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    Wyświetlanie 1-6 z 6
    Tytuł:
    Chemopreventive properties of young green barley extracts in in vitro model of colon cancer
    Autorzy:
    Kawka, K.
    Lemieszek, M.K.
    Rzeski, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/2082991.pdf
    Data publikacji:
    2019
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    Hordeum vulgare
    barley
    colon cancer
    chemoprevention
    Opis:
    Introduction and objective. Young green barley is the most valuable source of nutrients and bioactive substances. It has a broad spectrum of health-promoting properties such as antioxidant, anti-inflammatory, hypoglycaemic, anti-depressant, anti-atherosclerotic and anticancer. The presented study is an attempt to extend this knowledge with particular emphasis on the possibility of using green barley in colon cancer prevention. Materials and method. Extracts were prepared on the basis of two commercial products: ground dried barley grass (YGB INT) and powder of young green barley juice (YGB GW). Their influence on colon epithelial cells (CCD841 CoN) viability and proliferation were analyzed by LDH and MTT assays. Anticancer properties of extracts were screened on colon cancer cell lines (LS180, HT-29) by MTT and BrdU assays. Changes in cells morphology induced by extracts were investigated after May-Grünwald-Giemsa staining. Results. Tested extracts were not toxic against CCD841 CoN and did not affected their proliferation or morphology (LDH test, MTT test, microscopy observation). The MTT revealed that extracts significantly inhibited proliferation of colon cancer cells in a dose-dependent manner. Results of BrdU test confirmed antiproliferative properties of extracts, but opposite to MTT test, indicated YGB GW as a better anticancer agent. Light microscopy observation proved the data obtained from both MTT and BrdU tests and additionally suggested the ability of the extracts to induce necrosis in LS180 and HT-29 cells. Conclusions. The study demonstrated that YGB extracts specifically inhibit proliferation of colon cancer cells without any undesirable effect on colon epithelial cells. Obtained results will provide a rationele for the future development of dietary supplements which could be beneficial in colon cancer chemoprevention.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2019, 26, 1; 174-181
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Levels of interleukin-2 in patients with colon cancer and diabetes type 2
    Autorzy:
    Bosek, Irina
    Sulich, Agnieszka
    Rabijewski, Michał
    Kaleta, Beata
    Kniotek, Monika
    Miłek, Tomasz
    Piątkiewicz, Paweł
    Powiązania:
    https://bibliotekanauki.pl/articles/972606.pdf
    Data publikacji:
    2016
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    diabetes type 2
    colon cancer
    interleukin-2
    Opis:
    Introduction and objective: The risk of development colon cancer (CC) is increased significantly among patients with the type 2 diabetes (T2DM). A mechanism responsible for the higher prevalence of CC among diabetic patients may be associated with the immunity system. The aim of this study is to point out the differences in the immunity state in terms of interleukin 2 level among patients with T2DM suffering from CC, and patients without these diseases Material and Methods: 79 patients were included the tests, divided into 4 groups: Group 1–23 people with T2DM, Group 2–23 people with large intestine CC, Group 3–10 people with large CC and T2DM, and Group 4–23 people without T2DM or CC. Each patient had a colonoscopy and those with cancer were confirmed in a histopathological examination. Laboratory measurements included fasting glucose, insulin, C-peptide. The concentration of interleukin-2 in serum was determined with the immunoenzymatic (ELISA) method. Results: The results obtained showed that in patients with T2DM and CC the concentration of interleukin-2 was statistically higher than in the other groups.(4.21±1.61 pg/ml vs. Group 1 -1.64±0.44 pg/ml, Group 2–1.54±0.21 pg/ml, and Group 4–1.70±0.36 pg/ml; p<0.05). Insulin levels, C-peptide and HOMA-IR did not differ significantly between groups, but a tendency was observed to higher values of HOMA-IR and insulin levels in the groups with T2DM alone and T2DM with concomitant CC. Conclusions: The data show differences in the immunity state of patients with T2DM and CC, compared with people without those two diseases. Elevated level of interleukin 2 found in this group, after confirmation in other studies with more patients, could be used as a marker of an increased risk of CC in people with T2DM
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2016, 10, 1; 1-5
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The value of abdominal ultrasound in the diagnosis of colon cancer - case report
    Autorzy:
    Rola, Sylwia
    Migaryt, Emilia
    Prystupa, Andrzej
    Makaruk, Bogusław
    Kowalik, Marcin
    Sobstyl, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/972538.pdf
    Data publikacji:
    2017
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    abdominal ultrasound
    colon cancer
    pseudokidney sign
