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Wyświetlanie 1-15 z 16
Tytuł:
The effect of proteolysis inhibitors from Ascaris lumbricoides suis on developing chicken embryos
Autorzy:
Blaszkowska, J.
Wojcik, A.
Powiązania:
https://bibliotekanauki.pl/articles/840148.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
Ascaris lumbricoides suis
trypsin inhibitor
proteolysis
chicken
inhibitor
embryo
alpha-chymotrypsin inhibitor
Źródło:
Annals of Parasitology; 1998, 44, 3
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Developmental abnormalities in chicken embryos after injection proteolysis inhibitors from Ascaris suum
Autorzy:
Błaszkowska, J.
Powiązania:
https://bibliotekanauki.pl/articles/2147678.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
Ascaris suum
teratogen
proteolysis inhibitor
developmental abnormality
inhibitor
chicken embryo
injection
Opis:
It bas been found that trypsin and α-chymotrypsin inhibitors isolated from Ascaris suum act embryotoxically and teratogenically on White Leghorn clucken embryos. Mortatity rate for the chicken embryos on day 15 of incubation was 45.0 ± 3.5% after injection of trypsin inbibitor and 44.0 ± 3.5% after adminstration α-chymotrypsin inbibitor. Gross examination of surviving embryos and their dissection revealed pathological changes (abdominal dropsy, umbilical hernia, subcutaneous oedema, hemoperitoneum, hemopericardium), symptoms indicating retardation in growth (lack of down, retarded ossification of long bones, decreased mean body weight) as well as malformations (schistocelia, micrognathia, cyclopia, crossed beak, cranial deformities) after injection of inhibitors from Ascaris. The highest incidence of embryos with pathological changes and malformations was found after administralion of α-chymotrypsin inbibitor. The most commonly occurring abnormality was schistocelia (21.4 ± 3.88%). Growth malformations were not found in the control groups. The trypsin and α-chymotrypsin inhibitors present in Ascaris homogenate have a significant disturbing effect on the development of the chicken embryo.
Źródło:
Wiadomości Parazytologiczne; 2002, 48, 1; 55-64
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Developmental abnormalities in chicken embryos after injection proteolysis inhibitors from Ascaris suum
Autorzy:
Blaszkowska, J
Powiązania:
https://bibliotekanauki.pl/articles/840466.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
Ascaris suum
teratogen
proteolysis inhibitor
developmental abnormality
inhibitor
chicken embryo
injection
Opis:
It bas been found that trypsin and α-chymotrypsin inhibitors isolated from Ascaris suum act embryotoxically and teratogenically on White Leghorn clucken embryos. Mortatity rate for the chicken embryos on day 15 of incubation was 45.0 ± 3.5% after injection of trypsin inbibitor and 44.0 ± 3.5% after adminstration α-chymotrypsin inbibitor. Gross examination of surviving embryos and their dissection revealed pathological changes (abdominal dropsy, umbilical hernia, subcutaneous oedema, hemoperitoneum, hemopericardium), symptoms indicating retardation in growth (lack of down, retarded ossification of long bones, decreased mean body weight) as well as malformations (schistocelia, micrognathia, cyclopia, crossed beak, cranial deformities) after injection of inhibitors from Ascaris. The highest incidence of embryos with pathological changes and malformations was found after administralion of α-chymotrypsin inbibitor. The most commonly occurring abnormality was schistocelia (21.4 ± 3.88%). Growth malformations were not found in the control groups. The trypsin and α-chymotrypsin inhibitors present in Ascaris homogenate have a significant disturbing effect on the development of the chicken embryo.
Źródło:
Annals of Parasitology; 2002, 48, 1
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of Ascaris trypsin inhibitor on fetal development of mice
Autorzy:
Błaszkowska, J.
Powiązania:
https://bibliotekanauki.pl/articles/2146383.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
mouse
mice
trypsin inhibitor
fetal development
Ascaris suum
Opis:
In this study, maternal toxicity and developmental effects of exposure to Ascaris trypsin inhibitor were evaluated in mice. Pregnant BALB/c females were injected intraperitoneally by Ascaris inhibitor /AIT/ at 200, 300, and 400 mg/kg body weight/day, on days 12 to 15 of gestation (stage of fetal development). At day 19 of pregnancy, uterine contents were inspected for implantation sites, early resorptions (moles), living fetuses and dead fetuses. The living fetuses were weighed and examined for external, internal and skeletal abnormalities. The results showed that AIT induced maternal toxicity, evidenced by maternal deaths, abortions, bleeding from uterus and reduced body weight gain as compared to control (p <0.01). There were no differences between the control group and the rest of all groups investigated for total implantation sites and early resorptions. Fetotoxicity was observed as shown by the decrease in the number of living fetuses and mean fetal weight, a high rate of intrauterine fetal deaths, delayed skeletal ossification, occurrence of pathological changes of fetal organs and tissues. Only one type of congenital malformations (hydronephrosis) was noted in fetuses after injection of higher doses of AIT.
