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Tytuł:
Lactate / albumin ratio as prognostic tool for risk stratification in septic patients admitted to ICU
Autorzy:
Mourya, Vasant
Gupta, Rakesh
Yadav, Amlendu
Yadav, Rupesh
Powiązania:
https://bibliotekanauki.pl/articles/29432047.pdf
Data publikacji:
2023-12
Wydawca:
Towarzystwo Pomocy Doraźnej
Tematy:
Albumin
lactate
mortality
sepsis
Opis:
INTRODUCTION: Sepsis stands as the primary cause behind intensive care unit (ICU) admissions. The most critical parameters in sepsis management have been shown to be early recognition. Management delays have been associated with increased mortality and morbidity The aim of this study is to study the lactate/albumin (L/A) ratio as prognostic tool for risk stratification in septic patients admitted to ICU. MATERIALS AND METHODS: This prospective observational study was conducted with100 patients. Admitted in ICU with sepsis and septic shock were studied. Serum lactate/albumin ratio was calculated at the time of admission. Apache 2 and SOFA score was calculated at admission. All patients received initial treatment according standard protocol. All patients were followed up till discharge. An adverse outcome in terms of in hospital mortality, length of ICU stays and inotropic support was used in this study. RESULTS: Lactate/albumin ratio >1.5(AUC 0.89) correctly predicted in-hospital mortality among 27% patients with sensitivity and specificity of 90% and 78.6% respectively (p value =0.001). Lactate/albumin ratio <1.50 (AUC 0.73) correctly predicted length of ICU stays <72 hours among 17% patients with sensitivity and specificity of 85% and 58.8% respectively (p value =0.001). Lactate/albumin ratio >1.50 (AUC 0.91) correctly predicted requiring inotropic support among 36% patients with sensitivity and specificity of 83.7% and 89.5% respectively (p value =0.001). CONCLUSIONS: We concluded that lactate/albumin ratio was a stronger parameter than lactate, albumin, APACHE score and SOFA alone in predicting mortality, length of ICU stay and requiring noradrenaline inotropic support among sepsis patients in the ICU.
Źródło:
Critical Care Innovations; 2023, 6, 4; 11-22
2545-2533
Pojawia się w:
Critical Care Innovations
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Obraz kliniczny i następstwa zakażenia pałeczką Yersinia enterocolitica
Clinical consequences of Yersinia enterocolitica infections
Autorzy:
Bartoszewicz, Ludmiła
Kalicki, Bolesław
Grad, Anna
Jung, Anna
Żuber, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1031068.pdf
Data publikacji:
2008
Wydawca:
Medical Communications
Tematy:
enterocolitis
enterotoxin
pseudoapendicitis
sepsis
yersiniosis
zoonoses
Opis:
Yersinia enterocolitica (Y. enterocolitica) is a Gram-negative bacteria belonging to Enterobacteriaceae group since 60’s. Basing on specific biochemical and serological characteristics there where isolated serological types and biotypes of Yersinia enterocolitica. Most widespread of these are biotypes 1B, 2, 4 and belonging to them respectively serotypes O:8, O:9, O:3. Among them, the most frequent pathogen is serotype O:3. Currently, in Poland and other European countries, there is notified growth in number of infections caused by highly virulent serotype O:8 till now appearing only in USA. Yersinia causes zoonosis called yersiniosis. Contaminated food infects human. Clinical appearance of yersiniosis varies depending on bacterial virulence, age and immunological status of ill patient. Usually disease appears as mild enterocolitis. Yersinia together with Campylobacter pylori and Salmonella is the most frequent bacterial factor causing enterocolitis in Europe. In state of immunological deficiency infection with Yersinia can cause severe purulent complications and highly mortal sepsis. The source of serotype O:8 infections in Poland is still not found. It has been isolated on the territory of whole country, from ill people in different age and with different clinical picture of yersiniosis. Serological and microbiological methods are used in diagnostic process of yersiniosis. Both of this are not perfect and should cover each other. Because of unclear epidemiological status of Yersinia enterocolitica type O:8 in Poland, if this infection is suspected, there is a duty to send probes of infected material and serum, together with detailed interview to Instytut Bakteriologii Państwowego Zakładu Higieny. There is serotyping processed and virulence factors estimated. As important as diagnosis is promotion of preventive actions like sanitary principles or avoidance of eating of uncooked food.
Yersinia enterocolitica (Y enterocolitica) jest pałeczką Gram-ujemną zaliczaną od 1964 roku do grupy Enterobacteriaceae. Na podstawie właściwości biochemicznych i serologicznych wyodrębniono szereg biotypów i serotypów Y. enterocolitica. Najbardziej rozpowszechnione są biotypy 1B, 2, 4 i należące do nich odpowiednio serotypy O:8, O:9, O:3. Spośród serotypów zachorowania na całym świecie najczęściej wywołuje serotyp O:3. Obecnie w Polsce i w innych krajach europejskich notuje się stały wzrost zakażeń spowodowanych wysoce zjadliwym szczepem O:8, który do tej pory występował tylko na terenie USA. Pałeczka Yersinia jest przyczyną odzwierzęcej choroby zwanej jersiniozą. Człowiek najczęściej zaraża się nią drogą pokarmową, spożywając zakażone produkty pochodzenia zwierzęcego. Przebieg kliniczny jersiniozy jest zróżnicowany i zależny od zjadliwości bakterii oraz wieku i stanu odporności chorego. Zakażenie najczęściej wywołuje łagodne objawy nieżytu jelitowego. Do najczęstszych czynników bakteryjnych wywołujących zapalenie jelit na terenie Europy oprócz zakażeń bakteryjnych zalicza się także Campylobacter pylori i Salmonella. W stanach obniżonej odporności organizmu zakażenie pałeczką Yersinia może wywołać ciężkie powikłania ropne, a także sepsę o wysokiej śmiertelności. Na terenie Polski nie udało się jeszcze ustalić źródła zakażeń serotypem O:8. Izolowano go na terenie całego kraju od chorych w różnym wieku i o odmiennym przebiegu klinicznym jersiniozy. Diagnostyka jersiniozy polega na wykonywaniu zarówno badań mikrobiologicznych, jak i serologicznych. Ponieważ metody te nie są doskonałe, w terapii jersiniozy powinny się one wzajemnie uzupełniać. Ze względu na niejednoznaczną sytuację epidemiologiczną zakażeń Y enterocolitica typu O:8 w przypadku podejrzenia zakażenia należy zebrać dokładny wywiad i wraz z pobranymi próbkami przesłać go do Instytutu Bakteriologii Państwowego Zakładu Higieny w celu przeprowadzenia szczegółowego serotypowania i oceny czynników zjadliwości. Równie istotne jak diagnostyka jest propagowanie działań zapobiegawczych chroniących przed zakażeniem, a także przestrzeganie podstawowych zasad higieny i unikanie spożywania niedogotowanych produktów pochodzenia zwierzęcego.
Źródło:
Pediatria i Medycyna Rodzinna; 2008, 4, 3; 164-168
1734-1531
2451-0742
Pojawia się w:
Pediatria i Medycyna Rodzinna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
High mobility group B1 levels in sepsis and disseminated intravascular coagulation
Autorzy:
Eskici, Zeynep
Açıkgöz, Şerefden
Pişkin, Nihal
Mungan, Görkem
Can, Murat
Güven, Berrak
Köktürk, Fürüzan
Powiązania:
https://bibliotekanauki.pl/articles/1039652.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
HMGB1
disseminated intravascular coagulation
sepsis
Opis:
Cytokines trigger coagulant and fibrinolytic systems in sepsis to result in Disseminated Intravascular Coagulation (DIC) that is an important complication and leads to disseminated hemorrhages and multi-organ failure. High Mobility Group B1 DNA Binding (HMGB1) protein is a cytokine taking part in systemic inflammatory response. The objective of this study was to investigate HMGB1 levels in groups of septic patients with and without DIC.Twenty-one septic patients without DIC and 12 septic patients with DIC from the Intensive Care Unit (ICU) were included in the study. In addition, 20 patients admitted to the ICU without sepsis or DIC and 20 healthy volunteers served as controls. Levels of HMGB1, prothrombin time, activated partial thromboplastin time, fibrinogen, D-dimer, protein C, protein S, anti-thrombin III (ATIII), platelet (thrombocyte) and leukocyte count were determined. Levels of fibrinogen, protein C, ATIII and platelet count were significantly lower and D-dimer was significantly higher in the group with sepsis plus DIC compared to the group with sepsis without DIC. Levels of HMGB1 were higher in the group with sepsis and DIC compared to the group with sepsis; however, the difference was not statistically significant and the levels of HGMB1 of both groups were significantly higher compared to ICU and healthy control groups. HMGB1 levels were not significantly different in survivor and non survivor patients. HMGB1 levels did not differ in lower respiratory tract infection (LRTI) and urinary tract infection (UTI) in regard to the etiology of sepsis.
