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    Wyświetlanie 1-4 z 4
    Tytuł:
    Influence of a chosen auxiliary substance on the properties of hydrophilic powders containing lactic acid complexed with chitosan
    Autorzy:
    Małolepsza-Jarmołowska, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1035192.pdf
    Data publikacji:
    2014
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    anti-inflammatory drugs
    hydrophilic powders passing gels
    lactic acid complexed with chitosan
    physiological environment of vagina
    vaginal infections
    vaginal mucosa
    Opis:
    Hydrophilic powders passing gels containing lactic acid complexed with chitosan at a stoichiometric ratio of 1:1 and 8:1 revealed pH ranged from 3.92 to 4.44 and 2.36 to 2.84. Rheological studies demonstrated that the research gels obtained from powders possess the dynamic viscosity ranging from 53 to 398 mPa.s for the 1:1 stoichiometric ratio in the complex and from 19 to 242 mPa.s for the 8:1 ratio. As a result of the research, preparations with different pH values, including physiological range, were obtained. Powders show that the adhesion of the gel covering the surface of the apparatus simulates the conditions in the vagina. The gels obtained from the powders were characterised by the specific dynamic viscosity and possess the work of adhesion. The results obtained in the experimental studies proved that it is possible to produce a preparation with optimal pharmaceutical and application properties.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 87-93
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Use polyvinylpyrrolidone in technology of gynaecological powders containing lactic acid complexed with chitosan
    Autorzy:
    Małolepsza-Jarmołowska, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1035193.pdf
    Data publikacji:
    2014
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    anti-inflammatory drugs
    hydrophilic powders passing gels
    lactic acid complexed with chitosan
    physiological environment of vagina
    vaginal infections.
    vaginal mucosa
    Opis:
    metric ratio of 1:1, 2:1, 3:1, 4:1 and 8:1. Their pH ranged from 3.92 to 4.44 for 1:1 gels and from 2.36 to 2.84 for the 8:1 ratio. The addition of 5% polyvinylpyrrolidone K-90 increased the pH from 4.28 to 4.52 for 1:1 and from 2.58 to 3.30 for the 8:1 ratio. The addition of 5% polyvinylpyrrolidone K-90 increased the dynamic viscosity from 84 to 510 mPa.s for 1:1 gels and from 47 to 386 mPa.s for the 8:1 ratio. The gels obtained from powders possess the work of adhesion - the energy needed to separate the gel from the probe was 15.2 g/s for gels with 5% polyvinylpyrrolidone K-15, 52.76 g/s for gels with 5% polyvinylpyrrolidone K-30, and 56.6 g/s for gels containing 5% polyvinylpyrrolidone K-90. The results proved that it is possible to produce a preparation with optimal pharmaceutical and application properties.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 103-110
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Research of pharmaceutical properties of hydrophilic powders containing lactic acid complexed with chitosan
    Autorzy:
    Małolepsza-Jarmołowska, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1035180.pdf
    Data publikacji:
    2014
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    anti-inflammatory drugs
    hydrophilic powders passing gels
    lactic acid complexed with chitosan
    physiological environment of vagina
    vaginal infections
    vaginal mucosa
    Opis:
    Hydrophilic powders passing gels containing lactic acid complexed with chitosan at a stoichiometric ratio of 1:1 and 8:1 revealed pH ranged from 3.92 to 4.44 and 2.36 to 2.84. Rheological studies demonstrated that the research gels obtained from powders possess the dynamic viscosity ranging from 53 to 398 mPa.s for the 1:1 stoichiometric ratio in the complex and from 19 to 242 mPa.s for the 8:1 ratio. As a result of the research, preparations with different pH values, including physiological range, were obtained. Powders show that the adhesion of the gel covering the surface of the apparatus simulates the conditions in the vagina. The gels obtained from the powders were characterised by the specific dynamic viscosity and possess the work of adhesion. The results obtained in the experimental studies proved that it is possible to produce a preparation with optimal pharmaceutical and application properties.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 79-85
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pharmaceutical assessment of gynaecological powders with the addition of hydrophilising substances containing lactic acid complexed with chitosan
    Autorzy:
    Małolepsza-Jarmołowska, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1035187.pdf
    Data publikacji:
    2014
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    anti-inflammatory drugs
    hydrophilic powders passing gels
    lactic acid complexed with chitosan
    physiological environment of vagina
    vaginal infections
    vaginal mucosa
    Opis:
    Research on gynaecological preparations followed that of optimising their pharmaceutical properties, which is beneficial for gynaecological powders. Gels obtained from powders containing lactic acid complexed with chitosan revealed a stoichiometric ratio 1:1, 2;1, 3:1, 4:1 and 8:1. Their pH ranged from 3.92 to 4.44 for 1:1 gels and from 2.36 to 2.84 for the 8:1 ratio. The addition of 5% polyethylene glycol-400 increases the pH from 4.52 to 4.92 for 1:1 gels and from 2.54 to 3.41 for the 8:1 ratio. A modification of the composition of the tested powders containing 5% polyethylene glycol-400 increased the range of the dynamic viscosity of formulations suitably from 78 to 520 mPa.s for 1:1 gels and from 39 to 423 mPa.s for the 8:1 ratio. Measurements performed in a biopharmaceutical model revealed that the gels obtained from powders containing lactic acid complexed with chitosan are able to move from 25 to 28 cm.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 95-101
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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