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    Wyświetlanie 1-13 z 13
    Tytuł:
    Syntezy wybranych leków pochodnych 2-amino-1H-benzimidazolu
    Synthesis of Selected drugs 2-amino-1H-benzimidazole derivatives
    Autorzy:
    Nowicka, A.
    Nawrocka, W. P.
    Powiązania:
    https://bibliotekanauki.pl/articles/172049.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    synteza leków
    leki przeciwrobacze
    leki przeciwhistaminowe
    leki przeciwwirusowe
    leki przeciwnowotworowe
    Opis:
    2-Amino-1H-benzimidazole fragment occurs in broad spectrum of drugs with anticancer, antiviral, antifungal, anthelmintic and antihistamine properties. There are 30 drugs, 2-amino-1H-benzimidazole derivatives, registered in the world. Mebendazole, Albendazole and another derivatives are antihelmintic drugs which are believed to work by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubes in their intestinal [9, 12, 14]. Astemizole was a second-generation antihistamine drug that has a long duration of action. It has been withdrawn from the market in most countries because of rare but potentially fatal side effects [19]. Mizolastine is non-sedating antihistamine drug [21]. It blocks H1 receptors and doesn’t prevent the actual release of histamine from mast cells, but just prevents it binding to receptors. Enviroksim and its isomer Zinviroksim and Enviraden are antivirial drugs [26, 27]. They inhibit multiplication of 15 different serotypes of rhinovirus. Benomyl is a systemic fungicide that is selectively toxic to microorganisms [29]. Benomyl binds to microtubules, interfering with cell functions, such as meiosis and intracellular transportation. Carbendazim is a widely used, broad-spectrum fungicide and a metabolite of Benomyl [29]. It’s also shown an anticancer activity. Oncodazole shows antifungal, antineoplastic and antihelmintic activities, which exerts its effect in cells by binding to tubulin and interfering with the polymerization of microtubules [33].
    Źródło:
    Wiadomości Chemiczne; 2013, 67, 7-8; 695-714
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Adenozyno-5’-o-(n-acylosulfamoilowe) pochodne jako potencjalne leki przeciwgruźlicze
    5’-o-[n-(acyl)sulfamoyl]adenosine derivatives as potential antituberculosis drugs
    Autorzy:
    Kulik, K.
    Baraniak, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/172072.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    leki przeciwgruźlicze
    prątek gruźlicy
    acyloadenylany
    antituberculosis drugs
    Mycobacterium tuberculosis
    acyladenylates
    Opis:
    Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), is the leading bacterial cause of infectious disease mortality. The current WHOapproved treatment for TB involves a three- or four-drug regimen comprising isoniazid, rifampin, pyrazinamide, and/or ethambutol for a minimum of 6 months. While these first-line agents remain useful in treating susceptible Mycobacterium tuberculosis strains, the emergence of multidrug resistant tuberculosis demands the development of new drugs [1]. Iron acquisition is an essential process for M. tuberculosis as well as almost all other microorganisms. However, this essential micronutrient is highly sequestered in a mammalian host. In response to iron starvation, Mtb produces small-molecule iron chelators, a pair of related peptidic siderophores known as mycobactin and carboxymycobactins that vary by the appended lipid residue termed siderophores [4, 5, 7, 8]. Because mycobactins are critical for growth and virulence of M. tuberculosis, they have emerged as attractive targets for the development of anti-TB agents [4]. Biosynthesis of mycobactin is initiated by the aryl acid adenylation enzyme MbtA which activates salicylic acid forming an acyladenylate intermediate (Sal- AMP). MbtA is also responsible for loading the acyladenylate intermediate onto the thiolation domain of MbtB-SH – the enzyme taking part in the next step of biosynthesis process [10]. Given the documented importance of many siderophores for virulence and lack of human aryl acid adenylation enzymes homologues, several analogues possessing stable linkers as bioisosteres of the labile acyl phosphate function have been synthesized as the potent enzyme inhibitors [13]. The initial lead compound 5’-O-[N- (salicyl)sulfamoyl]adenosine (Sal-AMS) has emerged as a promising inhibitor of MbtA and was shown to possess promising whole-cell activity toward M. tuberculosis.
