- Tytuł:
- Synthesis and characterization of 1,3,5-trisubstituted pyrazoline derivatives by ultrasonic irradiation method and evaluation of its antibacterial activity
- Autorzy:
-
Raguraman, A.
Santhi, N. - Powiązania:
- https://bibliotekanauki.pl/articles/412019.pdf
- Data publikacji:
- 2014
- Wydawca:
- Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
- Tematy:
-
4-methylacetophenone
ultrasonic irradiation
chalcone
2-pyrazoline
antibacterial
antifungal - Opis:
- A series of novel 1,3,5-trisubstituted pyrazoline derivatives (P1-P10) have been synthesized by the reaction of substituted chalcones (C1-C10) with 4-hydroxybenzhydrazide. The starting material, chalcones were prepared by claisen Schmidt condensation of 4-methylacetophenone with substituted aldehydes in the presence of sodium hydroxide in ethanol. 4-hydroxybenzhydrazide was synthesized by condensing methyl 4-hydroxybenzoate with hydrazine hydrate. The cycloaddition of chalcones with 4-hydroxybenzhydrazide gives 1, 3, 5-trisubstituted pyrazoline derivatives. The structures of synthesized derivatives were confirmed by IR, 1HNMR and 13C NMR spectrum. The synthesized compounds were screened for their antibacterial and antifungal activity.
- Źródło:
-
International Letters of Chemistry, Physics and Astronomy; 2014, 20, 2; 219-233
2299-3843 - Pojawia się w:
- International Letters of Chemistry, Physics and Astronomy
- Dostawca treści:
- Biblioteka Nauki
Artykuł