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    Wyświetlanie 1-63 z 63
    Tytuł:
    Singlet oxygen lifetime and diffusion measurements
    Autorzy:
    Ożog, Łukasz
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/454834.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    photodynamic therapy
    singlet oxygen
    diffusion
    Opis:
    Introduction. Photodynamic therapy (PDT) is considered to be a promising antitumor methodology due the cytotoxicity of singlet oxygen (1 O2 ). Aim. To present singlet oxygen which is highly reactive and decomposes to the ground state rapidly. Material and methods. Analysis of literature. Results. This review presents techniques to measure lifetime and diffusion of 1 O2.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 2; 123-126
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Methods of singlet oxygen generation and detection for understanding photodynamic processes
    Autorzy:
    Ożog, Łukasz
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/455005.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    photodynamic therapy
    ifetime of singlet oxygen photosensitizing agent
    Opis:
    Introduction. Photodynamic therapy (PDT) is a clinically approved therapeutic procedure that exerts selective cytotoxic activity toward malignant cells. Aim. Our goal is to present the PDT procedure which involves administration of a photosensitizing agent followed by irradiation at a wavelength corresponding to the absorbance band of the photosensitizer and energy transfer to ground state oxygen to generate cytotoxic singlet oxygen Material and methods. Analysis of literature. Results. In this paper we described the basics of PDT and lifetime of singlet oxygen in different media.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 3; 228-232
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Nanomedicine – a review
    Autorzy:
    Dynarowicz, Klaudia
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/2053956.pdf
    Data publikacji:
    2022-03-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    nanomedicine
    nanoscale
    nanostructure
    Opis:
    Abstract Introduction and aim. Nanomedicine is a discipline of technology and science, the potential of which has recently fascinated scientists in the fields of physics, biotechnology, chemistry and medicine. This department deals with everything on the nano scale, i.e. on the level of individual atoms and molecules. This work presents the nano scale, i.e. on the level of individual atoms and molecules. Nanotechnology is currently one of the most popular and dynamically developing fields, not only in electronics, but above all in pharmacy and medicine. Material and methods. In this article a narrative review regarding nanomedicine. Analysis of the literature. The desire to summarize information about nanomedicine application of singlet oxygen is presented. Nanotechnology is a discipline of technology and science, the potential of which has recently fascinated scientists in the fields of physics, biotechnology, chemistry and medicine. Conclusion. The use of nanostructures is currently very efficient. The areas in which the potential of nanoparticles is constantly researched and confirmed by numerous articles are: radio- and chemotherapy, cancer diagnostics and imaging medicine (MRI and fluorescence imaging).
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2022, 1; 102-108
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Chemiluminescence-driven Dye Excitation for Dark Photodynamic Therapy
    Autorzy:
    Ożóg, Łukasz
    Tabarkiewicz, Jacek
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/454676.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    singlet oxygen
    chemiluminescence bioluminescence
    photodynamic therapy
    Opis:
    Photodynamic therapy is a treatment that uses a combination of light-absorbing photosensitizers and dissolved oxygen to kill cancer. One specific limitation of photodynamic therapy is that the visible light used for photosensitizer excitation has a short tissue penetration depth of several millimeters. This limits the application of photodynamic therapy to surface cancers in the absence of a technique to illuminate deeper tissue. Efforts to extend tissue depth to which photodynamic therapy can be applied have been attempted with use of up-conversion and persistent-luminescent nanoparticles that absorb near infrared light and emit visible light for photosensitizer excitation, yet an initial excitation with an external light source is still required. More recently, systems employing chemiluminescence as an excitation energy source designed to bypass the use of external light have been developed and investigated as potential agents that could overcome the problem of achieving photodynamic therapy in deep tissue. We wish to provide an overview of several systems that have been recently reported that employ both radiative and non-radiative chemiluminescent energy transfer for photosensitizer excitation that have been developed in the hope of achieving “dark” photodynamic therapy. This article reviews several of these important new developments in the design of photodynamic therapeutic systems that utilize chemiluminescence.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 95-98
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Brachial artery injury
    Autorzy:
    Milik, Krzysztof
    Pasternak, Grzegorz
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/2037693.pdf
    Data publikacji:
    2020-06-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    broken bone
    traumatic joint dislocation
    vascular injuries
    Opis:
    Introduction. Arterial damage associated with musculoskeletal injuries at room conditions is very common. Aim. It is worth remembering that examining a patient who has suffered an accident with a broken bone or traumatic joint dislocation may be accompanied by vascular damage. A dislocation or fracture often masks damage to the artery. Description of the case. In this paper, a 20-year-old patient being a passenger suffered upper right limb trauma in a car accident. Conclusion. The effects of vascular injuries appear only after a few hours after setting the fracture. It is not known then whether the artery was damaged at the same time with the fracture, whether the injury occurred during the adjustment, or whether the ischemia is finally the result of the pressure exerted by too tight plaster casts.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 2; 141-145
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biological properties of Cistus species
    Autorzy:
    Stępień, Agnieszka
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454751.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    biological properties
    Cistus sp.
    medicinal plants
    Opis:
    Aim. This paper presents a review of scientific studies analyzing the biological properties of different species of Cistus sp. Materials and methods. Forty papers that discuss the current research of Cistus sp. as phytotherapeutic agent were used for this discussion. Literature analysis. The results of scientific research indicate that extracts from various species of Cistus sp. exhibit antioxidant, antibacterial, antifungal, anti-inflammatory, antiviral, cytotoxic and anticancer properties. These properties give rise to the possibility of using Cistus sp. as a therapeutic agent supporting many therapies
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 2; 27-132
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The role of MRI in the central nervous system
    Autorzy:
    Leksa, Natalia
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454852.pdf
    Data publikacji:
    2020-03-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    1H MRI
    functional MRI
    metabolic brain disfunctions
    Opis:
    Introduction. Magnetic Resonance Imaging (MRI) has modified the practice of radiology. MRI is base on safe interaction between radiowaves at a particular frequency and hydrogen nuclei in the body. Metabolic encephalophaties are by definition those disorder of the central nervous system that are not due primarily to structural abnormalities. Aim. Here we present the 1H MRI and functional MRI (fMRI) method applied to diagnosis of disorders of the central nervous system. Material and methods. Analysis of literature and self-research. Results.We have discussed the major MRI applications in the characteristic of the central nervous system. The relationship beteen the motion of flowing blood and the representation of the blood on images is complex. This work is an introduction to the basic ideas and techniques of fMRI. Therefore, both, 1H MRI and functional MRI, methods are ued in neuroscience. Conclusion. Nonivasive MRI and functional MRI are daily diagnostics methods in neurology.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 1; 28-31
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Anticancer properties of Viburnum
    Autorzy:
    Stępień, Agnieszka
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454949.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    antitumor activity
    Viburnum species
    cytotoxic activity
    Opis:
    Aim. The aim of this paper is to provide an overview of the anticancer properties of different species of Viburnum. Materials and methods. Forty nine papers that discuss the medicinal history and current research of Viburnum species as phytotherapeutic agent were used for this discussion. Literature analysis. The results of scientific research conducted in vitro indicate that the compounds present in the extracts of Viburnum significantly affect the development of cancer cells such as leukemia, cervical cancer, breast, colon, lung, skin and stomach. This indicates that they may be used as a therapeutic agent to support oncological therapies.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 1; 47-52
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Efficacy and safety of biosimilar IFX (CT-P13) and adalimumab in patients with active fistulizing perianal Crohn’s disease naïve to anti-TNF therapy: preliminary results from the POLIBD study
    Autorzy:
    Pękala, Anna
    Aebisher, David
    Pardak, Piotr
    Filip, Rafał
    Powiązania:
    https://bibliotekanauki.pl/articles/454795.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    adalimumab, Crohn’s disease
    IFX
    perianal fistula
    Opis:
    Introduction. The development of perianal fistulas are a risk factor in colonic and rectal disease. Perianal CD treatment requires a combination of surgical and therapeutic treatments aimed to prevent septic complications, reduce fistula discharge and ultimately heal fistulas. Aim. The purpose of the study was to evaluate the efficacy and safety of biosimilar IFX (CT-P13) and adalimumab in active fistulizing perianal Crohn’s disease (CD) in patients from the Subcarpathian Region (South-Eastern Poland). Material and methods. Thirty patients with CD with perianal fistulas naïve to anti-TNF therapy were enrolled (13 females/ 17males) ranging from 18 to 64 years of age. Twenty-one were treated with biosimilar infliximab (CT-P13), nine were treated with adalimumab (ADA). The treated patients had ileal CD (4), ileo-colonic CD (13) or colonic CD (13). All of them received standard immunosuppression with no additional steroid therapy. Response was evaluated at week 16 and 40 after the first CT-P13 dose, and 16 and 40 weeks after the first ADA dose. Remission was defined as the complete closure of all fistulas and partial response as a reduction (≥50%) in the number of draining fistulas. Results. Treatment outcomes with CT-P13 and ADA were both effective and similar in the percentage of patients with perianal fistula improvement, perianal fistula remission, no effect or observed adverse events. Conclusion. In patients with active fistulizing CD, both CT-P13 and ADA were effective and safe, however a slight superiority of CT-P13 was visible
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 1; 12-15
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Bladder leiomyoma: diagnostics, laparoscopy, and treatment
    Autorzy:
    Godlewski, Dominik
    Pszczółkowski, Patryk
    Fedus, Tadeusz
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/2038414.pdf
    Data publikacji:
    2020-09-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    bladder leiomyoma
    endometriosis
    laparoscopic surgery
    Opis:
    Introduction. Leiomyosarcoma is the most common benign tumor of the bladder. However, it is only a small percentage of all proliferative changes of this organ. Aim. Presentation based on two clinical cases of diagnostics and surgical treatment from laparoscopic access of bladder leiomyoma. Description of the cases. Case 1. The work contains a diagnosis based on transvaginal ultrasound (TVUS), cystoscopy and computed tomography (CT), as well as partial laparoscopic bladder re section of leiomyoma in young women. Case 2. The case of young women with the histopathological result confirmed bladder leiomyoma. Conclusions. Leiomyoma is a rare bladder cancer. Laparoscopic bladder resection is a safe method that leads to healing
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 3; 237-241
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Numerous gastrointestinal tumors
    Autorzy:
    Przyczyna, Piotr
    Trojnar, Elżbieta
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/2040144.pdf
    Data publikacji:
    2020-12-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    gastrointestinal stromal tumor histopathological examination multiple neoplasms
    small intestine
    Opis:
    Introduction. Gastrointestinal stromal tumor (GIST) is most often locate in the region of the stomach and the proximal part of the small intestine. Aim. The multiple histopathological examination is described. Description of the case. Multiple GISTs are rare neoplasms that originate from the interstitial cells are described. Conclussion. GIST can occur in any part of the gut, they are most common in the stomach and small intestine, and less frequent in the colorectum and esophagus. Although their pathogenesis and clinical manifestations are different, these tumor syndromes confer a high risk for developing multiple neoplasms.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 4; 328-330
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mixed adenocarcinoma-neuroendocrine cancer – a case report
    Autorzy:
    Gustalik, Joanna
    Aebisher, David
    Kaznowska, Ewa
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/2040147.pdf
    Data publikacji:
    2020-12-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    central nervous system
    MANEC
    mixed adenocarcinoma-neuroendocrine cancer
    Opis:
    Introduction. Mixed adenocarcinoma-neuroendocrine cancer (MANEC) is a rare cancer that is characterized by aggressive course and poor prognosis. Aim. A case report and literature review. Description of the case. This article presents the case of a 63-year-old patient who was hospitalized due to the occurrence of neurological symptoms such as nausea, dizziness and headache as well as double vision and numbness of the hands. Suspected ischemic stroke, meningitis with bacterial etiology or brainstem pathology. Conclusion. MANEC composed of large neuroendocrine cells have better survival and clinical behavior than patients with small, intermediate or mixed large and intermediate cells.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 4; 335-337
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Plant medicinal products and drug interactions
    Autorzy:
    Ożóg, Łukasz
    Aebisher, David
    Bober, Zuzanna
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454688.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    drug interactions
    natural products
    drug
    therapeutic material
    Opis:
    Introduction. Some herbal medicinal products may be beneficial in certain respects but many can be dangerous for patients taking doctor-prescribed medications. Plant medicinal products are often taken with conventional drugs by patients. Interactions are possible between herbal medicinal products and conventional medications that can lead to toxicity due to increaseddrug plasma levels or drug treatment failure. Aim. The aim of the study was to review the study of plant medicinal products and drug interactions. Materials and method. Analysis of literature.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 1; 37-40
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Receiver operating characteristic analysis of the FeNO biomarker in the diagnosis of asthma
    Autorzy:
    Biesiadecki, Marek
    Galiniak, Sabina
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/454725.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    asthma
    nitric oxide
    ROC curve
    Opis:
    Introduction. The fraction of exhaled nitric oxide (FeNO) is used as a non-invasive biomarker that reflects inflammation in the airways. It is so versatile that it used to control asthma severity as well as to monitor response to treatment. However, the exact cut-off point of the nitric oxide level which allows one to make a precise diagnosis of asthma is unclear. Aim. To examine the possibility of using advanced statistical methods such as receiver operating characteristic for the analysis of FeNO concentrations for improving the diagnosis of asthma. Materials and methods. Receiver operating characteristic (ROC) was used for analyzing results to determine levels of nitric oxide which may be a prognostic indicator of asthma. The studied group consisted of 111 children including 69 asthmatic patients, and 42 age- and sex-matched healthy subjects. Measurement of exhaled nitric oxide was conducted in all subjects included in this study. Results. FeNO level was higher in asthmatic patients. The analysis of results showed that the cut-off point for the FeNO concentration is 11.5 ppb. Sensitivity and specificity with the FeNO level allowed us to determine a value of the diagnostic variable of FeNO concentration of 14.0 ppb. A comparison of FeNO level and sex of the subjects showed there is no correlation between these parameters of patients. Conclusions. Currently, the FeNO measurement provides complementary d
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 4; 253-258
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Physical fatigue measured by functional MRI
    Autorzy:
    Truszkiewicz, Adrian
    Aebisher, David
    Ożog, Łukasz
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454820.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    functional MRI
    physical fatigue
    physiological condition
    temporary and chronic fatigue
    Opis:
    Introduction. Physical fatigue is a physiological condition that can be measured by functional Magnetic Resonance Imaging (fMRI). Aim. Therefore, this work aims to present the research results currently reported in the scientific literature between the years 2014 and 2018 in the field of chronic fatigue syndrome using the functional MRI method. Material and methods. Analysis of literature. Results. We reviewed here the differences between temporary and chronic fatigue.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 3; 239-244
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Granular cell tumor of the neurohypophysis – a case report
    Autorzy:
    Dziedzic, Rafał
    Leksa, Natalia
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454840.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    granulomatous tumor
    pituitary gland
    MRI
    Turkish saddle
    Opis:
    Introduction. The granulomatous tumor (GCT) is formed from the posterior pituitary (neurohypophysis) or its pedicle. The location of such a tumor in the region of the Turkish or supra saddle is a very rare matter. Aim. To present a case report. Description of the case. This article describes the case of a 39-year-old man admitted to the Department of Neurosurgery with a MR-diagnosed head tumor in the suprasellar area growing out of the pituitary funnel. The tumor appeared to be an epileptic fit. Conclusion. Herein we described a clinical case of granulomatous tumor. GCTs in the pituitary nerves are benign tumors, which makes treatment dependent on the individual case. After the operation, the H-P study showed a granulomatous tumor (GCT) of the posterior pituitary gland.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 4; 378-380
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Inflammatory bowel disease: clinical aspects
    Autorzy:
    Pasternak, Grzegorz
    Aebisher, David
    Filip, Rafał
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454879.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    inflammatory bowel diseases Leśniowski-Crohn’s disease ulcerative colitis
    mataloproteinases
    Opis:
    Introduction. Inflammatory bowel disease is a complex disease which arises as a result of an interaction between environmental and genetic factors leading to immunological responses and inflammation in the intestine. Aim. To review medical approaches used in inflammatory bowel disorders. Materials and methods. An analysis of literature regarding inflammatory bowel diseases, Leśniowski-Crohn’s disease, ulcerative colitis and mataloproteinases. Results. Current evidence suggests that patients with inflammatory bowel disease may have an elevated risk of endothelial dysfunction and coronary artery disease. Over the past two decades, great advances have been made in our understanding of the interplay between the inflammatory bowel disease. Conclusions. Inflammatory bowel diseases are increasing in Europe. The diagnosis is usually confirmed by biopsies on colonoscopy
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 4; 341-345
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Treating kidney cancer – a review
    Autorzy:
    Przyczyna, Piotr
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Kaznowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/454983.pdf