Źródło:
Acta Biochimica Polonica; 2012, 59, 4; 561-566
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of the activity of thermostable DNA polymerases in the presence of heme, as a key inhibitor in the real time PCR method in diagnostics of sepsis
Autorzy:
Gosiewski, Tomasz
Brzychczy-Włoch, Monika
Pietrzyk, Agata
Sroka, Agnieszka
Bulanda, Małgorzata
Powiązania:
https://bibliotekanauki.pl/articles/1039451.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
polymerase inhibitor
heme
real time PCR
sepsis
Opis:
The study aim was evaluation of the usefulness of several thermostable DNA polymerases in real time PCR conducted in the presence of the heme. Our study had the advantage of testing several different polymerases, one of which proved to be the least sensitive to heme activity. We also found that there is no need of supplementing the reaction mixture with protective substances like BSA. Selection of the appropriate polymerase can increase the efficiency of the PCR reaction which is very important for diagnosis of sepsis and for other analyses performed on DNA template isolated from the blood.
Źródło:
Acta Biochimica Polonica; 2013, 60, 4; 603-606
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prognostic value of using neutrophil-lymphocyte ratio in patients with burn injury for the diagnosis of sepsis and bacteraemia
Autorzy:
Fuss, Julia
Voloboyeva, Anna
Poliovyj, Victor
Powiązania:
https://bibliotekanauki.pl/articles/1392898.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
burns
sepsis
diagnostic
procalcitonin
neutrophil-lymphocyte ratio.
Opis:
Objective: Despite the progress in the treatment of burn injuries, the mortality rate among seriously ill patients still remains high nowadays. The main causes of fatal cases with extensive deep burns are generalized infectious complications, the major of which is sepsis. According to the authors, 25%–85% of those who died of burn injuries in later periods, died from sepsis. The frequency and severity of infectious complications in patients with burn injuries requires an accurate diagnosis of infection that will determine the tactics of therapeutic and surgical treatment of such patients (Di Lonardo A. et al., 1993). However, the clinical diagnosis of wound infection in patients with burn injuries is quite difficult. Materials and methods: The clinical material included 188 patients with burn injuries. The average age of those patients ranged from 20 to 59 years. Men - 98 (52.1%), women - 90 (47.9%). The survey was conducted from April 2014 to July 2016. Results: In our opinion, the strength of NLR (neutrophil-lymphocyte ratio) is the possibility of implementing this parameter simply by using already available biomarkers (neutrophil count and lymphocyte count). Therefore, this ratio is easy to integrate in clinical practice and cost effective. Conclusion: The application of NLR for the diagnosis of sepsis in patients with burn injuries is the option of choice, since its determination requires only a general blood test.
Źródło:
Polish Journal of Surgery; 2018, 90, 5; 13-16
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zadania pielęgniarki w opiece nad pacjentem z ostrą niewydolnością nerek
Supporting the patients care after aacute renal failure
Autorzy:
Pawlak, Natalia
Szlachciak, Ida
Haor, Beata
Powiązania:
https://bibliotekanauki.pl/articles/1029904.pdf
Data publikacji:
2018
Wydawca:
Państwowa Uczelnia Zawodowa we Włocławku
Tematy:
acute renal failure
oliguria
sepsis
nursing
icnp®.
