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    Wyświetlanie 1-12 z 12
    Tytuł:
    Aktywność biologiczna pochodnych 2-amino -1H-benzimidazolu. Część II
    Biological activity of 2-amino -1Hbenzimidazole derivatives. Part II
    Autorzy:
    Nawrocka, W. P.
    Nowicka, A.
    Liszkiewicz, H.
    Powiązania:
    https://bibliotekanauki.pl/articles/171652.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne 2-aminobenzimidazolu
    aktywność biologiczna
    2-aminobenzimidazole derivatives
    biological activity
    Opis:
    2-Aminobenzimidazole occur in a broad spectrum of drugs and pharmacological agents with hypotensive [26], antihistaminic, immunotropic [16], antiarrhythmic [25], analgesic [21, 22] or antiaggregatory properties [27]. There are 30 drugs, 2-aminobenzimidazole derivatives, registered in the world which exhibit diverse pharmacological activities. Carbendazim is an antifungal drug, but in 2003 it has been registered as anticancer [1]. They are also voltage sensitive calcium channel blockers [33], inhibitors of vascular endothelial growth factor [12]. The main goal of this article is to present a various biological activity of 2-aminobenzimidazole derivatives. During the past 20 years the biological activity of 2-aminobenzimidazole have been studied. Based on a review of the chemical literature, derivatives of 2-aminobenzimidazole showed a multipharmacological effects such as hypotensive effect [28], antiinflammatory effect [20] or antibacterial activity. Some chemical compounds, which contain in their structure 2-aminobenzimidazole system inhibit neurodegeneration and in the future they may be used in a treatment of Alzheimer’s disease or Parkinson’s disease [32]. Some of described derivatives of 2-aminobenimidazole can be used in a treatment of metabolic syndrome and diabetes [38]. Synthesis of new 2-aminobenzimidazole derivatives with anticancer activity is now one of the most important direction of research conducted on this group of compounds. Present compounds exhibit anticancer, antiproliferate, neuroprotetic and antiinflaminatory activity. Some of them can be used in a treatment of diabetes and hypertension.
    Źródło:
    Wiadomości Chemiczne; 2012, 66, 9-10; 840-865
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Aktywność biologiczna pochodnych 2-amino -1H-benzimidazolu. Część I
    Biological activity of 2-amino -1H-benzimidazole derivatives. Part I
    Autorzy:
    Nawrocka, W. P.
    Nowicka, A.
    Liszkiewicz, H.
    Powiązania:
    https://bibliotekanauki.pl/articles/171654.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne 2-aminobenzimidazolu
    aktywność biologiczna
    2-aminobenzimidazole derivatives
    biological activity
    Opis:
    The main goal of this article is to present a various biological activity of 2-aminobenzimidazole derivatives. During the past 20 years the biological activity of 2-aminobenzimidazole have been studied. 2-Aminobenzimidazole occurs in a broad spectrum of drugs and pharmacological agents with anticancer [21], antibacterial [14], antiviral [10], analgesic or antiaggregatory properties. There are 30 drugs, 2-aminobenzimidazole derivatives, registered in the world. Mebendazole represents a big group of antiparasitic drugs [25]. Antihistaminic II-nd generation drug with selective activity towards H1 receptors represents Astemizol [2]. Antiviral drugs are: Enviroksym and its isomer Zinviroksym and Enviraden [3–5]. Synthesized 2-aminobenzimidazole derivatives are active against HCV [7], HIV [8, 9] or HCHV [11]. Selected compounds exhibit antiviral [3–5], antifungal [22–24] and antiparasitic [26–28] activity. Some of them can be used in the treatment of bacterial infections [12–14]. Many of 2-aminobenzimidazole analogues are histamine H1, H2, H3 and also H4 receptor antagonists [30, 33, 35, 39].
    Źródło:
    Wiadomości Chemiczne; 2012, 66, 9-10; 811-838
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Naturalne i syntetyczne analogi strukturalne jononów
    Natural and synthetic structural analogs of ionones
    Autorzy:
    Grabarczyk, M.
    Wińska, K.
    Mączka, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/172354.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne jononów
    aktywność biologiczna
    biotransformacja
    ionone derivatives
    biological activity
    biotransformation
    Opis:
    Both plants and animals in the process of evolution gained the ability to produce compounds that affect their existence in the wild. These compounds may affect the organisms producing them, and may also be used by completely different individuals. Among huge number of molecules characterized by extremely essential features are, among others, ionones and their derivatives. Ionones are ketones composed of 13 carbon atoms. They are found in many essential oils being the products of degradation of carotenoids. Both they and their structural analogues can play various biological functions such as being deterrent to other individuals or, conversely, atractant. Compounds found in plants, containing like ionone carbon skeleton, and having in their structure additional hydroxyl groups or epoxide ring (4)–(23) often exhibit allelopathic activity [1–15] (Fig. 2–5). Marine animals may in turn use them as ichtyotoxic compounds (27) and (28) [19] (Fig. 7). A compound called luciferin Latia (29) is responsible for the bioluminescent properties of marine snail [20] (Fig. 8). Plants used for centuries in traditional folk medicine of different countries are a source of glycoside derived α- and β-ionone (37)–(55) [22–31] (Fig. 11–14). These compounds may also be used in modern medicine, inter alia, in the regulation of neurodegenerative diseases or for the treatment of osteoporosis. Because of the potential biological properties of structural analogs of ionones they are also obtained by chemical synthesis (56)–(69) [32–39] (Fig. 15–18) or biotransformation (70)–(89) [40–47] (Fig. 19–25), and then subjected to careful examination of their biological activities. By applying these methods we can also obtain a molecules whose acquisition from natural sources is unprofitable. We have received such derivatives which have no counterpart in nature.
    Źródło:
    Wiadomości Chemiczne; 2015, 69, 11-12; 997-1018
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Syntezy i aktywność biologiczna pochodnych pirydopirydazyny
    Synthesis and biological activity of pyridopyridazine derivatives
    Autorzy:
    Nawrocka, W. P.
    Nowicka, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/171526.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne pirydopirydazyn
    struktury
    syntezy
    aktywność biologiczna
    pyridopyridazine derivatives
    structures
    syntheses
    biological activity
    Opis:
    For many years all six isomers of pyridopyridazines have been an interesting class of heterocyclic compounds because of their biological and chemical properties. Endralazine is a hypotensive drug, which contain pyrido[4,3-c]pyridazine structure. Presented in this paper selected compounds exhibit antiviral [20] and antibacterial [21, 22] activity. Based on review of the chemical literature, derivatives of pyridopyridazine showed a multipharmacological effects such as analgesic [23–29] and diuretic [33–38] activity. Some chemical compounds, containing pyridopyridazine moiety showed anticancer activity in vitro with different mechanism of action [12, 15, 18, 19]. Novel pyrazolopyridopyridazine derivatives have been identified as more potent and selective phosphodiesterase 5 (PDE5) inhibitors than sildenafil [41]. Pyrido[2,3-d] pyridazine derivatives were synthesized as selective PDE4 inhibitors [44–46], with good selectivity profile and less undesiderable side effects. 2,3,8-Trisubstituted pyrido[ 2,3-d]pyridazines were novel classes of GABA-A receptor benzodiazepine binding site ligands [30, 31]. While pyrido[2,3-c]pyridazine derivatives were selective agonists for the benzodiazepine site of GABA-A receptor [32]. Some of new substituted pyrido[3,2-c]pyridazine derivatives possess molluscicidal activity [54] and can be used as biodegradable agrochemicals.
    Źródło:
    Wiadomości Chemiczne; 2014, 68, 1-2; 67-94
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Aktywność biologiczna pochodnych 2,7-naftyrydyny
    Biological activity of 2,7-naphthyridine derivatives
    Autorzy:
    Wójcicka, A.
    Wagner, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/171766.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne 2,7-naftyrydyny
    aktywność biologiczna
    2,7-naphthyridine derivatives
    biological activity
    Opis:
    2,7-Naphthyridine is one of the six structural isomers of pyridopyridines. More than one hundred years ago, Gabriel and Colman discovered the isomer 2,7-naphthyridine, and named it “copiryne” [3]. From among of all naphthyridines, the synthesis and properties of the copyrine derivatives have not yet been thoroughly investigated. This paper reviews the synthetic and natural 2,7-naphthyridine derivatives which have been reported to possess various biological activity. A large number alkaloids containing the 2,7-naphthyridine scaffold have been isolated from plants and marine organisms [13–18]. The natural marine alkaloids can be classified into two groups. The bicyclic lophocladines were isolated from the red alga Lophocladia sp. [12]. The pyridoacridines represent a large and growing class the polycyclic alkaloids from sponges, ascidians or tunicates [15, 16]. Many of this natural compounds exhibited cytotoxic, antibacterial, antiviral, antifungal and sedative activity. The broad spectrum of biological activity of copyrine alkaloids is the main of reason for the preparation of new 2,7-naphthyridine derivatives also by the synthetic route. So far, about fifty different methods of synthesizing the 2,7-naphthyridine ring have been published. This study described synthesis only biologically active 2,7-naphthyridine analogues. Biological investigations have shown that copyrine derivatives have a wide spectrum of actions. Antitumor, antimicrobial, analgesic and anticonvulsion activities have been found. Most of 2,7-naphthyridine derivatives have been studied as antitumor agents. Many papers described synthesis and pharmacological properties the best active and highly selective PDE5 inhibitor (T-0156) [55]. So far, none of 2,7-naphthyridine derivatives has been applied as a drug.
