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    Wyświetlanie 1-5 z 5
    Tytuł:
    Synthesis, characterization and antifungal activity of some fluorine containing 1,3,5-trisubstituted pyrazoline derivatives
    Autorzy:
    Manivannan, C.
    Santhi, N.
    Powiązania:
    https://bibliotekanauki.pl/articles/1118150.pdf
    Data publikacji:
    2017
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    antifungal activity
    chalcone
    disc diffusion method
    pyrazoline
    ultrasonic irradiation
    Opis:
    A series of (E)-1-(4-fluorophenyl)-3-substitutedphenylprop-2-en-1-one (3-7) were ultrasonically prepared by the reaction of 4-fluoroacetophenone with different aromatic aldehydes in the presence of alkali . Reaction of the prepared chalcones (3-7) with 3,4,5-trimethoxybenzohydrazide (8) afforded the corresponding substituted pyrazoline (9-13). Ultrasonic irradiation method provides several advantages over current reaction methodologies, including a simple work-up procedure, shorter reaction times and good yields. All the prepared compounds have been characterized by FT-IR and 1H-NMR spectra. These compounds were screened for their antifungal activity using disc diffusion method. Compound 10 and 11 was found to exhibit the most potent in-vitro anti-fungal activity with against all the fungal strains.
    Źródło:
    World News of Natural Sciences; 2017, 10; 86-94
    2543-5426
    Pojawia się w:
    World News of Natural Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synthesis, characterization and biological activities of some azetidin-2-one as potential antifungal agents
    Autorzy:
    Sulthana, R. Munavar
    Quine, S. Darlin
    Powiązania:
    https://bibliotekanauki.pl/articles/1157576.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    2-azetidinone
    Antifungal activity
    Hydrazone
    disc diffusion
    spectral studies
    Opis:
    A new series of 2-azetidinone compounds 5(a-g) were synthesized. The structures of all the synthesized compounds were confirmed by chemical and spectral analyses such as IR, 1H NMR and 13C NMR. The compounds were screened for their antimicrobial activity against Aspergillus flavus, Aspergillus niger, Penicillim chryogenum, Trigoderma veride & Fusarium oxysporum and the zone of inhibition was determined by disc diffusion technique. All the synthesized compounds exhibited promising antidungal activity against the studied set of microorganisms. However, the activity was less than that of standard drugs used in this study.
    Źródło:
    World Scientific News; 2018, 92, 2; 247-259
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The evaluation of the in-vitro antimicrobial activity of Alangium salvifolium (Linn)
    Autorzy:
    Khan, Mohammad Nadeem
    Powiązania:
    https://bibliotekanauki.pl/articles/1109620.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Alangium salvifolium
    Antimicrobial activity
    disc diffusion
    secondary metabolites
    soxhelt apparatus
    Opis:
    Finding healing power in plants is an ancient idea, and people of all continents and civilization have been using plants in one form or the other for poultices or as decoctions. Alangium salvifolium (Linn), family Alangeaceae, is a tree that grows in the wild throughout India. The plant has been used in the Indian traditional system of medicine for skin diseases (e.g. leucoderma), articular diseases, and anti-inflammation, anti-poisonous, anti-pyretic, and anti-emetic requirements. However, no scientific evidence is available regarding its antimicrobial activity. An investigation of Alangium salvifolium as an antimicrobial activity agent is the objective of our present study. The ATCC culture used in this study was collected from department of Microbiology, G.M.C., Bhopal (M.P.). Shade dried crude powder (200 grams) of seed of Alangium salvifolium was separately extracted with methanol in a soxhelt apparatus. The Antimicrobial activities were then studied by applying the Disc–Diffusion method. Our results indicate that the observed antimicrobial activity of the fraction appears to be due to unknown secondary metabolites in it. H.P.L.C. (high performance liquid chromatography) and chemical studies may, thus be useful in analyzing the presence of unknown secondary metabolites in the fractions.
    Źródło:
    World News of Natural Sciences; 2018, 20; 176-181
    2543-5426
    Pojawia się w:
    World News of Natural Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Bioactive 3-methyl-2,6-diarylpiperidin-4-one, oxime and its copper(II) complex
    Autorzy:
    Thirunarayanan, G.
    Lakshmanan, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/1070862.pdf
    Data publikacji:
    2019
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Antimicrobial activities
    Copper(II) complex
    Disc diffusion
    Drug dilution
    Piperidine-4-one
    Piperidine-4-oneoxime
    Opis:
    namely 3-methyl-2,6-diphenylpiperidin-4-oneoxime and copper(II) complex of this oxime was prepared by literature procedure. The purities of these ketone, oxime and copper complex was analyzed by physico-chemical and spectroscopic methods reported in the literature. The physicochemical analysis results confirmed that the structure of the complex was distorted octahedral. The antimicrobial activities of these substrates such as ketone, oxime and its copper complex were investigated using Bauer-Kirby disc diffusion technique against several antimicrobes by measuring the mm of zones of inhibitions. Further these activities were concluded using drug dilution method. From the analysis report, the copper (II) complex of the oxime shows significant antimicrobial activities against their antimicrobial stains. The oxime shows moderate antimicrobial activity. The ketone shows satisfactory antibacterial and antifungal activities against their stains in both disc diffusion and drug dilution methods.
    Źródło:
    World Scientific News; 2019, 123; 124-140
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Screening for ESβL producing E. coli isolated from clinical urine samples collected from different places of Kalaburagi city
    Autorzy:
    Ramachar, Raghavendra
    Gaddad, Subhashchandra M.
    Shivannavar, Channappa T.
    Powiązania:
    https://bibliotekanauki.pl/articles/1177430.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Antibiogram
    Double-disc diffusion test
    ESβL
    Green Metallic Sheen
    Phenotypic detection
    Uropathogenic E. coli
    Opis:
    Bacteria are capable of invading and infecting humans, leading to disease and sometimes death. Different body tissues, organs and systems are vulnerable to different organisms. This study was aimed to isolate and identify the bacteria causing Urinary Tract Infection (UTI) in different age groups and also screened for ESβL production. The mid-stream urine samples showing symptoms of urinary tract infections were collected in a wide container from different hospitals and diagnostic centres of Kalaburagi city. The isolation of uropathogen was done by semi-quantitative method of inoculating the samples on the selective and differential media such as Eosin Methylene Blue (EMB) and MacConkey (MAC) agar media respectively. The isolated pathogen was identified by conventional methods like cultural, morphological and biochemical tests. The antibiotic susceptibility test was carried out by Kirby-Bauer disc diffusion technique and ESβL production by double disk-diffusion test (DDDT) as per CLSI guidelines (2013). Out of 550 samples screened, a total of 288 bacteria were isolated of those half of them (146) were E. coli isolates and all were found to be multidrug resistant and half of them (50%) were of ESβL producers. All ESβL producing E. coli isolates were resistant to ceftazidime and exhibited higher level of resistance to Cephalothin, Erythromycin, Cotrimoxazole and Aztreonam. As ESβL producing organisms limits the available treatment options, so, the timely administration of sensitive antibiotic and avoiding antibiotic abuse will help in curing the disease without going for the costly drugs such as Carbapenems. Our study revealed that nitrofurantoin, ofloxacin and cefoxitin may be considered as drug of choice for the treatment of UTI patients. The ESβL production in uropathogens should be continuously monitored in the clinics and hospitals as to avoid the emergence of more multi drug resistance strains.
    Źródło:
    World Scientific News; 2018, 103; 107-118
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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