Źródło:
Wiadomości Parazytologiczne; 2005, 51, 2; 133-138
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of Ascaris chymotripsin inhibitor on fetal development of mice
Autorzy:
Błaszkowska, J.
Powiązania:
https://bibliotekanauki.pl/articles/2147464.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
mouse
mice
fetal development
Ascaris suum
chymotrypsin inhibitor
Opis:
BALB/c mice were given daily doses of 40-80 mg of Ascaris chymotrypsin inhibitor /AChl/ per kg body weight from 12" until 15" day of gestation (stage of fetal development). It has been found that injection of AChI disturbed the course of pregnancy (bleeding from uterus, abortions, decreased body weight gain as compared to control /p < 0.05/). AChI exhibited embryotoxic effects (a high rate of intrauterine deaths, decreased number of living fetuses and mean fetal weight, delayed skeletal ossification, induced pathological changes of fetal organs and tissues). Congenital malformation (hydronephrosis) was noted in fetuses after injection of higher doses of the chymotrypsin inhibitor from Ascaris.
Źródło:
Wiadomości Parazytologiczne; 2004, 50, 3; 513-518
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of Ascaris lumbricoides suis trypsin inhibitor on RNA, DNA, and protein biosyntheses in developing A.lumbricoides suis eggs - Part I
Autorzy:
Ochecka-Szymanska, A.
Turski, W.A.
Powiązania:
https://bibliotekanauki.pl/articles/838472.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
RNA
Ascaris lumbricoides suis
trypsin inhibitor
biosynthesis
protein
DNA
egg
Źródło:
Annals of Parasitology; 1998, 44, 3
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparison of the effect of Ascaris trypsin inhibitor and ovomucoid on fetal development in mice
Autorzy:
Blaszkowska, J.
Wojcik, A.
Powiązania:
https://bibliotekanauki.pl/articles/839125.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
Ascaris lumbricoides suis
pathological change
mouse
mice
trypsin inhibitor
Ascaris
fetus
Źródło:
Annals of Parasitology; 1998, 44, 3
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preliminary evaluation of maternotoxic effect of Ascaris alpha-chymotrypsin inhibitor in mice
WSTĘPNA OCENA TOKSYCZNEGO DZIAŁANIA INHIBITORA о-СНУМОТВУРЗУМУ 7 ASCARIS NA ORGANIZM CIĘŻARNYCH MYSZY
Autorzy:
Blaszkowska, J.
Kadłubowski, R.
Powiązania:
https://bibliotekanauki.pl/articles/2148308.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
pregnancy
mouse
mice
Ascaris
host organism
toxic effect
alpha-chymotrypsin inhibitor
Opis:
Administration intraperitoneally of the Ascaris α-chymotrypsin inhibitor (40-300 mg/kg/day.) at a late stage of organogenesis (8-12 days of gestation) disturbed course of mouse pregnancy. The low doses of α-chymotrypsin inhibitor (40-80 mg/kg/day) significantly decreased the number of live fetuses per litter, increased the number of fetal resorptions. The symptoms of matemal toxicity that occurred after administration of the highest doses of the inhibitor (80-300 mg/kg/day) to pregnant mice included: decreased body weight gain as compared to control, vaginal hemorrhage, intrauterine resorption of litters, abortions, altered behaviour of animals immediately after injection and death. There is a linear interrelationship between the logarithm of the doses of the inhibitor and mortality of pregnant mice. The DL50 value of the inhibitor for female was 116 mg/kg /day (confidence interval: 95.5-140.0 mg/kg/day).
Źródło:
Wiadomości Parazytologiczne; 2001, 47, 4; 705-710
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of Ascaris lumbricoides suis trypsin inhibitor on hydrolytic activity of developing ascarid eggs
Autorzy:
Wojcik, A.
Blaszkowska, J.
Powiązania:
https://bibliotekanauki.pl/articles/836676.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
Ascaris lumbricoides suis
trypsin inhibitor
helminth
hydrolytic activity
female
egg
Źródło:
Annals of Parasitology; 1998, 44, 3
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of Ascaris lumbricoides suis trypsin inhibitor on RNA, DNA and protein biosyntheses in developing A.lumbricoides suis eggs - Part II
Autorzy:
Ochecka-Szymanska, A.
Turski, W.A.
Powiązania:
https://bibliotekanauki.pl/articles/836869.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
RNA
Ascaris lumbricoides suis
trypsin inhibitor
biosynthesis
protein
DNA
egg
Źródło:
Annals of Parasitology; 1998, 44, 3
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preliminary evaluation of maternotoxic effect of Ascaris alpha-chymotrypsin inhibitor in mice
Autorzy:
Blaszkowska, J
Kadlubowski, R.
