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Wyszukujesz frazę "microparticles" wg kryterium: Temat


Wyświetlanie 1-8 z 8
Tytuł:
Novel strategies for aminoglycoside antibiotic delivery in skeletal tissues - a review
Autorzy:
Posadowska, U.
Pamuła, E.
Powiązania:
https://bibliotekanauki.pl/articles/285107.pdf
Data publikacji:
2012
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
aliphatic polyesters
biopolymers
gentamicin administration
microparticles
osteomyelitis
Opis:
This paper reviews recent advances concerning antibiotic-loaded microparticles application in osteomyelitis treatment. We discuss different methods utilized for microparticles' preparation, i.e. double emulsification, simple emulsification and spray drying. Materials comprised of sphere-shaped matrices are also presented. We point out that the most commonly used microsphere-building components are biodegrad¬able aliphatic polyesters such as poly(lactide-co-glicolide) PLGA, poly(sebacic-ricinoleic-ester-anhydride) P(SA-RA) and poly(lactic-co-hydroxymethyl glycolic acid) PLHMGA. Biopolymers like gelatin, starch or chitosan are also applied as antibiotic carriers. Relationship between preparation method, type of material and its crosslinking degree, microparticles' immobilization steps and the amount of loaded antibiotic are reported as the main factors controlling release rate of drugs in osteomyelitis treatment. And finally, several approaches to produce injectable formulations as well as implantable three dimensional scaffolds with the use of microparticles are described. All in all, this proves that antibiotic-loaded microspheres are a versatile form of biomaterials in osteomyelitis therapy.
Źródło:
Engineering of Biomaterials; 2012, 15, 114; 3-7
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sedymentacja mikrocząstek osadów wodociągowych
Sedimentation of microparticles from water supply system
Autorzy:
Hofman, A.
Dziubiński, M.
Sowiński, J.
Powiązania:
https://bibliotekanauki.pl/articles/2073144.pdf
Data publikacji:
2015
Wydawca:
Stowarzyszenie Inżynierów i Techników Mechaników Polskich
Tematy:
sedymentacja
mikrocząstki
wodociągi
sedimentation
microparticles
water supply system
Opis:
Przedstawiono wyniki badań i obliczeń prędkości sedymentacji zawiesin mikrocząstek osadów pochodzących z płukania systemu wodociągowego. Wykonano również badania wielkości mikro-cząstek osadów wodociągowych i rozkładu ich średnic. Eksperymentalnie określono prędkość sedymentacji zawiesin mikrocząstek oraz porównano ją z obliczoną wg wybranych modeli sedymentacji. Stwierdzono znaczne rozbieżności. Przedyskutowano wpływ średniej średnicy arytmetycznej i geometrycznej mikro-cząstek na obliczeniową prędkość sedymentacji mikrocząstek.
The paper presents the results of research and calculations of sedimentation velocity of microparticle suspensions from a flushing water supply system. Investigations of microparticle diameters and distribution of their size were also carried out. Determined experimentally values of sedimentation velocities were compared with selected sedimentation models. The significant discrepancies between the experimental and calculated values of sedimentation velocities of micro-particles suspensions were found. The influence of arithmetic and geo-metric average diameters of microparticle on the description of experimental data concerning sedimentation velocities of microparticles are discussed.
Źródło:
Inżynieria i Aparatura Chemiczna; 2015, 6; 326--327
0368-0827
Pojawia się w:
Inżynieria i Aparatura Chemiczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of circulating microparticles in healthy medical workers occupationally exposed to ionizing radiation: A preliminary study
Autorzy:
Al-Massarani, Ghassan
Najjar, Fadi
Aljapawe, Abdulmunim
Ikhtiar, Adnan
Powiązania:
https://bibliotekanauki.pl/articles/2162036.pdf
Data publikacji:
2018-12-20
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
biomarkers
flow cytometry
occupational exposure
microparticles
ionizing radiation
cellular damage
Opis:
Objectives Ionizing radiation was known to cause disruption of cytoskeleton. However, the disorganization of the cytoskeleton leads to form microparticles (MP) that carry membrane and cytoplasmic constituents from their parent cells they are released from. Therefore, authors investigated the effect of the occupational exposure to low doses of ionizing radiation on MP levels. Material and Methods The current study was conducted on 38 healthy medical workers occupationally exposed to low doses of ionizing radiation and 29 controls matched by gender, age, and smoking habits. The MP levels measured by flow cytometry were classified as positive or negative phosphatidylserine (PS⁺ or PS⁻), and phenotyped according to their cellular origin. Results Total MP (PS–/PS+) levels, regardless of phenotype, were significantly higher in workers occupationally exposed to ionizing radiation than in healthy individuals (p = 0.0004). Negative phosphatidylserine microparticles were predominant in medical exposed workers