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Tytuł:
Experiment-based FE simulation of oncology knee endoprosthesis
Autorzy:
Zach, L.
Konvickova, S.
Ruzicka, P.
Powiązania:
https://bibliotekanauki.pl/articles/286127.pdf
Data publikacji:
2011
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
endoprotheses
biomaterials
oncology
Opis:
This paper presents two FE simulations of an oncology knee-joint endoprosthesis. Firstly dynamic experiment-based analysis traditionally made on special knee simulator has been calculated. Another FE simulation of an oncology knee-joint endoprosthesis was made on a complex model based on previously developed geometric model of a lower limb. The presented paper aims to prove the potential of finite element method in biomechanics, especially in development of joint endoprosthesis.
Źródło:
Engineering of Biomaterials; 2011, 14, no. 106-108; 10-12
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A potential usage of probiotics in prevention and treatment of neutropenic enterocolitis
Autorzy:
Gałązka, Jakub Krzysztof
Homa, Piotr
Domagalski, Łukasz
Powiązania:
https://bibliotekanauki.pl/articles/2211811.pdf
Data publikacji:
2023-03-25
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
oncology
neutropenic enterocolitis
probiotics
Opis:
Introduction and aim. Neutropenic enterocolitis is a severe disease that affects patients with immunodeficiency and is often related with the chemotherapy of the hematologic malignancies. Its pathophysiology is not fully understood. Neutropenic colitis may lead to sepsis, gastrointestinal bleeding and even perforations requiring surgical management. The therapy consists of antibiotic therapy, transfusions, hematopoietic growth factor treatment, usage of fluids and electrolytes, bowel rest and even surgical operations. The aim of this review is to consider the potential usage of probiotics in the prevention and treatment of neutropenic enterocolitis. Material and methods. References for that article were found through PubMed and Google Scholar, using terms: “neutropenic enterocolitis” and “probiotics”, or “gut microbiota” and “neutropenic enterocolitis”. The research was limited to abstracts and available full-text articles. Analysis of the literature. The most possible mechanism of neutropenic enterocolitis development appoints bacterial invasion with co-existing immunodeficiency. The probiotics appeal as beneficial agents in both prevention and treatment of neutropenic enterocolitis in according to their impact on gut immune barrier improvement. However older societies’ guidelines were cautious, the most modern ones appoint probiotics as a promising agent in neutropenic enterocolitis, what corresponds with results from current randomized clinical trials. Conclusion. As neutropenic enterocolitis is a severe disease we need to look for better or alternative therapies of that state. The probiotics seems to have beneficial effects in terms of prevention and treatment of neutropenic enterocolitis due to their impact on gut immune barrier. Benefits of such therapy are reflected in current societies’ guidelines which consider probiotics as a promising agent in neutropenic enterocolitis.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 1; 129-132
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nanotechnology in oncology - current state of knowledge
Autorzy:
Laskowska, Dorota
Ziółkowska, Ewa
Mitura, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/286080.pdf
Data publikacji:
2019
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
nanotechnology
oncology
nanostructures
cancer treatment
Opis:
Nanotechnology is an interdisciplinary area of science devoted to the production and testing of nanostructures - defined as forms of the matter organizations the size of which does not exceed 100 nm. It is a quickly developing area of science with many applications in different areas of life, for example in engineering, computing, medicine, pharmacy, andagriculture. One of the problems of contemporary oncology is the low specificity of applied therapies. Most currently used chemiopharmaceuticals have systemic effects which not only affect cancer cells but alsohealthy tissues. Complications after chemotherapy observed in many patients are bone marrow deficiency(neutropenin, thrombocytopenia, anemia), damageto the nervous system (neurotoxicity), myocardium(cardiotoxicity) and pulmonary parenchyma. Similarly, in radiotherapy, ionizing radiation destroys the healthy tissues in the irradiation field. The side effects of radiation therapy may include fatigue, skin reactions, and impairment of tissue and organ functions. According to studies, nanostructures are an opportunity to overcome these limitations. The most popular nanostructures used in medicine are liposomes, silver and gold nanoparticles, magnetic nanoparticles, carbonnanotubes, and dendrimers. The purpose of this article is to present the current state of knowledge on the use of available nanotechnology solutions in pharmacology and cancer treatment.