    Źródło:
    Wiadomości Chemiczne; 2016, 70, 7-8; 455-472
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Strategia repozycjonowania, czyli nowe zastosowanie dla starych leków
    Repositioning strategy, a new uses for old drugs
    Autorzy:
    Fajkis, N.
    Kołaczkowski, M.
    Marcinkowska, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/172100.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    leki repozycjonowane
    selektywna optymalizacja działań
    SOSA
    repositioning strategy
    selective optimization of side activities
    Opis:
    Drug discovery and development is associated with enormous costs, time consumption and high risk of failure. To increase the productivity, pharmaceutical companies are constantly looking for new strategies to deliver a new drug faster, with relatively lower costs. Recently, the drug repositioning has been recognized as a fruitful approach, which enables to diminish the cost and time associated with bringing a drug to the market. This review discusses the repositioning strategy, their advantages and disadvantages, along with several successful examples of drugs that have been approved for a different purpose than at the beginning of the application. The report will focus on examples of drugs that act on the central nervous system such as duloxetine, thioridazine, thalidomide and methylene blue. In addition, the article briefly describes the selective optimization of side activities of drug molecules (the SOSA approach), another highly efficient strategy, which enables to generate new biologically active compounds.
    Źródło:
    Wiadomości Chemiczne; 2018, 72, 11-12; 907-928
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Nowe kierunki badań i wyzwania w analizie leków heparynowych
    New directions of research and challenges in the analysis of heparin drugs
    Autorzy:
    Sadowski, Radosław
    Krysztofiak, Dominika
    Gadzała-Kopciuch, Renata
    Buszewski, Bogusław
    Powiązania:
    https://bibliotekanauki.pl/articles/1413253.pdf
    Data publikacji:
    2021
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    technika rozdzielania
    chromatografia cieczowa
    leki przeciwzakrzepowe
    heparyny
    LMWHs
    separation technique
    liquid chromatography
    anticoagulants
    heparin
    Opis:
    The complexity of the structure of heparin anticoagulants requires appropriate sample preparation to be able to perform the analysis correctly. This stage of the analytical procedure is the most time-consuming and has a key impact on the obtained information. Therefore, it is important to improve the current and search for new solutions for the preparation of samples of anticoagulants as well as the separation and identification of components of such drugs. This paper discusses heparin drugs and new research directions and challenges related to the analytics of heparin anticoagulants.
    Źródło:
    Wiadomości Chemiczne; 2021, 75, 7-8; 935-942
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wybrane metody separacyjne i woltamperometryczne w analizie leków i substancji endogennych dla diagnostyki i terapii klinicznej
    Selected separation and voltammetric methods in the analysis of drugs and endogenous substances for diagnostics and clinical therapy
    Autorzy:
    Baranowska, Irena
    Bajkacz, Sylwia
    Markowski, Piotr
    Płonka, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1413240.pdf
    Data publikacji:
    2021
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    chromatografia
    woltamperometria
    leki
    aminy biogenne
    ekstrakcja
    spektrometria
    chromatography
    voltammetry
    drugs
    biogenic amines
    extraction
    spectrometry
    Opis:
    The developed chromatographic methods (HPLC and UHPLC/UV, DAD, FL, ED, MS-MS and GC-MS), for the determination of drugs from different therapeutic groups in body fluids, have been presented. Drugs were determined alongside their metabolites, in different concentration ranges, usually after a removal of the interferences from the biological material matrix. Extraction procedures, like LLE, SPE, MEPS, SALLE, USAEME, have been developed for the separation of analytes. Methods for the determination of endogenous compounds: L-camitine, L-arginine and their metabolites, dopamine and its metabolites, and other compounds resulting from their metabolism have also been developed. Cyclic voltammetry and differential pulse voltammetry methods for the determination of electrochemically active drugs have also been presented. Such methods can be used to verify the results of chromatographic determinations. This article presents the results of the research included in 35 publications from the JCR list.
