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Wyświetlanie 1-15 z 19
Tytuł:
Synthesis and in vitro antibacterial and antifungal evaluation of quinoline analogue azetidin and thiazolidin derivatives
Autorzy:
Prajapati, S. M
Vekariya, R. H.
Patel, K. D.
Panchal, S. N.
Patel, H. D.
Rajani, D. P.
Rajani, S.
Powiązania:
https://bibliotekanauki.pl/articles/412324.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
antibacterial
antifungal
quinoline
azetidin derivatives
thiazolidin derivatives
Opis:
A library of quinoline analog two novel series of azetidin (SH1-5) and thiazolidin (SHa-e) derivatives were designed and synthesized with simple and eco-friendly methodologies. The structures of the compounds were elucidated with the aid of elemental analysis, IR, 1H-NMR and mass spectral data. These novel synthesized compounds were evaluated for antibacterial activity against two gram-positive bacteria (Staphylococcus aureus, Staphylococcus pyogenus) and two gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli). The title compounds were also studied for their antifungal activity with Candida albicans, Aspergillus niger, Aspergillus clavatus using the broth dilution technique. Most of the compounds were the best bio-active desired antibacterial analog with less MIC value against different tested strains.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 20, 2; 195-210
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Green synthesis of pyrimidine derivative
Autorzy:
Sonawane, R. P.
Powiązania:
https://bibliotekanauki.pl/articles/412470.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
dihydropyrimidine derivatives
Biginelli reaction
Grindstone chemistry
Opis:
The majority of the drugs on the market today are entirely chemically synthesized in the laboratory. Several scientists had synthesized dihydropyrimidine (DHPMs) derivatives showing a wide spectrum of biological actions as antibacterials, antivirals as well as antitumor agents. This activity is principally due to presence of steriogenic carbon C4 in their structure. The current investigation is study and synthesis of dihydropyrimidinones efficiently and in high yields under mild, solvent free and eco-friendly conditions by using “Grindstone Chemistry Technique” catalyzed by CuCl2•2H2O and Conc. HCl. The obtained products have been identified by comparison with spectral data & their melting points. The synthesis of DHPMs derivative involves a multicomponent reaction (aldehyde derivative, urea /thiourea and 1,3-dicarbonyl compounds) in presence of HCl / NH4Cl as a catalyst. 3,4-dihydropyrimidin-2-(1H)-ones was synthesized and characterized using IR. The melting points was obtained 203 °C.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 2; 64-68
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparative Study of Chemical Synthesis of Pyrimidine Derivatives by Using Grindstone Chemistry Technique and Conventional Metod
Autorzy:
Sonawane, R. P.
Powiązania:
https://bibliotekanauki.pl/articles/412505.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
dihydropyrimidine derivatives
Biginelli reaction
Grindstone chemistry
Opis:
The majority of the drugs on the market today are entirely chemically synthesized in the laboratory. Several scientists had synthesized dihydropyrimidine (DHPMs) derivatives showing a wide spectrum of biological actions as antibacterials, antivirals as well as antitumor agents. This activity is principally due to presence of steriogenic carbon C4 in their structure. The current investigation is comparative study of chemically synthesis of two DHPMs derivatives by Biginelli Reaction using conventional method and grindstone chemistry technique. The synthesis of DHPMs derivative involves a multicomponent reaction (aldehyde derivative, urea /thiourea and 1,3-dicarbonyl compounds) in presence of HCl / NH4Cl as a catalyst. Two derivative viz. 3,4-dihydropyrimidin-2-(1H)-ones and 3,4-dihydropyrimidin-2-(1H)-thiones were synthesized and characterized using IR. The melting points were obtained are 208 °C and 210 °C respectively. “Grindstone Chemistry Technique” catalyzed by CuCl2•2H2O and Conc. HCl. gave more yield, solvent free and ecofriendly. The obtained products have been identified by comparison with spectral data & their melting points. This study will help to develop easy protocol for the synthesis of many more DHPMs derivative with high field.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 14, 1; 22-27
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and characterization of transition metal complexes of some novel pyrazolo-chalcone derivatives
Autorzy:
Odedra, Pratap
Rojivadiya, A. J.
Powiązania:
https://bibliotekanauki.pl/articles/1066234.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Pyrazolochalcone derivatives
Thermal gravimetric analysis
Transition metal complexes
Opis:
Some novel pyrazolo-chalcone molecules were synthesized by condensation of pyrzolo aldehyde with appropriate acetophenone. The synthesis of some metal complexes of transition metal was carried out with these pyrazoleo heterocyclic compounds. Each metal complex was synthesized by the reaction of new pyrazolochalcone derivatives with the metal salts such as Co(CH3COO)2·6H2O, Ni(CH3COO)2·6H2O, and Cu(CH3COO)2·2H2O. For the structure elucidation of ligand molecule various spectroscopic techniques such as 1H NMR, IR and mass has been used. The synthesized metal complexes were subjected to thermal study i.e., TGA and DTA in order to check structural conformation of synthesized metal complexes.
Źródło:
World Scientific News; 2019, 131; 242-255
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparative study of chemical synthesis of dihydropyrimidine (DHPMS) derivatives by Biginelli Reaction using microwave irradiation and conventional method
Autorzy:
Sonawane, R.P.
Powiązania:
https://bibliotekanauki.pl/articles/411784.pdf
Data publikacji:
2013
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
dihydropyrimidine derivatives
Biginelli reaction
microwave irradiation
conventional method
Opis:
The majority of the drugs on the market today are entirely chemically synthesized in the laboratory. Several scientists had synthesized dihydropyrimidine (DHPMs) derivatives showing a wide spectrum of biological actions as antibacterials, antivirals as well as antitumor agents. This activity is principally due to presence of steriogenic carbon C4 in their structure. The current investigation is comparative study of chemically synthesis of two DHPMs derivatives by Biginelli Reaction using microwave irradiation and conventional method. The synthesis of DHPMs derivative involves a multicomponent reaction (aldehyde derivative, urea /thiourea and 1,3-dicarbonyl compounds) in presence of HCl / NH4Cl as a catalyst. Two derivative viz. 3,4-dihydropyrimidin-2-(1H)-ones and 3,4-dihydropyrimidin-2-(1H)-thiones were synthesized and characterized using IR. The melting points were obtained are 203 °C and 211 °C respectively. Microwave irradiation was easy and gave more yield than conventional method. This study will help to develop easy protocol for the synthesis of many more DHPMs derivative with high yield.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2013, 5; 7-11
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Acoustical studies of some derivatives of 1,5-benzodiazepines at 298.15 K
Autorzy:
Baluja, S.
Godvani, N.
Powiązania:
https://bibliotekanauki.pl/articles/411868.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
benzodiazepine derivatives
ultrasonic Study
acoustical parameters
DMF
THF
Opis:
Some new derivatives of 1,5-Benzodiazepines have been synthesized and their structural characterizations are done by IR, NMR and Mass Spectral data. The ultrasonic velocity, density and viscosity of these synthesized compounds have been measured in dimethyl formamide and tetrahydrofuran at 298.15 K. From these experimental data, some acoustical parameters such as isentropic compressibility, intermolecular free path length, Rao’s molar sound function, relaxation strength, solvation number etc., have been calculated which helps in understanding the molecular interactions occurring in these solutions.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 19, 2; 132-142
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and thermal decomposition study of some dihydropyridine derivatives
Autorzy:
Baluja, Shipra
Talaviya, Rahul
Powiązania:
https://bibliotekanauki.pl/articles/1192993.pdf
Data publikacji:
2016
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
differential scanning calorimetry
dihydropyridine derivatives
thermo gravimetric analysis
Opis:
Some new dihydropyridine derivatives have been synthesized and their characterization was done by FT-IR, 1H NMR and Mass spectral data. Thermal analysis of these dihydropyridine derivatives have been carried out by thermao gravimetric (TG), differential thermal analysis (DTA) and differential scanning calorimetry (DSC) techniques. Further, from thermograms of these compounds, various kinetic parameters such as order of reaction (n), energy of activation (E), frequency factor (A) and entropy change (∆S) have been evaluated. The obtained results indicates that thermal stability of dihydropyridine derivatives have been depend on the type of substituent present in the compounds.
Źródło:
World Scientific News; 2016, 39; 1-16
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and antimicrobial activity of coumarinyl Schiff base derivatives
Autorzy:
Mishra, A.
Rathod, J.
Namera, D.
Thakrar, S.
Shah, A.