    Źródło:
    Wiadomości Chemiczne; 2011, 65, 3-4; 235-264
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synteza i aktywność biologiczna pochodnych 2,6-naftyrydyny
    Synthesis and biological activity of 2,6-nap hthyridine derivatives
    Autorzy:
    Wójcicka, A.
    Wagner, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/172545.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne 2,6-naftyrydyny
    synteza
    aktywność biologiczna
    2,6-naphthyridine derivatives
    synthesis
    biological activity
    Opis:
    2,6-Naphthyridine is one of the six structural isomers of pyridopyridines. This review presents most of the literature data about natural and synthetic 2,6-naphthyridine derivatives and their biological activity. The main goal of this paper is to present various methods for the preparation of 2,6-naphthyridine analogues. Compounds containing 2,6-naphthyridine moiety can be synthesized from different substrates. Most of them have been obtained by cyclocondensation of various pyridine derivatives. During the past twenty years the biological activity of 2,6-naphthyridines have been studied. Presented compounds exhibit anticancer [21, 41], antihypertension [10], and antidepression [25] activity. Some of them can be used in the treatment of heart diseases [22], appetite disturbance, and obsessive states [43, 44]. 2,6-Naphthyridine derivatives with different molecular targets, e.g. topoisomerase [41], SERT [27], and protein kinases [21, 22] inhibitors have also been reported. Many of the 2,6-naphthyridine analogues are histamine H3 [27] and serotonine 5-HT2 [42–44] receptor antagonists.
    Źródło:
    Wiadomości Chemiczne; 2012, 66, 3-4; 297-318
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synteza i aktywność biologiczna pochodnych pirolo[2,3-d]pirydazyny
    Synthesis and biological activity of pyrrolo[2,3-d]pyridazine derivatives
    Autorzy:
    Redzicka, A.
    Tylińska, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/171583.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne pirolo[2,3-d]pirydazyny
    aktywność biologiczna
    synteza
    pyrrolo[2,3-d]pyridazine derivatives
    biological activity
    synthesis
    Opis:
    Pyrrolo[2,3-d]pyridazines are one of the four structural isomers of the bicyclic ring system containing pyrrole moiety condensed with a pyridazine ring. This review presents most of the literature data about synthetic pyrrolo[2,3-d]pyridazine derivatives and their biological activity. These 5,6-diazaindole analogues were first synthesized by Fischer et. al. in 1928. Compounds containing the pyrrolo[2,3-d] pyridazine scaffold can be synthesized from different substrates, but the syntheses may be classified into two main categories: annulation of pyrrole ring on to pyridazine derivatives or annulation of pyridazine ring on to pyrrole derivatives. Pyrrolo[2,3-d]pyridazine derivatives have attracted considerable interest, owing to diverse biological activities. Most of them have been studied as antitumor and antiviral. Pyrrolo[2,3-d]pyridazines can also be used as acid pump antagonist.
    Źródło:
    Wiadomości Chemiczne; 2016, 70, 3-4; 141-161
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Aktywność biologiczna pochodnych tiazolo[4,5-d]pirymidyny
    Biological activity of thiazolo[4,5-d]pyrimidine derivatives
    Autorzy:
    Becan, L.
