Was Histamine toxicity known to Ayurveda & Siddha 5000 years ago?

Histamine was discovered in the year 1910 and subsequently histamine toxicity was reported from several marine foods especially from fish. Detailed research has proved that different species of fishes are known to accumulate large quantity of histamine and the histamine is heat stable. Reason for the histamine toxicity was due to the consumption of fishes with high level of histamine. Ancient systems of medicine such as Ayurveda and Siddha are 5000 years old. Ayurveda and siddha clearly dictates the avoidance of fish by patients who suffer from various diseases such as psoriasis, vitiligo, eczema, urticaria, anemia, duodenal ulcer, irritable bowel syndrome, rheumatoid arthritis etc. In all the above diseases histamine is either the trigger or the cause of the disease, therefore reducing histamine burden is also one of the treatment strategies. Histamine toxicity in fish and sea foods are great concern and the histamine is harmful to many diseases. Ancient siddhars have advised the patients to suffer from various diseases to avoid fish may be due to histamine toxicity. In the light of the present revelation about histamine toxicity in fish and the fish avoidance prescription of Ayurveda and Siddha clearly indicates that the Ayurveda and Siddha scholars were clearly aware of histamine toxicity 5000 years ago. Details are presented in the paper.