Źródło:
Engineering of Biomaterials; 2019, 22, 152; 2-9
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Koordynowana opieka w onkologii
Coordinated Care in Oncology
Autorzy:
Różalska, Anna
Czech, Marcin
Powiązania:
https://bibliotekanauki.pl/articles/525876.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Warszawski. Wydawnictwo Naukowe Wydziału Zarządzania
Tematy:
koordynowana opieka
onkologia
zmiany
pakiet onkologiczny
pacjent
coordinated care
oncology
changes
oncology package
patient
Opis:
Koordynowana opieka nad pacjentem stała się jednym z głównych tematów rozważań nad zmianami w polskim systemie ochrony zdrowia. Doświadczenia zaczerpnięte z praktyk międzynarodowych pozwoliły na stworzenie pewnej podstawy zarządzania procesem leczenia, jednak w dalszym ciągu widoczna jest silna potrzeba wprowadzania zmian. W artykule został poddany analizie sposób zarządzania pacjentem onkologicznym w ramach istniejącego pakietu onkologicznego. Przedstawiono założenia rozwiązania systemu kolejkowego oraz poddano ocenie skutki rozwiązań w polskiej onkologii. Z przeprowadzonej analizy wynika, że trudno jest wnioskować o efektywności kosztowej i klinicznej pakietu onkologicznego w ramach koordynacji opieki nad pacjentem z powodu braku istotnych danych w momencie jego wdrożenia. Poddany konstruktywnej krytyce pakiet onkologiczny obecnie jest w fazie zmian. Pozostaje postawić pytanie, na ile kryteria nowelizacji reformy są istotne z punktu widzenia klinicznego, społecznego i płatnika. Nie zapominajmy o ukierunkowaniu opieki koordynowanej, której celem w przypadku chorób nowotworowych jest szybka diagnostyka i celowane leczenie.
Coordinated patient care (disease management) has become one of the main topics of discussion in the Polish health care system. The experience drawn from international practices helped to create a basis for managing the process of treatment. Nevertheless, there is still a strong need for changes in the Polish healthcare. The article presents the management of oncological patients within the existing Package of Oncology. The assumptions of this consideration involve the analysis of oncology queue system solutions and their impact on the patients care. The analysis shows that it is difficult to conclude about the effectiveness and cost of the clinical oncology package within the framework of coordination of patient care due to the lack of relevant data at the time of its implementation. Having been subjected to constructive criticism, the oncology package is currently in the phase of changes. The question remains to what extent the criteria for amendment of the reform are important from clinical, social and the payer’s point of view. Moreover, one should not forget about the main assumptions of coordinated cancer care, which are: immediate diagnosis and fast introduction of effective treatment.
Źródło:
Problemy Zarządzania; 2017, 3/2017 (69), t.1; 146-158
1644-9584
Pojawia się w:
Problemy Zarządzania
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A role of ghrelin in cancerogenesis
Autorzy:
Majchrzak, K.
Szyszko, K.
Pawlowski, K.M.
Motyl, T.
Krol, M.
Powiązania:
https://bibliotekanauki.pl/articles/31726.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
ghrelin
cancerogenesis
growth hormone secretagogue receptor
cancer
mammary cancer
veterinary oncology
oncology
dog
animal disease
Opis:
Ghrelin is a 28 amino-acid multi-functional peptide hormone, which was identified as a natural ligand of the growth hormone secretagogue receptor (GHS-R). Pituitary growth hormone-releasing activity in both animals and humans has been well documented. It has various biological functions, including regulation of appetite and body weight, control of energy homeostasis, modulation of cardiovascular and gastrointestinal system and anti-inflammatory effect. However, both ghrelin and its receptor (GHS-R) are widely distributed in various tumors, which strongly implies their role in neoplastic cell growth trough autocrine/paracrine mechanism. Multiple studies have demonstrated the role of ghrelin in cancer cells proliferation, differentiation, invasiveness and apoptosis inhibition. The ghrelin axis is more complex than it was originally thought and consist of several compounds that might interact with each other and affect ghrelin activities. Here, we provide an overview of the ghrelin and its receptor role in tumor progression.
