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Wyszukujesz frazę "Szcześniak, Maria." wg kryterium: Autor

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    Wyświetlanie 1-11 z 11
    Tytuł:
    Application of chitosan in the formulation of dermatological hydrogels prepared on the basis of macromolecular compounds
    Autorzy:
    Szcześniak, Maria
    Grimling, Bożena
    Meler, Jan
    Karolewicz, Bożena
    Powiązania:
    https://bibliotekanauki.pl/articles/1034450.pdf
    Data publikacji:
    2018
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    hydrogels
    rheological parameters
    Opis:
    The effect of chitosan concentration on the properties of dermatological preparations prepared with 2% methylcellulose and 10% polyvinylpyrrolidone was studied. As the levels of chitosan, propylene glycol-1,2 and glycerol increased, the hardness, consistency and cohesiveness of the hydrophilic gels increased, while the dissipation capacity decreased. Gels based on methylcellulose and chitosan, compared to formulations containing polyvinylpyrrolidone, have a higher rate of loss of volatile compounds, higher pH values for 1,2-propylene glycol formulation and higher texture parameters. The tested hydrogels have good rheological properties, allowing extrusion from the tube and spreading on the skin.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2018, 23; 179-184
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of selected polymers on the rheological properties of hydrogels with chitosan applied on the skin
    Autorzy:
    Szcześniak, Maria
    Grimling, Bożena
    Meler, Jan
    Karolewicz, Bożena
    Powiązania:
    https://bibliotekanauki.pl/articles/1034591.pdf
    Data publikacji:
    2017
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    hydrogels
    pharmaceutical availability
    rheological parameters
    Opis:
    The aim of the study was to evaluate the effect of methylcellulose and carboxymethylcellulose on the rheological properties of hydrogels applied to skin on chitosan in the presence of the additives propylene glycol and glycerol. Rheological studies showed that the tested gels are non-newtonian systems, and have thixotropic properties. Substrates made of methylcellulose and chitosan are characterised by higher shear values than those obtained with carboxymethylcellulose. The addition of polymers had a positive influence on the dispersion of hydrogels, and the addition of excipients increased firmness, consistency and cohesiveness of the gels. Larger increases were observed with the addition of 10% of glycol propylene and glycerol contents for methylcellulose and of 20% of carboxymethylcellulose.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 201-206
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Application of chitosan in the formulation of methyl cellulose-based hydrogels
    Autorzy:
    Szcześniak, Maria
    Grimling, Bożena
    Meler, Jan
    Pluta, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1035190.pdf
    Data publikacji:
    2014
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    methylcellulose
    pharmaceutical availability
    rheological parameters
    Opis:
    The aim of this work was to study the properties of methylcellulose hydrogels with supplements containing chitosan and 1% hydrocortisone. Depending on the composition of the substrate, gels are characterised by a variety of pharmaceutical availabilities. Increasing the concentration of chitosan has an influence on increasing the viscosity, hardness, and cohesiveness of the tested gels.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 139-144
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of chitosan on the rheological properties of hydrogels based on sodium carboxymethylcellulose
    Autorzy:
    Szcześniak, Maria
    Grimling, Bożena
    Pluta, Janusz
    Meler, Jan
    Powiązania:
    https://bibliotekanauki.pl/articles/1034876.pdf
    Data publikacji:
    2015
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    pharmaceutical availability
    rheological parameters
    sodium carboxymethylcellulose
    Opis:
    The aim of the study was to evaluate the effect of changing the concentrations of chitosan on the rheological properties of the obtained formulation. Hydrogels were prepared with 1% hydrocortisone containing 4% sodium carboxymethylcellulose with the addition of chitosan, propylene glycol-1,2 or polyethylene glycol 400 and glycerol or paraffin. The concentration of chitosan and excipients affects the rheological properties of gels and the pharmaceutical availability of hydrocortisone. Increasing the concentration of chitosan have influence on increasing the viscosity, hardness, and cohesiveness of the tested gels.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 254-259
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    In vitro studies of adsorption of erythromycin on chitosans from dietary supplements
    Autorzy:
    Meler, Jan
    Grimling, Bożena
    Szcześniak, Maria
    Biernat, Paweł