Powiązania:
https://bibliotekanauki.pl/articles/839388.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
pregnancy
mouse
mice
Ascaris
host organism
toxic effect
alpha-chymotrypsin inhibitor
Opis:
Administration intraperitoneally of the Ascaris α-chymotrypsin inhibitor (40-300 mg/kg/day.) at a late stage of organogenesis (8-12 days of gestation) disturbed course of mouse pregnancy. The low doses of α-chymotrypsin inhibitor (40-80 mg/kg/day) significantly decreased the number of live fetuses per litter, increased the number of fetal resorptions. The symptoms of matemal toxicity that occurred after administration of the highest doses of the inhibitor (80-300 mg/kg/day) to pregnant mice included: decreased body weight gain as compared to control, vaginal hemorrhage, intrauterine resorption of litters, abortions, altered behaviour of animals immediately after injection and death. There is a linear interrelationship between the logarithm of the doses of the inhibitor and mortality of pregnant mice. The DL50 value of the inhibitor for female was 116 mg/kg /day (confidence interval: 95.5-140.0 mg/kg/day).
Źródło:
Annals of Parasitology; 2001, 47, 4
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of alpha-chymotrypsin inhibitor from Ascaris lumbricoides suum on chick embryos
Autorzy:
Blaszkowska, J
Powiązania:
https://bibliotekanauki.pl/articles/838045.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
pathological change
alpha-chymotrypsin
Ascaris lumbricoides suum
mortality
host organism
Leghorn breed
inhibitor
chicken
embryo
Opis:
It has been found that alpha-chymotrypsin inhibitor isolated from Ascaris lumbricoides suum acts embryotoxically on the Leghorn chicken embryo. An increase in embryo mortality with increasing dose of the inhibitor has been observed after its administration into the yolk sac on day 4, 8 or 13 of incubation. There is a linear interrelationship between the logarithm of the dose of alpha-chymotrypsin inhibitor and the mortality of chickens. The LD50 values foralpha-chymotrypsin inhibitor increased for injections performed at later stages of embryo development. A significant decrease of mean mass of chicks injected with alpha-chymotrypsin inhibitor in comparison with control groups was observed. There was a more frequent occurrence of developmental abnormalities and pathological changes in groups of hatched chicks which received the Ascaris inhibitor.
Źródło:
Annals of Parasitology; 1998, 44, 1
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of Ascaris trypsin inhibitor on proteolytic activity of lungs and kidneys of guinea pig with larval ascariosis and after ascarid homogenate administration
Autorzy:
Wojcik, A
Kadlubowski, R.
Powiązania:
https://bibliotekanauki.pl/articles/837331.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
trypsin inhibitor
Ascaris
ascarid homogenate
ascariasis
Ascaris suum
guinea pig
kidney
larva
lung
proteolytic activity
Opis:
Trypsin inhibitor, isolated from Ascaris suum tegument reduces in vitro proteolytic activity (pH 7) of lungs and kidneys post-nuclear fractions of guinea pigs with larval ascariosis, pigs after subcutaneous ascarid homogenate administration as well as the activity in control groups. The comparative analysis of effect curves of trypsin inhibitor on the organ proteases revealed stronger reduction of the activity of post-nuclear lung proteases in ascariosis and of kidneys proteases after the injection of Ascaris homogenate than the inhibition of the fractions activity from respective control groups.
Źródło:
Annals of Parasitology; 2001, 47, 4
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of Ascaris trypsin inhibitor on proteolytic activity of lungs and kidneys of guinea pig with larval ascariosis and after ascarid homogenate administration
DZIAŁANIE INHIBITORA TRYPSYNY ASCARIS NA AKTYWNOŚĆ PROTEOLITYCZNĄ PŁUC I NEREK ŚWINEK MORSKICH Z ASKARYDOZĄ LARWALNĄ I PO PODANIU HOMOGENATU GLISTY
Autorzy:
Wójcik, A.
Kadłubowski, R.
Powiązania:
https://bibliotekanauki.pl/articles/2148472.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
trypsin inhibitor
Ascaris
ascarid homogenate
ascariasis
Ascaris suum
guinea pig
kidney
larva
lung
proteolytic activity
Opis:
Trypsin inhibitor, isolated from Ascaris suum tegument reduces in vitro proteolytic activity (pH 7) of lungs and kidneys post-nuclear fractions of guinea pigs with larval ascariosis, pigs after subcutaneous ascarid homogenate administration as well as the activity in control groups. The comparative analysis of effect curves of trypsin inhibitor on the organ proteases revealed stronger reduction of the activity of post-nuclear lung proteases in ascariosis and of kidneys proteases after the injection of Ascaris homogenate than the inhibition of the fractions activity from respective control groups.
Źródło:
Wiadomości Parazytologiczne; 2001, 47, 4; 711-716
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 16

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