    Powiązania:
    https://bibliotekanauki.pl/articles/171536.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne tiazolo[4,5-d]pirymidyny synteza
    aktywność biologiczna
    thiazolo[4,5-d]pyrimidine derivatives synthesis
    biological activity
    Opis:
    Thiazolo[4,5-d]pyrimidine is one of the six structural isomers of the bicyclic ring system containing thiazole moiety fused with the pyrimidine. There are six structural isomers depending on the position of the nitrogen atoms. The isomer [4,5-d] does not contain the bridge-head nitrogen and can be considered as 7-thio analogue of the natural purine bases such as guanine and adenine. Due to the great of their biological potential the newly synthesized compounds are evaluated for various pharmacological activities. This review presents numerous thiazolo[4,5-d]pyrimidine derivatives reported for their interesting biological activity including antibacterial [2, 3, 5, 7, 8, 10, 19], antifungal [2–6, 9, 10], antiviral [11–13], analgesic [18, 19], antidepressant [17] and anticancer properties [23–26]. Some urea and thiourea derivatives exhibited significant antiparkinsonian activity [14–16]. Tumor necrosis factor (TNF) promotes an inflammatory response, which in turn causes many of the clinical problems associated with autoimmune disorders. Ethyl 4-(2-amino-5,7-dioxo-3,4,5,7-tetrahydro-thiazolo[4,5-d]pyrimidin- 6(2H)-yl)butanoate derivatives 29 (Fig. 24) as a TNFα inhibitors have a potential use in the treatment of diseases such as refractory asthma, psoriasis, rheumatoid arthritis, irritable bowel syndrome, and other [21]. Blocade of the CXCR2 receptor by thiazolo[4,5-d]pyrimidine-2(3H)-ones also represents an attractive strategy for treatment of inflammatory diseases [20]. Recently there have been developed CX3CR1 receptor antagonists for the treatment of multiple sclerosis [22]. Isatoribine, 5-amino-3-β-D-ribofuranosyl-3H-thiazolo[4,5-d]pyrimidin-2-one (20) (Fig. 15) is a small molecule toll-like receptor 7 (TLR7) agonist and an activator of innate immunity. Its orally bioavailable analogue ANA 975 (Fig. 16) has been reported for probable use in treating disease states associated with abnormal cell growth, such as cancer and has anti HCV activity [13]. Thiazolo[4,5-d]pyrimidines inhibit the growth of the weeds which implies that they have a potential as herbicides [27].
    Źródło:
    Wiadomości Chemiczne; 2013, 67, 11-12; 1051-1074
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Syntezy wybranych, nowych pochodnych 2-amino-1H-benzimidazolu i ich mechanizmy działania biologicznego
    Synthesis of Selected, New 2-amino-1H-benzimidazole derivatives and Their mechanism of biological activity
    Autorzy:
    Nowicka, A.
    Nawrocka, W. P.
    Powiązania:
    https://bibliotekanauki.pl/articles/172102.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne 2-amino-1H-benzimidazolu
    syntezy
    aktywność biologiczna
    2-amino-1H-benzimidazole derivatives
    synthesis
    biological activity
    Opis:
    Many 2-amino-1H-benzimidazole drugs such as antihistaminic mizolastine and norastemizole or antiparasitic mebendazole, albendazole and thiabendazole have been used in clinic [1, 2]. Benomyl and its metabolite Carbendazim are both antifungal and anticancer drugs [4]. Recently, a lot of literature has revealed that 2-amino-1H-benzimidazole derivatives could effectively inhibit the growth of various microorganisms, what suggests that 2-aminobenzimidazole compounds should have large potential as a new type of antibacterial [15] and antifungal [18] agents. A number of 2-aminobenzimidazoles have exhibited antiproliferative in vitro properties [11]. Some new compounds, containing in theirs structures 2-aminobenzimidazole, show interesting and diverse cytotoxic mechanism of action, e.g. induce apoptosis of cancer cells [13]. Some of 2-aminobenzimidazole analogues are histamine and serotonin receptors antagonists [32]. 2-Aminobenzimidazoles derivatives have been frequently found to display a variety of biological activities like anti-inflammatory, antioxidant and anticoagulant [32] properties.
    Źródło:
    Wiadomości Chemiczne; 2013, 67, 3-4; 203-225
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synteza i aktywność biologiczna pochodnych pirolo [3,4-c]pirydyny
    Synthesis and biological activity of pyrrolo[3,4-c]pyridine derivatives
    Autorzy:
    Wójcicka, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/172668.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne pirolo[3,4-c]pirydyny
    synteza
    aktywność biologiczna
    pyrrolo[3,4-c]pyridine derivatives
    synthesis
    biological activity
    Opis:
    Pyrrolo[3,4-c]pyridine is one of the six structural isomers of the bicyclic ring system containing pyrrole moiety condensed with a pyridine nucleus. This review presents most of the literature data about synthetic pyrrolo[3,4-c]pyridine derivatives and their biological activity. S. Gabriel and J. Colman [4] discovered this isomer for the first time and named it “merimine” [Fig. 3]. The main goal of this study is the presentation of various methods for the preparation of pyrrolo[3,4-c]pyridine derivatives. Compounds containing the pyrrolo[3,4-c]pyridine scaffold can be synthesized from different substrates, but the syntheses may be classified into two main categories: annulation of pyrrole ring onto pyridine derivatives or annulation of pyridine ring onto pyrrole derivatives. Biological investigations have shown that pyrrolo[3,4-c]pyridine derivatives have a wide spectrum of actions. Most of them have been studied as analgesic and sedative agents [35–40]. Antitumor [19, 42, 45], antiviral [27], antituberculostatic [43] activities have been found. Pyrrolo[3,4-c]pyridine derivatives can also be used in the treatment of nervous [20, 41] and immune [19, 42] system diseases.
