and identification from biological samples of plant and human origin. The development of extraction techniques will allow for the widespread use of the drug in experimental and clinical pharmacology, toxicology and forensic medicine.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 797-804
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 18

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