    Data publikacji:
    2020-03-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    kidney cancer
    malignant tumors
    MRI
    Opis:
    Introduction. Kidney cancer in the structure of registered cases was in 6th place in men and 8th in women. Aim. Understanding the molecular biology of renal cell carcinoma has made it possible to produce new diagnostic methods. Material and methods. This review was performed according to a systematic literature search. Results. Minimally invasive techniques seem to have a bright future in kidney cancer. However, they still require many clinical trials before they enter the general clinical use. Conclusion. Photodynamic therapy, thanks to research conducted in kidney cancer, will find application in cancer of other organs.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 1; 38-41
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The significance of NGAL and KIM-1 proteins for diagnosis of acute kidney injury (AKI) in clinical practice
    Autorzy:
    Kubrak, Tomasz
    Podgórski, Rafał
    Aebisher, David
    Gala-Błądzińska, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/454694.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    NGAL proteins
    KIM-1 proteins
    acute kidney injury (AKI)
    Opis:
    Introduction. Despite advances in medical care AKI (acute kidney injury) is associated with high morbidity and mortality. The lack of adequate early renal injury biomarkers is often a problem for an early AKI diagnosis. In recent years, numerous scientific studies have been carried out which reveal new urine and serum markers to assess the period of the kidney injury before revealing its late clinical effects. In most clinical settings, AKI is due to acute renal tubular necrosis which results in protein accumulation in urine. Determination of the concentrations of proteins such as NGAL (neutrophil gelatinase-associated lipocalin) and KIM-1 (kidney injury molecule-1) are of great significance in the diagnosis of AKI. Aim. The purpose of the study was to review the literature about significance of NGAL and KIM-1 proteins for diagnosis of acute kidney injury (AKI) in clinical practice. Materials and method. Analysis of Polish and foreign literature.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 1; 28-33
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Neoadjuvant therapy in breast cancer – objectives and tasks
    Autorzy:
    Ostańska, Elżbieta
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Kaznowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/454710.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    neoadjuvant therapy (NCT)
    breast cancer (BC)
    triple negative breast cancer (TNBC)
    Opis:
    Introduction. Neoadiuvant therapy (NCT) in the treatment of breast cancer is employed for patients with early stage disease or with inoperable disease. NCT can decrease the tumor volume. It can facilitate breast conservation therapy. Response to NCT is a strong predictor of outcome breast cancer (BC). Direct target therapies has markedly improved the result of treatment BC. Aim. Therapy for breast cancer continues to improve. The importance of tumor burden on local control rates will be in the future. Material and methods. This analysis was performed using a systematic literature search. Results. The latest scientific reports give hope for greater safety and a better life for patients based on optimized and effective therapy. Conclusion. Currently, improving the effectiveness of breast cancer treatment is mainly related to the optimal use of classic therapeutic strategies. New classes of substances have been approved for treatment or are in advanced stages of clinical development.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 2; 153-156
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Inflammatory bowel disease: the function of metalloproteinases
    Autorzy:
    Pasternak, Grzegorz
    Aebisher, David
    Filip, Rafał
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454718.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    inflammatory bowel disease
    matrix metalloproteinases extracellular matrix
    Opis:
    Introduction. Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. Aim. The aim of this work was to review the current literature regarding matrix metalloproteinases. The databases such as PubMed, ScienceDirect and Springer were utilized to search the literature for relevant articles. Materials and methods. An analysis of literature. We collected information, data, and examples of the function of metalloproteinases. Results. Herein we show that metalloproteinases play a role in such processes as the immune response, angiogenesis, the epithelial barrier function, fibrosis induced by the inflammatory process, and in the process of carcinogenesis. Conclusions. Further studies on the role of metalloproteinases in the process of carcinogenesis associated with inflammatory bowel diseases are required.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 4; 346-349
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Medicinal & Aromatic Plants
    Autorzy:
    Domka, Wojciech
    Aebisher, David
    Truszkiewicz, Adrian
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454771.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    phytotherapy
    medicinal plants
    otorhinolaryngology
    Opis:
    Introduction. The objective of this study is to discuss the potential of plants species in medical applications. Aim. The main purpose of this study is to discuss ethnobotanically selected plants used in medicine. Materials and methods. We analysed literature and collected information, data, and examples of selected plants used in medicine. Results. The literature shows that for several decades, the properties of medicinal plants have been investigated and reported in the biomedical and pharmaceutical literature. Conclusions. This review includes studies on plants material. The properties of various plants physiology were discuuses with the option for the use in phythotherapy
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 4; 350-358
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Imaging methods of early detection and screening for breast cancer. A review
    Autorzy:
    Gustalik, Joanna
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Kaznowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/454888.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    breast cancer
    breast MRI
    early detection
    screening
    Opis:
    Introduction. Breast cancer is the most frequent neoplasm among women. That is the reason why scientists all over the world are attempting to improve early detection methods of this particular malignancy. Aim. The most common and most widely used examination methods for screening for and detecting breast cancer is presented herein. Material and methods. This review was performed according to systematic literature search of three major bibliographic databases. Results. Available data suggest that incidence and mortality in high-resource countries has been declining whereas incidence and mortality in low-resource countries has been increasing. Conclusion. The role of a physician is to select the most suitable one for each patient in order to obtain the best result. No matter the method however, between 2005 and 2011, the 5-year relative survival was found to be 89%. This is thought to be due to both the increase in utilization of population-wide screening, as well as advances in treatment.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 2; 142-145
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Bladder Mullerianosis – a case report
    Autorzy:
    Ostańska, Elżbieta
    Aebisher, David
    Kaznowska, Ewa
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454913.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    endocericosis
    endosalpingiasis
    mullerianosis
    urinary bladder
    Opis:
    Introduction. Bladder mullerianosis is a rare and proliferative lesion that contains at least two types of ectopic Mullerian tissue in its wall. Aim. To present case of bladder mullerianosis. Description of case. The text contains a description of a clinical case of a 50-year-old woman admitted to a gynecological ward due to diarrheal symptoms and abdominal pain. In a CT examination of the abdominal cavity with contrast, within the posterior left-sided wall of the bladder a 43x25mm proliferative lesion suggestive of neoplastic character was revealed. Transurethral resection of the lesion (TURB) was performed. Histopathology revealed endosalpingiosis with small endocervical foci. The picture of hyperplasia met the criterion of mullerianosis. Conclusion. Bladder Mullerianosis is a very rare disease that occurs mainly in women of reproductive age. It has very good prognosis. It is important to differentiate the lesion with malignant tumor. The basis for the diagnosis is the histopathological examination of the lesion tissues taken during the surgery.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 3; 277-280
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Hyalinising clear cell carcinoma of salivary gland: a case report
    Autorzy:
    Osuchowski, Michał
    Bartusik-Aebisher, Dorota
    Kaznowska, Ewa
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/2037686.pdf
    Data publikacji:
    2020-06-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    cancer
    hyalinising clear cell carcinoma salivary gland
    Opis:
    Introduction. Clear cell carcinoma, not otherwise specified/hyalinising clear cell carcinoma of the salivary gland (HCCC) is a malignancy that arises in minor salivary glands. It rarely leads to distant metastases or cancer-related death but has the potential for recurrence and focal metastases. Aim. A case is reported. Description of the case. A 72 years old female patient has reported to the Clinic of Otolaryngology with a tongue lesion. The patient had no history of malignancy. The lymph node has been surgically removed for further examination. Cords and nests of clear cells and cells with eosinophilic cytoplasm in a hyalinized stroma were identified within the lymph node. After the diagnosis the patient has been transferred to another Oncology Hospital for further treatment. Conclusion. The diagnosis of clear cell carcinoma may be challenging because many of it‘s features frequently overlap with other salivary gland lesions.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 2; 127-130
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The larynx cancer in vitro study by MRI relaxtion time of water
    Autorzy:
    Domka, Wojciech
    Ożóg, Łukasz
    Bartusik-Aebisher, Dorota
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/2038279.pdf
    Data publikacji:
    2020-09-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    larynx tissue
    magnetic resonance imaging
    T2 mapping
    T2 relaxation time
    Opis:
    Introduction. Squamous cell carcinoma (SCC) of the larynx accounts for a significant percentage of all head and neck cancers. Aim. In this paper we determine the differences in magnetic resonance relaxation time (MRI) of water in cancerous and healthy larynx tissues. Material and methods. This study is aimed on T2 MRI modalities for monitoring morphology of larynx tissue. Results. Our results showed that T2 MRI relaxation time measured in larynx tissue can be used to assess early cancer condition of larynx tissues. The changes of T2 MRI correspond to tumor growth within normal tissue. Conclusion. The study showed potential of MRI for the non-invasive monitoring of larynx condition.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 3; 185-187
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Primary breast angiosarcoma – a case report
    Autorzy:
    Ostańska, Elżbieta
    Aebisher, David
    Kaznowska, Ewa
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/2040145.pdf
    Data publikacji:
    2020-12-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    breast biopsy histopathological examination
    immunohistochemistry
    Opis:
    Introduction. Angiosarcoma is a rare breast cancer that can be primary or secondary after surgery or after breast cancer radiotherapy. It is important that breast angiosarcoma belongs to tumors with a non-specific clinical and radiological picture. Aim. The study of the biopsies contained aggressive vasomotor hyperplasia. Description of the case. The presented case concerns the primary angiosarcoma of the right breast in a 56-year-old woman who had never had a surgical procedure before, nor radiotherapy in the area of the breast. Conclusion. Histopathological examination supported by immunohistochemistry is a reliable and indispensable diagnostic element in the diagnosis of vascular sarcoma.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 4; 331-334
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Vascular surgery and an occurrence of stroke
    Autorzy:
    Leksa, Natalia
    Uryniak, Adam
    Aebisher, David
    Leksa, David
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/2038333.pdf
    Data publikacji:
    2020-09-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    cerebral arteries
    diagnosis
    stroke
    Opis:
    Introduction. The brain responds to metabolic disorders with a limited array of symptoms and signs. The brain has enormous needs in terms of substrate and blood flow. Aim. This paper presents a case report reporting episode of stroke. Description of the case. The incidence of cerebral vascular episodes in the form of strokes, transient episodes of cerebral ischemia is reported. Conclusion. The chemical constituency of the brain are generally quite different from those of other tissues. Stroke is a clinical syndrome characterized by sudden focal or generalized brain dysfunction.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 3; 233-235
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Multiparametric MRI and other imaging methods suitable to stage prostate carcinoma
    Autorzy:
    Osuchowski, Michał
    Aebisher, David
    Galiniak, Sabina
    Bartusik-Aebisher, Dorota
    Kaznowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/454672.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    Prostate cancer
    multiparametric MRI (mpMRI) biparametric MRI (bpMRI)
    staging
    Opis:
    Introduction. The role of multiparametric magnetic resonance imaging (mpMRI) in staging prostate carcinoma has been increasing over the last years. It’s high sensitivity is indispensable when diagnosing this disease. It is a very accurate imaging method that helps the physician choose the best treatment method for his patient. Aim. Assessment of mpMRI which uses both anatomic and functional imaging techniques as a method to diagnose prostatic lesions. Advantages and disadvantages of staging prostate carcinoma with the use of biparametric MRI (bpMRI). Methods. The literature search was performed. Results. MpMRI can be used in pre-operative staging of prostate cancer. The technique is accurate in diagnosing and assessment of prostate carcinoma with Gleason Score (GS) of 7 and above. It is also recommended when planning a second biopsy of the prostatic gland.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 4; 331-333
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The advancement of imaging in diagnosis of prostate cancer
    Autorzy:
    Osuchowski, Michał
    Aebisher, David
    Gustalik, Joanna
    Bartusik-Aebisher, Dorota
    Kaznowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/454680.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    MRI
    PET
    prostate carcinoma
    Opis:
    Introduction. Multiple imaging methods have been used to stage prostate carcinoma. Some of them are easily accessible, others very accurate. The advancements over many years have been taken under consideration and now every imaging method has a specific role in the diagnosis of this malignancy. Aim. There are over 1,100,000 cases of prostate carcinoma diagnosed every year around the world. Imaging examinations have to be introduced to accurately stage, and therefore properly treat this disease. This review concentrates on advantages and disadvantages of different imaging methods. Material and methods. The literature search was performed. Results. Imaging methods serve specific goals. TRUS is recommended for acquiring biopsy specimen due to high accessibilityand low cost of the examination. Conclusion. The best tool for staging prostate carcinoma and finding suspicious lesions when attempting second biopsy is mpMRI or bpMRI
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 1; 67-70
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Fundamentals of the use of Berberis as a medicinal plant
    Autorzy:
    Bober, Zuzanna
    Stępień, Agnieszka
    Aebisher, David
    Ożóg, Łukasz
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454712.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    medicinal plants
    phythotherapy
    Berberis
    Opis:
    Introduction. The daily use of medicinal plants has increased in recent years. The study of drugs of natural origin as an academic discipline and its applications in healthcare has changed remarkably but still focus on the quality of products and the development of new medicines. Aim. This study covers all fundamental aspects of pharmacognosy as well as topics relating to the therapeutic use of plant drugs known as phythotherapy. The purpose of the study was to review the literature about the use of Berberis. Materials and method. We reviewed the literature regarding the use of Berberis published between 1933 and 2018. We found more than 500 articles studying the properties of Berberis for digestive disorders, antibacterial, antidiabetic, hypotensive effects, anti-inflammatory effects, cholesterol regulation, cardiovascular disease, hyperlipidemia, cerebral ischemia trauma, mental disease, Alzheimer disease and osteoporosis. Our review includes recent studies regarding chemical composition and medicinal outcomes of Berberis
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 1; 41-46
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Functional MRI – how does it work?
    Autorzy:
    Truszkiewicz, Adrian
    Aebisher, David
    Przypek, Aneta
    Guz, Wiesław
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454947.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    deoxyhemoglobin
    oxyhemoglobin
    Magnetic Resonance Imaging functional Magnetic Resonance Imaging
    Opis:
    Magnetic Nuclear Resonance (MRI) is a non-invasive tissue imaging method. This technique is based on the influence of a strong magnetic field and electromagnetic wave of strictly defined frequency on the nucleus of elements with non-zero spin. The study describes one of the variants of functional MRI, (fMRI), which has become a key technique in brain imaging. This technique has excellent spatial and temporal resolution and involves a changing signal intensity depending on the degree of oxygenation of the blood. Blood oxygenation levels are known to vary in accordance with neural activity and these differences can be used to detect brain activity. This is due to increased demand for energy and oxygen in the area of increased neural activity. The basis of this imaging is the so-called Blood Oxygenation-Level Dependent (BLOD) effect. The aim of this paper is to present the scope of fMRI as a diagnostic method in neurology and in neurosurgery. This paper presents the principles of fMRI, methods of application, research result development, and suggests areas of possible medical applications. The limitations of fMRI as a clinical tool in medical applications will also be addressed. Studies presented in this paper are based on clinical fMRI experience and a literature review.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 120-126
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The potential of phythotherapy in otorhinolaryngology
    Autorzy:
    Domka, Wojciech
    Aebisher, David
    Bober, Zuzanna
    Ożóg, Łukasz
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454662.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    phytotherapy
    medicinal plants
    otorhinolaryngology
    Opis:
    Introduction. The objective of this paper is to review the evidence of the use of herbs in phytotherapy. Aim. To discuss plant properties and applications in otorhinolaryngology. Materials and methods. We analysed literature and collected information of phythotherapy in otorhinolaryngology. Results. The databases were searched using various keywords such as phytotherapy, otorhinolaryngology, and herbs such as: echinacea, eucalyptus, garlic, ginkgo, ginseng, kava, pelargonium sidoides, rosemary, spirulina, St John’s wort, and thyme. Conclusions. Due to the beneficial impact of meicinal plants in medicine there is a growing interest in analytical identification and quantification for clinical medicine and forensic toxicology.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 4; 359-365
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The usefulness of relaxation time using MRI measurements
    Autorzy:
    Bober, Zuzanna
    Aebisher, David
    Truszkiewicz, Adrian
    Ożóg, Łukasz
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454698.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    Magnetic Resonance Imaging
    T1 relaxation
    field strength 1.5 Tesla
    Opis:
    Introduction. Magnetic Resonance Imaging methods are now frequently used for the analysis of the diseased tissue. These methods are based on the fact that the spin-lattice, T1 , and the spin-spin, T2 , relaxation times are different in diseased tissue as compared to that of normal tissue. Aim. Here we present measurements of spin-lattice relaxation time T1 on a Magnetic Resonance Imaging scaner with field strength 1.5 Tesla. Material and methods. Measurements of T1 relaxation time and analysis of literature. Results. We provide procedure for measurements of T1 relaxation time with field strength 1.5 Tesla and present a discussion of current applications.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 3; 224-227