and, to a lesser extent, in controls (68% and 57%, respectively). With regard to phenotypic characterization of cellular origin, MP derived from platelets (CD41a+), endothelial (CD146+), leucocytes (CD45+) and erythrocytes (CD235a+) MP were significantly enhanced in exposed workers compared with controls (p < 0.0001). However, no significant difference was found in the proportion of the other blood elements in the peripheral circulation between the 2 groups. Serum levels of C-reactive protein were normal for all individuals. In addition, no association was observed between MP levels and the studied confounding factors. Conclusions The results suggest that elevated circulating MP levels represent an indicator of cellular damage caused by medical exposure to low doses of ionizing radiation. By consequence, the quantification of MP seems to be a useful biomarker for assessing the negative effects of occupational exposure to ionizing radiation. Int J Occup Med Environ Health 2018;31(6):783–793
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2018, 31, 6; 783-793
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The use of LA-ICP-MS as an auxiliary tool to assess the pulmonary toxicity of molybdenum(IV) sulfide (MoS2) nano- and microparticles
Autorzy:
Kuraś, Renata
Stępnik, Maciej
Domeradzka-Gajda, Katarzyna
Janasik, Beata
Powiązania:
https://bibliotekanauki.pl/articles/28761978.pdf
Data publikacji:
2024-03-05
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
microparticles
LA-ICP-MS
molybdenum(IV) disulfide
bioimaging
rat tissues
nanoparticles
Opis:
Objectives Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has considerable applicative potential for both qualitative and quantitative analyses of elemental spatial distribution and concentration. It provides high resolutions at pg-level detection limits. These qualities make it very useful for analyzing biological samples. The present study responds to the growing demand for adequate analytical methods which would allow to assess the distribution of nanostructured molybdenum(IV) disulfide (MoS₂) in organs. It was also motivated by an apparent lack of literature on the biological effects of MoS₂ in living organisms. The study was aimed at using LA-ICP-MS for comparing micro- and nanosized MoS2 ditribution in selected rat tissue samples (lung, liver, brain and spleen tissues) after the intratracheal instillation (7 administrations) of MoS₂ nano- and microparticles vs. controls. Material and Methods The experimental study, approved by the Ethics Committee for Animal Experiments was performed using albino Wistar rats. This was performed at 2-week intervals at a dose of 5 mg/kg b.w., followed by an analysis after 90 days of exposure. The MoS₂ levels in control tissues were determined with the laser ablation system at optimized operating conditions. The parameter optimization process for the LA system was conducted using The National Institute of Standards and Technology (NIST) glass standard reference materials. Results Instrument parameters were optimized. The study found that molybdenum (Mo) levels in the lungs of microparticle-exposed rats were higher compared to nanoparticle-exposed rats. The opposite results were found for liver and spleen tissues. Brain Mo concentrations were below the detection limit. Conclusions The LA-ICP-MS technique may be used as an important tool for visualizing the distribution of Mo on the surface of soft samples through quantitative and qualitative elemental mapping.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2024, 37, 1; 18-33
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modelowanie suszenia rozpyłowego układów wieloskładnikowych
Modeling of spray dring of multicomponent systems
Autorzy:
Gac, J.
Gradoń, L.
Powiązania:
https://bibliotekanauki.pl/articles/2071494.pdf
Data publikacji:
2011
Wydawca:
Stowarzyszenie Inżynierów i Techników Mechaników Polskich
Tematy:
suszenie rozpyłowe
modelowanie numeryczne
mikrocząstki
aerozol leczniczy
spray drying
numerical modeling
microparticles
therapeutic aerosols
Opis:
Sformułowano model numeryczny suszenia rozpyłowego układów wieloskładnikowych, uwzględniający niejednorodność stężeń i temperatur oraz możliwość krystalizacji jednego ze składników. W wyniku przeprowadzonych symulacji stwierdzono, że dla małych kropli niejednorodności składu powstających cząstek są na ogól niewielkie. Większe niejednorodności mogą wystąpić w przypadku bardzo wysokiej temperatury powietrza suszącego oraz gdy rozpuszczalność jednego ze składników kropli jest stosunkowo niska.
The numerical model of spray drying, taking into account inhomogcncity of concentrations and temperature as well as possibility of crystallization of one of the component, has been built. As a result of simulations it has been found that for small droplets the inhomogeneity of composition of the particles produced are very small. Noticeable inhomogenities may appear only in the case of very high temperature of drying air or when the solubility of one of the droplet component of is quite small.