Źródło:
Polish Journal of Veterinary Sciences; 2012, 15, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
On becoming a mother after cancer survival: a comprehensive literature review
Autorzy:
Sousa, Helena
Castro, Sónia
Pereira, M. Graça
Powiązania:
https://bibliotekanauki.pl/articles/2047212.pdf
Data publikacji:
2021-07-13
Wydawca:
Medical Education
Tematy:
cancer
oncology
fertility
motherhood
survivorship
review
Opis:
Problem identification: The desire for motherhood is one of the top priorities for most female young cancer survivors. The risk of infertility after cancer therapy is an important concern with several physical and emotional consequences. This comprehensive literature review aims to summarize and contextualize recent research that has been carried out on female fertility after cancer, suggesting future research and clinical directions. Literature search: Searches included the keywords “cancer”, “female”, “adults”, and “fertility”. Studies were selected if focused on infertility issues in female cancer survivors. Data synthesis: Eight themes were identified: the effects of anticancer treatments on fertility; fertility preservation methods; international recommendations regarding infertility risk; health professionals’ attitudes towards fertility preservation; patient’s concerns regarding the risk of infertility; patients' information needs; and the impact of the risk of infertility in patient’s quality of life. Conclusions: Psycho-oncologists should be integrated in the oncofertility teams to assess patients’ needs before cancer treatment initiation.
Źródło:
OncoReview; 2021, 11, 2; 48-55
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evoking esophageal speech after the completely removed of the larynx: case study
Nauka mowy przełykowej po całkowitym usunięciu krtani. Studium przypadku
Autorzy:
Kokot, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/24201067.pdf
Data publikacji:
2021-12-31
Wydawca:
Wydawnictwo Uniwersytetu Śląskiego
Tematy:
laryngektomia
mowa przełykowa
ćwiczenia mowy przełykowej
psychoonkologia
onkologopedia
laryngectomy
esophageal speech
esophageal speech exercises
psycho-oncology
oncology
Opis:
For many speech therapists, regardless of their work experience, undertaking therapy with a patient after complete removal of the larynx is a huge challenge that they often cannot cope with. This state of affairs is caused by the still small number of practical studies containing detailed guidelines for post-laryngectomy therapy. The article presents detailed recommendations on evoking esophageal voice along with an explanation of the causes of possible failures during the voice and speech rehabilitation process. Possible actions range from those that are possible a few days after laryngeal surgery to those for practicing the prosodic elements of speech.
Dla wielu logopedów, niezależnie od stażu pracy, podjęcie terapii z pacjentem po całkowitym usunięciu krtani stanowi ogromne wyzwanie, któremu nierzadko nie umieją sprostać. Taki stan rzeczy jest spowodowany wciąż niewielką liczbą praktycznych opracowań zawierających szczegółowe wskazówki dotyczące terapii po laryngektomii. W artykule przedstawiono szczegółowe zalecenia dotyczące terapii mowy przełykowej wraz z objaśnieniem przyczyn możliwych niepowodzeń podczas procesu rehabilitacji głosu i mowy. Omówiono możliwe działania począwszy od kilku dób od operacji usunięcia krtani aż do momentu trenowania prozodycznych elementów mowy.