Opis:
Introduction. The acute renal failure is a complication that is often reported in patients treated in the ICU. At least 20% of patients staying in this ward suffer from the acute renal failure. Therefore patient care in the event of immediate danger to life should be liable to an early recognition of the symptoms indicating renal impairment. Aim. The aim of the study is to define nurses’ role in supporting patients suffering from the acute renal failure. Case study. Patient (male), 52- year- old, admitted to the AIIT ward. He was diagnosed with acute renal failure, caused by sepsis and the operative treatment of the abdominal aortic aneurysm. Discussion. In patients with the acute renal failure the main concern regarding patient care is the risk of dehydration. Dehydration can cause fluid or electrolyte imbalance and it is essential to prevent such situation in order to be able to improve patient's quality of life. Conclusions. Applying ICNP ® in planning the nursing care for patients in OAiIT with severe renal impairment enables to monitor the number, character as well as the quality of nursing services provided.
Wstęp. Ostra niewydolność nerek jest powikłaniem często obserwowanym u chorych leczonych na Oddziale Intensywnej Terapii . Pojawia się u co najmniej 20% pacjentów przebywających w tym oddziale. W związku z tym opieka na pacjentem w stanie zagrożenia życia powinna być nastawiona m.in. na zatrzymanie oraz wczesną identyfikację objawów wskazujących na zaburzenie czynności nerek. Cel pracy. Celem pracy jest określenie zadań pielęgniarki w opiece nad pacjentem z ostrą niewydolnością nerek. Prezentacja przypadku. Pacjent w wieku 52 lat przyjęta do oddziału AiIT. Zdiagnozowano i niego ostrą niewydolność nerek, spowodowaną przebytą sepsą oraz operacją tętniaka aorty brzusznej. Dyskusja. U pacjentów z ostrą niewydolnością nerek głównym problemem pielęgnacyjnym jest ryzyko odwodnienia. Kluczową rolę w pielęgnacji odgrywa prewencja zaburzeń gospodarki wodno – elektrolitowej, która umożliwia poprawę jakości życia pacjentów. Wnioski. Zastosowanie ICNP® w projektowaniu opieki pielęgniarskiej wobec pacjenta w OAiIT z ostrą niewolnością nerek umożliwia monitorowanie liczby, charakteru oraz jakości udzielanych świadczeń pielęgnacyjnych.
Źródło:
Innowacje w Pielęgniarstwie i Naukach o Zdrowiu; 2018, 3, 2; 106-128
2451-1846
Pojawia się w:
Innowacje w Pielęgniarstwie i Naukach o Zdrowiu
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluating the effectiveness of antiseptic solution Decasan in treatment of necrotic soft tissue diseases
Autorzy:
Fuss, Julia
Palii, Victor
Voloboyeva, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1393910.pdf
Data publikacji:
2016
Wydawca:
Index Copernicus International
Tematy:
necrosis of soft tissues
sepsis
antiseptics
Decasan
Opis:
Sepsis is a severe generalised infection caused usually by pathogenic bacteria. It is often the cause of hospitalization and death in patients treated in intensive care and other hospital wards. Latest research brought to better understanding of patomechanisms, took place significant development of therapy heading to improvement of general patients condition treated as a basis and additionally supported by local therapy. The aim of the study was to evaluate the possibility of using the solution Decasan in the comprehensive treatment of patients necrosis of soft tissues. Material and methods. The study included 192 patients (W/M 103/89; average -aged 53.35 ± 5.36 years). According to the classification of septic states (Chicago, 1991), patients were divided into three groups: first – patients to the local form of the infection, the second – with Systemic Inflammatory Response Syndrome (SIRS), which lasted up to 72 hours and the third – patients with various forms of sepsis, SIRS in which lasted 72 hours. Results. As a result of our studies carried out in patients where the wound was made decontamination solution Decasanu, received: pain reduction, decrease tissue swelling, early debridement of the wound and the appearance in the wound granulation, to reduce delays wound healing. Proposed algorithms treatment of various forms of sepsis, pointed out the essential elements, ie.: a comprehensive approach to the treatment of infection by early surgical intervention, intensive supportive therapy (fluid resuscitation), antibiotic therapy directed to microorganisms that cause infections and topical antiseptics therapy (solution Decasanu). Conclusions. The preparation antiseptic Decasan can be safely used for disinfection of skin, mucous membranes and wounds in the foci of infections caused by bacteria, fungi and protozoa.
