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    Wyświetlanie 1-7 z 7
    Tytuł:
    Evaluation of neutrophil phagocytic, complement functions, and cytokines expression among diabetic patients in Abuja, Nigeria
    Autorzy:
    Babandina, Musa Muhammad
    Mainasara, Abdullahi Suleiman
    Bakare, Mustapha
    Emeribe, Anthony Uchenna
    Shuwa, Halima Ali
    Haruna, Shamsuddeen
    Muhammad, Aminu Said
    Abdullahi, Idris Nasir
    Powiązania:
    https://bibliotekanauki.pl/articles/454973.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    diabetes mellitus
    effector molecules
    pro-inflammatory markers
    Opis:
    Introduction. Inflammatory response in Diabetes Mellitus (DM) begins with chronic sub-clinical inflammations as a result of insulin resistance and activation of both innate and adaptive immune system as the disease progresses to complicated diabetes. Hence, the present study investigated the neutrophil phagocytic, complement function (CH50), and some cytokine profiles among diabetic and non-diabetic patients attending the National Hospital in Abuja, Nigeria. Aim. To evaluate the neutrophil phagocytic, complement function (CH50), and some cytokine profiles among post-operative septic diabetic and post-operative septic non-diabetic patients at the National Hospital in Abuja, Nigeria. Material and methods. Subjects were recruited by convenient sampling technique through interviewer-administered questionnaires. Subsequently, blood samples were collected. Fasting blood sugar (FBS) (mmol/L) was determined using glucose oxidase method. Neutrophil function test (Fmol/phag) was assayed using nitroblue tetrazolium reduction test (NBT). Hemolytic complement function (CH 50) test was conducted using serum harvested from sheep sensitized with human group (ORh D +ve) red blood cells. While serum Interleukin-4, -6, -10 and TNF- α were determined using Enzyme Linked Immunosorbent Assay (ELISA). Results. Mean ± Standard deviation (SD) of FBS concentration of 10.5 ± 1.3 (mmol/|L) among diabetic and 4.7 ± 0.9 (mmol/L) among non-diabetics was recorded. There is a decrease in neutrophil phagocytic function with a mean ± SD of 5.4 ± 2.1 (Fmol/ phag) in diabetics compared to 9.2 ± 2.1 (Fmol/phag) in non-diabetics. Similarly, complement (CH 50) function and C-reactive protein were significantly lower in diabetics when compared to non-diabetics (p<0.001). There was a significant difference in IL-6 concentration between diabetics and non-diabetics groups, but no significant difference was observed in TNF-α, IL-4 and IL-10 concentrations between study groups (p>0.05). TNF-α and IL-6 was significantly higher in diabetics with cardiovascular disorders compared to non-diabetics subjects with cardiovascular disorders (p<0.001). Conclusion. Findings from this study revealed the association of complement, neutrophil phagocytic function, CRP and IL-6 among septic diabetic patients,. In addition TNF-α and IL-6 expression was higher in DM patients with cardiovascular disorders.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 3; 229-235
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Infuence of HbA1c, serum lipids, blood pressure and BMI on Auditory Brainstem Response in diabetic patients
    Autorzy:
    Dąbrowski, Mariusz
    Mielnik-Niedzielska, Grażyna
    Nowakowski, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/454729.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    auditory brainstem response diabetes mellitus
    serum lipids
    Opis:
    Introduction. Impaired hearing organ function including abnormalities in auditory brainstem response (ABR) are more frequent in diabetic subjects compared to the general population. The aim of our study was to assess the impact of selected modifiable factors on ABR latencies in diabetic subjects. Material and Methods. 58 patients with type 1 and type 2 diabetes, aged <45 years, with diabetes duration <10 years, and without clinically overt hearing impairment or diabetic neuropathy, were included. In all subjects vital signs and blood samples were obtained, and ABR audiometry was performed. Results. Significantly delayed latencies in ABR were found in patients with total cholesterol <192 mg/dL, with HDL-cholesterol <49.5 mg/dL, with triglycerides >89 mg/dL, with presence of hypertension, and with systolic and diastolic blood pressure >135 and >78 mm Hg respectively. A linear correlation between triglycerides and wave I and III latencies, and between systolic blood pressure and wave III latency were revealed. A relationship between ABR latencies and HbA1c, LDL-cholesterol or BMI was not found. Conclusions. Several modifiable factors affect functioning of the retrocochlear part of the auditory pathway. If these results were confirmed in further studies, a vast area of possible therapeutic interventions to preserve hearing function in diabetic patients would become available.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 3; 185-191
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Stigma and its relationship with life satisfaction in patients with type 2 diabetes mellitus
    Autorzy:
    Turen, Sevda
    Yurtsever, Melike
    Powiązania:
    https://bibliotekanauki.pl/articles/40418503.pdf
    Data publikacji:
    2024-03-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    life satisfaction
    stigma
    type 2 diabetes mellitus
    Opis:
    Introduction and aim. This study aims to determine the level of stigma in patients with type 2 diabetes mellitus (T2DM) and evaluate its relationship with their life satisfaction. Material and methods. This is a descriptive and cross-sectional study conducted in a single tertiary care center. Two hundred and ten patients ≥18 years old diagnosed with T2DM were included in this study. The relationship between the “Type 2 diabetes stigma assessment scale” and the “Satisfaction with life scale” was assessed using Pearson correlation analysis. Results. The average age of the participants was 54.85±15.81 years. The majority of patients reported adherence to diabetes treatment and having comorbidities. Stigma levels were higher in patients ≤65 years, those with less than a high school education, and those receiving insulin or oral anti-diabetic treatment, but lower with a T2DM diagnosis duration of ≤ 5 years (p<0.05). Life satisfaction was influenced by age, education status, economic status, adherence to treatment, dietary compliance, and the presence of comorbidities. A moderately negative relationship between stigma level and life satisfaction was identified. Conclusion. The study’s results indicate that an increase in stigma level is associated with a decrease in life satisfaction in patients with type 2 diabetes mellitus.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2024, 22, 1; 128-133
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prevalence of depression in Indian patients with type 2 diabetes mellitus and/or hypertension: DEPTH Study
    Autorzy:
    Lalwani, Raj Kumar
    Shah, Jayesh Dashrathlal
    Chatterjea, Tapas
    Nadakuduru, Papa Rao
    Erande, Suhas
    Powiązania:
    https://bibliotekanauki.pl/articles/454720.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    comorbidity
    diabetes
    depression
    hypertension prevalence
    type 2 diabetes mellitus
    Opis:
    ABSTRACT Introduction. Depression, a common psychiatric mood disorder, is a leading cause of disability and a significant contributor to the overall global burden of disease. Aim. To determine the prevalence of depression in patients with controlled and uncontrolled type-2 diabetes mellitus (T2DM) and/or hypertension (HTN) in India. The association of depression with socio-demographic profile and clinical risk factors was also assessed. Material and methods. In this cross-sectional epidemiological study, T2DM and/or HTN patients attending outpatient department at tertiary care hospitals and private clinics across 54 cities in India were enrolled. The primary outcome measure was to determine the prevalence of depression in T2DM, HTN and T2DM + HTN patients. Association of depression with patients’ demography, socio-economic status, anxiety, and clinically diagnosed insomnia were also investigated. Results. Of 1829 patients, the prevalence of depression in T2DM, HTN and T2DM+HTN cases were found to be 51.03%, 46.94% and 48.64%, respectively. A higher proportion of patients with uncontrolled T2DM and HTN reported depression (T2DM: 77.64% vs. 22.36%; HTN: 72.49% vs. 27.51%). There was a significant association between anxiety and severity of depression across all indications (p<0.0001). Depression was significantly associated with complications in T2DM (p=0.0001) and comorbidities in T2DM + HTN (p=0.0023) cases. Conclusion. Depression is highly prevalent and has a direct significant association with various socio-demographic variables and anxiety in Indian patients with T2DM and/or HTN.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 4; 315-325
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The effect of diabetes on the connective tissue and the bone-joint system
    Autorzy:
    Chwalba, Artur
    Otto-Buczkowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/454871.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    diabetes mellitus
    diabetic osteopathy
    limited joint mobility
    joint disorders
    Opis:
    Introduction. Diabetes is associated with a number of complications, including renal disease, peripheral neuropathy, retinopathy, and vascular events. Aim. Article presents the research results reported in the scientific literature about the influence of diabetes on connective tissue and the bone-joint system. Material and methods. Analysis of literature. Conclusion. Due to its multi-systemic nature, the development of additional manifestations, such as musculoskeletal complications, is possible including, for example diabetic osteopathy, limited joint mobility, joint disorders, and other, many of which are subclinical and correlated with the disease duration and its inadequate control. They should be recognized and treated properly, because their management improves the patients’ quality of life.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 3; 233-238
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Brazilians living with diabetes do not meet basic physical activity guidelines for health – a cross-sectional study
    Autorzy:
    Ferrari de Lima, Dartel
    Anguera Lima, Lohran
    Cristina de Souza, Dayane
    Aparecido Sampaio, Adelar
    Machado, Daiana
    Powiązania:
    https://bibliotekanauki.pl/articles/40570867.pdf
    Data publikacji:
    2024-06-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    diabetes mellitus
    exercise
    health promotion
    preventive medicine
    public health
    Opis:
    Introduction and aim. The purpose of this study was to describe the profile of physical activity (PA) of Brazilian adults living with diabetes mellitus living in large Brazilian urban centers, as well as to determine whether the practice aligns with the physical activity guidelines recommended for people with diabetes. Material and methods. Cross-sectional data were acquired from the 2020 Surveillance System for Risk and Protective Factors for Chronic Non-communicable Diseases, in which about 54,000 persons aged 18 and older in all Brazilian state capitals were contacted in a telephone survey. Participants reported on their engagement in recreational physical activity and active commuting to school and/or work in the three months preceding the interview, as well as the weekly frequency and duration of these activities. They also stated whether they were living with diabetes. A descriptive analysis was performed, and statistical significance was determined using Pearson’s chi-squared test. Results. In 2020, 7.9% of the population identified themselves living with diabetes. There was a greater frequency among older women and those with less education. Walking, water aerobics, and general gymnastics were the most common kinds of physical activity reported by people with diabetes. Moreover, over half of them (54.5%) were inactive, and 15% matched the physical activity criteria. The majority (90%) practiced PA for 30 minutes or more per day, while 87% of those who were active and exercised 1 to 2 times per week did not meet the requirements of the Ministry of Health. Conclusion. In 2020, 7.9% of the population identified themselves as having diabetes. There was a higher frequency among older women and those with less schooling. In the sample as a whole, approximately 70% of people living with diabetes were inactive (54.5%) or did not meet the minimum BP recommendations for people with diabetes. The duration of each session seemed to be in line with the recommendations, however, the lack of regularity caused by the low weekly frequency meant that the minimum recommended target could not be achieved. Efforts involving the continued monitoring of people living with diabetes and counseling in Primary Health Care to opt for a more physically active life, seem to be promising acts for a healthier life, pending a definitive resolution to the disease.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2024, 22, 2; 396-403
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Vitamin D deficiency as a risk factor of type 2 diabetes in children and adolescents
    Niski poziom witaminy D u dzieci i młodzieży jako czynnik sprzyjający rozwojowi cukrzycy typu 2
    Autorzy:
    Sobek, Grzegorz
    Mazur, Artur
    Powiązania:
    https://bibliotekanauki.pl/articles/437664.pdf
    Data publikacji:
    2014
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    diabetes mellitus type 2
    obesity abdominal
    vitamin D deficiency
    cukrzyca typu 2
    otyłość brzuszna
    niedobór witaminy D
    Opis:
    Obesity is a global problem, more and more children have a weight above the norm. Obesity is related to circulatory system and metabolic disorders. Relations between obesity and metabolic disorders are known, however factors affecting the risk of such syndromes may extend beyond mentioned relations. Existence of vitamin D receptors in many of body cells, especially in pancreas islets of Langerhans indicates the possibility of significant role played by vitamin D in glucose homeostasis. Several epidemiological studies have reported that low 25-hydroxy vitamin D levels, the most common vitamin D indicator in plasma, very frequent in obese children, is correlated with insulin resistance. Moreover, mechanism of vitamin D is associated both with calcium level in tissues, that regulate insulin synthesis and insulin secretion, and direct secretion of pancreatic beta cells. Parathormone PTH, often defined as obesity indicator, is also crucial. Its high level indicates the risk of metabolic disorders. There is no doubt that reducing of body mass together with complementation of vitamin D insufficiency is the best solution for obese children to decrease the risk of incidence and limit the consequences of type 2 diabetes, one of most common civilization disease.
    Otyłość jest problemem na poziomie globalnym i dotyczy w coraz większym stopniu dzieci. Prowadzi do wielu chorób, w tym głównie związanych z układem krążenia i zaburzeniami metabolicznymi. Zależności pomiędzy otyłością a chorobami metabolicznymi są powszechnie znane, jednak okazuje się, że czynniki wpływające na ryzyko zachorowalności mogą wykraczać poza wspomniane zależności. Obecność receptorów witaminy D w wielu komórkach ciała, w tym w obszarze trzustkowych wysp Langerhansa, wskazuje na możliwą istotną rolę tej witaminy w przemianach, które warunkują zachowanie właściwej glikemii. Wiele badań wskazuje, że niski poziom 25 hydroksywitaminy D, często spotykany u dzieci z nadwagą, jest skorelowany ze zwiększoną insulinoopornością. Mechanizm działania witaminy D jest nie tylko związany z regulacją poziomu wapnia w tkankach, ale także wiąże się z bezpośrednim wydzielniczym działaniem trzustkowych komórek beta, czyli regulacją syntezy i sekrecji insuliny. Nie bez znaczenia jest stężenie parathormonu PTH, często nazywanego wyznacznikiem otyłości, którego wysoki poziom świadczy o możliwym ryzyku zachorowania na choroby metaboliczne. Wątpliwości nie budzi fakt, iż obniżenie masy ciała wraz z uzupełnieniem niedoborów witaminy D u dzieci otyłych jest właściwym sposobem zminimalizowania ryzyka zachorowania lub ograniczenia skutków jednej z najczęstszych chorób cywilizacyjnych naszych czasów, cukrzycy typu 2.
    Źródło:
    Medical Review; 2014, 3; 289-293
    2450-6761
    Pojawia się w:
    Medical Review
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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