Źródło:
Logopedia Silesiana; 2021, 10, 2; pp. 1-17: English language version; pp. 18-34: Polish language version
2300-5246
2391-4297
Pojawia się w:
Logopedia Silesiana
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Intraoperative Difficulties and the Reasons for Conversion in Patients Treated with Laparoscopic Colorectal Tumors
Autorzy:
Tarnowski, Wiesław
Uryszek, Mariusz
Grous, Aleksander
Dib, Naser
Powiązania:
https://bibliotekanauki.pl/articles/1396686.pdf
Data publikacji:
2012-07-01
Wydawca:
Index Copernicus International
Tematy:
laparoscopic surgery
colorectal tumors
conversion
complications
oncology
Opis:
The aim of the study was an evaluation of conversion causes and intraoperative difficulties in patients treated with laparoscopic surgery due to colorectal tumours on the basis of authors' own material.Material and methods. in the period 2009-2012 160 patients were operated on because of large bowel cancer, 79 women and 81 men. Average age of patients was 66 years. The conversion was recognized as desuflation of peritoneal cavity, trocars removal and making laparotomy.Results. The conversion was made in 22 cases (13,7%). More in men (16.1%) than in women. The conversion was made twice as likely in T3 and T4 tumors than in T1 and T2.Conclusions. The main cause of conversion in laparoscopic operations of colorectal cancer is local tumor progression.
Źródło:
Polish Journal of Surgery; 2012, 84, 7; 352-357
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of physical therapy in cancer treatment
Autorzy:
Sidor, M.
Jeziorski, K.
Powiązania:
https://bibliotekanauki.pl/articles/2052454.pdf
Data publikacji:
2015
Wydawca:
Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:
oncology
physical therapy
cancer rehabilitation
holistic care
Opis:
Cancer is a very important problem in both medical and social respects. In recent years, there has been a shift in approach to oncological prevention, diagnostics and treatment. As a result, oncology has become an interdisciplinary field. Factors relevant for successful oncological treatment are: sequence, type and scope of intervention, including diagnosis of the cancer, assessment of its progression, systemic treatment, surgery, radiotherapy, supportive therapy and rehabilitation. Rehabilitation addresses the realm of psychology (psychooncology), as well as somatic and social issues. Physical therapy is a notion inseparably related to medical rehabilitation and it encompasses a range of treatments which are based on the body’s reactivity to stimuli. The purpose of this article is to present the specific character, the methods and the role of physical therapy in oncology, as an increasingly popular strategy in medicine, which helps to improve performance and physical function in cancer patients. Physical therapy is essential in primary and secondary cancer prevention and it greatly contributes to improving the quality of life of patients and helps them recover quicker. Four basic kinds of intervention in oncological rehabilitation include: preventive interventions, restorative interventions, supportive interventions and palliative interventions. The main principle in rehabilitating a patient with an advanced cancer is progressing steadily but gradually. The primary and essential form of rehabilitation for cancer patients is movement exercise i.e. kinesiotherapy. Integration and cooperation during group exercise are also among the strategies that therapists seek to employ while working to improve the condition of patients diagnosed with cancer. Kinesiotherapy prevents pulmonary and thromboembolic complications in cancer patients. One method of physical therapy applied in cancer treatment is lymphatic drainage (massage), which improves circulation of lymph. To sum up, physical therapy plays an increasingly important role in holistic care of cancer patients. It is indispensable and should become a standard approach, as a method of reducing the risk of complications, helping in faster recovery and limiting the economic and social costs of treatment.
Źródło:
Health Problems of Civilization; 2015, 09, 1; 29-32
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Beginnings of Hospice Care in the Czech Republic
Autorzy:
Polák, Jan
Opatrná, Marie
Svatošová, Marie
Powiązania:
https://bibliotekanauki.pl/articles/19322797.pdf
Data publikacji:
2022
Wydawca:
Uniwersytet Opolski. Redakcja Wydawnictw Wydziału Teologicznego
Tematy:
Czechoslovakia
palliative care
communism
oncology
hospice
Caritas
funding
Opis:
The aim of this paper is to review the situation in communist and post-revolutionary Czechoslovakia in the area of palliative care. It will familiarize readers with the enormous efforts of two big personalities in the history of Czech health care: Marie Opatrná and Marie Svatošová, who tried to change the old and inconvenient Soviet health care system and make the care of terminal and dying people more human. At the end, it will present some challenges which the current Czech hospice care is confronted with.