    Powiązania:
    https://bibliotekanauki.pl/articles/1035189.pdf
    Data publikacji:
    2014
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    Erythromycin
    adsorption
    chitosan
    Opis:
    In clinical practice, in the treatment of obesity, a plurality of natural high-molecular compounds are used, the activity of which supports weight loss. During the use of dietary supplements containing chitosan, illness sometimes develops and other therapeutic agents are applied as antibiotics The aim of our study was to determine the binding capacity of the antibiotic erythromycin depending on variable physicochemical factors, in the model of the gastrointestinal tract, by chitosans found in slimming dietary supplements Erythromycin adsorption phenomenon was studied by static and dynamic pharmaceutical model (according to the modified method of the Polish Pharmacopoeia) simulating in vitro conditions. The amount of bound drug was used to calculate the average percentage of the adsorbed dose. The results obtained show that erythromycin is adsorbed by chitosans at various pH ranges, and the binding capacity of the environment depends on the pH, viscosity and concentration of the antibiotic, as well as the chitosan and type and additional substances present in the gastrointestinal tract. The average level of the adsorption of erythromycin in the chitosan-nutrients system depends on the pH of the medium. The highest amount of adsorption was noted above pH 7 (chitosan precipitated polymer forming the emulsion-gel system).
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 119-123
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Adsorption studies of ketoconazole with chitosan
    Autorzy:
    Meler, Jan
    Szcześniak, Maria
    Pluta, Janusz
    Grimling, Bożena
    Powiązania:
    https://bibliotekanauki.pl/articles/1035196.pdf
    Data publikacji:
    2014
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    absorption
    chitosan
    ketokonazol
    Opis:
    Combinations of polymers and biopolymers of biologically active compounds in the last period have been the subject of intensive research. The active substance linked to a polymer often has a modified function and sometimes no action. On the other hand, the use of unsuitable polymers may result in a type of mismatch of drug-polymer. The aim of the study was to examine whether the active substance ketoconazole causes incompatibility with dietary supplements containing chitosan. Antifungal drug adsorption phenomenon was investigated by the static method in the concentration range of the single dose using a pharmaceutical model of the gastrointestinal tract. The test results show that the antifungal agent is adsorbed onto the chitosan in the pH ranges used, and the binding ability of the chitosan depends on the variety, or indirectly from the reaction environment. It was observed that the average sorption, depending on the variety of chitosan, was located in the limit from 94% to 100%. The increase of the size of the adsorption of anti-inflammatory drugs on the polymer with increasing pH from 7.6 to 8.0 can be explained by the swelling properties of chitosan, which grow with increasing pH of the environment in the direction of alkaline pH. Thus, the specific surface area and polymer sorption capacity is increased. Based on the above considerations, it can be concluded that, between the test drug and the polymer, there is antagonistic interaction involving the adsorption of the drug of this group on a polymer which is chitosan.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 111-117
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Atorvastatin adsorption studies on chitosans in an in vitro pharmaceutical model
    Autorzy:
    Meler, Jan
    Grimling, Bożena
    Szcześniak, Maria
    Karolewicz, Bożena
    Biernat, Paweł
    Powiązania:
    https://bibliotekanauki.pl/articles/1034415.pdf
    Data publikacji:
    2018
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    Atorvastatin
    adsorption
    chitosan
    Opis:
    During the pharmacological therapy of specific diseases, drugs are used which, with other preparations or foods, can create connections, in many cases changing or even blocking their action. On the other hand, the use of unsuitable polymers as excipients may result in drug-polymer incompatibilities. Interactions consisting mainly of the occurrence of the adsorption phenomenon and on the formation of complex bonds that reduce the effect of the drugs are of particular importance. The aim of the study was to investigate whether the active substance atorvastatin is incompatible with dietary supplements containing chitosan. The phenomenon of the adsorption of the drug was examined using a static model of a pharmaceutical gastrointestinal tract, in the concentration range generally ingested in a single dose. Measurement results of the amount of bound drug were used to determine the average percentage of adsorbed drug dose. The results of the study prove that the anticholinesterase drug