Źródło:
Polish Journal of Surgery; 2016, 88, 5; 233-237
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
An Uncommon Course Of Acute Appendicitis With Sepsis – A Case Report
Autorzy:
Żyluk, Andrzej
Jagielski, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/1395636.pdf
Data publikacji:
2015-05-01
Wydawca:
Index Copernicus International
Tematy:
acute appendicitis – complications
acute appendicitis – diagnosis
sepsis
Opis:
Authors report a case of 54-years-old patient, who presented to the hospital due to three-day history of weakness, abdominal pain and diarrhea. His general shape was severe, abdomen was tender at palpation in hypogastrium, peritoneal signs were positive, and blood tests showed highly elevated markers of inflammation, including procalcitonin, what suggested the sepsis. Despite unclear clinical picture, the presence sepsis was an argument to give the patient surgery. Intraoperatively, perforated appendix was found, being in mass with the omentum and small bowel. An appendectomy was performed. Postoperative course was complicated by the wound infection, but recovery progressed quickly and patient was dismissed at 5 days after operation. In the discussion the authors referred to the similar cases reported in the literature, concluding that acute appendicitis can be a life threating event for – to date – healthy adult person. Although a tendency to treat conservatively an uncomplicated acute appendicitis and to delay operations is supported by scientific evidence, the cases may occur in which only prompt surgical intervention protects the patient from serious complications.
Źródło:
Polish Journal of Surgery; 2015, 87, 5; 272-276
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Impact of the Types of Microorganisms Isolated from Blood and Wounds on the Results of Treatment in Burn Patients with Sepsis
Autorzy:
Glik, Justyna
Kawecki, Marek
Gaździk, Tadeusz
Nowak, Mariusz
Powiązania:
https://bibliotekanauki.pl/articles/1396591.pdf
Data publikacji:
2012-01-01
Wydawca:
Index Copernicus International
Tematy:
burns
sepsis
burn wound infections
blood infection
Opis:
Despite development of combustiology, infections continue to be the most important cause of death among patients with burns. Sepsis is the most severe clinical presentation of infection in patients after thermal injuries who require immediate treatment. Early diagnosis and proper treatment of sepsis are important in the clinical management that is often hampered for multiple reasons, e.g. impaired patient immunity, problems with microorganisms with multi-antibacterial drug resistance.The aim of the study was to assess effect of type of a microorganism isolated from blood and wound on results of treatment of sepsis in patients with burns.Material and methods. Effect of type of microorganisms isolated from blood and wound on the result of treatment of sepsis was studied in 338 patients hospitalized immediately after an injury in Centre for Burn Treatment in Siemianowice Śląskie in years 2003 - 2004 (at the age of 18 - 96 years, 66 women and 272 men). Clinical symptoms of generalized infection were found in all study subjects. The study group was divided into two subgroups: cured patients and patients who died of sepsis. The following parameters were assessed in both subgroups: type of microorganism isolated from blood, type of microorganism isolated from wound as well as occurrence of the same and different infections of blood and burn wound.Results. positive blood cultures were found in 165 patients (48.8%), 106 (64.2%) were cured, 59 (35.8%) died. The most commonly isolated microorganisms in cured patients were Gram(+) Staphylococcus epidermidis MRSE (19.81%) and Staphylococcus aureus MRSA (18.87%). Gram(-) intestinal rods were least commonly isolated from this group. The most commonly isolated microorganisms from blood of patients who were to die, included non-fermenting Gram(-) rods Acinetobacter baumannii (35.59%) and Pseudomonas aeruginosa (22.03%). Mixed bacterial flora was found in the blood of 22.03% patients. Among patients who were to die, the same microorganisms were found in the blood and in the wound in 32.2% of patients, while this rate was 17.92 in cured patients. The most commonly found bacteria in the blood and burn wound in the cured patients included Staphylococcus aureus MRSA (31.58%) and Staphylococcus aureus (21.05%). In the group of patients who were to die, the most common bacteria isolated simultaneously from the blood and burn wound included Acinetobacter baumannii (47.37%) and Pseudomonas aeruginosa (36.84%).Conclusions. 1. The patients with thermal injuries are at higher risk of death in the event of sepsis caused by Gram(-) bacteria versus Gram(+) bacteria. 2. Infection of blood and burn wound caused by the same bacteria Pseudomonas aeruginosa and Acinetobacter baumanni increases the risk of death due to sepsis in patients with burns following thermal injuries.