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Medicinal benefits from the use of Black pepper, Curcuma and Ginger
    Autorzy:
    Bober, Zuzanna
    Stępień, Agnieszka
    Aebisher, David
    Ożog, Łukasz
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454723.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    medicinal plants
    phythotherapy
    Black pepper
    Curcuma
    Ginger
    Opis:
    Introduction. Black pepper, Curcuma and Ginger are three of the most popular and most frequently used spices. Due to their beneficial medical and pharmacological properties, they are increasingly appreciated phytotheraputic plants. Most of their actions are attributed to their biochemical compositions. Aim. Our intention is to equip the reader with the information and knowledge necessary to understand the role of natural products in the drug discovery process and to enable the assessment of potential benefits and harms of plant-based medicines when advising patients who wish to use them. Material and methods. Analysis of literature. Results. In this paper, we reviewed the use of Black pepper, Curcuma and Ginger documented in the treatment of colds and flu,
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 2; 133-145
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Glycosaminoglycan concentration in cancer tissue
    Autorzy:
    Bar, Piotr
    Galiniak, Sabina
    Bartusik-Aebisher, Dorota
    Filip, Rafał
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/454799.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    fixed charge density glycosaminoglyca
    magnetic resonance imaging
    Opis:
    Introduction. Glycosaminoglycans (GAGs) play a widespread role in tissue modelling. GAG polymers may affect several receptor pathways in parallel. Aim. To present difference in concentration of GAG in healthy and cancer tissues. Material and methods. The literature search was performed nd reviewed using selected keywords. Results. We revieved the methods of detection various types of glycans measured by Magnetic Resonance Imaging. Conclusion. MRI methodology provides an efficient tool forstudy of cellular composition. The use T1 aof T2 measurements to study cancer tissue is a promising assay.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 2; 175-178
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Radio Frequency MRI coils
    Autorzy:
    Truszkiewicz, Adrian
    Aebisher, David
    Bober, Zuzanna
    Ożóg, Łukasz
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454860.pdf
    Data publikacji:
    2020-03-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    field strength 1.5 Tesla
    magnetic resonance imaging
    radio frequency coil
    Opis:
    Introduction. Magnetic Resonance Imaging (MRI) coils technology is a powerful improvement for clinical diagnostics. This includes opportunities for mathematical and physical research into coil design. Aim. Here we present the method applied to MRI coil array designs. Material and methods. Analysis of literature and self-research. Results. The coils that emit the radiofrequency pulses are designed similarly. As much as possible, they deliver the same strength of radiofrequency to all voxels within their imaging volume. Surface coils on the other hand are usually not embedded in cylindrical surfaces relatively close to the surface of the body. Conclusion. The presented here results relates to the art of magnetic resonance imaging (MRI) and RF coils design. It finds particular application of RF coils in conjunction with bore type MRI scanners.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 1; 24-27
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Infliximab in therapy of inflammatory bowels diseases
    Autorzy:
    Bar, Piotr
    Galiniak, Sabina
    Bartusik-Aebisher, Dorota
    Filip, Rafał
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/454884.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    infliximab
    TNFα
    ulcerative colitis
    Opis:
    Introduction. Infliximab is a monoclonal antibody that acts against tumor necrosis factor TNF-α. The drug is used in the treatment of autoimmune diseases. Aim. This article reviewed the efficacy and safety of infliximab for the treatment in severe ulcerative colitis. This review included studies that evaluated the clinical use of infliximab. Material and methods. This meta-analysis was performed according to systematic literature search of three major bibliographic databases (Scopus, PubMed, and Cochran). Results. Infliximab has been approved by the US Food and Drug Administration (FDA) as a medicine to treat Leśniowski and Crohn’s disease, ulcerative colitis, psoriasis, psoriatic arthritis, ankylosing spondylitis, and rheumatoid arthritis. However, further trials are required to compare other parameters of efficacy such as the clinical response with infliximab. Conclusion. In patients suffering from Crohn’s disease or ulcerative colitis under infliximab maintenance therapy, sustained good trough levels are associated with: better response and remission rates, more mucosal healing and less loss of response.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 1; 79-82
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Plants – a source of therapeutic material?
    Autorzy:
    Bober, Zuzanna
    Stępień, Agnieszka
    Aebisher, David
    Ożóg, Łukasz
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454997.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    plants
    natural products
    drug
    therapeutic material
    Opis:
    Introduction. The use of plants with therapeutic or medicinal properties is as ancient as human civilization and for many years prior to the 20th century, plants and animal products were the main source of therapeutic medicinal drugs. Aim. The discovery of new plant-derived drugs continues to be an active field of research in medical science today. The aim of this article is to describe several main classes of natural products currently under investigation. Material and methods. Analysis of literature.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2018, 1; 34-36
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Laparoscopic partial cystectomy for bladder endometriosis – case report
    Autorzy:
    Godlewski, Dominik
    Pszczółkowski, Patryk
    Góra, Tomasz
    Futyma, Łukasz
    Fedus, Tadeusz
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/454809.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    CT
    endometriosis
    MRI
    ultrasonography
    Opis:
    Introduction. Endometriosis is defined as a presence of endometrial glands and stroma outside the uterus. Urinary track endometriosis is a rare occurrence (1-2%) usually associated with bladder involvement (85%). Aim. The diagnostic evaluation is not complicated but can be delay because of the lack of specific symptoms. Description of the case. We present a case of 20-years old female with bladder endometriosis localized on the posterior wall. The patient was effective treated with laparoscopic partial cystectomy Conclusion. The patient was effective treated with laparoscopic partial cystectomy
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 4; 364-367
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of photodynamic therapy with hypericin on the secretion of selected cytokines of colorectal cancer cells tested in vitro
    Autorzy:
    Międzybrodzka, Anna
    Kawczyk-Krupka, Aleksandra
    Aebisher, David
    Cieślar, Grzegorz
    Czuba, Zenon Paweł
    Powiązania:
    https://bibliotekanauki.pl/articles/25102362.pdf
    Data publikacji:
    2023-06-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    colorectal cancer
    hypericin
    photodynamic therapy
    Opis:
    Introduction and aim. Photodynamic therapy is a complex process involving the introduction of photosensitizers into the patient’s body and irradiation of them in order to destroy the lesion, and activate the immune system. An important role in photodynamic therapy is played by photobiochemical and physical mechanisms that affect the tumor vessels and lead to the death of the damaged cell. The aim of the study is to determine the effect of photodynamic therapy with the use of Hypericin (Hyp) on the secretion of selected cytokines by colorectal cancer cells. Material and methods. Two colorectal cancer cell lines SW480 and SW620 were used in the study. Cells treated Hypericin were exposed to visible light. Then cell viability was determined by the MTT assay with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium. Assays were performed for control samples without hypericin and light exposure, with Hyp without light exposure, without Hyp and irradiated with light, and test samples with Hyp and light exposure. Results. In the experiment we reveal, that Hyp- photodynamic activity does not influence the secretion of cytokines. Conclusion. The obtaining results confirming the destructive effect of Hyp- PDT on the colon cancer cells, show a possibility of extending the indication for photodynamic therapy using Hyp, qualification of precancerous changes.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2023, 2; 194-201
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effects of hypericin-mediated photodynamic therapy on GM-CSF, MIF, VCAM-1 and ICAM-1 secretion in colorectal cancer cells in vitro
    Autorzy:
    Międzybrodzka, Anna
    Kawczyk-Krupka, Aleksandra
    Aebisher, David
    Cieślar, Grzegorz
    Czuba, Zenon Paweł
    Powiązania:
    https://bibliotekanauki.pl/articles/25102366.pdf
    Data publikacji:
    2023-06-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    colorectal cancer
    hypericin
    photodynamic therapy
    Opis:
    Introduction and aim. Photodynamic therapy with hypericin (HYP-PDT) is gaining importance as a potential treatment method for malignant neoplasms. The following study investigated whether HYP-PDT influences the secretion of certain factors of colon cancer cells in vitro. Material and methods. Two colon cancer cell lines were used in this experiment: SW480 and SW620. The cells were properly prepared and then treated with photodynamic therapy with hypericin at concentrations of 0.25 µM and 0.5 µM and irradiation at the doses of 1 J/cm2 , 5 J/cm2 and 10 J/cm2 . After using HYP-PDT, changes in the concentrations of four factors: GM-CSF, MIF, VCAM-1 and ICAM-1 were analyzed in the test tubes. Results. In the case of SW480 cells: a notable decrease in GM-CSF, MIF, VCAM-1 and ICAM-1 secretion was noted after HYP-PDT. In the case of SW620 cells, after HYP-PDT: no effect on GM-CSF secretion was noted; it inhibited the secretion of VCAM-1 and MIF and increased the secretion of ICAM-1. Conclusion. Photodynamic therapy with hypericin shows immunomodulatory potential in an in vitro cell line experiments. This may indicate its possible ability to modify the course of malignant tumors and therefore requires further research.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2023, 2; 202-216