is adsorbed on chitosan in the pH ranges used, and that the binding capacity depends on the chitosan variety, which indirectly affects the reaction of the environment. It was observed that the average size of sorption depending on the chitosan variety ranged from 38% to 86%. The fact that the lowest value of adsorption was at pH 6.4 can be explained by the chemical properties of chitosan, which shows a charge only at pH >6.7. Under such conditions, the phenomenon of electrostatic adsorption may occur in relation to the healing substances of weak acids. At a pH above 7.6, corresponding to the intestinal fluid-filled intestine, the mean sorption for the highest dose of chitosan was from 38–86%. The increase in the adsorbed amount of anticholinesterase drugs on the polymer along with the increase in pH from 7.6 to 8.0 can be explained by the chitosan swelling properties, which increase with an increase in the pH. As a result, the specific surface area of the polymer and its sorption capacity increase. Based on the above considerations, it can be concluded that there is an antagonistic interaction between the drug and the polymer studied, which involves the adsorption of a drug from this group on the polymer (chitosan) and a decrease in its bioavailability
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2018, 23; 140-148
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The adsorption of simvastatin on chitosans in an in vitro pharmaceutical model
    Autorzy:
    Meler, Jan
    Grimling, Bożena
    Szcześniak, Maria
    Pluta, Janusz
    Biernat, Paweł
    Powiązania:
    https://bibliotekanauki.pl/articles/1034541.pdf
    Data publikacji:
    2017
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    adsorption
    chitosan
    simvastatin
    Opis:
    In clinical practice for the treatment of obesity, several natural macromolecular compounds are used, whose operation is based on supporting weight loss. During the use of dietary supplements containing chitosan, disease sometimes occurs and treatment for this often comprises different therapeutic agents and antibiotics. The aim of our study was to determine the binding capacity of simvastatin to chitosan, which is found in dietary supplements promoting weight loss, depending on variable physicochemical factors in the gastrointestinal tract model. The phenomenon of adsorption of simvastatin was investigated by a static and dynamic pharmaceutical model (according to the Modified method of Polish Pharmacopoeia IX) simulating the conditions in vitro. The amount of bound drug is used to calculate the average percentage of the adsorbed dose. The obtained results showed that simvastatin is adsorbed by chitosan in the used pH ranges, and the binding capacity is dependent on the environmental pH, viscosity, the concentration of the drug, the type of chitosan and additional substances present in the gastrointestinal tract. The average adsorption of simvastatin in the system of chitosan-nutrients, depending on the pH of the medium, was in the range of 27 to 95%. The highest amount of adsorption was noted above pH 7 (chitosan precipitated polymer forming the emulsion-gel system), when the bioavailability of dietary supplement using chitosan was almost zero.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 151-158
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The study of physicochemical properties of solid dispersions of ibuprofen in the presence of chitosan
    Autorzy:
    Grimling, Bożena
    Meler, Jan
    Szcześniak, Maria
    Pluta, Janusz
    Górniak, Agata
    Powiązania:
    https://bibliotekanauki.pl/articles/1034797.pdf
    Data publikacji:
    2015
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    dissolution
    ibuprofen
    solid dispersion
    Opis:
    The aim of the present study was to increase the solubility of ibuprofen. Among the methods to increase the solubility selected solid dispersions of the drug with the polymer. Chitosan was used as the polymer. Solid dispersion obtained. Ibuprofen was incorporated into the chitosan type 652 with molar masse chitosan Mη = 429 kDa. Solid dispersions were prepared by using different ratios of ibuprofen and chitosan (1:9. 3:7 and 5:5). Formulations were tested dissolution rate of the ibuprofen. The highest dissolution of ibuprofen, amounting to 12.59%, was observed after 60 minutes from solid dispersion prepared by the evaporation method and 12.18% from physical mixtures with drug-polymer weight ratio 1:9 in the presence chitosan. The solubility of the drug improved more than 60-fold. XRPD analysis indicates the presence of the ibuprofen in amorphous form in the solid dispersion obtained by the modified solvent evaporation.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 64-72
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Physicochemical characterization and dissolution studies of solid dispersions of clotrimazole with chitosan
    Autorzy:
    Grimling, Bożena
    Jasińska, Justyna
    Meler, Jan
    Szcześniak, Maria
    Pluta, Janusz M.