Źródło:
Polish Journal of Surgery; 2012, 84, 1; 6-16
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sepsis caused by Chromobacterium violaceum – probably the first case in Europe, or Macbeth read anew
Autorzy:
Jędruszczak, A.
Węgrzyn-Bąk, M.
Budzyńska-Nosal, R.
Maciejewski, M.
Marczewski, K.
Powiązania:
https://bibliotekanauki.pl/articles/2085058.pdf
Data publikacji:
2019
Wydawca:
Instytut Medycyny Wsi
Tematy:
infection
sepsis
bacteria
medicine
climate change
Chromobacterium violaceum
Opis:
Rare diseases, almost by definition, present us with diagnostic as well as therapeutic difficulties as. They also include infectious diseases outside endemic areas. Without expecting them, we are not preparing to fight them. Like Macbeth, we feel safe, convinced that tropical diseases do not reach us, like Birnam forest towards his castle. Nevertheless, the forest moved according to the prophecy of the three witches, and in a similar way tropical flora is moving towards us according to the predictions of environmentalists. This is illustrated by the history of the presented patient, who was admitted to hospital because of sepsis caused by Chromobacterium violaceum (CV), a Gram-negative facultatively anaerobic, oxidase- positive bacterium producing a dark violet antioxidant pigment called violacein. This is probably the first documented case report of sepsis in this part of the world. To the best of the authors’ knowledge, the patient is the first to require dialysis after Chromobacterium violaceum infection.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 3; 508-510
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of patients with candida infections in a tertiary care hospital’s general intensive care unit in Turkey.
Autorzy:
Ceylan, İlkay
Korkmaz, Hamide Ayben
Karakoç, Ebru
Powiązania:
https://bibliotekanauki.pl/articles/2054911.pdf
Data publikacji:
2022-06-30
Wydawca:
Towarzystwo Pomocy Doraźnej
Tematy:
Candidemia
sepsis
non-albicans
intensive care unit
candida species
Opis:
INTRODUCTION: : Studies indicate that approximately 90% of the patients followed in the ICU have Candida spp colonization. In this study we aimed to elucidate the epidemiology, characteristics, management and outcomes of patients with candidemia in the intensive care unit of a training and research hospital. MATERIAL AND METHODS: All patients over the age of 18 who were hospitalized in general intensive care unit more than 24 hours between 2013 and 2019 were included in the this retrospective study. RESULTS: A total of 43 critically ill patients with blood cultures positive for Candida spp. have been enrolled in this retrospective analysis. The duration of stay in the intensive care unit of the survivors was approximately 53 days, while the average length of stay in the intensive care unit of the non survivors was 16 days, and this difference was statistically significant (p<0.05), 89.7% of septic patients with candidemia died the intensive care unit. There was a statistically significant difference between the two groups in terms of platelets, urea and systolic blood pressure (p<0.05), the mean platelet and systolic blood pressure values of the surviving patients were higher than the deceased individuals, while the urea value was lower. The average fungal growth time of the surviving individuals was 17 days, while this period was 1 day in the non-survivor patients. CONCLUSIONS: The mortality rate was higher in patients with sepsis and concomittant candida infection at very soon days of ICU hospitalization. Early administration of empirical antifungal therapy with coverage of non-albicans should be considered for septic patients.
