- Tytuł:
- Impact of CpG oligodeoxynucleotide stimulation on percentage of T and B cells in chicken
- Autorzy:
-
Chrzastek, K.
Piasecki, T.
Wieliczko, A. - Powiązania:
- https://bibliotekanauki.pl/articles/30568.pdf
- Data publikacji:
- 2013
- Wydawca:
- Polska Akademia Nauk. Czytelnia Czasopism PAN
- Opis:
- TLR stimulation in chickens has been shown to play a role in the initiation and regulation of innate and adaptive immune responses. The aim of this study was to use flow cytometry to establish the percentage of T and B subset in blood and lymphoid organs in chicks after CpG oligodeoxynucleotide (ODN) stimulation. It was demonstrated that the percentages of CD3⁺, CD4⁺, TCRγ δ⁺ cells and Bu-1⁺MHC class II⁺ cells in blood 24 h post-injection were significantly higher than in the control groups. It was also shown that the percentages of CD3⁺ and CD4⁺ cells in the spleen at 48 h post-injection were significantly higher than in control groups. The percentage of Bu-1⁺ cells in the bursa of Fabricius after CpG ODN stimulation (98.38 ± 0.84) was significantly higher than that found in the non-CpG ODN control group (94.54 ± 2.51) (p ≤ 0.05). The results indicate that class B CpG ODN increases the percentage of both T (especially CD4⁺ cells) and B cells.
- Źródło:
-
Polish Journal of Veterinary Sciences; 2013, 16, 3
1505-1773 - Pojawia się w:
- Polish Journal of Veterinary Sciences
- Dostawca treści:
- Biblioteka Nauki