Źródło:
Family Forum; 2022, 12; 293-306
2084-1698
Pojawia się w:
Family Forum
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Place of residence does not significantly influence radiological morphology of cervical cancer
Autorzy:
Burdan, Franciszek
Mocarska, Agnieszka
Klepacz, Robert
Walocha, Jerzy
Kubiatowski, Tomasz
Surdyka, Dariusz
Kieszko, Dariusz
Patyra, Krzysztof
Żelazowska-Cieślińska, Iwonna
Starosławska, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/989572.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
cervical cancer
rural-urban differences
magnetic resonance
oncology
Opis:
Introduction and objective. Cervical squamous cell carcinoma is one of the most common malignancies of women. Its incidence and morphology was analyzed based on the magnetic resonance (MR) data among rural and urban residents. Materials and method. The study involved 61 Caucasian women (58.26±9.63 years) preliminary diagnosed with a cervical cancer without any previous treatment. Standard MR examination, including diffusion weighted imagining, apparent diffusion coefficient (ADC) value measurement and dynamic contrast enhancement, was performed. Results. The rural residents (n=22) were insignificantly older. Their first and last menstruation were observed later and number of pregnancy was higher than in urban women (n=39). However, the incidence of miscarriage was insignificantly rarer. All the tumour linear diameters as well as its volume were insignificantly higher in rural women. The ADC value of the cervical tumor was insignificantly lower, while ADC of lymphatic nodules was higher in rural women. Insignificant changes in tumour grade between both examined groups were found in histological, clinical and radiological examinations. Place of residence did not influence any clinical symptoms nor tumour volume and its ADC. Colporrhoea and colpodynia were insignificantly more often observed in urban women, while parametrium, urinary bladder and rectal infiltrations were more commonly seen in rural residents. Higher risk of lymphatic spread to the internal iliac and parametral lymphatic nodes was reported in the rural community. Conclusion. Cervical cancer had similar morphology and growth pattern, regardless of the place of residence. However, a insignificantly larger tumour size among rural residents may suggest a higher incidence of lymphatic spread, probably as a result of less aaccess to modern health care.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The small neuroendocrine intestine tumor as the cause of acute gastrointestinal obstruction and diffuse peritonitis – case report
Autorzy:
Łanowy, Patrycja
Bichalski, Miłosz
Waniczek, Dariusz
Bichalska-Lach, Magda
Dzindzio, Jakub
Powiązania:
https://bibliotekanauki.pl/articles/1062793.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
GEP-NETs
NET
cancer
intestinal obstruction
oncology
surgery
tumor
Opis:
NET is a group of mostly malignant neoplasms with neuroendocrine differentiation. NET tumors are usually located in the small bowel (sbNET), in most cases their symptoms are the non-specific and surgical treatment of this pathogenic lesions is usually planned. Currently used classification of this group of tumors was created World Health Organization and is based on the rank expression of the Ki-67 (the mitotic index), angioinvasion and size of the tumor. GEP-NETs (gastroenteropancreatic neuroendocrine tumors) are known for expressing specific extracellular markers, such as synaptophysin and chromogranin A (CgA), which are used in a diagnostic process and can be detected with immunohistochemistry methods. The occurrence of clinical symptoms only at the advanced stage of the tumor development explains a low rate of life expectancy. At present, surgical removal of the tumor is the most effective treatment method. This case report describes a 67-year-old female with acute symptoms of gastrointestinal obstruction, complicated with acute peritonitis, who was diagnosed with sbNET during an ad hoc treatment.
Źródło:
World Scientific News; 2019, 133; 204-215
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Does regular physical exercises during radiotherapy influence on fatigue, and physical endurance in high-risk prostate cancer patients?