Źródło:
Critical Care Innovations; 2022, 5, 2; 1-10
2545-2533
Pojawia się w:
Critical Care Innovations
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of omeprazole on treatment outcomes in patients with severe traumatic brain injury and sepsis
Wpływ omeprazolu na wynik leczenia pacjentów z ciężkimi urazowymi obrażeniami mózgu i sepsą
Autorzy:
Oliynyk, O.
Powiązania:
https://bibliotekanauki.pl/articles/2048796.pdf
Data publikacji:
2021
Wydawca:
Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:
omeprazole
ventilator-associated pneumonia
acute renal injury
sepsis
clostridial
infection
Opis:
Background. The interrelation between omeprazole use and the possibility of developing nosocomial pneumonia, acute kidney damage and Clostridium difficile-induced diarrhea in patients with sepsis requires further study. Material and methods. 200 patients with severe craniocerebral injury that underwent surgery for the pathology and developed sepsis in the postoperative period were examined in a blind, randomized placebo-controlled research study. The patients were divided into two groups. Patients in Group 1, as part of their therapy regimen for sepsis, received a daily dose of 0.2 mg/kg omeprazole as an intravenous infusion; patients in Group 2 received placebo instead of omeprazole, in addition to a similar therapy regimen as Group 1. Results. Among patients receiving omeprazole, the number of concomitant ventilatorassociated pneumonia cases increased by 1.32 times, the number of acute kidney damage cases by 1.33 times and the number of cases of Clostridium difficile toxin secretion with feces by 1.75 times. Conclusions. The routine use of omeprazole in the management of patients with sepsis may worsen treatment results.
Wprowadzenie. Kwestia korelacji stosowania omeprazolu z możliwym rozwojem szpitalnego zapalenia płuc, ostrego uszkodzenia nerek czy biegunki wywołanej przez Clostridium difficile u pacjentów z sepsą wymaga dalszych badań. Materiał i metody. W ślepym i randomizowanym badaniu kontrolowanym placebo przebadano 200 pacjentów z poważnymi obrażeniami czaszkowo-mózgowymi, którzy w wyniku tej patologii przeszli operację, i u których w okresie pooperacyjnym rozwinęła się sepsa. Zostali oni podzieleni na dwie grupy. Grupa 1 przyjmowała omeprazol w formie wlewu dożylnego w dziennej dawce 0,2 mg/kg jako część kompleksowego leczenia sepsy; grupa 2 przyjmowała placebo zamiast omeprazolu jako dodatek do głównej terapii, podobnej do tej stosowanej w przypadku grupy 1. Wyniki. Wśród pacjentów przyjmujących omeprazol liczba przypadków towarzyszącego respiratorowego zapalenia płuc wzrosła o 1,32 raza, ostrego uszkodzenia nerek – o 1,33 raza, a wydalenia toksyn Clostridium difficile w kale – o 1,75 raza. Wnioski. Rutynowe stosowanie omeprazolu w leczeniu pacjentów z sepsą może pogorszyć wyniki terapii.
Źródło:
Health Problems of Civilization; 2021, 15, 2; 137-141
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans.
Autorzy:
Reiter, Russel
Tan, Dun-xian
Mayo, Juan
Sainz, Rosa
Leon, Josefa
Czarnocki, Zbigniew
Powiązania:
https://bibliotekanauki.pl/articles/1043401.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
neurodegeneration
respiratory distress
melatonin
sepsis
free radicals
antioxidant enzymes
antioxidant
Opis:
This brief resume enumerates the multiple actions of melatonin as an antioxidant. This indoleamine is produced in the vertebrate pineal gland, the retina and possibly some other organs. Additionally, however, it is found in invertebrates, bacteria, unicellular organisms as well as in plants, all of which do not have a pineal gland. Melatonin's functions as an antioxidant include: a), direct free radical scavenging, b), stimulation of antioxidative enzymes, c), increasing the efficiency of mitochondrial oxidative phosphorylation and reducing electron leakage (thereby lowering free radical generation), and 3), augmenting the efficiency of other antioxidants. There may be other functions of melatonin, yet undiscovered, which enhance its ability to protect against molecular damage by oxygen and nitrogen-based toxic reactants. Numerous in vitro and in vivo studies have documented the ability of both physiological and pharmacological concentrations to melatonin to protect against free radical destruction. Furthermore, clinical tests utilizing melatonin have proven highly successful; because of the positive outcomes of these studies, melatonin's use in disease states and processes where free radical damage is involved should be increased.