    Źródło:
    Wiadomości Chemiczne; 2021, 75, 7-8; 869-892
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Chemiczne aspekty celowanej terapii przeciwnowotworowej II. Połączenia nośnik -lek
    Chemical aspects of targeted anticancer therapy II . Bond of carrier to drug
    Autorzy:
    Werengowska, K. M.
    Wiśniewski, M.
    Terzyk, A.P.
    Gurtowska, N.
    Drewa, T. A.
    Olkowska, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/172570.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    nanonośniki leków
    leki przeciwnowotworowe
    wiązania kowalencyjne
    adsorpcja
    nanocarriers of drugs
    anticancer drugs
    covalent bonds
    adsorption
    Opis:
    Traditional anticancer therapy is usually low effective. Popular and common drugs applied in anticancer therapy are characterized by low solubility and nonspecific biodistribution in an organism. The chemotherapy kills not only cancer but also healthy cells [4]. Building of modern drug delivery systems based on nanocarriers is a new method of anticancer treatment. The present study is directed towards nanomaterials (as carbon nanotubes, liposomes, polymeric micelles) as modern drug carriers. Thus, we characterized mechanisms of actions of traditional chemotherapeutics: paclitaxel, cisplatin and doxorubicin (Figs. 3–5) [1, 15, 21]. The purpose of this study is a description of the bioconjugation of drug-nanocarrier. Chemotherapeutics can be connected to external or internal surfaces of nanocarriers (Fig. 6) [6]. We described two main methods of drug delivery from internal space of nanocarriers: nanoextraction and nanocondensation (Fig. 7) [32]. The type of drug-carrier bonding can be covalent or noncovalent. We report recent advances in the field showing the formation of esters (Figs. 10–11) [28, 29, 53, 54], acethylhydrazone (Fig. 12) [55–61], amides [62–64], and disulfides groups [12, 65]. These reactions depend on functional groups in structures of drugs and require suitable modification of nanocarrier surfaces. In practice, the functionalization of nanocarrier surface is associated with the covering with polymers including PE G, HPMA, PG and PL GA [3]. Adsorption is the most popular process of bonding chemotherapeutic and nanomaterials (Fig. 13) [66]. Special attention is paid to electrostatic interaction between drugs: paclitaxel [74], cisplatin [59, 76, 77], doxorubicin [67–73] and nanocarriers: carbon nanotubes and/or polymeric micells. By application of modern anticancer therapy, drugs are preserved from lysosomal degradation and to fast reaction in biological environment. Finally, nanocarriers improve adsorption of drug and increase concentration of drug only in cancer tissues [6, 7].
    Źródło:
    Wiadomości Chemiczne; 2012, 66, 7-8; 637-670
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biblioteki związków chemicznych
    Libraries of chemical compounds
    Autorzy:
    Zwoliński, K. M.
    Leśnikowski, Z. J.
    Powiązania:
    https://bibliotekanauki.pl/articles/172580.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    biblioteka chemiczna
    biblioteka wirtualna
    przestrzeń chemiczna
    związki naturalne
    leki
    virtual library
    chemical library
    chemical space
    drugs
    natural products
    Opis:
    Over the past decade one can observe a scientific revolution taking place resulting in an explosion of new biotechnologies. Moreover, with the end of the human genome project and following expansion of the extensive genetic research an unprecedented number of new biological targets useful in drug design have been identified. Simultaneously, new methods such as combinatorial synthesis have expanded the overall size of chemical libraries and high-throughtput technologies have enabled to screen more than one million compounds a day [43]. However, an increasing size of chemical libraries in a random fashion may not necessary increase a probability of success and the overall number of successfully identified leads. Thus, success of any drug discovery program depend heavily on the assumed selection criteria of appropriate molecules [58] which properties should maximize the chances of identifying ligands for any given target. Selection criteria used for compounds to generate diverse as well as focused chemical libraries are briefly discussed in the present overview. We describe the most important quality factors such as size, diversity and chemical tractability which should be always kept in mind during the design of chemical libraries. Chemical space is enormous and limited only by a chemist`s imagination. The number of possible drug-like molecules within chemical space has been estimated to be around 1060 [17]. In contrast the overall number of atoms in the observable Universe is approximately 1080. It is obvious that it is impossible to synthesize every possible molecule so one need to explore only those regions of chemical space which are enriched with molecules of appropriate structure and function. Recent strategies for the design of high-quality collections of structurally diverse sets of small molecules are discussed in the context of probing the chemical space in order to find new biologically active structures.
    Źródło:
    Wiadomości Chemiczne; 2012, 66, 7-8; 741-765
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Enzymatyczne reakcje rozszczepienia wiązania C–C : zastosowanie w syntezie związków zapachowych, farmaceutyków oraz w bioremediacji
    Enzymatic reactions of the C–C bond cleavage : applications in synthesis of aroma compounds, pharmaceuticals and in bioremediation
    Autorzy:
    Panek, A.
    Milecka-Tronina, N.
    Świzdor, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/172055.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    β-oksydacja
    wanilina
    γ-dekalakton
    metyloketony
    leki steroidowe
    bioremediacja
    β-oxidation
    vanillin
    γ-decalactone
    methyl ketones
    steroid drugs
    bioremediation
    Opis:
    The microorganisms are able to utilize natural and synthetic compounds of broad structural diversity as a source of carbon and energy, converting these substrates into low molecular weight products (mainly H2O, CO2 and NH3). The main role in this metabolism is played by the enzymes that catalyze reactions of the C–C bond cleavage. Such reactions are the key step of the primary metabolism of fatty acids in eukaryotic cells by the β-oxidation. The enzymatic systems associated with the C–C bond cleavage have been applied in the synthesis of valuable natural products and in the bioremediation processes. Microbial transformations of natural compounds, in which the reactions of β-oxidation cycle are used, allow the formation of natural aromatic compounds (used as food additives), pharmaceuticals and ingredients of cosmetic compositions. Using this path one can obtain methyl ketones (e.g. responsible for the characteristic smell of cheeses), γ-lactones determining the scent of several popular fruits, and vanillin. A modification of the natural steroids: saponins, alkaloids, sterols, bile acids to products useful in the synthesis of steroid drugs is the most important area of use of the enzymatic C–C bond cleavage, due to the practical significance of the products. Enzymes that catalyze the C–C bonds cleavage are important in the process of biodegradation of toxic aromatic hydrocarbons and their derivatives (bioremediation).
    Źródło:
    Wiadomości Chemiczne; 2015, 69, 5-6; 337-368
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Poszukiwanie nowych leków immunosupresyjnych
    Quest for new immunosuppressive drugs
    Autorzy:
    Dzierzbicka, K.
    Cholewiński, G.
    Iwaszkiewicz-Grześ, D.
    Trzonkowski, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/171863.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    aktywność immunosupresyjna
    leki immunosupresyjne
    glikokortykosteroidy
    takrolimus
    CsA
    FK506
    MPA
    kwas mykofenolowy
    MMF
    MPS
    immunosuppressive activity
    immunosuppressive drugs
    glicocorticosteroids
    tacrolimus
    Opis:
    Transplantology is getting more and more important in medicine. Development of surgical techniques and immunosuppressive treatment enabled to establish successful transplantations with various organs and tissues. However, allografts are recognized as foreign tissues and stimulate rejection, i.e. a strong immunological response which, if not stopped, results in complete destruction of the transplanted tissue. In order to prevent the rejection patients have to be treated with immunosuppressive drugs after transplantation. Unfortunately, such a damping of immune system poses a risk of cancer or severe infections. The treatment itself is also toxic, notably when applied in a long-term maintenance therapy. Currently, adverse effects of immunosuppressive drugs are recognized as the ones to be involved significantly in chronic rejection and limitation of long survival of grafted tissues. Whereas prevention of acute rejection is mostly successful, there is still no efficient treatment for chronic graft rejection. Reduction of a dose of immunosuppressive drugs or an invention of new active substances is considered the most promising solution. Nowadays, immunosuppressive drugs can be divided into the three main groups: agents which inhibit production of cytokines taking part in cells’ activation (glicocorticosteroids, calcineurine inhibitors, mTOR inhibitors), antiproliferative compounds (azathiopirin, mycophenolate mofetil, mycophenolic acid sodium salt), and antibodies. In this article we present new investigations towards immunosuppressive drugs, their structures and synthetic methods.
    Źródło:
    Wiadomości Chemiczne; 2011, 65, 1-2; 59-92
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mechanizm oporności na leki platynowe oraz strategie pokonywania tego zjawiska
    The mechanism of resistance to platinum drugs and strategies to overcome this phenomenon
    Autorzy:
    Weiss-Gradzińska, W.
    Krzempek, W.
    Trynda-Lemiesz, L.
    Powiązania:
    https://bibliotekanauki.pl/articles/172324.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    leki platynowe
    oporność lekowa
    leczenie nowotworów
    influx
    efflux
    nanorurki węglowe
    cisplatyna
    platinum drugs
    drug resistance
    cancer therapy
    carbon nanotubes
    cisplatin
    Opis:
    Platinum drugs belong to one of the oldest [2] and best investigated groups of cytotoxic drugs. On account of their high efficacy and alkylating-like action [14] they are used in a treatment of various types of neoplasms [3–5]. Despite investigators’ best efforts survival time of patients diagnosed with cancer is still short. Responsible for the fact is high toxicity of used therapeutic methods and development of resistance to them [3–5, 19]. In this paper authors review reasons behind decreased sensitivity of neoplastic cells to platinum treatment and discuss the newest promising trends in its overcoming. Due to different properties of neoplastic cells, availability of a chemotherapeutic agent inside a tumour is limited [9–12]. Moreover continuous development of resistance to platinum drugs further decreases their cellular concentration and inactivates their functions. Also owing to increased activity of DNA repair systems, higher tolerance to genome deformations and numerous mechanisms that lead to impaired apoptosis, drug efficacy is reduced [3-5, 19]. In order to increase a potency of platinum agents new therapeutic strategies are investigated. Coadministration with resistance modulators [20, 22, 23] and combination therapy with other antineoplastic drugs [8, 24–30] have already proved their effectiveness. Additionally, newer generations of platinum drugs are developed [15–18]. Mostly platinum(IV) prodrug complexes often releasing axial ligands with their own pharmacological action [5, 6, 31], but also multi-nuclear platinum compounds that form more complex DNA-adducts [32–35]. Other strategies include the development of innovative dosage forms such as single walled carbon nanotubes (SWCNTs), multiwalled carbon nanotubes (MWCNTs) [38, 39] or encapsulation [36, 37]. Finally utilisation of oncolytic viruses could be a way to selectively destroy neoplastically transformed cells [40].
    Źródło:
    Wiadomości Chemiczne; 2013, 67, 11-12; 1105-1128
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Inhibitory cholinoesteraz w terapii choroby Alzheimera
    Cholinesterase inhibitors in Alzheimer disease therapy
    Autorzy:
    Zawadzka, A.
    Czarnocki, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/172066.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    choroba Alzheimera
    inhibitory cholinoesteraz
    leki hybrydowe
    związki o wielokierunkowym działaniu
    Alzheimer's disease
    cholinesterase inhibitors
    hybrid drugs
    multi target directed ligands
    MTDLs
    Opis:
    In recent years, a progressive increase in age-related disorders could be observed in most western countries, among which Alzheimer’s disease (AD) is one of the most challenging. The progress of AD is characterized by a severe loss in memory and cognition, leading to behavioral changing, depression and death. Currently approved treatments, including the acetylcholinesterase inhibitors (AChEIs) donepezil, galantamine and rivastigmine and N-methyl-d-aspartate (NMDA) antagonist memantine, do not halt the progression of the disease. The discovering of multifunctional compounds considering that several dual binding site AChEIs were able to reach different targets, guided the development of new drug design strategy, the multi-target-directed ligand (MTDL) approach. This review shows briefly summaries past and present research on the cholinesterase inhibitors (ChIs) able to interact with other targets contributing in aetiology of Alzheimer’s disease.