Czy regularny trening fi zyczny w trakcie radioterapii wpływa na zmęczenie i wytrzymałość fi zyczną u chorych z rakiem prostaty o wysokim ryzyku progresji?
Autorzy:
Hojan, Katarzyna
Milecki, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1790843.pdf
Data publikacji:
2020-05-26
Wydawca:
Akademia Wychowania Fizycznego im. Bronisława Czecha w Krakowie
Tematy:
rehabilitation
oncology
radiation
health care
rehabilitacja
onkologia
opieka zdrowotna
Opis:
Background: During radiotherapy (RT) prostate cancer (PCa) patients very often report fatigue, which impairs functional capacity, psychological status, and quality of life (QoL). It is well known that physical exercise plays an important role in healthy adults, has a positive role in immunological aspects of health and improves QoL in cancer patients. Previous studies have shown that physical exercise in cancer patients undergoing RT improves cardiac fitness and QoL. However, it is still not well understood how physical exercise affects physical fitness or fatigue in PCa patients during RT. Therefore, the purpose of this study was to examine the effect of supervised physical exercise on physical endurance and fatigue in high-risk PCa patients undergoing RT. Material and Methods: This was a prospective, two-arm randomized controlled clinical trial. The study was performed with outpatients of the Greater Poland Cancer Center. Seventy-two high-risk PCa men were randomly allocated to two groups prior to undergoing RT. Thirty-six patients performed supervised moderately intense physical exercise (exercise group; EG) and the other 36 formed a control group that carried out normal daily physical activity (usual group; UG). The following parameters were assessed before and after RT: physical endurance, fatigue scores. Results. No significant differences existed between the study groups at pre-RT assessment. After RT, there was a significant improvement in physical endurance (p<0.05) and important smaller fatigue scores in EG. Conclusion. Regular, moderately intense physical exercise improves physical endurance and has a positive influence on symptoms of fatigue during RT in high-risk PCa patients. Therefore, this patient group should conduct regular physical training during RT to decrease the side effects of treatment.
Wstęp: Podczas radioterapii (RT) pacjenci z rakiem prostaty (PCa) bardzo często zgłaszają uczucie zmęczenia, które upośledza sprawność funkcjonalną, stan psychiczny i jakość życia (QoL). Powszechnie wiadomo, że ćwiczenia fizyczne odgrywają ważną rolę u zdrowych osób ale mają też pozytywny wpływ na wiele aspektów immunologicznych zdrowia i poprawiają QoL u pacjentów z nowotworami. Wcześniejsze badania wykazały, że ćwiczenia fizyczne u pacjentów z chorobą nowotworową poddawanych RT poprawiają wydolność serca i QoL. Nadal jednak nie jest dobrze znane, jak ćwiczenia fizyczne wpływają na sprawność fizyczną czy uczucie zmęczenia u pacjentów z PCa w czasie RT. Dlatego celem tego badania było zbadanie wpływu nad zorowanego treningu fizycznego na wytrzymałość fizyczną oraz uczucie zmęczenia u pacjentów z PCa o wysokim ryzyku progresji, poddanych RT. Materiały i metody: Było to prospektywne, dwuramienne, randomizowane i kontrolowane badanie kliniczne. Przeprowadzono je u pacjentów leczonych ambulatoryjnie w Wielkopolskim Centrum Onkologii. Przed podjęciem RT, siedemdziesięcioro dwóch mężczyzn z PCa o wysokim ryzyku progresji, zostało losowo przydzielonych do dwóch grup. Trzydziestu sześciu pacjentów wykonywało regularne, nadzorowane ćwiczenia fizyczne o umiarkowanej intensywności (grupa ćwiczeń, ang.exercise group, EG), a pozostałe 36 osób utworzyło grupę kontrolną, która wykonywała normalną codzienną aktywność fizyczną (zwykła grupa; ang. usual group, UG). Zarówno przed jak i po RT oceniano następujące parametry: ogólną wytrzymałość fizyczną, zmęczenie. Wyniki: Nie stwierdzono istotnych różnic pomiędzy grupami w badaniu przed RT. Natomiast po RT nastąpiła znacząca poprawa wytrzymałości fizycznej (p <0,05) i mniejsze objawy zmęczenia w EG. Wniosek: Regularne, umiarkowanie intensywne ćwiczenia fizyczne poprawiają wytrzymałość fizyczną i mają pozytywny wpływ na zmniejszenie objawów zmęczenia podczas RT u pacjentów z PCa o wysokim ryzyku progresji choroby. Dlatego aby zmniejszyć skutki uboczne leczenia w czasie RT, ta grupa pacjentów powinna przeprowadzać regularny trening fizyczny.
