Wybrane metody separacyjne i woltamperometryczne w analizie leków i substancji endogennych dla diagnostyki i terapii klinicznej

The developed chromatographic methods (HPLC and UHPLC/UV, DAD, FL, ED, MS-MS and GC-MS), for the determination of drugs from different therapeutic groups in body fluids, have been presented. Drugs were determined alongside their metabolites, in different concentration ranges, usually after a removal of the interferences from the biological material matrix. Extraction procedures, like LLE, SPE, MEPS, SALLE, USAEME, have been developed for the separation of analytes. Methods for the determination of endogenous compounds: L-camitine, L-arginine and their metabolites, dopamine and its metabolites, and other compounds resulting from their metabolism have also been developed. Cyclic voltammetry and differential pulse voltammetry methods for the determination of electrochemically active drugs have also been presented. Such methods can be used to verify the results of chromatographic determinations. This article presents the results of the research included in 35 publications from the JCR list.