- Tytuł:
- Prenyl sulfates as alkylating reagents for mercapto amino acids
- Autorzy:
-
Maltsev, Sergey
Sizova, Olga
Utkina, Natalia
Shibaev, Vladimir
Chojnacki, Tadeusz
Jankowski, Wieslaw
Swiezewska, Ewa - Powiązania:
- https://bibliotekanauki.pl/articles/1040690.pdf
- Data publikacji:
- 2008
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
cysteamine
geraniol
cysteine
S-prenylation
nerol
lipidated amino acids - Opis:
- A new methodology for prenylation of thiol compounds has been developed. The approach is based on the use of prenyl sulfates as new reagents for S-prenylation of benzenethiol and cysteamine in aqueous systems. The C10-prenols geraniol and nerol that differ in the configuration (E or Z, correspondingly) of the α-isoprene unit were efficiently O-sulfated in the presence of a pyridine-SO3' complex. The obtained geranyl and neryl sulfates were tested as alkylating agents. These compounds were chosen to reveal the influence of the α-isoprene unit configuration on their alkylation (prenylation) ability. S-Geranyl cysteine was prepared to demonstrate the applicability of this method for prenylation of peptides containing mercapto amino acids.
- Źródło:
-
Acta Biochimica Polonica; 2008, 55, 4; 807-813
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł