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Wyszukujesz frazę "Toxicity" wg kryterium: Temat


Tytuł:
Phytoplankton Susceptibility Towards Toxic Heavy Metal Cadmium: Mechanism and Its Recent Updates
Autorzy:
Permana, Rega
Akbarsyah, Nora
Powiązania:
https://bibliotekanauki.pl/articles/1839870.pdf
Data publikacji:
2021
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Cadmium
Heavy Metals
Phytoplankton
Toxicity
Opis:
Environmental pollution particularly heavy metal pollution into aquatic ecosystem has led to multiple damage in almost all life forms. Cadmium is one of the priority pollutant listed by United States Environmental Protection Agency or US EPA that widely known to have an adverse effect to organisms as well as human health. One type of organism that is susceptible to the effects of metal pollution is phytoplankton. Phytoplankton is a group of microalgae that are easy to find and are primary producers in aquatic environments. Phytoplankton plays an important role in aquatic ecosystems because they serve as primary producers. They are representing the water total primary productivity and reinforcing the aquatic life on the higher food chain. Thus, any threats that endangered the population of phytoplankton can lead to trophical cascade or even worse, biodiversity loss. The exposure of cadmium in high concentration to phytoplankton can lead to various impact including cell damage and disruption, biosynthesis inhibition of photosynthetic pigment (e.g. chlorophyll and carotenoid), chlorphyll degradation or known as chlorosis, thylakoid membrane degradation, inhibition of cellular metabolism and cell division. It is important to study the impact of cadmium to phytoplankton in a cellular level to better understand what mechanism lies and to what extent that the cadmium will be transferred to higher trophical organism via bioaccumulation or biomagnification.
Źródło:
World News of Natural Sciences; 2021, 38; 83-97
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Was Histamine toxicity known to Ayurveda & Siddha 5000 years ago?
Autorzy:
Aruna, V.
Amruthavalli, G. V.
Gayathri, R.
Powiązania:
https://bibliotekanauki.pl/articles/1077270.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Fish
Histamine toxicity
Siddha / Ayurveda
Tridosha
Opis:
Histamine was discovered in the year 1910 and subsequently histamine toxicity was reported from several marine foods especially from fish. Detailed research has proved that different species of fishes are known to accumulate large quantity of histamine and the histamine is heat stable. Reason for the histamine toxicity was due to the consumption of fishes with high level of histamine. Ancient systems of medicine such as Ayurveda and Siddha are 5000 years old. Ayurveda and siddha clearly dictates the avoidance of fish by patients who suffer from various diseases such as psoriasis, vitiligo, eczema, urticaria, anemia, duodenal ulcer, irritable bowel syndrome, rheumatoid arthritis etc. In all the above diseases histamine is either the trigger or the cause of the disease, therefore reducing histamine burden is also one of the treatment strategies. Histamine toxicity in fish and sea foods are great concern and the histamine is harmful to many diseases. Ancient siddhars have advised the patients to suffer from various diseases to avoid fish may be due to histamine toxicity. In the light of the present revelation about histamine toxicity in fish and the fish avoidance prescription of Ayurveda and Siddha clearly indicates that the Ayurveda and Siddha scholars were clearly aware of histamine toxicity 5000 years ago. Details are presented in the paper.
Źródło:
World News of Natural Sciences; 2019, 23; 166-172
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Environmental, economic and health perspectives of arsenic toxicity in Bengal Delta
Autorzy:
Bhattacharya, Sayan
Ghosh, Uday Chand
Powiązania:
https://bibliotekanauki.pl/articles/1194026.pdf
Data publikacji:
2015
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Arsenic
Bengal Delta
Bioaccumulation Groundwater
Phytoremediation
Toxicity
Opis:
Arsenic is a metalloid of great environmental concern because of its highly toxic nature and wide abundance. Arsenic contamination in groundwater has been reported in Bangladesh, India, China, Taiwan, Vietnam, USA, Argentina, Chile and Mexico. The clinical symptoms of arsenic toxicity in human body include skin itching to sun rays, burning and watering of the eyes, weight loss, loss of appetite, weakness, fatigue, limited physical activities and working capacities, chronic respiratory problems, moderate to severe anemia etc. The Bengal basin is regarded to be the most acutely arsenic infested geological province in the world. Heavy withdrawal of groundwater for fulfilling the needs of the increasing population in Bengal Basin resulted in increased arsenic level in the groundwater. Mobilization of arsenic in Bengal delta is further interfered by microbial activities and interactions. Different microbial strains have been isolated from Bengal Delta which can tolerate, transform and resist arsenic. The use of arsenic contaminated groundwater for irrigation purpose in crop fields elevates arsenic concentration in surface soil and in the plants grown in these areas. Several plant species have been studied for their ability to accumulate arsenic in the Bengal Delta. Rice is generally grown in submerged flooded condition, where arsenic bioavailability is high in soil. As arsenic species are very much toxic to plants and can execute oxidative stresses, they can also affect the overall production of rice and other vegetables, and can affect the agricultural and economic development of Bengal Basin. Cattle population also consume arsenic infested water in those areas and usually eat edible plants contaminated with arsenic, which, in turn, can further increase the toxicity level in their bodies and also can increase the arsenic bioaccumulation in meat and milk. In the rural areas of the Bengal Delta, arsenic contamination raised a number of social problems which are continuously weakening the structural integrity of rural society. Uses of phytoremediation and microbial remediation technologies, rainwater harvesting, use of arsenic resistant plant varieties for cultivation are some sustainable methods which can be applied for arsenic remediation. Besides, nano-agglomerates of mixed oxides have been synthesized and successfully employed for arsenic removal from aqueous solutions. Intensive investigation on a complete food chain is urgently needed in the arsenic contaminated zones, which should be our priority in future researches.
Źródło:
World Scientific News; 2015, 10; 59-87
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Total safety management through standardization of formulated ayurvedic Kajal using Eclipta alba and Vernonia cinerea herbs
Autorzy:
Puthalath, Sajitha
Dang, Raman
Das, Kuntal
Powiązania:
https://bibliotekanauki.pl/articles/1194038.pdf
Data publikacji:
2015
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Eclipta alba
Safety
Standardization
Toxicity study
Vernonia cinerea
Opis:
Traditionally Kajal is known as Surma or Kohl which is used as an eye liner. Designing Ayurvedic Kajal with medicinal plants as a cosmetic product for beautification was thought of as a novel and an innovative technique. The main advantages of these cosmetic products are more patient compliance, water resistant property, stability and of course economical to formulate. Looking at that the present study was carried out with the aim of formulation of Ayurvedic Kajal with the help of two medicinal plants viz. Eclipta alba (EA) and Vernonia cinerea (VC) and evaluate their potential for sustained ocular delivery. Standardization of the herbs was performed based on different physiochemical parameters and revealed the values were within the prescribed limits. Ingredients used for this present investigation was standardized using TLC method whereas process standardization was carried out with organoleptic characters and was resulted similar characters in terms of color, odor and consistency. Furthermore product consistency was standardized by penetrometer test, moisture content test, TLC of the different extracts, microbial contamination and finally skin toxicity test. Different extracts like methanolic extract, lamp black extract, methanolic Kajal extract and hexane extracts for both the plants were carried out and revealed good results with all the extracts except hexane extract. Thereafter all the method revealed significant results without any allergic reaction when tested on New Zealand white strain rabbits. Hence the results concluded that the formulated Kajal with EA and VC is totally safe and can be used for novel cosmetic formulations.
Źródło:
World Scientific News; 2015, 11; 31-43
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cadmium effects on growth and photosynthetic pigment content of Chaetoceros gracilis
Autorzy:
Ferdian, Ferdian
Hindarti, Dwi
Permana, Rega
Powiązania:
https://bibliotekanauki.pl/articles/1030841.pdf
Data publikacji:
2020
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Carotenoids
Cell density
Chaetoceros gracilis
Chlorophyll-a
Toxicity test
Opis:
Cadmium wastewater released by human activities will eventually enter the aquatic environment. Living organism that lives around could potentially exposed by these cadmium, including C. gracilis which play a critical role as a primary producer. Cadmium can reduce the growth rate and pigment content in C. gracilis. Therefore, toxicity testing becomes important to do considering that C. gracilis has many benefits such as shrimp feed and have active compounds for antibacterial and biodiesel. Toxicity test was performed in 96-hours with a series of concentration 0, 0.56, 1.0, 1.8, 3.2, 5.6 mg/L. IC50 cadmium results in concentrated cell density and chlorophyll-a C. gracilis were 1.62 mg/L and 3.4 mg/L, while carotenoids were not in accordance with the contribution of cadmium. NOEC and cadmium LOEC to C. gracilis cell density were 0.56 mg/L and 1.0 mg/L.
Źródło:
World Scientific News; 2020, 145; 245-255
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Uptake of Microplastics by Plant: a Reason to Worry or to be Happy?
Autorzy:
Ebere, Enyoh Christian
Wirnkor, Verla Andrew
Ngozi, Verla Evelyn
Powiązania:
https://bibliotekanauki.pl/articles/1066238.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Agricultural soil
Food
Human health
Microplastic
Phytoremediation
Plant
Toxicity
Opis:
Microplastic (MP, 1 μm − 5 mm) pollution has become a global environmental concern with potential risk to ecosystem and human health. Information on the accumulation of MPs in aquatic species has been well documented, while information on the uptake and accumulation of MPs by higher plants is still very scarce. Terrestrial edible plants are directly exposed to MPs when soil was applied with sludge, organic fertilizer, plastic mulching, waste water irrigation, plastic littering, surface runoff or from atmospheric deposition of airborne MP. One study using fluorescent marker recently showed that plant can accumulate MP through uptake from MP polluted soil. Thus, potentially contaminating the base of the food-web and also indicating new exposure route to MP ingestion. This review present a discuss of the implication of these findings to human, who may be ingesting an estimated 80 g of MP through eating of plant daily as global consumption rate of plant continually increase. Also, benefit for the terrestrial ecosystem is discussed, by which plant acts as a potential remediator of MP polluted soil either by phytoextraction, phytostabilization and phytofilteration. We conclude by pointing knowledge gap and suggesting key future areas of research for scientists and policymakers.
Źródło:
World Scientific News; 2019, 131; 256-267
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Validation of tropical artificial soil by chronic toxicity studies on Eisenia fetida against superphosphate
Autorzy:
Abbiramy, K.S.
Ross, P.R.
Paramanandham, J.
Powiązania:
https://bibliotekanauki.pl/articles/10839.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
validation
tropical soil
artificial soil
chronic toxicity
Eisenia fetida
superphosphate
Opis:
The research methodology recommended by the OECD (Organization of Economic Co-operation and Development) and ISO (International Organization for Standardization) guidelines for testing of chemicals meets the most criteria expected for ecotoxicological testing except the testing condition and the organic matter. The guidelines were initially developed by temperate countries, with testing conditions as 20 °C and the organic matter as sphagnum peat which is commonly available in those countries. But these two criterions are difficult to be followed in tropical countries. Thus there arises a need of modifying these criterions for toxicity studied in tropical regions. In this study a trial was made for substituting the fermented coir pith for sphagnum peat and the validation of the modified tropical artificial soil (TAS) was done by conducting chronic toxicity studies on Eisenia fetida against an inorganic fertilizer, superphosphate (SP) under tropical condition, i.e., 28 ±2 °C. The performed study showed that the SP determined lower earthworm mortality in TAS comparing to OECD soil for all tested concentration levels. The number of juveniles produced in OECD soil was also significantly reduced (p < 0.05) than in TAS. This may be due to the production of large amount of hydrogen ions when the temperature increases and making the medium acidic. The fermented coir pith was more suitable for ecotoxicity studies under tropical condition than sphagnum peat.
Źródło:
International Letters of Natural Sciences; 2014, 08, 1
2300-9675
Pojawia się w:
International Letters of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Study of venturi scrubber efficiency for pesticide industry
Autorzy:
Desai, R.
Sahu, O.P.
Powiązania:
https://bibliotekanauki.pl/articles/11827.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
venture
scrubber efficiency
pesticide
industry
air pollution
human health
air pollutant
toxicity
Opis:
A venturi scrubber is designed to effectively use the energy from the inlet gas stream to atomize the liquid being used to scrub the gas stream. This type of technology is a part of the group of air pollution controls. The air pollution generated from the industry is now become serious problem for the environment, which affect the living and non living thing on the Earth. Among all the air pollution monitoring equipment venturi scrubber found to suitable for prevention of air pollution by pesticide. It was found that scrubber shows 99.1 % efficiency.
Źródło:
International Letters of Natural Sciences; 2014, 04
2300-9675
Pojawia się w:
International Letters of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Toxicity study of Achyranthus aspera
Autorzy:
Reddy, C.V.
Kamble, A.
Powiązania:
https://bibliotekanauki.pl/articles/10950.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
toxicity
Achyranthes aspera
methanol extract
Albino rat
rat
mice
mouse
health hazard
Opis:
The objectives of present work focuses to check the acute and sub acute toxicity studies for the Achyranthes aspera L methanol extract as per OECD guideline in Swiss mice. The dose of 100, 200, 250 gm/kg body weight methanol extract by administering drug intraperitoneally and recorded the growth, body weight, organ weight, general symptoms, morphological and physiological behavior, mortality. These parameters on various organs system in mice were studied. It was considered necessary to assess its potential health hazard in man and to find the safe and effective dose. The observations of changes in body weight, food and water intake as well as cage side observations were reported. There was no abnormality observed in all groups. The whole plant powder methanol extract of Achyranthes Aspera L were found to be nontoxic.
Źródło:
International Letters of Natural Sciences; 2014, 09
2300-9675
Pojawia się w:
International Letters of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of cytotoxicity of sodium benzoate and fresh and boiled green chili pepper (Capsicum annuum L.) on human red blood cells
Autorzy:
Kopczyńska, Klaudia
Król, Katarzyna
Ponder, Alicja
Hallmann, Ewelina
Erniati, Erni
Rungkat, Franziska Zakaria
Powiązania:
https://bibliotekanauki.pl/articles/1162723.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Capsicum annuum
antioxidant
cytotoxicity
extracts
green chili pepper
red blood cells
toxicity test
Opis:
Peppers (Capsicum spp.) are a rich source of different bioactive compounds with potential health-promoting properties. Pepper fruits have numerous uses in culinary preparations that make this one of the most important vegetables and spices. This study investigated the evaluate the antioxidant activity of green chili pepper extracts on human red blood cells by comparison of different extraction method and treatments. Two solvents (water and methanol) was used to extract from green pepper compounds (fresh and after boiling process). The cytotoxic effect of sodium benzoate and fresh and boiled green chili pepper on human red blood cells was investigated. The obtained results show the protective effect of the extract from hot chili peppers on the negative effect of sodium benzoate. This effect was significantly dependent (p<0.05) on the type of source (fresh or boiled), not on the concentration of extract. Used type of solvent had statistical significant matter in C3 concentration of fresh vegetable. The highest protection gave fresh chili pepper extract.
Źródło:
World Scientific News; 2018, 110; 1-12
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
QSAR modeling for prediction of acute toxicity and mutagenicity in different test models by established common phytochemicals present in Phyllanthus niruri
Autorzy:
Dhar, Shrinjana
Gupta, Kaushik
Talapatra, Soumendra Nath
Powiązania:
https://bibliotekanauki.pl/articles/1192089.pdf
Data publikacji:
2016
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
QSAR modeling
Common phytochemicals
Phyllanthus niruri
T.E.S.T. software
Predictive toxicity and mutagenicity
Opis:
In globe, Pyllanthus niruri is a well-established medicinal herb studied by many researchers, grown widely in many parts of West Bengal. The present study was aimed to predict the acute toxicity as LC50 in Daphnia magna and Pimephales promelas and rat oral LD50 value as well as Ames mutagenicity by using QSAR modeling software, T.E.S.T. (Toxicity Estimation Software Tool) for commonly found phytochemicals in Pyllanthus niruri. In present works, the data were obtained for LC50, few phytochemicals were toxic to D. magna and P. promelas and also mutagenic but rat oral LD50 determined less toxic. The present QSAR modeling work is suggesting that more researches should be required through experimental as well as predictive study with other prescribed software to know the mechanisms of toxicity and mutagenicity for these combined form of phytochemicals after separating each natural chemical from extract prior to drugs development for therapeutic usage.
Źródło:
World Scientific News; 2016, 37; 202-219
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dosage and temporal dependent arsenic-induced mortality in Ceriodaphnia dubia: An effective biomarker for arsenic pollution
Autorzy:
Talapatra, S.N.
Bhattacharya, S.
Guha, G.
Dutta, S.
Chattopadhyay, D.
Mukhopadhyay, A.
Powiązania:
https://bibliotekanauki.pl/articles/11321.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
dosage
arsenic
mortality
Ceriodaphnia dubia
biomarker
metal pollution
water pollution
toxicity
water quality
water contaminant
Opis:
Arsenic (As) is a metalloid that causes severe water pollution due to its extravagant toxicity. Ceriodaphnia dubia, a freshwater crustacean, was selected as a model system to evaluate the degree of time and dosage dependent acute toxicity caused by pentavalent As [As(V)]. C. dubia were collected from a natural pond and treated with different concentrations of As(V) for 24 hours and 48 hours. For both 24 hours and 48 hours treatment periods, the mortality rates were increased significantly ( P< 0.05) with increase in As(V) concentrations. Simultaneously, it was also observed that As(V) - induced mortality in C. dubia also depended on the time of exposure to the metalloid. We propose this model as a low-cost technique towards rapid screening of water quality in relation to As contamination.
Źródło:
International Letters of Natural Sciences; 2014, 02
2300-9675
Pojawia się w:
International Letters of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Heavy metals in sediment ecosystem of Bhavans College Lake of Andheri, Mumbai
Autorzy:
Singare, P. U.
Talpade, M. S.
Dagli, D. V.
Bhawe, V. G.
Powiązania:
https://bibliotekanauki.pl/articles/412407.pdf
Data publikacji:
2013
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
lake sediments
heavy metal toxicity
Central Pollution Control Board (CPCB)
World Health Organisation (WHO)
AAS technique
Opis:
The present study was initiated to understand the accumulation of toxic heavy metals in sediments of Bhavan's College Lake of Andheri, Mumbai. The study was performed for a period of one year starting from June 2011 to May 2012 to quantify the toxic heavy metals like Cu, Pb, Cr, Ni, Fe, Hg, As and Cd by atomic absorption spectroscopy technique coupled with cold vapour technique (for Hg analysis) and hydride generation technique(for As analysis). It was observed that the yearly average concentrations of these heavy metals in lake sediments were 0.53, 0.25, 0.42, 0.43, 4.6, 0.14, 0.12 and 0.11 ppm respectively which were above the WHO limits for aquatic life and CPCB limits for inland surface water. These heavy metals accumulated in lake sediments may enter the water thereby creating threat to aquatic life. They may enter the food chain through biomagnifications and may create adverse effect on human health. It is expected that in addition to the water analysis which is practiced for years, sediment analysis performed in the present investigation will help in evaluating quality of the total ecosystem of the lake. It will also provide environmentally significant information about natural and anthropogenic influence on the water body.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2013, 8, 2; 105-112
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chromium toxicity in Sesbania sesban (L.) Merr
Autorzy:
Bakiyaraj, R.
Mahakavi, T.
Baskaran, L.
Powiązania:
https://bibliotekanauki.pl/articles/10775.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
chromium
toxicity
Sesbania grandiflora
pot experiment
toxic effect
plant
germination
chlorophyll
enzyme
metal accumulation
seedling
shoot
Opis:
Chromium is one of the most common toxic metals present in the environment that induces various toxic effects in plants. A pot experiment was conducted to determine the effects of chromium on germination percentage, seedling growth, chlorophyll ‘a’, ‘b’ and proline content of Sesbania sesban (L.) Merr. The seedlings were treated with different concentrations of control, 0.10, 0.25, 0.50, 0.75 and 1.00 g kg-1 of chromium. The parameters such as germination percentage, root and shoot length, seedling fresh weight dry weight, chlorophyll ‘a’, ‘b’ and proline content of leaves were measured. Our results indicated that a significant inhibitory effect was observed at all levels of chromium compared to control. Increasing the concentration of chromium to 1.00 g kg-1 showed a significant decrease in seed germination, shoot and root length, fresh weight, dry weight and chlorophyll ‘a’ and ‘b’ content of plant. While proline, catalase and peroxidase contents were increased by increasing Cr concentration. It was also noted that accumulation of chromium in the roots was much higher than the shoots of the seedlings under treatment.
Źródło:
International Letters of Natural Sciences; 2014, 04
2300-9675
Pojawia się w:
International Letters of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Predictive acute toxicity comparison in Daphnia magna for common organic chemicals present in cosmetics by using two QSAR modeling softwares
Autorzy:
Talapatra, Soumendra Nath
Konar, Sarnali
Powiązania:
https://bibliotekanauki.pl/articles/1190143.pdf
Data publikacji:
2016
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
QSAR modelling
Cosmetic organic chemicals
T.E.S.T. and ECOSAR software
Predictive acute toxicity
Daphnia magna
Opis:
Different types of organic compounds, which are used in cosmetics from decades. The usage of cosmetic products are mainly by people in office, culture, festival, recreation etc. All of these chemicals are of synthetic origin. The present study aims to predict comparative acute toxicity as LC50 (median lethal concentration) values in Daphnia magna for common types of cosmetic compounds. The predictions of LC50 values were determined by using two QSAR modeling softwares, T.E.S.T. or Toxicity Estimation Software Tool and ECOSAR (Ecological Structure Activity Relationship), for established 23 types of chemicals commonly present in cosmetics. These two softwares help to predict of LC50 values by easy screening. In present result, predictive data with statistical interpretation (R2 or correlation coefficient values) were obtained easily in T.E.S.T. but not in ECOSAR and the statistical data interpretation was not found. Among all these chemicals, it was observed that major compounds are not toxic to D. magna except few chemicals viz. ascorbyl palmitate, triclosan, methyl triclosan and triclocarbon. Further researches are suggested to compare these predicted data with other available 2-dimentional and 3-dimentional softwares and these chemicals should be studied in combinations of cosmetic chemicals with this test model in vivo because they are major food sources for fish in freshwater ecosystem.
Źródło:
World Scientific News; 2016, 42; 101-118
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł

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