Powiązania:
https://bibliotekanauki.pl/articles/411623.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
gram positive bacterial
gram negative bacterial
derivatives of coumarin
Opis:
We have reported some novel N’-[(1)-ethylidene]-2-(6-methyl-2-oxo-2H-chromen-4-yl) acetohydrazide synthesized by conventional method. The reaction of 2-(6-methyl-2-oxo-2H-chromen-4-yl)acetohydrazide with substituted benzaldehyde in methanol as a solvent yielded a series of (7a-l). The structures of all synthesized compounds are well characterized by Mass, FT-IR, 1H NMR, 13C NMR and elemental analysis. Moreover, all synthesized compounds were screened for in vitro antimicrobial activity against the gram positive (Staphylococcus aureus, Bacilluas subtilis) and gram negative (Escherichia coli, P. aeruginosa, K. pneunonae, Enterobacter) bacterial strain. In which some the compounds show potential inhibition against the test organisms.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 11, 3; 193-201
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ultrasonic velocity, density and viscosity measurement of pyrimidine derivatives in 1,4-dioxane and DMF at various temperatures
Autorzy:
Baluja, Shipra
Nandha, Kajal
Ramavat, Paras
Powiązania:
https://bibliotekanauki.pl/articles/1190220.pdf
Data publikacji:
2016
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Pyrimidine derivatives
ultrasonic velocity
viscometry
molecular interaction
apparent molar compressibility
Opis:
The estimation of density, viscosity and ultrasonic velocity of solution of pyrimidine derivatives in 1,4-dioxane and N,N-dimethylformamide was carried out as functions of concentration (0.01 to 0.1 M) and temperature (298.15 to 318.15 K). Some acoustical and apparent parameters such as acoustical impedance (Z), intermolecular free length (Lf), adiabatic compressibility (κs), molar compressibility (W), Vander Waals constant (b), relaxation strength (r), internal pressure (π), apparent molar compressibility (fk), apparent molar volume (fv) etc., have been evaluated using experimental data of ultrasonic velocity (U), density (ρ) and viscosity (η). The characterization of these synthesized compounds was done by IR, 1H NMR and mass spectral data.
Źródło:
World Scientific News; 2016, 44; 257-278
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Highly efficient and eco-friendly one-pot synthesis of penta substitute pyrrole derivatives under catalyst-free conditions
Autorzy:
Viradiya, D. J.
Baria, B. H.
Kakadiya, R.
Kotadiya, V. C.
Shah, A.
Powiązania:
https://bibliotekanauki.pl/articles/412605.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
one-pot synthesis
penta-substituted pyrrole derivatives
multi-component reactions
Opis:
An eco-friendly and efficient one-pot synthesis of penta-substituted pyrrole derivatives via a four-component reaction of maldrum’s acid, arylglyoxal monohydrate, dimethyl but-2-yne-dioate and amines under catalyst-free conditions in an environmentally friendly medium is described. The simple experimental procedure, catalyst-free reaction conditions, short period of conversion, and excellent yields are the advantages of the present method. Good chemical yields have been achieved without the need for chromatography and recrystallization or other purification methods.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 11, 3; 257-264
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of temperature on thermo-physical properties of pyrazolo quinazoline derivatives by ultrasonic studies
Autorzy:
Baluja, Shipra
Ramavat, Paras
Nandha, Kajal
Powiązania:
https://bibliotekanauki.pl/articles/1192659.pdf
Data publikacji:
2016
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
pyrazolo quinazoline derivatives
Acoustical parameter
Molecular interactions
Density
apparent molar compressibility
Opis:
Density (ρ), Sound velocity (U) and viscosity (ɳ) of pure solvent N,N-dimethylformamide (DMF) and solutions of pyrazolo quinazoline derivatives in DMF were taken at different concentration range and at different temperatures by using Antone paar. From these experimental data, some acoustical parameters such as adiabatic compressibility (κs), intermolecular free length (Lf), solvation number (Sn), apparent molar compressibility (fk), apparent molar volume (fv), internal pressure (π) etc., have been determined and correlated with the concentration (C).With concentration and temperatures, Linear or non-linear increases or decreases of acoustical parameters shows the existence of strong molecular interactions between solute and solvent. The results are interpreted in terms of solute-solute and solute-solvent interactions to understand the behavior of synthesized compounds in solutions.