    Źródło:
    Wiadomości Chemiczne; 2015, 69, 9-10; 767-788
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Zastosowanie związków kompleksowych platyny, palladu i kobaltu w medycynie. Cz. 1
    Application of coordination compounds of platinum, palladium and cobalt in medicine. Part 1
    Autorzy:
    Pawlak, Marta
    Drzeżdżon, Joanna
    Jacewicz, Dagmara
    Powiązania:
    https://bibliotekanauki.pl/articles/1409835.pdf
    Data publikacji:
    2020
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    związki kompleksowe platyny
    związki kompleksowe palladu
    związki kompleksowe kobaltu
    leki przeciwnowotworowe
    coordination compounds of platinum
    coordination compounds of palladium
    coordination compounds of cobalt
    anticancer drugs
    Opis:
    The complex compounds containing metal ions are a group of compounds widely used in medicine. More and more metals are also being used to create cancer drugs or to help with other very serious diseases. Anticancer drugs are a particular use of complex compounds. Many thousands of platinum(II) compounds have been synthesized in cancer therapy, but only six of them have found use in the treatment of cancer. The most popular and the most commonly used compound is cisplatin, it has become the basis for the treatment of bladder, cervical, head, esophagus and many cancers occurring in children. The mechanism of action of platinum(II) and platinum(IV) compounds against cancer cells is to inhibit DNA replication, then RNA transcription and stop the G2 phase of the cell cycle and lead to programmed cell death or apoptosis. Coordination compounds containing more than one metal ion in their composition open new possibilities in the fight against cancer. Pt-DNA connections created by compounds containing at least two metal atoms are different from those formed by cisplatin. The basic dinuclear structure allows for great flexibility in forming DNA-DNA or DNA-protein bonds. The cobalt(III) complexes began to be used to image areas of hypoxia in cancer cells. It is believed, that cobalt(III) complexes undergo bioreduction, which leads to the release of the labile cobalt(II) complex and one or more bioactive ligands. Studies on nitro-Co(III) complexes containing acetylacetone and a nitrogen mustard ligand have shown that it is a particularly effective anti-cancer drug. Due to the fact that many people have cancer new effective anti-cancer drugs with low toxicity and no side effects are still being sought.
    Źródło:
    Wiadomości Chemiczne; 2020, 74, 11-12; 797-822
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Enzymatyczne i chemiczne modyfikacje fosfolipidów
    Enzymatic and chemical modifications of phospholipids
    Autorzy:
    Chojnacka, Anna
    Niezgoda, Natalia
    Powiązania:
    https://bibliotekanauki.pl/articles/27310043.pdf
    Data publikacji:
    2023
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    fosfolipidy strukturyzowane
    koniugaty fosfolipidowe
    bioaktywne kwasy tłuszczowe
    modyfikacje fosfolipidów
    sprzężony kwas linolowy
    dehydroepiandrosteron
    niesteroidowe leki przeciwzapalne
    lipaza
    fosfolipaza
    structured phospholipids
    phospholipid conjugates
    bioactive fatty acids
    phospholipid modification
    dehydroepiandrosterone
    NSAIDs
    lipase
    phospholipase
    Opis:
    At the moment, phospholipids are among the most interesting molecules. The possibilities of chemical and enzymatic modifications, while maintaining their integrity and unique nature, also contribute to these compounds' great interest. This review paper concerns the preparation of new phospholipid conjugates containing fragments of biologically active compounds not found naturally in phospholipids, and phospholipids enriched with specific fatty acids with health-promoting properties (structured phospholipids). Chemical methods for the synthesis of phospholipids containing conjugated linolenic acid (CLA), dehydroepiandrosterone (DHEA) or selected non-steroidal anti-inflammatory drugs (NSAIDs) at the sn-1 and/or sn-2 position have been described. In addition, the evaluation of the antiproliferative activity of the obtained conjugates against selected cancer cell lines was also described. Enzymatic methods of modifying natural phospholipids leading to their enrichment with bioactive polyunsaturated fatty acids and conjugated acids have also been described.
    Źródło:
    Wiadomości Chemiczne; 2023, 77, 5-6; 449--477
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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