    Źródło:
    Wiadomości Chemiczne; 2013, 67, 3-4; 251-276
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Syntezy, struktury i aktywność biologiczna pochodnych imidazo[4,5-b] pirydyny. Część 1
    Synthesis, structures and biological activity of imidazo [4,5-b]pyridine derivatives. Part 1
    Autorzy:
    Liszkiewicz, H.
    Nowicka, A.
    Nawrocka, W. P.
    Powiązania:
    https://bibliotekanauki.pl/articles/171672.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne imidazo[4,5-b]pirydyny
    aktywność biologiczna
    synteza
    struktura
    imidazo[4,5-b]pyridine derivatives
    biological activity
    synthesis
    structure
    Opis:
    This review presents most of the literature data about imidazo[4,5-b]pyridine derivatives and their biological activity. The main goal of this paper is to present various methods for the preparation of imidazo[4,5-b]pyridine analogues. There are some drugs, imidazo[4,5-b]pyridine derivatives, registered in the world, which exhibit diverse pharmacological activities. Noberastine [4] represent antihistaminic II generation drug with selective activity to H1 receptors. Tenatoprazole [5] is a novel proton pump inhibitor with a prolonged plasma half-life which possesses antiulcer activity. Sulmazole [3] is a new cardiotonic agent, an A1 adenosine receptor antagonist. Based on the review of the chemical literature, derivatives of imidazole[4,5-b] pyridine showed a multipharmacological effects. Presented compounds exhibit anticancer [14, 17, 19], antidepressant [44, 45], cardiotonic, anticoagulant [37] activities. Some of them can be used in the treatment of heart diseases [3]. There were also described derivatives of imidazo[4,5-b]pyridine with the potential use in the treatment of diabetes [48], hypertension and hyperlipidemia. Some chemical compounds which contain in their structure the imidazo[4,5-b]pyridine system inhibit neurodegeneration [34, 38] and can be used in the treatment of neurodegenerative disorders eg. Parkinson’s disease, Alzheimer’s disease or multiple sclerosis. In addition, some of the imidazo[4,5-b]pyridine possess antivirial [40–42], antimicrobial and cytotoxic activities.
    Źródło:
    Wiadomości Chemiczne; 2012, 66, 11-12; 1071-1095
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Syntezy, struktury i aktywność biologiczna pochodnych imidazo[4,5-b] pirydyny. Część II
    Synthesis, structures and biological activity of imidazo[4,5-b]pyridine derivatives. Part 2
    Autorzy:
    Liszkiewicz, H.
    Nowicka, A.
    Nawrocka, W. P.
    Powiązania:
    https://bibliotekanauki.pl/articles/171764.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne imidazo[4,5-b]pirydyny
    aktywność biologiczna
    syntezy
    struktury
    imidazo[4,5-b]pyridine derivatives
    biological activity
    synthesis
    structures
    Opis:
    The main goal of this article is to present selected syntheses, structures and a various biological activity of imidazo[4,5-b]pyridine derivatives. During the past 20 years the biological activity of imidazo[4,5-b]pyridine have been intensively studied. Based on the review of the chemical literature, it was shown that derivatives of imidazole[4,5-b]pyridine showed a multipharmacological effects such as antibacterial effect [20–22] and antituberculotic activity [25–33], nonsteroidal antiinflammatory activity [35–43] and analgesic [44, 45] effect. Among compounds of this class antagonists of angiotensin II receptors that exhibit hypotensive activity are also known [9–11]. Compounds containing imidazo[4,5-b]pyridine moiety can be synthesized from different substrates. The most useful starting compounds for the synthesis of imidazo[4,5-b]pyridine are derivatives of 2,3-diaminopyridine [1–3].
    Źródło:
    Wiadomości Chemiczne; 2013, 67, 3-4; 227-250
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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