    Górniak, Agata
    Powiązania:
    https://bibliotekanauki.pl/articles/1034642.pdf
    Data publikacji:
    2016
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    FTIR
    XRPD
    chitosan
    clotrimazole
    solid dispersion
    Opis:
    The aim of the present study was to increase the solubility of clotrimazole. Among the methods to increase the solubility selected solid dispersions of the drug with the polymer. Chitosan was used as the polymer. Clotrimazole was incorporated into the chitosan type 652 with molar masse chitosan Mη = 429 kDa. Solid dispersions were prepared by using different ratios of clotrimazole and chitosan (1:9, 3:7, 5:5, 7:3, 9:1). Formulations were tested dissolution rate of the drug. The highest dissolution of clotrimazole, amounting to 47.95%, was observed after 60 minutes from solid dispersion prepared by grinding method and 42.84% from physical mixtures with drug-polymer weight ratio 1:9 in the presence chitosan. The solubility of the drug improved more than 37-fold. XRPD analysis indicates the presence of the clotrimazole in crystalline form in the solid dispersion obtained by kneading method.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 63-72
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of a dental formulation prepared with chitosan on the pharmaceutical availability of clotrimazole
    Autorzy:
    Grimling, Bożena
    Meler, Jan
    Szcześniak, Maria
    Kocoń, Martyna
    Karolewicz, Bożena
    Złocińska, Adrianna
    Górniak, Agata
    Powiązania:
    https://bibliotekanauki.pl/articles/1034568.pdf
    Data publikacji:
    2017
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    FTIR
    carrier XRPD
    chitosan
    clotrimazole
    hydrogel
    solid dispersion
    Opis:
    The present work involves the development of a dental gel composition obtained on the basis of clotrimazole incorporated into chitosan in order to improve drug solubility. Solid dispersions were prepared by using two methods: grinding and kneading. The solid dispersion varied the ratio of chitosan to drug to increase the volume of the drug; the ratios were 5:5, 3:7, 2:8, 1:9. The mixtures were subjected to the dissolution rate of clotrimazole. The presence of chitosan improved the drug solubility; a better solubility from the solid dispersion prepared by the grinding method was obtained from the ratio of drug to polymer of 1+9. The rate of dissolution of clotrimazole was improved 17 times compared to the pure drug. Fourier transform infrared spectroscopy (both infrared and X-ray diffraction) revealed no new chemical structure of the tested connections and concluded that there was no interaction between the drug and the polymer in the test diffractions. Solid dispersions with the best parameters were used to prepare hydrogels, and the pharmaceutical availability of clotrimazole was analysed. The best properties were characterized by a hydrogel that was composed of the ratio of the amount of drug to polymer 5:5. The study demonstrated the availability of a pharmaceutical drug release at a therapeutic concentration in the first hour of the study. The use of the appropriate balance between clotrimazole and chitosan and the development of the hydrogel composition may affect the improvement of the drug solubility and may create the possibility of obtaining sustained or controlled release of the drug substance.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 42-53
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-11 z 11

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