Źródło:
Medical Rehabilitation; 2019, 23(4); 21-27
1427-9622
1896-3250
Pojawia się w:
Medical Rehabilitation
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The current state of knowledge on small cell and non-small cell lung cancer and the position of durvalumab immunotherapy in lung cancer treatment
Autorzy:
Poboży, Kamil
Domańska, Julia
Domański, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/3200762.pdf
Data publikacji:
2023-01-24
Wydawca:
Medical Education
Tematy:
PD-L1
immunotherapy
durvalumab
neoplasm
oncology
SCLC
NSCLC
Opis:
Lung cancer is the second most frequently diagnosed cancer and the leading cause of cancer-related deaths in the world. These statistics make lung cancer one of the most important targets for modern medicine. The identification of multiple risk factors, including tobacco smoking, has been fundamental in understanding the disease. Late-stage detection is a significant contributor to the high mortality rate of lung cancer. Nonetheless, the role of screening is still debatable. The selection of therapy is primarily based on distinguishing between small-cell and non-small cell lung cancer. Despite the major differences in treatment, in both types in specific situations the treatment involves durvalumab – a monoclonal antibody targeting the programmed cell death ligand 1 molecule, which is often present on tumor cells and protects them against the patient’s immune system. The efficacy of durvalumab has been demonstrated in two randomized, multicenter clinical trials. The aim of this study is to summarize the current state of knowledge about lung cancer and durvalumab. Despite the current 5-year survival rate of 19% in lung cancer, the development of immunotherapeutics such as durvalumab may be the key to improving the unfavorable prognosis of lung cancer in the future.
Źródło:
OncoReview; 2022, 12, 4; 75-82
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Radiologia interwencyjna w onkologii: możliwości terapeutyczne leczenia nowotworów wątroby – pierwotnych oraz przerzutów do wątroby
Autorzy:
Mól, M.
Ćwikła, J.
Nowicki, M.
Zawadzki, M.
Kordecki, K.
Walecki, J.
Powiązania:
https://bibliotekanauki.pl/articles/261840.pdf
Data publikacji:
2010
Wydawca:
Politechnika Wrocławska. Wydział Podstawowych Problemów Techniki. Katedra Inżynierii Biomedycznej
Tematy:
onkologia
radiologia interwencyjna
wątroba
nowotwór
oncology
interventional radiology
liver
tumor
Opis:
Od niedawna radiologia interwencyjna znajduje zastosowanie również w onkologii. W artykule przedstawiono kilka relatywnie innowacyjnych technologii i technik stosowanych w terapii nowotworów pierwotnych wątroby oraz pochodzenia przerzutowego. Kliniczne wskazania i przeciwwskazania do stosowania opisywanych metod i zabiegów nie są przedmiotem rozważań autorów pracy.
Interventional radiology has recently found a place in oncology. This article will describe some relatively new techniques and agents used in the treatment of primary and metastatic malignancies of the liver. The article will not describe clinical indications nor the contraindications to the procedures listed as this is beyond the scope of this publication.
Źródło:
Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna; 2010, 16, 2; 153-156
1234-5563
Pojawia się w:
Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna
Dostawca treści:
Biblioteka Nauki
Artykuł
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