    rosette sign
    Opis:
    Introduction. Abdominal ultrasound is considered an initial examination of the the gastrointestinal tract. The case is presented in which ultrasound (US) detected a ‘pseudokidney’ sign that enabled the tentative diagnosis of a colonic neoplastic lesion. Case report. A 78-year-old patient was admitted to the Department of Internal Diseases due to weight loss and anaemia. US demonstrated abnormalities in the form of intestinal wall thickening with a hyperechoic centre. This finding led to the tentative diagnosis of a neoplastic lesion. After further diagnostic procedures, i.e. colonoscopy and histopathological examination of biopsy specimens, the patient was diagnosed with colon adenocarcinoma. Conclusions. In many cases, experienced US radiologists can initially assess the intestinal wall and other organs, which effectively directs towards further diagnostic management, hence accelerates the diagnosis and decision to apply a given therapeutic option or otherwise.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2017, 11, 2; 160-161
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of anticancer activity of water and juice extracts of young Hordeum vulgare in human cancer cell lines HT-29 and A549
    Autorzy:
    Czerwonka, Arkadiusz
    Kawka, Katarzyna
    Cykier, Klaudia
    Lemieszek, Marta Kinga
    Rzeski, Wojciech
    Powiązania:
    https://bibliotekanauki.pl/articles/989841.pdf
    Data publikacji:
    2017
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    hordeum vulgare
    colon cancer
    lung cancer
    inhibition of proliferation
    necrosis
    Opis:
    Introduction and objective. Barley (Hordeum vulgare L.) is known as a rich source of different bioactive compounds. At present, considerable attention of researchers is focused on young barley grass. It can be a good source of dietary minerals, vitamins, carbohydrates, amino acids, phenolic compounds and proteins. It is possible that the composition of chemical ingredients beneficial for health may induce an anticancer potential of young barley in human colon adenocarcinoma (HT-29) and human lung adenocarcinoma (A549) cell lines. Materials and method. Hordeum vulgare water extract (HWE) and Hordeum vulgare juice extract (HJE) were prepared. Cell proliferation and viability were examined with the use of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and NR (neutral red) methods. Induction of necrosis was assessed by propidium iodide/Hoechst staining. Progress of the cell cycle involved in cell proliferation, apoptosis, and regulation of transcription was estimated using flow cytometry analysis. Additionally, the capability of free radical scavenging was evaluated with the DPPH assay. Results. The study revealed that extracts inhibited the proliferation of cancer cells. The NR study confirmed the low cytotoxic activity of the tested extracts to normal human colon epithelial cells (CCD 841 CoTr) and human skin fibroblasts (HSF). Furthermore, a dose-dependent cytotoxicity against HT-29 cells, but not A549 cells, has been reported. The free radical scavenging activity was observed in the case of the HWE but not the HJE. Conclusions. The obtained results indicate a cancer chemopreventive potential of young barley as a safe dietary agent in colon carcinoma.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2017, 24, 2
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Nawozy sztuczne, azotyny, a nowotwory złośliwe
    Artifi cial fertilizers, nitrates and malicious cancer
    Autorzy:
    Koscianska, B.
    Rodecka-Gustaw, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/941342.pdf
    Data publikacji:
    2011
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    azotany
    azotyny
    nitrozoaminy
    nawozy sztuczne
    rak żołądka
    rak jelita grubego
    konserwacja żywności
    nitrates
    nitrites
    nitrosamines
    artificial fertilizers
    gastric cancer
    colon cancer
    food preservation
    Opis:
    Azot jest jednym z najważniejszych pierwiastków w przyrodzie, będąc głównym składnikiem atmosfery oraz składnikiem budulcowym DNA i białek wszystkich organizmów. Zawartość związków azotowych w glebie decyduje o jej żyzności. Dlatego więc związki azotu są szeroko stosowane w postaci sztucznych nawozów w celu zwiększenia plonów. Nadmiar zastosowanych nawozów, nie zbilansowany z intensywnością produkcji roślinnej, może stać się źródłem zanieczyszczenia azotanami wód powierzchownych oraz żywności. Związki azotu stosowane są również jako konserwanty żywności, zapobiegające rozwojowi bakterii jadu kiełbasianego (peklowanie). Podczas przetwarzania konserwowanych produktów azotany wchodzą w reakcję z zawartymi w mięsie aminami tworząc karcinogenne nitrozoaminy. Opisuje się związek nitrozoamin z rozwojem nowotworów przewodu pokarmowego (rak żołądka, rak jelita grubego, rak przełyku). Sygnalizowana jest również obecność w nawozach sztucznych soli metali ciężkich (ołów, arsen, kadm), które między innymi, mają wpływ na rozwój nowotworów przewodu pokarmowego i układu moczowego. Przedstawiono pokrótce sytuację epidemiologiczną i czynniki etiologiczne nowotworów żołądka, jelita grubego i przełyku.