Źródło:
Acta Biochimica Polonica; 2003, 50, 4; 1129-1146
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wyrzut zewnątrzkomórkowych sieci neutrofilowych (NET) przez neutrofile i co dalej? Konsekwencje tworzenia i nieprawidłowego usuwania NET
Beyond release of neutrophil extracellular traps (NETs) by neutrophils: on collateral consequences of their release and impaired removal
Autorzy:
Santocki, Michał
Kołaczkowska, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/1034006.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Przyrodników im. Kopernika
Tematy:
macrophages
NET
neutrophil
sepsis
tissues damage
makrofagi
neutrofil
sepsa
uszkodzenie tkanek
Opis:
Neutrofilowe sieci zewnątrzkomórkowe (NET) to niedawno odkryty mechanizm, dzięki któremu neutrofile mogą skutecznie walczyć z patogenami. W wyniku aktywacji neutrofile wyrzucają zdekondensowany DNA, połączony z histonami i białkami pochodzącymi z ziarnistości. Te przestrzenne struktury mogą wyłapywać, ograniczać rozprzestrzenianie się, a w niektórych przypadkach zabijać patogeny. Pomimo korzystnych efektów, NET są także odpowiedzialne za patogenezę różnych chorób autoimmunizacyjnych, takich jak reumatoidalne zapalenie stawów, łuszczyca czy toczeń rumieniowaty układowy, a także przyczyniają się do uszkodzeń narządów w trakcie sepsy. Jak dotąd niewiele wiadomo o tym jak NET są usuwane z naczyń krwionośnych i narządów oraz przez które komórki. Istniejące, nieliczne doniesienia wskazują na udział makrofagów w usuwaniu NET, jednakże wyniki te pochodzą tylko z eksperymentów in vitro. Otwartym pozostaje zatem pytanie o mechanizmy tego procesu w skomplikowanym środowisku żywego organizmu. W związku z patologicznym aspektem tworzenia NET, ważnym będzie opracowanie skutecznego środka farmakologicznego zdolnego do usuwania tych struktur.
Neutrophil extracellular traps (NET) represent a recently discovered mechanism by which neutrophils can efficiently fight pathogens. Upon activation, neutrophils release decondensed extracellular DNA decorated with histones and granular proteins. These three-dimensional structures can trap pathogens, limit their spread and sometimes kill them. Despite their beneficial effects, NETs are also involved in pathogenesis of various autoimmune diseases, such as rheumatoid arthritis, psoriasis or systemic lupus erythematosus, and also contribute to organ damage during sepsis. So far, little is known on how NETs are removed from vasculature and tissues, and by which cells. Limited available studies indicate that macrophages might remove NETs, but these results were obtained in vitro. Thus it remains unknown how this process occurs in a complex milieu of the body. Due to the pathological aspect of NET formation, a challenge for the near future will be development of pharmacological agents capable of NET removal.
Źródło:
Kosmos; 2017, 66, 4; 623-634
0023-4249
Pojawia się w:
Kosmos
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Studies on the effects of lipopolysaccharide on lipid peroxidation of erythrocyte and its reversal by mannitol and glycerol
Autorzy:
Bhattacharyya, J.
Datta, A.G.
Powiązania:
https://bibliotekanauki.pl/articles/70788.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
infection
mannitol
lipopolysaccharide
sepsis
erythrocyte
blood
septic shock
lipid peroxidation
glycerol
Źródło:
Journal of Physiology and Pharmacology; 2001, 52, 1
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
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