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The use of imaging tests to obtain optimal margins in breast surgery
    Autorzy:
    Ostańska, Elżbieta
    Bartusik-Aebisher, Dorota
    Gustalik, Joanna
    Aebisher, David
    Galiniak, Sabina
    Kaznowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1597322.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    breast conserving surgery
    ductal carcinoma in situ
    extensive itraductal component invasive breast cancer
    lobular carcinoma in situ
    Opis:
    Introduction. The proper negative margins (R0) breadth in the breast - conserving surgery for invasive breast cancer (IBC) and ductal carcinoma in situ (DCIS) is very important. The presence positive surgical margins (R1) is associated with the necessity of reoperation. It delays the adjuvant therapy and psychologically burdens the patient. The re-operation increases the costs of treatment. The introduction of mammography (MMG) increased detection of DCIS by 20%. With the increase in malignancy, cancer detection decreases in MMG, inversely in MRI groving. Effective preoperative and intraoperative diagnosis aims to reduce the number of R1 resections. Aim. The size of the tumor next to its biology, determines the clinical course of the tumor. The accurate analysis of imaging tests is important. Material and methods. This analysis was performed using a systematic literature search. Results. Adequate surgical margins in breast cancer surgery for breast cancer have been reviewed. It is important to know if the cancer is multifocal and what the extent of the tumor is. Conclusion. The adequacy of margins is important for adjusting the volume of excision. It is avoiding unnecessary resection of healthy breast tissue. It is essential for a good cosmetic result and the local recurrence rate. The combination of breast MRI with conventional breast imaging resulted in the lover rate of the R1 resectios and the lower rate of the re-operation.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 3; 246-249
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Investigation of pharmaceuticals by nuclear magnetic resonance imaging and spectroscopy
    Autorzy:
    Bober, Zuzanna
    Aebisher, David
    Tabarkiewicz, Jacek
    Guz, Wiesław
    Tutka, Piotr
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454783.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    drug delivery systems
    drug forms
    magnetic resonance imaging pharmaceuticals
    Opis:
    Currently, new and easier ways of analyzing pharmaceutical drug forms and drug delivery mechanisms are being sought. Magnetic resonance imaging (MRI) is a non-invasive imaging technique that images drug forms such as tablets, liquids and topicals and drug form behavior in living organisms on both the tissue and cellular scale. The advantages of MRI include noninvasiveness, variable sample capacity and ease of transfer of phantom results to in vitro and in vivo studies. This review concerns the usefulness of clinical MRI that cannot be understated as this technique provides non-invasive and non-destructive insight into the properties of drug delivery systems. The research discussed here concerns the use of magnetic resonance, spectroscopy and chromatography to investigate selected pharmaceuticals and covers work of selecting drugs and antibodies for modification by synthesis for evaluation by MRI. Modifications have been aimed at improving therapeutic efficacy, delivery, and MRI. Modification conditions such as (pH, concentration, temperature, and the influence of other components present in the solutions) will be discussed to understand drug delivery system improvements and the reliability and repeatability of the results obtained. We hope to explore and expand the scope of pharmaceutical imaging with MRI for application in clinical medicine.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 110-119
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    19F MRI As a tool for imaging drug delivery to tissue and individual cells
    Autorzy:
    Bober, Zuzanna
    Aebisher, David
    Ożóg, Łukasz
    Tabarkiewicz, Jacek
    Tutka, Piotr
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454941.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    drug delivery
    drug tracking
    fluorine
    magnetic resonance imaging
    Opis:
    Over the past few decades, magnetic resonance imaging (MRI) has proven to be extremely successful in medical applications. More recently, the biomedical applications of MRI have been gaining more use in the field of clinical pharmacy. In 1977, perfluorocarbon compounds (PFC), which form emulsions that can carry drugs, were analyzed by 19F MRI and emulsified PFC compounds have been investigated as potential blood substitutes since the early 1960s and now a wide variety of PFC compounds are currently available as 19F MRI biomarkers. Molecules with 19F substituents are particularly attractive for use in drug tracking by 19F MRI due to 100% 19F abundance, high 19F MRI sensitivity (0.83 relative to 1H MRI) and an impressively large chemical shift range (400 ppm). Another benefit in the use of 19F MRI is a zero background signal in biological samples due to lack of endogenous fluorine. Therefore, drugs containing fluorine atom have potential for 19F MRI imaging drug delivery to tissue. This article will review recent developments in the use of 19F MRI in imaging drug delivery to tissue and individual cells.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 99-109
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Magnetic Resonance Elastography – noninvasive method to assess liver disease
    Autorzy:
    Ożóg, Łukasz
    Aebisher, David
    Bober, Zuzanna
    Bartusik-Aebisher, Dorota
    Guz, Wiesław
    Cholewa, Marian
    Powiązania:
    https://bibliotekanauki.pl/articles/454714.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    fibrosis
    liver stiffness
    MRE
    magnetic resonance imaging
    Opis:
    Currently, liver disease is widespread and the awareness of these diseases is low. Early symptoms of liver disease do not necessarily indicate problems with this organ and patients are usually informed of their problems when the stage of the disease is already advanced. Invasive biopsies are the clinical diagnostic method most commonly used in the evaluation of liver disease. A biopsy is associated with a high risk of false results and additional complications. Finding new non-invasive imaging methods has led to the discovery of a new method called Magnetic Resonance Elastography (MRE). This technique allows one to evaluate the mechanical properties of tissues and to distinguish between pathological states. Testing using this technique can be performed on a conventional magnetic resonance system by using few additional components and properly prepared software. Studies have shown that there is a strong correlation between MRE-measured liver stiffness and the degree of fibrosis. MRE is also useful in characterizing liver tumors. Studies show that this technique is highly credible in both health volunteers and patients with liver fibrosis. MRE has tremendous diagnostic potential. The described technique is not currently widely used and has the 127-132potential to serve as a safe and accurate alternative in clinical diagnostics in the future.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 127-132
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Imaging studies of kidney cancer
    Autorzy:
    Przyczyna, Piotr
    Aebisher, David
    Gustalik, Joanna
    Galiniak, Sabina
    Bartusik-Aebisher, Dorota
    Kaznowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1597349.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    Kidney cancer
    MRI
    PET
    Opis:
    In 2017 in the USA about 5% in men and 3% in women newly diagnosed cases of malignant tumors were kidney and renal pelvis cancer. Aim. Kidney cancer in adults includes malignant tumors derived from kidney parenchyma and renal pelvis. The dominating types are kidney parenchyma, and mainly renal cell carcinomas Material and methods. This review was performed according to systematic literature search of three major bibliographic databases (Scopus, PubMed, and Cochran). Results. Imaging studies play a very important role in kidney cancer. They allow one to assess the clinical stage, justify the extent of surgery and have an impact on the prognosis. Conclusion. The field for research involves the use of magnetic resonance and positron emission tomography in diagnosing kidney changes.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 4; 334-337
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Sciatic vessels – a case report
    Autorzy:
    Gałuszka, Łukasz
    Leksa, Natalia
    Leksa, Dawid
    Uryniak, Adam
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/2040141.pdf
    Data publikacji:
    2020-12-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    artery
    sciatic vessels
    surgical treatment
    Opis:
    Introduction. Sciatic vessels most often accompany the sciatic nerve. Sciatic vessels are very rare. Aim. In this paper we determine the procedure in sciatic vessels surgical treatment. Description of the case. We present the case of a 75-year-old patient with symptoms of acute right lower limb ischemia. The patient was discharged home in good condition, and remains in outpatient control to this day. Conclusion. The popliteal artery proved to be available, but much deeper than usual.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 4; 326-327
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Adrenomyeloneuropathy – a case report
    Autorzy:
    Leksa, Natalia
    Aebisher, David
    Galiniak, Sabina
    Uberman-Kluz, Dominika
    Bartosz, Serweryn
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454995.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    adrenoleukodystrophy
    fatty acids
    steroid therapy
    Opis:
    Introduction. Adrenoleukodystrophy is a genetic disorder linked to the X chromosome, in which the peroxisomal beta-oxidation process is disturbed. It is a metabolic disease that results in the accumulation of very long chain fatty acids (VLCFAs - very long chain fatty acids) responsible for the symptoms of damage to the adrenal cortex, gonads and the brain. Aim. A clinical case is reported. Description of case. This article describes the case of a 64-year-old woman who had neurological symptoms for many years, gradually increasing without significant improvement after the treatment (periodic steroid therapy). Conclusion. Based on tests (including the determination of the ABCD1 gene and very long chain fatty acids - VLCFA), adrenoleukodystrophy was suspected.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 3; 274-276
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    An iliac artery aneurysm
    Autorzy:
    Leksa, Natalia
    Leksa, Dawid
    Gałuszka, Łukasz
    Uryniak, Adam
    Aebisher, David
    Galiniak, Sabina
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/2038415.pdf
    Data publikacji:
    2020-09-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    arteriograph
    iliac artery aneurysms
    intravascular therapy
    Stent-Graft
    Opis:
    Introduction. Isolated common iliac artery aneurysms (CIAs) are rare. The rarer are rupture of the common iliac artery. We can treat them surgically: classic or endovascular. Open surgery has a main role in the management of aneurysms not suitable for repair by endovascular techniques. Aim. The aim of the study is to present the possibility of occurrence of such a disease at a young age, to indicate non-characteristic symptoms that may predict the above-mentioned disease entity at the level of a primary care physician or SOR. Review of medical publications from 2000-2019 regarding guidelines or methods of conduct in that cases. Description of the case. A patient 39 years old, admitted to the Department of Vascular Surgery, in an interview: about 15 years ago severely beaten, as a result of injuries total loss of hearing, memory and basic skills such as: speech, writing, reading, hospitalized over 6 months. Conclusion. Good rehabilitation and patient persistence restored cognitive skills. Advances in surgical has lowered the mortality and morbidity rates even in patients.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 3; 242-244
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Stroke masks – a case report
    Autorzy:
    Chmielewska, Beata
    Leksa, Natalia
    Aebisher, David
    Galiniak, Sabina
    Leksa, Dawid
    Bartosz, Seweryn
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/2038416.pdf
    Data publikacji:
    2020-09-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    brain metabolic disorders
    MRI
    stroke
    Opis:
    Introduction. Stroke is a common vascular disease encountered in the work of a practitioner. Despite this, his differentiation is difficult. This is due to a variety of diseases that can be a “mask” for stroke. These are neurological diseases other than vascular (brain tumors, epilepsy), head injuries and a number of metabolic disorders (fluctuations in glucose, electrolytes). Aim. This work aims to approximate the differentiation of this common disease entity. Case reports show both clinical view and diagnostic difficulties. Description of the cases. Case 1. The patient 59 years old treated for bipolar disorder, hypertension and alcohol abuse. Case 2. The patient 68 years old treated for type 2 diabetes, hypertension, ischemic heart disease, cholecystolithiasis – cholecystectomy. Conclusion. Stroke is a significant clinical and social problem both in Poland and in the world. Despite this, its diagnostics and especially differentiation is difficult. When analyzing the case of each patient with suspected sudden CNS vascular disease, all of them should be remembered. It should also be borne in mind that differential diagnosis cannot delay specific treatment for stroke
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 3; 245-249
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Infliximab MRI relaxation time in solution
    Autorzy:
    Bober, Zuzanna
    Bar, Piotr
    Pasternak, Grzegorz
    Galiniak, Sabina
    Bartusik-Aebisher, Dorota
    Filip, Rafał
    Aebisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/454757.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    infliximab
    magnetic resonance imaging relaxation time
    Opis:
    Introduction. The use of Quantitative Magnetic Resonance Imaging to drug monitoring in vitro or in vivo can provides a powerful means to map the effects of drugs on tissue activity. Aim. The purpose of this study was to measure relaxation time of antibody phantom. For this purpose, infliximab sample was used. Material and methods. The selected methods to detect relaxation time of antibody was Magnetic Resonance Imaging technique. We detected spin-lattice (T1 ) relaxation time and discuss differences where compare to water. Results. The measurements ofspin-lattice (T1 ) relaxation time showed significant differences. The results obtained in phantom indicate that we can use this result for measurements of relaxation time in vitro. Conclusion. Infliximab is approved for severe cases of rheumatoid arthritis, together with methotrexate, for pronounced psoriasis and psoriasis-arthritis, ankylosing spondylitis as well as for chronic inflammatory bowel disease. We conclude, that Quantitative Magnetic Resonance Imaging can be used to monitor drug effects
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 1; 22-25
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Lycopene activity on lung and kidney cancer cells by T2 relaxation time 1 H Magnetic Resonance Imaging in vitro
    Autorzy:
    Pogoda, Katarzyna
    Pucka, Maria
    Tabarkiewicz, Jacek
    Bober, Zuzanna
    Aebisher, David
    Galiniak, Sabina
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/454731.pdf
    Data publikacji:
    2020-03-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    cell cultures
    lung cancer
    lycopene
    kidney cancer
    magnetic resonance imaging relaxation times
    Opis:
    Introduction. The paper presents the results of a study of cell cultures of lung cancer and kidney cancer using lycopene performed using clinical magnetic resonance imaging. Aim. The aim of the study was to evaluate lycopene activity on tumor cell cultures. Material and methods. For this purpose, MR tests were performed using the technique of determining transverse relaxation. Results. Described here studies demonstrated that lycopene may inhibit the growth of A549 and ACHN cell lines. Conclusion. We determine changes in spin lattice relaxavity T2 to monitor treatment of lung cancer cell line A549 and kidney cancer cell line ACHN cells treatment with lycopene.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 1; 5-9
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Diagnostic and therapeutic difficulties of tick-borne encephalitis – a two case reports
    Autorzy:
    Przetacznik, Dominika
    Leksa, Natalia
    Aebisher, David
    Galiniak, Sabina
    Bartosz, Seweryn
    Leksa, Dawid
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/2037691.pdf
    Data publikacji:
    2020-06-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    diagnostic
    tick borne encephalitis
    treatments
    Opis:
    Introduction. The paper presents epidemiology, routes of infection, forms of the disease, diagnostic and treatment methods, and prophylaxis of tick-borne encephalitis. Aim. In this paper, we present two descriptions of the cases of tick-borne encephalitis. Description of the cases. Case 1. A 60-year-old man with fever up to 39 degrees for 3 days, multi-site headache and other body aches, as well as an earstuck feeling. The day before hospitalization, there was a feeling of numbness on the right side of the face from eye level to the chin and speech distortion. Case 2. A 60-year-old patient with headaches and an increase in temperature to 39 degrees for 3 days, who, approximately, three weeks earlier was ticked by a tick in the lower parts of the back. Conclusion. It is also important for doctors to take a broader view and to make society aware of that Lyme disease is not associated only with Lyme disease. Further work is also needed towards effective treatments for Tick-borne encephalitis (TBE).
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 2; 135-140
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Generation of retractive spine circuits in the process of vitamin B12 deficiency
    Autorzy:
    Mucha, Patrycja
    Leksa, Natalia
    Aebisher, David
    Galiniak, Sabina
    Bartosz, Seweryn
    Leksa, Dawid
    Bartusik-Aebisher, Dorota
    Powiązania:
    https://bibliotekanauki.pl/articles/2037833.pdf
    Data publikacji:
    2020-06-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    ataxia
    B12 avitaminosis
    retinal spinal cord degeneratio
    Opis:
    Introduction. Subacute degeneration of the posterior and lateral spinal cord is a rare neurological complication of B12 avitaminosis. Aim. In this paper, we present the case of a 65-year-old man who, in the course of long-term vitamin B12 deficiency associated with atrophic gastritis, developed a severe set of neurological symptoms that are part of the retinal spinal cord degeneration with characteristic features in MR imaging of the cervical spine in the form of an inverted “V mark” ‘in axial images and typical localization in the spinal cord. Description of the case. After careful analysis of the syndrome and making an early diagnosis, parenteral vitamin B12 supplementation began, resulting in improved neurological status, laboratory parameters as well as regression of changes in magnetic resonance imaging. Conclusion Significant symptoms of this syndrome are paresthesia in the distal parts of the limbs, ataxia, spastic paresis.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 2; 131-134
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    ASL (Arterial Spin Labeling) – historical and current perfusion MR methods
    Autorzy:
    Guz, Wiesław
    Bober, Zuzanna
    Ożóg, Łukasz
    Truszkiewicz, Adrian
    Przypek, Aneta
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Urbanik, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/454978.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    perfusion
    MR
    ASL
    Opis:
    Despite continuous scientific and technological advances in MR imaging, MR perfusion methods have not yet been widely deployed for routine clinical diagnostics. This is especially true for ASL (arterial spin labelling) methods used to evaluate cerebral perfusion. This method does not require a contrast agent, as new discoveries about gadolinium accumulation in the cerebellum and brain nucleus appear to be a valuable asset and provide the opportunity to be more widely deployed in clinical practice. The aim of this paper is to present the historical determinants of the development of MR perfusion techniques, the disadvantages and advantages and possible clinical applications and prospects of ASL development. Both historical articles published on MR in the 1990s and current research between 2006-2016 have been reviewed. The authors present in the work the MR perfusion method focusing on issues related to arterial spin labeling (ASL). Historically CASL (continuous ASL) and PCSL (pulsed ASL) techniques have been described and the pseudocontinuous ASL (pseudocontinuous ASL) 3D technique presents its technical and methodological considerations, advantages and disadvantages over previous methods. The methods of test protocol optimization and accompanying artifacts, as well as possible clinical applications and development perspectives, have been described.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 145-150