    Nitrogen, as the main component of the atmosphere, and a component of the construction of DNA and proteins of all organisms, is among the most important elements in nature. The content of nitrogen compounds in soil decides about its fertility. Therefore, nitrogen compounds are widely applied in the form of artifi cial fertilizers in order to increase yield. An excess of the fertilizers used, unbalanced with the intensity of plant production, may become the source of contamination of surface waters and food with nitrates. Nitrogen compounds are also applied as food preservatives, preventing the development of Clostridium botulinum bacteria in food products (pickling meat). While processing conserved food products, nitrates enter into the reaction with amines which are present in meat and form carcinogenic nitrosamines. There are reports describing the relationship between nitrosamines and the development of gastrointestinal cancer (gastric cancer, colorectal cancer, oesophageal cancer). In addition, the presence of heavy metals salts in artifi cial fertilizers is also signaled, such as lead, arsenic and cadmium which, among other things, exert an eff ect on the development of cancer of the gastrointestinal tract and urinary system. The epidemiological situation and etiologic factors of gastric, colorectal and esophageal cancer are briefly presented.
    Źródło:
    Medycyna Ogólna i Nauki o Zdrowiu; 2011, 17(46), 1; 34-38
    2083-4543
    Pojawia się w:
    Medycyna Ogólna i Nauki o Zdrowiu
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Results of screening in Lublin Province, Poland, for colorectal cancer and neoplastic polyps - the role of environmental factors
    Autorzy:
    Cichoż-Lach, Halina
    Szumiło, Justyna
    Celiński, Krzysztof
    Kasztelan-Szczerbińska, Beata
    Szczerbiński, Mariusz
    Swatek, Jarosław
    Wronecki, Lech
    Wargocki, Janusz
    Słomka, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/989962.pdf
    Data publikacji:
    2017
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    neoplastic polyps of colon
    advanced adenoma of colon
    colorectal cancer screening
    Opis:
    Introduction and objective. Screening colonoscopy is a recommended tool, and the most sensitive and cost-effective method for reducing the incidence of colorectal cancer (CRC). Objective. The purpose of the study was to present the results of a 5-year screening for early detection of CRC carried out among the population of the central-eastern regions of Poland, primarily in Lublin Province. Materials and method. Screening colonoscopy was conducted in a group of 1,009 patients – 636 women and 373 men, aged 40–65 years. Results. Neoplastic polyps were found in 275 patients, advanced adenomas in 49 patients and adenocarcinoma in 13. 70.55% of neoplastic polyps was located in the distal colon, 18.9% in the proximal part and 10.55% in both regions, advanced adenomas in 79.59%, 8.16% and 12.25%, respectively. Adenocarcinoma was located in the proximal colon in 2 cases and in the distal region in 11 cases. Neoplastic polyps and advanced adenomas occurred significantly more frequently in smokers than in non-smokers. Neoplastic polyps were found statistically more frequent in males than in females, among the overweight and obese patients, than in subjects with normal BMI, and more frequently in the group of urban, compared to rural patients. However, the frequency of advanced adenomas and CRC was not statistically different in those groups. The incidence of CRC was statistically more frequent in males than in females. Smoking and male gender were significant risk factors for developing neoplastic polyps. Male gender seemed to predispose to CRC. Obesity was found to favour advanced adenomas. Conclusions. The results of screening found neoplastic polyps in every third person (mean) who did not have any symptoms suggestive of colon pathology. Advanced adenomas were found in 5% of the examined and CRC was detected in 1.29% of participants. Smoking, male gender and overweight were significant risk factors for developing neoplastic polyps. No correlation was found between gender and the location of neoplastic polyps and advanced adenomas in the colon.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2017, 24, 1
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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