Źródło:
World Scientific News; 2016, 47, 2; 89-111
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis of thiazolylazomethine substituted pyrazole derivative using conventional and one pot multicomponent synthetic routes
Autorzy:
Ladwa, Paresh
Dhuda, Gautamkumar
Godhaniya, Bhavna
Modha, J. J.
Powiązania:
https://bibliotekanauki.pl/articles/1058101.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Catalyst free
DMFDMA
Multi component reaction
Pyrazole
Thiazole
Thiazolo-Pyrazole - derivatives
Opis:
Knowing the importance of thiazole and pyrazole ring systems in various useful natural products and based on the reported biological activities of the synthetic derivatives of these ring system containing compounds against different types of microbes, we have synthesized novel thiazolo - pyrazole derivatives by one pot multi component catalyst free synthetic method. The product yields have been optimized by varying the reaction parameters which includes use of different solvents and temperature. Synthesised compounds were characterised by different spectoscopic method such as 1H NMR, IR and Mass.
Źródło:
World Scientific News; 2019, 134, 2; 242-257
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Solubility of pyrimidine derivatives in different organic solvents at different temperatures
Autorzy:
Baluja, Shipra
Powiązania:
https://bibliotekanauki.pl/articles/1190176.pdf
Data publikacji:
2016
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
pyrimidine derivatives
Apelblat equation
Buchowski-Ksiazack λh equation
Gibb׳s energy
Opis:
The objective of this study was to measure and correlate the solubility of pyrimidine derivatives in five different solvents namely chloroform, N,N-dimethylformamide, tetrahydrofuran, 1,4-dioxane and ethyl acetate from 298.15 to 328.15 K under atmospheric pressure of 0.1 MPa using gravimetric method. The characterization of all the synthesized compounds was done by IR, NMR and mass spectra. The modified Apelblat and Buchowski-Ksiazczak λh equations were used to correlate the experimental solubility data. Using Van’t Hoff and Gibb’s equations, some thermodynamic parameters such as Gibb’s free energy, enthalpy and entropy of dissolution were evaluated from solubility data. It is found that solubility increases with temperature.
Źródło:
World Scientific News; 2016, 44; 13-34
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analytical Cartesian coordinate solutions of Laplace equations by separation of variable method in mathematical physics
Autorzy:
Madububa, B. I.
Mbagwu, JP. C.
Jonas, C. I.
Odionyenma, U. B.
Powiązania:
https://bibliotekanauki.pl/articles/1193372.pdf
Data publikacji:
2021
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Cartesian coordinates
Dimensions of space
Laplace equations
Partial derivatives
Potential
Separation of variables
Opis:
This research aimed at solving the Cartesian coordinates of two and three dimensional Laplace equations by separation of variables method. It was painstakingly solved with appropriate boundary conditions of steady states. However, the solution of potential (V) of a partial differential equation (PDE) in three real variables x,y and z are functionally obtained using separation of variable approach by stating the boundary conditions of the Cartesian coordinates.
Źródło:
World Scientific News; 2021, 155; 80-97
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Structure Activity Relationships, QSAR Modeling and Drug-like calculations of TP inhibition of 1,3,4-oxadiazoline-2-thione Derivatives
Autorzy:
Almi, Z.
Belaidi, S.
Lanez, T.
Tchouar, N.
Powiązania:
https://bibliotekanauki.pl/articles/971332.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
SAR
QSAR
drug-like
TP inhibitory
MLR
1,3,4-oxadiazoline-2-thione derivatives
Opis:
QSAR studies have been performed on twenty-one molecules of 1,3,4-oxadiazoline-2-thiones. The compounds used are among the most thymidine phosphorylase (TP) inhibitors. A multiple linear regression (MLR) procedure was used to design the relationships between molecular descriptor and TP inhibition of the 1,3,4-oxadiazoline-2-thione derivatives. The predictivity of the model was estimated by cross-validation with the leave-one-out method. Our results suggest a QSAR model based of the following descriptors: logP, HE, Pol, MR, MV, and MW, qO1, SAG, for the TP inhibitory activity. To confirm the predictive power of the models, an external set of molecules was used. High correlation between experimental and predicted activity values was observed, indicating the validation and the good quality of the derived QSAR models.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 18; 113-124
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 19

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