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Epidemiology of breast cancer in Podkapackie voivodship
    Autorzy:
    Gustalik, Joanna
    Bartusik-Aebisher, Dorota
    Ostańska, Elżbieta
    Przyczyna, Piotr
    Osuchowski, Michał
    Aebisher, David
    Galiniak, Sabina
    Kaznowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/454657.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    breast cancer
    statistics
    epidemiology
    podkarpackie voivodship
    Opis:
    Introduction. Breast cancer is the second most prevalent reason for cancer deaths after lung cancer. Incidence rates have increased worldwide. Aim. To present epidemiology of breast cancer in Podkapackie voivodship. Material and methods. This analysis was performed using a systematic literature search. Results. In the Podkarpackie voivodship up until 2014, the incidence rate of female breast cancer was rising and in 2015 it dropped by 68 cases. Even though the survival rate is increasing, it is still one of the leading causes of cancer deaths placing second after lung cancer. Conclusion. Mortality rate, unfortunately, rose gradually. This shows that even though there is a National Health Program aiming at breast cancer awareness and prevention, it is still not enough to reduce the number of breast cancer deaths.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 3; 242-245
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Clinical application of advanced neuroimaging techniques – Magnetic Resonance Spectroscopy
    Autorzy:
    Guz, Wiesław
    Bober, Zuzanna
    Ożóg, Łukasz
    Truszkiewicz, Adrian
    Przypek, Aneta
    Aebisher, David
    Bartusik-Aebisher, Dorota
    Urbanik, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/454826.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    spectroscopy
    MR
    SVS
    CSI
    Opis:
    Continuous scientific research and the increasing saturation of the medical market in Poland implements the possibilities of using advanced MR techniques including MRS in everyday practice. This method, which has so far been used primarily for research purposes, can bring measurable benefits to patients not only in terms of clarifying diagnosis and narrowing differential diagnosis, but also monitoring the course of various diseases and their treatment. Here we present the basic principles of performing and interpreting spectroscopic spectra and possible clinical applications and development prospects of MRS. The literature reviewed both Polish and foreign articles both historically and in the past 10 years. The paper presents methodological issues related to the proper performance of magnetic resonance spectroscopy (MRS) and spectral composition and the role of major metabolites, as well as current clinical applications and directions of MRS development.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2017, 2; 133-140
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Coagulation markers in diagnostic and monitoring of thromboembolic complication in COVID-19
    Autorzy:
    Czarnecka-Czapczyńska, Magdalena
    Bartusik-Aebisher, Dorota
    Krupka-Olek, Magdalena
    Aebisher, David
    Cieślar, Grzegorz
    Latos, Wojciech
    Kawczyk-Krupka, Aleksandra
    Powiązania:
    https://bibliotekanauki.pl/articles/2040166.pdf
    Data publikacji:
    2021-09-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    anticoagulation
    coagulation abnormalities
    COVID-19
    Opis:
    Introduction. Coronavirus disease 2019 (COVID-19) was first observed in China in Wuhan city, Hubei province in December, 2019, and specified as a pandemic by the World Health Organization (WHO). COVID-19 is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV2). Aim. The aim of this article is to discuss epidemiology of thromboembolic complication in COVID-19. Material and methods. This article is a review done in regards to discuss clinical features of the anticoagulation treatment in COVID-19. Analysis of the literature. A review is discussed an anticoagulation treatment in 41 manuscripts. Conclusion. Most commonly coagulation abnormalities in patient with COVID-19 is mild thrombocytopenia. Apart from their typical role in thrombosis and hemostasis, platelets mediate key aspects of immune and inflammatory.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2021, 3; 241-245
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The role of new biomarkers for the diagnosis and treatment of colon cancer
    Autorzy:
    Czarnecka-Czapczyńska, Magdalena
    Bartusik-Aebisher, Dorota
    Krupka-Olek, Magdalena
    Aebisher, David
    Cieślar, Grzegorz
    Latos, Wojciech
    Kawczyk-Krupka, Aleksandra
    Powiązania:
    https://bibliotekanauki.pl/articles/2040510.pdf
    Data publikacji:
    2021-12-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    colon cancer
    diagnosis
    treatment
    Opis:
    Introduction. Colorectal cancer may be benign or malignant. According to the World Health Organization and CDC, it is the second most common cancer worldwide, after lung cancer. The mortality of colorectal cancer has been dropping for more than 20 years due to the improvements in screening techniques and treatments. Aim. The aim of this article is to discuss the role of new biomarkers for the diagnosis and treatment of colon cancer. Material and methods. This article is a review done in regards to discuss the role of new biomarkers for the diagnosis and treatment of colon cancer. Analysis of the literature. A review is discussed the role of new biomarkers for the diagnosis and treatment of colon cancer using current literature. Conclusion. The screening tests based on diagnostic new biomarkers may cause faster detection of cancer and risk factors, and provide prognostic information in order to adjust individual therapy.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2021, 4; 326-329
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cytisine parameters measured in the 1.5 Tesla magnetic field
    Autorzy:
    Bober, Zuzanna
    Galiniak, Sabina
    Leksa, Dawid
    Dynarowicz, Klaudia
    Aebisher, David
    Ostańska, Elżbieta
    Czmil, Anna
    Bar, Piotr
    Bartusik-Aebisher, Dorota
    Tutka, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/454807.pdf
    Data publikacji:
    2020-03-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    cytisine
    desmoxan
    magnetic resonance imagin
    tabex
    Opis:
    Introduction. Cytisine, Cytisinum (C11H14N2O), is an organic chemical compound. Cytisine is heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family. Aim. The aim of the study is to measure the influence of water on the form of drug in the magnetic field 1.5 Tesla. Material and methods. For this purpose, magnetic resonance imaging tests were performed to check the solubility of pure cytisine, Desmoxan tablets and Tabex capsules. Results. From a pharmacological point of view, both Desmoxan tablets and Tabex capsules should exert the same effect on the human body, this is due to the identical content of the active substance, in this case cytisine (1.5 mg). Conclusion. The differences in the results obtained may be related to additional excipients that contain medications, but it is believed that they should not have a negative impact on the action of the active substances.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 1; 16-19
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A 16-year-old patient with Charcot Marie Tooth disease in variant c.217G>C of the INF2 gene and focal glomerulosclerosis – a case report
    Autorzy:
    Przygoda, Maria
    Matias, Dawid
    Jurczak, Maciej
    Sokołowska, Aldona
    Raba, Karolina
    Wołkanowski, Juliusz
    Rydzanicz, Małgorzata
    Kosińska, Joanna
    Płoski, Rafał
    Aebisher, David
    Pyrkosz, Antoni
    Powiązania:
    https://bibliotekanauki.pl/articles/2040499.pdf
    Data publikacji:
    2021-12-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    exome sequencing
    neuropathy
    nephropathy
    Opis:
    Introduction. Charcot Marie Tooth disease (CMT) is currently one of the most commonly diagnosed and commonly hereditary sensorimotor neuropathies. Concluding from the literature, this is the first study describing the case of a patient with CMT disease in the c.217G> C variant of the INF2 gene and focal segmental glomerulosclerosis. Aim. To present a case of a 16-year-old patient suffering from CMT disease in variant c.217G> C of the INF2 gene and focal glomerulosclerosis. Description of the case. The text describes the CMT disease in a patient who underwent the WES / WGS-NGS genetic test and found a mutation within the INF2 gene at the chromosomal position hg38 14: 104701582-G> C, cDNA level c.217 G> C , notation at the p protein level (Gly73Arg). Genotype record according to Human Genome Variation Society: NM_022489.4: c. [217G> C]; [217 =]. The publication includes data on genetics, molecular mechanisms of the disease, diagnostic methods, rehabilitation and surgical treatment. Conclusion. CMT disease is a heterogeneous group of diseases caused by mutations in various genes. The incidence of this pathology has increased significantly in the last century. Currently, there are no treatments available to combat this disease, and symptomatic treatment is the only treatment available.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2021, 4; 341-346
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The potential of intracellular 13C MR spectroscopy to study the absolute configuration of endogenous and polarized alanine
    Autorzy:
    Leksa, Natalia
    Pękala, Anna
    Pardak, Piotr
    Dziedzic, Rafał
    Bartusik-Aebisher, Dorota
    Filip, Rafał
    Galiniak, Sabina
    Aeisher, David
    Powiązania:
    https://bibliotekanauki.pl/articles/454702.pdf
    Data publikacji:
    2020-03-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    13C NMR
    dynamic nuclear polarization hyperpolarized carbon
    Opis:
    Introduction. Quantitative and accurate monitoring of tumor makes hyperpolarized carbon (13C) Magnetic Resonance Imaging and Spectroscopy (MRI/S) a powerful tool for in vivo metabolic and structural study. Moreover, the studies of the properties and functions in tumor tissue of the compounds of carbon (C) that are organic, are fundamental to tumor biochemistry. Aim. To review 13C MR spectroscopy to study the absolute configuration of endogenous and polarized alanine. Material and methods. An analysis of literature regarding 13C MR spectroscopy of polarized alanine. Results. Current evidence suggests that the determination of absolute configurations of amino acids play significant role in physiological mechanisms during tumor growth and treatment. Conclusions. Nearly 50% nuclear polarization for 13C can be achieved in various organic molecules when Dynamic Nuclear Polarization DNP is performed in a strong magnetic field and at cryogenic temperatures.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2020, 1; 20-23
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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