Źródło:
Inżynieria i Aparatura Chemiczna; 2011, 5; 32-33
0368-0827
Pojawia się w:
Inżynieria i Aparatura Chemiczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Doświadczalne i numeryczne badanie wytwarzania cząstek o różnej morfologii w procesie suszenia rozpyłowego
Experimental and numerical study of the production of different morphology particles by means of spray drying process
Autorzy:
Gac, J.M.
Odziomek, M.
Sosnowski, T. R.
Gradoń, L.
Powiązania:
https://bibliotekanauki.pl/articles/2072819.pdf
Data publikacji:
2014
Wydawca:
Stowarzyszenie Inżynierów i Techników Mechaników Polskich
Tematy:
suszenie rozpyłowe
modelowanie numeryczne
mikrocząstki
aerozol leczniczy
spray drying
numerical modeling
microparticles
therapeutic aerosols
Opis:
Przedstawiono doświadczalne i numeryczne wyniki badania morfologii cząstek dekstranu otrzymywanych techniką suszenia rozpyłowego. W wyniku tego procesu można otrzymać cząstki puste w środku typu hollow particles o różnej średnicy oraz grubości powłoki (shell). Do opisu teoretycznego procesu suszenia zastosowano model o parametrach rozłożonych. Pozwolił on na przedstawienie wpływu, jaki na kształt i budowę cząstek wywierają takie parametry procesu, jak temperatura powietrza suszącego oraz wielkość kropli.
The paper presents the experimental and numerical results of dextran par¬ticles morphology obtained by means of spray drying method. This process can produce hollow particles which differ in diameter and shell thickness. For theoretical description of spray drying process the distributed parameter model was used. The model allowed one to present the influence of such process parameters as drying air temperature and droplet size on particle shape and its structure.
Źródło:
Inżynieria i Aparatura Chemiczna; 2014, 4; 241--242
0368-0827
Pojawia się w:
Inżynieria i Aparatura Chemiczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Manufacturing and characterization of gellan gum – zinc oxide composites as potential biomaterials for wound treatment
Autorzy:
Macyk, Alicja
Kusibab, Anna
Pamuła, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/27324040.pdf
Data publikacji:
2023
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
gellan gum
zinc oxide nanoparticles
zinc oxide
microparticles
wound healing
L929 fibroblasts
cynk
fibroblasty
biomateriały
Opis:
This study aimed to produce gellan gum-based hydrogels with the addition of zinc oxide as a potential dressing material. Hydrogels with ZnO concentrations of 0.01%, 0.02% and 0.04% were prepared, micrometric and nanometric ZnO particles were used, and a CaCl2 crosslinker was added to one part of the samples. All samples (14 types) produced by the freeze drying method were characterized with high swelling properties (>2000%), what is important to ensure the absorption of exudates from wounds. Samples with ZnO particles cross-linked with CaCl2 lost less mass after incubation in aqueous media and were characterized by better dimensional stability than those without crosslinking. The pH of the extracts of the samples containing ZnO particles was more neutral (pH 7.0-7.6) than that of the control gellan gum samples (pH of 5.5-6.1). The zinc release from cross-linked samples was twice as high for those containing nanometric particles than for micrometric particles (1.94 ± 0.04 mg/l and 0.93 ± 0.02, respectively). Relatively large amounts of released zinc species in the case of samples containing ZnO nanoparticles are promising in the context of the antibacterial properties and treatment of infected wounds. A lower amount of zinc released from samples with ZnO microparticles could be sufficient to prevent the development of the infection. Furthermore, both materials show satisfactory cytocompatibility with L929 fibroblasts, as shown by Alamar blue and live/dead viability tests, making them prospective candidates for wound healing
Źródło:
Engineering of Biomaterials; 2023, 26, 168; 2--8
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis of hydroxyapatite in a continuous reactor : a review
Autorzy:
Latocha, J.
Wojasiński, M.
Sobieszuk, P.
Ciach, T.
Powiązania:
https://bibliotekanauki.pl/articles/185159.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
hydroxyapatite
synthesis in continuous reactor
continuous precipitation
microparticles
nanoparticles
hydroksyapatyt
synteza w reaktorze ciągłym
ciągłe opady
mikrocząsteczki
nanocząsteczki
Opis:
Because of excellent properties, similar to natural bone minerals, and variety of possible biomedical applications, hydroxyapatite (HAp) is a valuable compound among the calcium phosphate salts. A number of synthesis routes for producing HAp powders have been reported. Despite this fact, it is important to develop new methods providing precise control over the reaction and having potential to scale-up. The main motivation for the current paper is a view of continuous synthesis methods toward medical application of produced hydroxyapatite, especially in the form of nanoparticles.
Źródło:
Chemical and Process Engineering; 2018, 39, 3; 281--293
0208-6425
2300-1925
Pojawia się w:
Chemical and Process Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-8 z 8

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